412
Views
8
CrossRef citations to date
0
Altmetric
Systematic Review

Salivary biomarkers associated with obstructive sleep apnea: a systematic review

, , &
Pages 223-233 | Received 23 Nov 2020, Accepted 05 Jan 2021, Published online: 17 Jan 2021

References

  • Mansukhani MP, Kolla BP, Ramar K. International Classification of sleep disorders 2 and American academy of sleep medicine practice parameters for central sleep apnea. Sleep Med Clin. 2014;9:1–11.
  • Young T, Palta M, Dempsey J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin sleep cohort study. WMJ. 2009;108:246–249.
  • George CFP. Sleep apnea, alertness, and motor vehicle crashes. Am J Respir Crit Care Med. 2007;176:954–956.
  • Lorenzi-Filho G, Drager LF. Type I diabetes: a new risk factor for obstructive sleep apnea. Revista Portuguesa de Pneumologia (English Edition). 2015;21:53–54.
  • Wallace A, Bucks RS. Memory and obstructive sleep apnea: a meta-analysis. Sleep. 2013;36:203–220.
  • Wheaton AG, Perry GS, Chapman DP, et al. Sleep disordered breathing and depression among U.S. adults: national health and nutrition examination survey, 2005-2008. Sleep. 2012;35:461–467.
  • Chen Y-H, Keller JK, Kang J-H, et al. Obstructive sleep apnea and the subsequent risk of depressive disorder: a population-based follow-up study. J Clin Sleep Med. 2013;9:417–423.
  • Liu L, Kang R, Zhao S, et al. Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis. J Sex Med. 2015;12:1992–2003.
  • Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010;122:352–360.
  • Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology. 2016 Sep 27;87(13):1407–16. doi: 10.1212/WNL.0000000000003037
  • Diken ÖE, Arslan M, Deniz H, et al. The association between hypertension and neutrophil to lymphocyte ratio in patients with obstructive sleep apnea syndrome. Eur Respir J. 2016;48:2067.
  • Kay JM, Michael Kay J. Hypoxia, obstructive sleep apnea syndrome, and pulmonary hypertension. Hum Pathol. 1997;28:261–263.
  • Cheitlin MD. Frequency and impact of pulmonary hypertension in patients with obstructive sleep apnea syndrome. Yearb Cardiol. 2010;2010:513–516.
  • Kosseifi S, Bailey B, Price R, et al. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients. Mil Med. 2010;175:913–916.
  • Greenberg H, Rajan P. Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus. Nat Sci Sleep. 2015;7:113.
  • Türkay C, Ozol D, Kasapoğlu B, et al. Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia. Respir Care. 2012;57:244–249.
  • Blagojevic-Bucknall M, Mallen C, Muller S, et al. The risk of gout among patients with sleep apnea: a matched cohort study. Arthritis Rheumatol. 2019;71:154–160.
  • Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–1235.
  • Duarte RLM, da Silveira FJM, Morbid O. Obstructive sleep apnea and breathe. How different are they in a sleep laboratory population? Am J Respir Crit Care Med. 2010;181:A5081.
  • Singh P, Somers VK. Obstructive sleep apnea, diabetes, and obesity: partners in crime? Sleep Med. 2016;25:162–163.
  • Silverberg D. Sleep related breathing disorders are common contributing factors to the production of essential hypertension but are neglected, underdiagnosed, and undertreated. Am J Hypertens. 1997;10:1319–1325.
  • Kapur V, Blough DK, Sandblom RE, et al. The medical cost of undiagnosed sleep apnea. Sleep. 1999;22:749–755.
  • Finkel KJ, Searleman AC, Tymkew H, et al. Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center. Sleep Med. 2009;10:753–758.
  • Yamagishi K, Ohira T, Nakano H, et al. Cross-cultural comparison of the sleep-disordered breathing prevalence among Americans and Japanese. Eur Respir J. 2010;36:379–384.
  • Watson NF. Health Care Savings: the Economic Value of Diagnostic and Therapeutic Care for Obstructive Sleep Apnea. J Clin Sleep Med. 2016;12:1075–1077.
  • Vgontzas AN, Li Y, He F, et al. Mild-to-moderate sleep apnea is associated with incident hypertension: age effect. Sleep. 2019;42:zsy265.
  • Won CHJ, Qin L, Selim B, et al. Varying hypopnea definitions affect obstructive sleep apnea severity classification and association with cardiovascular disease. J Clin Sleep Med. 2018;14:1987–1994.
  • Gozal D. Serum, urine, and breath-related biomarkers in the diagnosis of obstructive sleep apnea in children. Curr Opin Pulm Med. 2012;18:561–567.
  • Shih JL, Malhotra A. Could vitamins be helpful to patients with sleep apnea? Chest. 2011;139:237–238.
  • Montesi SB, Bajwa EK, Malhotra A. Biomarkers of sleep apnea. Chest. 2012;142:239–245.
  • Archontogeorgis K, Nena E, Papanas N, et al. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med. 2014;2014:1–15.
  • De Luca Canto G, Pachêco-Pereira C, Aydinoz S, et al. Biomarkers associated with obstructive sleep apnea and morbidities: a scoping review. Sleep Med. 2015;16:347–357.
  • Spielmann N, Wong DT. Saliva: diagnostics and therapeutic perspectives. Oral Dis. 2011;17:345–354.
  • Al-Tarawneh SK, Border MB, Dibble CF, et al. Defining salivary biomarkers using mass spectrometry-based proteomics: a systematic review. OMICS. 2011;15:353–361.
  • Allen RK, Edelmann AR, Abdulmajeed A, et al. Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review. Orthod Craniofac Res. 2019;22(Suppl 1):14–20.
  • Bencharit S, Mack CR, Howard-Williams EL. Recent studies and patents in salivary protein biomarkers for diabetes. Recent Pat Biomarkers. 2012;2:1–5.
  • Border MB, Schwartz S, Carlson J, et al. Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst. 2012;8:1304–1310.
  • Bencharit S, Baxter SS, Carlson J, et al. Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis. Mol Biosyst. 2013;9:2785–2797.
  • Moher D, Liberati A, Tetzlaff J, et al. Reprint—preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Phys Ther. 2009;873–880. DOI:10.1093/ptj/89.9.873
  • Siber-Hoogeboom R, Schicht M, Hoogeboom S, et al. Obstructive sleep apnea and rhonchopathy are associated with downregulation of trefoil factor family peptide 3 (TFF3)—Implications of changes in oral mucus composition. Plos One. 2017;12:e0185200.
  • Zheng H, Li R, Zhang J, et al. Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases. Sci Rep. 2014;4:7046.
  • Akpinar ME, Yigit O, Altundag A, et al. Salivary and serum myeloperoxidase in obstructive sleep apnea. J Otolaryngol Head Neck Surg. 2012;41:215–221.
  • Tóthová Ľ, Celec P, Mucska I, et al. Short-term effects of continuous positive airway pressure on oxidative stress in severe sleep apnea. Sleep Breath. 2019;23:857–863.
  • Nizam N, Basoglu OK, Tasbakan MS, et al. Salivary cytokines and the association between obstructive sleep apnea syndrome and periodontal disease. J Periodontol. 2014;85:e251–e258.
  • Nizam N, Basoglu OK, Tasbakan MS, et al. Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case–control study. Arch Oral Biol. 2015;60:134–143.
  • Nizam N, Basoglu OK, Tasbakan MS, et al. Is there an association between obstructive sleep apnea syndrome and periodontal inflammation? Clin Oral Investig. 2016;20:659–668.
  • Ghiciuc CM, Dima Cozma LC, Bercea RM, et al. Restoring the salivary cortisol awakening response through nasal continuous positive airway pressure therapy in obstructive sleep apnea. Chronobiol Int. 2013;30:1024–1031.
  • Ghiciuc CM, Dima-Cozma LC, Bercea RM, et al. Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study. Braz J Otorhinolaryngol. 2016;82:529–535.
  • Kawai M, Kirkness JP, Yamamura S, et al. Increased phosphatidylcholine concentration in saliva reduces surface tension and improves airway patency in obstructive sleep apnoea. J Oral Rehabil. 2013;40:758–766.
  • Raff H, Ettema SL, Eastwood DC, et al. Salivary cortisol in obstructive sleep apnea: the effect of CPAP. Endocrine. 2011;40:137–139.
  • Liu -Y-Y, Gao L, Zong J, et al. Identification of differential proteins in pharyngeal airway surface liquid of the patients associated with obstructive sleep apnea syndrome by proteome analysis. 2013 10th IEEE International Conference on Control and Automation (ICCA). 2013; Hangzhou, China. doi:10.1109/icca.2013.6565164
  • Yan YR, Zhang L, Lin YN, et al. The association of salivary biomarkers with the severity of obstructive sleep apnea and concomitant hypertension. Am J Med Sci. 2019;357:468–473.
  • Traxdorf M, Wendler O, Tziridis K, et al. S100B in serum and saliva: a valid invasive or non-invasive biomarker in obstructive sleep apnea? Eur Rev Med Pharmacol Sci. 2016;20:4766–4774.
  • Thimgan MS, Toedebusch C, McLeland J, et al. Excessive daytime sleepiness is associated with changes in salivary inflammatory genes transcripts. Mediators Inflamm. 2015;2015:539627.
  • de Almeida PDV, Grégio AMT, Machado MAN, et al. Saliva composition and functions: a comprehensive review. J Contemp Dent Pract. 2008;9:72–80.
  • Ligtenberg AJM, Veerman ECI. Saliva: secretion and functions. Karger Medical and Scientific Publishers; 2014; Basel, Switzerland.
  • Humphrey SP, Williamson RT. A review of saliva: normal composition, flow, and function. J Prosthet Dent. 2001;85:162–169.
  • Pedersen AM, Bardow A, Beier Jensen S, et al. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 2002;8:117–129.
  • Bardow A, Nyvad B, Nauntofte B. Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ. Arch Oral Biol. 2001;46:413–423.
  • Xiao H, Wong DTW. Method development for proteome stabilization in human saliva. Anal Chim Acta. 2012;722:63–69.
  • Park NJ, Zhou X, Yu T, et al. Characterization of salivary RNA by cDNA library analysis. Arch Oral Biol. 2007;52:30–35.
  • Canto GDL, De Luca Canto G, Pachêco-Pereira C, et al. Biomarkers associated with obstructive sleep apnea: A scoping review. Sleep Med Rev. 2015:28–45. DOI: 10.1016/j.smrv.2014.11.004
  • Brown LL, Tomarken AJ, Orth DN, et al. Individual differences in repressive-defensiveness predict basal salivary cortisol levels. J Pers Soc Psychol. 1996;70:362–371.
  • Klimes–dougan B, Hastings PD, Granger DA, et al. Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Dev Psychopathol. 2001;13:695–719.
  • Rosmalen JGM, Oldehinkel AJ, Ormel J, et al. Determinants of salivary cortisol levels in 10–12 year old children; a population-based study of individual differences. Psychoneuroendocrinology. 2005;30:483–495.
  • Park C-S, Guilleminault C, Hwang S-H, et al. Correlation of salivary cortisol level with obstructive sleep apnea syndrome in pediatric subjects. Sleep Med. 2013;14:978–984.
  • Schmoller A, Eberhardt F, Jauch-Chara K, et al. Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea. Metabolism. 2009;58:848–853.
  • Tseng T, Iosif A-M, Seritan AL. Stress effects: a study of salivary cortisol levels in third-year medical students. Stress Health. 2011;27:436–440.
  • Patacchioli FR, Tabarrini A, Ghiciuc CM, et al. Salivary biomarkers of obstructive sleep apnea syndrome in children. Pediatr Pulmonol. 2014;49:1145–1152.
  • Celec P, Hodosy J, Behuliak M, et al. Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure. Sleep Breath. 2012;16:393–398.
  • Park C-S, Guilleminault C, Park H-J, et al. Correlation of salivary alpha amylase level and adenotonsillar hypertrophy with sleep disordered breathing in pediatric subjects. J Clin Sleep Med. 2014;10:559–566.
  • Yan W, Apweiler R, Balgley BM, et al. Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl. 2009;3:116–134.
  • Al-Tarawneh SK, Bencharit S. Applications of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry in defining salivary proteomic profiles. Open Dent J. 2009;3:74–79.
  • Jeong J-H, Guilleminault C, Park C-S, et al. Changes in salivary cortisol levels in pediatric patients with obstructive sleep apnea syndrome after adenotonsillectomy. Sleep Med. 2014;15:672–676.
  • Papaioannou I, Twigg GL, Kemp M, et al. Melatonin concentration as a marker of the circadian phase in patients with obstructive sleep apnoea. Sleep Med. 2012;13:167–171.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.