Monitoring hepatitis B by using point-of-care testing: biomarkers, current technologies, and perspectives

References

• Christopher S, Upadhyaya PM Gprevalence of hepatitis B and carrier rate in general popupation at a tertiary care hospital. Journal of Evolution of Medical and Dental Sciences-Jemds, 2018,7( 3):356–360.
   Google Scholar
• Wright Cameron M, Lydia B, Thi HN, et al. A systematic review of hepatitis B screening economic evaluations in low- and middle-income countries. BMC Public Health 2018,18(1):373.
   PubMedGoogle Scholar
• Hellard Margaret E, Roger C, Philippa E.WHO guidelines on testing for hepatitis B and C – meeting targets for testing. BMC Infect Dis,2017,17(1):703.
   PubMedGoogle Scholar
• Ganem D, Prince AM Mechanisms of disease: hepatitis B virus infection - Natural history and clinical consequences. N Engl J Med, 2004,350(11):1118–1129.
   PubMed Web of Science ®Google Scholar
• Yudong W, Weisheng G, Weipan P, et al. Enhanced fluorescence elisa based on hat triggering fluorescence “turn-on” with enzyme–antibody dual labeled AuNP probes for ultrasensitive detection of AFP and HBsAg. ACS Appl Mater Interfaces,2017,9(11):9369–9377.
   PubMed Web of Science ®Google Scholar
• Pfefferkorn M, Bohm S, Schott T, et al. Quantification of large and middle proteins of hepatitis B virus surface antigen (HBsAg) as a novel tool for the identification of inactive HBV carriers. Gut,2018,67(11):2045–2053.
   PubMed Web of Science ®Google Scholar
• van Campenhout Margo J, van Boemmel Florian H, Pfefferkorn M, et al. A.Host and viral factors associated with serum hepatitis B virus RNA levels among patients in need for treatment. Hepatology,2018,68(3):839–847.
   PubMed Web of Science ®Google Scholar
• Scardino PT, Hay AM Point of care testing: a welcome advance? nature clinical practice Urology,2007,4(8):401.
   PubMed Web of Science ®Google Scholar
• Foudeh Amir M, Fatanat DT, Teodor V, et al. Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics. Lab Chip,2012,12(18):3249–3266.
   PubMed Web of Science ®Google Scholar
• Chin Curtis D, Yin CS, Tassaneewan L, et al. Low-cost microdevices for point-of-care testing, in point-of-care diagnostics on a chip, Issadore D, Westervelt RM, Editors. 2013, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 3–21.
   Google Scholar
• Mohammadali S, Uddin AM, Andy N, et al. High-throughput real-time electrochemical monitoring of LAMP for pathogenic bacteria detection. Biosens Bioelectron,2014,58:101–106.
   PubMed Web of Science ®Google Scholar
• Mohammad H, Nasrin S, de la Guardia M.Iron and iron-oxide magnetic nanoparticles as signal-amplification elements in electrochemical biosensing. Trends Analyt Chem,2015,72:1–9.
   Web of Science ®Google Scholar
• Xianbo Q, Liuwei S, Shuo Y, et al. A fast and low-cost genotyping method for hepatitis B virus based on pattern recognition in point-of-care settings. Sci Rep,2016,6:28274. 1
   PubMedGoogle Scholar
• Gao Y, Deng X, Wen W, et al. Ultrasensitive paper based nucleic acid detection realized by three-dimensional DNA-AuNPs network amplification. Biosens Bioelectron,2017,92:529–535.
   PubMed Web of Science ®Google Scholar
• Jinyuan C, Zhoujie L, Yanjie Z, et al. B/C genotyping of hepatitis B virus based on dual-probe electrochemical biosensor. J Electroanal Chem,2017,785:75–79.
   Web of Science ®Google Scholar
• Yachao Z, Yan G, Xueli Z, et al. Electrochemical immunosensor for HBe antigen detection based on a signal amplification strategy: the co-catalysis of horseradish peroxidase and nanoporous gold. Sens Actuators B Chem,2019,284 :296–304.
   PubMed Web of Science ®Google Scholar
• Katz JF, Yucel EK Point-of-care Ultrasonography. N Engl J Med,2011,364(21):2075–2076.
   PubMed Web of Science ®Google Scholar
• Olga M, Cole Craig R, Laughlin Mary J, et al. Quantitative lateral flow assays for salivary biomarker assessment: a review. Front Public Health,2017,5. 10.3389/fpubh.2017.00133
   Web of Science ®Google Scholar
• Hayes B, Murphy C, Crawley A, et al. Developments in point-of-care diagnostic technology for cancer detection. Diagnostics,2018,8(2):18.
   Web of Science ®Google Scholar
• Torsten S, Alina E, Thomas S, et al. Aptamer-based lateral flow assays. AimsBioengineering,2018,5(2):78–102.
   Web of Science ®Google Scholar
• Marimuthu C, Tang T-H.Recent developments of aptasensors expedient for point-of-care (POC) diagnostics. Talanta,2019,199:556–566.
   PubMed Web of Science ®Google Scholar
• Yanli G, Fan N, Yang X, et al.New advances in microfluidic flow cytometry. Electrophoresis,2019,40(8):1212–1229.
   Web of Science ®Google Scholar
• Choi JR, Liu Z, Hu J, et al. Polydimethylsiloxane-paper hybrid lateral flow assay for highly sensitive point-of-care nucleic acid testing. Anal Chem,2016,88(12):6254–6264.
   PubMed Web of Science ®Google Scholar
• Brook G, Brockmeyer N, van de Laar T, et al. 2017 European guideline for the screening,prevention and initial management of hepatitis B and C infections in sexual health settings. Int J STD AIDS,2018,29(10):949–967.
   PubMed Web of Science ®Google Scholar
• Hassanpour S, Baradaran B, de la Guardia M, et al. Diagnosis of hepatitis via nanomaterial-based electrochemical, optical or piezoelectrical biosensors: a review on recent advancements. Mikrochim Acta,2018,185(12):24.
   Web of Science ®Google Scholar
• Stanaway JD, Flaxman AD, Naghavi M, et al. The global burden of viral hepatitis from 1990 to 2013: findings from the global burden of disease study 2013. Lancet,2016,388(10049):1081–1088.
   PubMed Web of Science ®Google Scholar
• Lok ASF, McMahon BJ Chronic hepatitis B. Hepatology,2007,45(2):507–539.
   PubMed Web of Science ®Google Scholar
• Schweitzer A, Horn J, Mikolajczyk RT, et al. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet,2015,386(10003):1546–1555.
   PubMed Web of Science ®Google Scholar
• Liaw YF, Chu CM Hepatitis B virus infection. Lancet,2009,373(9663):582–592.
   PubMed Web of Science ®Google Scholar
• Jake LT.Hepatitis B: the virus and disease. Hepatology,2009,49(S5):S13–S21.
   PubMedGoogle Scholar
• Agarwal K, Berg T, Buti M, et al. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection european association for the study of the liver. J Hepatol,2017,67(2):370–398.
   PubMed Web of Science ®Google Scholar
• Lok ASF, McMahon BJ Chronic hepatitis B. Hepatology,2001,34(6):1225–1241.
   PubMed Web of Science ®Google Scholar
• Blumberg BS, Alter HJ, Visnich S A new antigen in leukemia sera. J Am Med Assoc,1965,191(7):541.
   PubMed Web of Science ®Google Scholar
• Martinot-Peignoux M, Lapalus M, Asselah T, et al. HBsAg quantification: useful for monitoring natural history and treatment outcome. Liver Int,2014,34:97–107.
   PubMed Web of Science ®Google Scholar
• Coffin Carla S, Zhou K, Terrault Norah A New and old biomarkers for diagnosis and V management of chronic Hepatitis B virus infection. Gastroenterology,2018, 156 2 355–368.e3
   PubMed Web of Science ®Google Scholar
• Sreelakshmi K, ShuetFong N, Keyur P.Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma. Expert Rev Mol Diagn,2018,18(8):713–722.
   PubMed Web of Science ®Google Scholar
• Magnius LO, Espmark J A new specificities in australia antigen positive sera distinct from R lebouvier determinants. J Iimmunol,1972,109(5):1017
   PubMed Web of Science ®Google Scholar
• Yuan Q, Song LW, Liu CJ, et al. Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients. Gut,2013,62(1):182–184.
   PubMed Web of Science ®Google Scholar
• Chu CM, Liaw YF Increased incidence of fulminant hepatic failure in previously unrecognized HBsAg carriers with acute hepatitis independent of etiology. Infection,2005,33(3):136–139.
   PubMed Web of Science ®Google Scholar
• Thompson AJV, Nguyen T, Iser D, et al. A serum hepatitis b surface antigen and Hepatitis B e Antigen titers: disease phase influences correlation with viral load and intrahepatic Hepatitis B virus markers. Hepatology,2010,51(6):1933–1944.
   PubMed Web of Science ®Google Scholar
• Perz Joseph F, Armstrong Gregory L, Farrington Leigh A, et al. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol,2006,45(4):529–538.
   PubMed Web of Science ®Google Scholar
• Ching-Lung L, Edward G, Yun-Fan L, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med,2007,357(25):2576–2588.
   PubMed Web of Science ®Google Scholar
• Yang HC, Chen PJ The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA. Virus Res,2018,244:304–310.
   PubMed Web of Science ®Google Scholar
• Wang J, Shen T, Huang XB, et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol,2016,65(4):700–710.
   PubMed Web of Science ®Google Scholar
• Liu S, Zhou B, Valdes JD, et al. Serum Hepatitis B virus RNA: A new potential biomarker for Chronic Hepatitis B virus infection. Hepatology,2019,69(4):1816–1827.
   PubMed Web of Science ®Google Scholar
• Liu YY, Jiang M, Xue JY, et al. Serum HBV RNA quantification: useful for monitoring natural history of chronic hepatitis B infection. BMC Gastroenterol,2019,19:9.
   PubMed Web of Science ®Google Scholar
• Hadziyannis SJ, Lieberman HM, Karvountzis GG, et al. Analysis of liver disease, nuclear hbcag, viral replication, and hepatitis b virus dna in liver and serum of HBeAg VS anti-hbe possive carriers of Hepatitis-B virus. Hepatology,1983,3(5):656–662.
   PubMed Web of Science ®Google Scholar
• Bao SX, Zheng JM, Li N, et al. Serum MicroRNA levels as a noninvasive diagnostic biomarker for the early diagnosis of Hepatitis B virus-related liver Fibrosis. Gut Liver,2017,11(6):860–869.
   PubMed Web of Science ®Google Scholar
• Zhou N, Wang KF, Fang SH, et al. Discovery of a potential plasma protein biomarker panelfor acute-on-chronic liver failure induced by hepatitis b virus. Front Physiol,2017,8:12.
   PubMed Web of Science ®Google Scholar
• Wei YF, Cui GY, Ye P, et al. MicroRNAs may solve the mystery of chronic hepatitis B virusinfection. World J Gastroenterol,2013,19(30):4867–4876.
   PubMed Web of Science ®Google Scholar
• Kitab B, Alj HS, Ezzikouri S, et al. MicroRNAs as Important players in host-hepatitis B virusInteractions. J Clin Transl Hepatol,2015,3(2):149–161.
   PubMed Web of Science ®Google Scholar
• Hayes CN, Chayama K MicroRNAs as biomarkers for liver disease and HepatocellularCarcinoma. Int J Mol Sci,2016,17(3):17.
   Web of Science ®Google Scholar
• Wang TZ, Lin DD, Jin BX, et al. Plasma microRNA: A novel non-invasive biomarker forHBV-associated liver fibrosis staging. Exp Ther Med,2019,17(3):1919–1929.
   PubMed Web of Science ®Google Scholar
• Shun W, Jun J, Chao Z, et al. Serum lincRNA-p21 expression in primary liver diseasesand liver metastatic diseases. Pathol Res Pract,2019,215(4):779–783.
   PubMed Web of Science ®Google Scholar
• Tian YJ, Ou JH J.Hepatitis B virus-specific T cells as a biomarker for discontinuation ofnucleos(t)ide analogue therapy for chronic Hepatitis B. Hepatology,2019,69(3):1342–1344.
   PubMed Web of Science ®Google Scholar
• Xu ZJ, Liu LG, Pan XN, et al. Serum Golgi Protein 73 (GP73) is a diagnostic and prognosticmarker of chronic HBV liver disease. Medicine (Baltimore),2015,94(12):9.
   Web of Science ®Google Scholar
• Cao Z, Li Z, Wang Y, et al. Assessment of serum Golgi protein 73 as a biomarker for thediagnosis of significant fibrosis in patients with chronic HBV infection. J Viral Hepat,2017,24:57–65.
   PubMed Web of Science ®Google Scholar
• Tsai TY, Peng CY, Yang HI, et al. The human C-type lectin 18 is a potential biomarker inpatients with chronic hepatitis B virus infection. J Biomed Sci,2018,25:10.
   PubMed Web of Science ®Google Scholar
• Duan L, Yang QF, Yang J, et al. Identification of serum beta-catenin as a biomarker in patients with HBV-related liver diseases. J Transl Med,2018,16:11. 1
   PubMedGoogle Scholar
• Shi L, Bin Z, Valdes Juan D, et al. Serum HBV RNA: a new potential biomarker for chronic Hepatitis B virus infection. Hepatology,2018,67:86-96.
   Google Scholar
• Wang J, Yu Y, Li G, et al. Natural history of serum HBV-RNA in chronic HBV infection. J Viral Hepat,2018,25(9):1038–1047.
   PubMed Web of Science ®Google Scholar
• Hosaka T, Suzuki F, Kobayashi M Impact of hepatitis B core-related antigen on the incidence of hepatocellular carcinoma in patients treated with nucleos(t)ide analogues (vol 49, pg 457, 2019). Aliment Pharmacol Ther,2019,50(2):234–235.
   PubMed Web of Science ®Google Scholar
• Lai CL, Chien RN, Leung NWY, et al. Asia Hepatitis Lamivudine Study Grp.A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med,1998,339(2):61–68.
   PubMed Web of Science ®Google Scholar
• Davis HL, Michel ML, Whalen RG DNA-based immunization induced continous secretion of hepatitis-B surface-antigen and high levels of circulating antibody. Hum Mol Genet,1993,2(11):1847–1851.
   PubMed Web of Science ®Google Scholar
• Papatheodoridis G, Buti M, Cornberg M, et al. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol,2012,57(1):167–185.
   PubMed Web of Science ®Google Scholar
• Laskus T, Rakela J, Nowicki MJ, et al. Hepatitis-B virus core promoter sequence-analysis in fulminant and chronic hepatitis-B.Gastroenterology,1995,109(5):1618–1623.
   PubMed Web of Science ®Google Scholar
• Wu MD, Huang RL, Kuo LMY, et al. The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C-18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis. Chem Pharm Bull (Tokyo),2003,51(11):1233–1236.
   PubMed Web of Science ®Google Scholar
• Li T, Yuan J, Yin J, et al. Capillary electrophoresis with electrochemiluminescence detection for measurement of aspartate aminotransferase and alanine aminotransferase activities in biofluids. J Chromatogr A,2006,1134(1–2):311–316.
   PubMed Web of Science ®Google Scholar
• Gerlich WH, Uy A, Lambrecht F, et al. Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections. J Clin Microbiol,1986,24(2):288.
   PubMed Web of Science ®Google Scholar
• Rodella A, Galli C, Terlenghi L, et al. Quantitative analysis of HBsAg, IgM anti-HBc andanti-HBc avidity in acute and chronic hepatitis B. J Clin Virol,2006,37(3):206–212.
   PubMed Web of Science ®Google Scholar
• Tiollais P, Pourcel C, Dejean A The hepatitis B virus. Nature,1985,317(6037):489–495.
   PubMed Web of Science ®Google Scholar
• Chisari FV, Ferrari C Hepatitis-B virus immunopathogenesis. Annual Review ofImmunology,1995,13:29–60. 1
   Google Scholar
• Li LM, Hu ZB, Zhou ZX, et al. Serum microRNA profiles serve as novel biomarkers forHBV infection and diagnosis of HBV-positive Hepatocarcinoma. Cancer Res,2010,70(23):9798–9807.
   PubMed Web of Science ®Google Scholar
• Chen YY, Li LM, Zhou ZX, et al. A pilot study of serum microRNA signatures as a novelbiomarker for occult hepatitis B virus infection. Med Microbiol Immunol,2012,201(3):389–395.
   PubMed Web of Science ®Google Scholar
• Nagano T, Higashisaka K, Kunieda A, et al. Liver-specific microRNAs as biomarkers ofnanomaterial-induced liver damage. Nanotechnology,2013,24(40):7.
   Web of Science ®Google Scholar
• Drain PK, Hyle EP, Noubary F, et al. Diagnostic point-of-care tests in resource-limited settings.Lancet Infect Dis,2014,14(3):239–249.
   PubMed Web of Science ®Google Scholar
• Nichols JH, Poe S S.Quality assurance, practical management, and outcomes ofpoint-of-care testing: laboratory perspectives, part I. Clinical laboratory management review: official publication of the Clinical Laboratory Management Association,1999,13( 6):341–350.
   Google Scholar
• Poe SS, Nichols JH Quality assurance, practical management, and outcomes of point-of-caretesting: nursing perspectives, Part II. CLINICAL LABORATORY MANAGEMENT REVIEW,2000,14( 1):12–18.
   Google Scholar
• Birui J, Shurui W, Min L, et al. Upconversion nanoparticles based FRET aptasensor forrapid and ultrasenstive bacteria detection. Biosens Bioelectron,2017,90:525–533.
   PubMed Web of Science ®Google Scholar
• Birui J, Yexin Y, Rongyan H, et al. Lateral flow aptamer assay integrated smartphone-based portable device for simultaneous detection of multiple targets using upconversion nanoparticles. Sens Actuators B Chem,2018,276:48–56.
   Web of Science ®Google Scholar
• Weigl BH, Neogi T, McGuire H. Point-of-care diagnostics in low-resource settings andtheir impact on care in the age of the noncommunicable and chronic disease epidemic. Jala,2014,19(3):248–257.
   Google Scholar
• Goble JA, Rocafort PT. Point-of-care testing. Journal of pharmacypractice,2017,30(2):229–237.
   Google Scholar
• Mohd HK, Mary G, David A.Point-of-care testing and thecontrol of infectious diseases. Biomark Med,2013,7(3):333–347.
   PubMed Web of Science ®Google Scholar
• Ryu JH, Kwon M, Moon JD, et al. Development of a rapid automated fluorescent lateral flow immunoassay to detect hepatitis b surface antigen (HBsAg), antibody to hbsag, and antibody to hepatitis C. Ann Lab Med,2018,38(6):578.
   PubMed Web of Science ®Google Scholar
• Byoung-Gi A, Hong-Rae K, Min-Jung K, et al. Chemiluminescent lateral-flow immunoassays by using in-situ synthesis of CdS NW photosensor. Anal Chim Acta,2016,927:99–106
   PubMed Web of Science ®Google Scholar
• Yali G, Lam Albert WY, Chan Warren CW Automating quantum dot barcode assays using microfluidics and magnetism for the development of a point-of-care device. ACS Appl Mater Interfaces,2013,5(8):2853–2860
   PubMed Web of Science ®Google Scholar
• Pengfei Z, Huiqi L, Chen J, et al. Simple and sensitive detection of HBsAg by using a quantum dots nanobeads based dot-blot immunoassay. Theranostics,2014,4(3):307–315
   PubMed Web of Science ®Google Scholar
• Tsung-Liang C, Shih-Chung W, Szu-Yuan L, et al. A polycarbonate based surface plasmon resonance sensing cartridge for high sensitivity HBV loop-mediated isothermal amplification. Biosens Bioelectron,2012,32(1):89–95
   PubMed Web of Science ®Google Scholar
• Suk YK, Jin KH, Keun AJ, et al. Microfluidic chip with porous anodic alumina integrated with PDMS/glass substrate for immuno-diagnosis. Curr Appl Phys,2009,9(2, Supplement):e60–e65.
   Web of Science ®Google Scholar
• Talha Sheikh M, Petri S, Liisa H, et al. Array-in-well platform–based multiplex assay for the simultaneous detection of anti-HIV- and treponemal-antibodies, and Hepatitis B surface antigen. J Immunol Methods,2016,429:21–27.
   PubMed Web of Science ®Google Scholar
• Chih-Hsin C, Kun-Lin. Y Liquid crystal-based immunoassays for detecting hepatitis B antibody. Anal Biochem,2012,421(1):321–323.
   PubMed Web of Science ®Google Scholar
• Seok LB, Jung-Nam L, Jong-Myeon P, et al. A fully automated immunoassay from whole blood on a disc. Lab Chip,2009,9(11):1548–1555
   PubMed Web of Science ®Google Scholar
• Seto WK, Lo YR, Pawlotsky JM, et al. Chronic hepatitis B virus infection.Lancet,2018,392(10161):2313–2324
   PubMed Web of Science ®Google Scholar
• Evgeni E, Sarah G, Yuen AL, et al.Lateral flow immunoassays - frompaper strip to smartphone technology. Electroanalysis,2015,27(9):2116–2130.
   Web of Science ®Google Scholar
• Jie H, ShuQi W, Lin W, et al. Advances in paper-based point-of-care diagnostics. Biosens Bioelectron,2014,54:585–597.
   PubMed Web of Science ®Google Scholar
• Leila S, Maryam D, Mehrdad A, et al. Point of care testing: theimpact of nanotechnology. Biosens Bioelectron,2017,87:373–387.
   PubMed Web of Science ®Google Scholar
• Muhammad S, Abdel-Nasser K, Muhammad. D, Designs formats and applicationsof lateral flow assay: A literature review. J Saudi Chem Soc,2015,19(6):689–705.
   Web of Science ®Google Scholar
• Jinhong S, Jinfeng L, Ling Z, et al. A signal amplification system on a lateral flowimmunoassay detecting for hepatitis e-antigen in human blood samples. J Med Virol,2019 91 7 1301–1306
   Web of Science ®Google Scholar
• Ru CJ, Zhi L, Jie H, et al. Polydimethylsiloxane-paper hybrid lateral flow assay forhighly sensitive point-of-care nucleic acid testing. Anal Chem,2016,88(12):6254–6264. 10.1021/acs.analchem.6b00195
   PubMed Web of Science ®Google Scholar
• Xu H, Mao X, Zeng QX, et al. Aptamer-functionalized gold nanoparticles as probes in adry-reagent strip biosensor for protein analysis. Anal Chem,2009,81(2):669–675.
   PubMed Web of Science ®Google Scholar
• Luping L, Lei Z, Yang Y, et al. Development of up-converting phosphor technology-basedlateral-flow assay for rapidly quantitative detection of hepatitis B surface antibody. Diagn Microbiol Infect Dis,2009,63(2):165–172.
   PubMed Web of Science ®Google Scholar
• MinLi Y, Min L, Yan G, et al. Household fluorescent lateral flow strip platform forsensitive and quantitative prognosis of heart failure using dual-color upconversion nanoparticles. Acs Nano,2017,11(6):6261–6270.
   PubMed Web of Science ®Google Scholar
• Liang RL, Deng QT, Chen ZH, et al. Europium(III) chelate microparticle-based lateral flowimmunoassay strips for rapid and quantitative detection of antibody to hepatitis B core antigen. Sci Rep,2017,7:8.
   PubMed Web of Science ®Google Scholar
• Jun S, Yaofeng Z, Fen F, et al. Immunochromatographic assay for quantitative and sensitive detection of hepatitis B virus surface antigen using highly luminescent quantum dot-beads. Talanta,2015,142:145–149.
   PubMed Web of Science ®Google Scholar
• Zhe-Xiang Z, Jun W, Hua W, et al. An integrated electrochemical device based on immunochromatographic test strip and enzyme labels for sensitive detection of disease-related biomarkers. Talanta,2012,94:58–64.
   PubMed Web of Science ®Google Scholar
• Xueqing Z, Lin J, Chunlei Z, et al. A silicon dioxide modified magnetic nanoparticles–labeled lateral flow strips for HBs antigen. J Biomed Nanotechnol,2011,7(6):776–781.
   PubMed Web of Science ®Google Scholar
• Sven H, Martin H.Lateral flow assays for the diagnosis of invasive aspergillosis: current status. Current Fungal Infection Reports,2017,11( 2):45–51.
   Google Scholar
• Jia L, Joanne M.Multiplex lateral flow detection and binary encoding enables a molecular colorimetric 7-segment display. Lab Chip,2016,16(2):242–245.
   PubMed Web of Science ®Google Scholar
• Kozel TR, Burnham-Marusich AR Point-of-care testing for infectious diseases: past, present, and future. J Clin Microbiol,2017,55(8):2313–2320
   PubMed Web of Science ®Google Scholar
• Squires TM, Quake SR Microfluidics: fluid physics at the nanoliter scale. Rev Mod Phys,2005,77(3):977–1026
   Web of Science ®Google Scholar
• Tomáš R, František S, Simone H, et al. Hepatitis B plasmonic biosensor for the analysis of clinical serum samples. Biosens Bioelectron,2016,85(272–279.
   PubMed Web of Science ®Google Scholar
• Terry SC, Jerman JH, Angell JB A gas chromatographic air analyzer fabricated on a silicon wafer. IEEE Trans Electron Devices,1979,26(12):1880–1886.
   Web of Science ®Google Scholar
• Ling Y, Ming LC, Yingshuai L, et al.Flow-through functionalized PDMS microfluidic channels with dextran derivative for ELISAs. Lab Chip,2009,9(9):1243–1247.
   PubMed Web of Science ®Google Scholar
• Sanjay Sharma T, Maowei D, Jianjun S, et al. A paper/polymer hybrid microfluidic microplate for rapid quantitative detection of multiple disease biomarkers. Sci Rep,2016,6:30474.
   PubMed Web of Science ®Google Scholar
• Jisung K, Biondi Mia J, Feld Jordan J, et al. Clinical validation of quantum dot barcode diagnostic technology. Acs Nano,2016,10(4):4742–4753.
   PubMed Web of Science ®Google Scholar
• Klostranec JM, Xiang Q, Farcas GA, et al. Convergence of quantum dot barcodes with microfluidics and signal processing for multiplexed high-throughput infectious disease diagnostics. Nano Lett,2007,7(9):2812–2818.
   PubMed Web of Science ®Google Scholar
• Zhang H, Tao X, Cheuk-Wing L, et al. A microfluidic device with microbead array for sensitive virus detection and genotyping using quantum dots as fluorescence labels. Biosens Bioelectron,2010,25(11):2402–2407.
   PubMed Web of Science ®Google Scholar
• Yong-Hwan C, Ga-Yeon L, Hyuk K, et al. Development of SPR biosensor for the detection of human hepatitis B virus using plasma-treated parylene-N film. Biosens Bioelectron,2014,56:286–294.
   PubMed Web of Science ®Google Scholar
• Ming L, Cushing Scott K, Hongyan L, et al. Plasmonic nanorice antenna on triangle nanoarray for surface-enhanced raman scattering detection of hepatitis b virus dna. Anal Chem,2013,85(4):2072–2078.
   PubMed Web of Science ®Google Scholar
• Agnieszka K, Evelin W, Katarzyna W, et al. Detection of hepatitis B virus antigen from human blood: SERS immunoassay in a microfluidic system. Biosens Bioelectron,2015,66:461–467.
   PubMed Web of Science ®Google Scholar
• Xiang L, Karen S, Crooks Richard M Detection of hepatitis b virus dna with a paper electrochemical Sensor. Anal Chem,2015,87(17):9009–9015.
   PubMed Web of Science ®Google Scholar
• Elias A, Hedayatollah G, Mehdi BS.Gold nanoparticle based capacitive immunosensor for detection of hepatitis B surface antigen. Anal Methods,2013,5(17):4448–4453.
   Web of Science ®Google Scholar
• Il-Hoon C, Arun B, Joseph I.Rapid pathogen detection by lateral-flow immunochromatographic assay with gold nanoparticle-assisted enzyme signal amplification. Int J Food Microbiol,2015,206:60–66.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Min D, Hao Y, et al. A novel HBV genotypes detecting system combined with microfluidic chip, loop-mediated isothermal amplification and GMR sensors. Biosens Bioelectron,2014,54:372–377.
   PubMed Web of Science ®Google Scholar