1
Views
0
CrossRef citations to date
0
Altmetric
Special Report

Interpreting the results of rapid molecular diagnostic tests for carbapenem-resistant Enterobacterales infection: current clinical perspective while waiting for further evidence

, , , &
Pages 583-590 | Received 05 May 2024, Accepted 19 Jul 2024, Published online: 25 Jul 2024

References

  • Tzouvelekis LS, Markogiannakis A, Piperaki E, et al. Treating infections caused by carbapenemase-producing enterobacteriaceae. Clin Microbiol Infect. 2014 Sep;20(9):862–872. doi: 10.1111/1469-0691.12697
  • Karaiskos I, Galani I, Papoutsaki V, et al. Carbapenemase producing Klebsiella pneumoniae: implication on future therapeutic strategies. Expert Rev Anti Infect Ther. 2022 Jan;20(1):53–69. doi: 10.1080/14787210.2021.1935237
  • Isler B, Aslan AT, Akova M, et al. Treatment strategies for OXA-48-like and NDM producing Klebsiella pneumoniae infections. Expert Rev Anti Infect Ther. 2022 Nov;20(11):1389–1400. doi: 10.1080/14787210.2022.2128764
  • Bassetti M, Giacobbe DR, Giamarellou H, et al. Management of KPC-producing Klebsiella pneumoniae infections. Clin Microbiol Infect. 2018 Feb;24(2):133–144. doi: 10.1016/j.cmi.2017.08.030
  • Bassetti M, Di Pilato V, Giani T, et al. Treatment of severe infections due to metallo-β-lactamases-producing gram-negative bacteria. Future Microbiol. 2020 Nov;3(15):1489–1505. doi: 10.2217/fmb-2020-0210
  • Tsuji BT, Pogue JM, Zavascki AP, et al. International consensus guidelines for the optimal use of the polymyxins: endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-Infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy. Pharmacotherapy. 2019 Jan;39(1):10–39. doi: 10.1002/phar.2209
  • Maraolo AE, Corcione S, Grossi A, et al. The impact of carbapenem resistance on mortality in patients with Klebsiella Pneumoniae bloodstream infection: an individual patient data meta-analysis of 1952 patients. Infect Dis Ther. 2021 Mar;10(1):541–558. doi: 10.1007/s40121-021-00408-8
  • Giacobbe DR, Di Pilato V, Karaiskos I, et al. Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades. Ann Med. 2023 Dec;55(1):101–113. doi: 10.1080/07853890.2022.2152484
  • Karvouniaris M, Almyroudi MP, Abdul-Aziz MH, et al. Novel antimicrobial agents for gram-negative pathogens. Antibiotics (Basel). [2023 Apr 16];12(4):761. doi: 10.3390/antibiotics12040761
  • Giacobbe DR, Marelli C, Cattardico G, et al. Mortality in KPC-producing Klebsiella pneumoniae bloodstream infections: a changing landscape. J Antimicrob Chemother. [2023 Oct 3];78(10):2505–2514. doi: 10.1093/jac/dkad262
  • Zhang S, Liao X, Ding T, et al. Role of β-lactamase inhibitors as potentiators in antimicrobial chemotherapy targeting gram-negative bacteria. Antibiotics. 2024;13(3):260. doi: 10.3390/antibiotics13030260
  • Giacobbe DR, Bassetti M. Innovative β-Lactam/β-lactamase inhibitor combinations for carbapenem-resistant gram-negative bacteria. Future Microbiol. 2022 Apr;17(6):393–396. doi: 10.2217/fmb-2021-0301
  • Moerman A, De Waele JJ, Boelens J. An overview of point-of-care testing for infections in critically ill patients. Expert Rev Mol Diagn. 2024 Mar;24(3):193–200. doi: 10.1080/14737159.2024.2322146
  • Dessajan J, Timsit JF. Impact of multiplex PCR in the therapeutic management of severe bacterial pneumonia. Antibiotics (Basel). [2024 Jan 18];13(1):95. doi: 10.3390/antibiotics13010095
  • Giacobbe DR, Giani T, Bassetti M, et al. Rapid microbiological tests for bloodstream infections due to multidrug resistant gram-negative bacteria: therapeutic implications. Clin Microbiol Infect. 2020 Jun;26(6):713–722. doi: 10.1016/j.cmi.2019.09.023
  • Ramanan P, Bryson AL, Binnicker MJ, et al. Syndromic panel-based testing in clinical microbiology. Clin Microbiol Rev. 2018 Jan;31(1). doi: 10.1128/CMR.00024-17
  • Enne VI, Aydin A, Baldan R, et al. Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study. Thorax. 2022 Dec;77(12):1220–1228. doi: 10.1136/thoraxjnl-2021-216990
  • Messacar K, Hurst AL, Child J, et al. Clinical impact and provider acceptability of real-time antimicrobial stewardship decision support for rapid diagnostics in children with positive Blood culture results. J Pediatric Infect Dis Soc. [2017 Sep 1];6(3):267–274. doi: 10.1093/jpids/piw047
  • Buss BA, Baures TJ, Yoo M, et al. Impact of a multiplex PCR assay for bloodstream infections with and without antimicrobial stewardship intervention at a cancer hospital. Open Forum Infect Dis. 2018 Oct;5(10):ofy258. doi: 10.1093/ofid/ofy258
  • Bookstaver PB, Nimmich EB, Smith TJ 3rd, et al. Cumulative effect of an antimicrobial stewardship and rapid diagnostic testing bundle on early streamlining of antimicrobial therapy in gram-negative bloodstream infections. Antimicrob Agents Chemother. 2017 Sep;61(9). doi: 10.1128/AAC.00189-17
  • Salimnia H, Fairfax MR, Lephart PR, et al. Evaluation of the FilmArray blood culture identification panel: results of a multicenter controlled trial. J Clin Microbiol. 2016 Mar;54(3):687–698. doi: 10.1128/JCM.01679-15
  • Burrack-Lange SC, Personne Y, Huber M, et al. Multicenter assessment of the rapid unyvero blood culture molecular assay. J Med Microbiol. 2018 Sep;67(9):1294–1301. doi: 10.1099/jmm.0.000804
  • Monard C, Pehlivan J, Auger G, et al. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia. Crit Care. [2020 Jul 14];24(1):434. doi: 10.1186/s13054-020-03114-y
  • Peiffer-Smadja N, Bouadma L, Mathy V, et al. Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia. Crit Care. [2020 Jun 19];24(1):366. doi: 10.1186/s13054-020-03067-2
  • Mo Y. Rapid diagnostics for antibiotic resistance: urgent need for strong clinical evidence. Clin Infect Dis. [2022 Dec 19];75(12):2076–2078. doi: 10.1093/cid/ciac358
  • Poole S, Tanner AR, Naidu VV, et al. Molecular point-of-care testing for lower respiratory tract pathogens improves safe antibiotic de-escalation in patients with pneumonia in the ICU: results of a randomised controlled trial. J Infect. 2022 Dec;85(6):625–633. doi: 10.1016/j.jinf.2022.09.003
  • High J, Enne VI, Barber JA, et al. INHALE: the impact of using FilmArray pneumonia panel molecular diagnostics for hospital-acquired and ventilator-associated pneumonia on antimicrobial stewardship and patient outcomes in UK critical care-study protocol for a multicentre randomised controlled trial. Trials. [2021 Oct 7];22(1):680. doi: 10.1186/s13063-021-05618-6
  • Fartoukh M, Nseir S, Megarbane B, et al. Respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in severe SARS-CoV-2 pneumonia: a multicentre randomized controlled trial. Clin Microbiol Infect. 2023 Jun;29(6):734–743. doi: 10.1016/j.cmi.2023.01.009
  • Enne V, Stirling S, Barber J, et al. LB2304. INHALE WP3: results of a multi-centre randomised controlled trial (INHALE) testing the utility of rapid multiplex PCR at point-of-care for the antibiotic management of hospital-acquired and ventilator-associated pneumonia in critical care. Open Forum Infect Dis. 2022;9(Supplement_2):ofac492.1894. doi: 10.1093/ofid/ofac492.1894
  • Darie AM, Khanna N, Jahn K, et al. Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of gram-negative bacterial infection (flagship II): a multicentre, randomised controlled trial. Lancet Respir Med. 2022 Sep;10(9):877–887. doi: 10.1016/S2213-2600(22)00086-8
  • Banerjee R, Teng CB, Cunningham SA, et al. Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing. Clin Infect Dis. [2015 Oct 1];61(7):1071–1080. doi: 10.1093/cid/civ447
  • Rule R, Paruk F, Becker P, et al. Clinical utility of the BioFire FilmArray Blood culture identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient. PLOS ONE. 2021;16(7):e0254389. doi: 10.1371/journal.pone.0254389
  • Maataoui N, Chemali L, Patrier J, et al. Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit. Eur J Clin Microbiol Infect Dis. 2021 Oct;40(10):2227–2234. doi: 10.1007/s10096-021-04213-6
  • Giacobbe DR, Crea F, Morici P, et al. T2Bacteria and T2Resistance assays in critically Ill patients with sepsis or septic shock: a descriptive experience. Antibiotics (Basel). [2022 Dec 15];11(12):1823. doi: 10.3390/antibiotics11121823
  • Satlin MJ, Chen L, Gomez-Simmonds A, et al. Impact of a Rapid Molecular Test for Klebsiella pneumoniae Carbapenemase and Ceftazidime-Avibactam Use on Outcomes After Bacteremia Caused by Carbapenem-Resistant Enterobacterales. Clin Infect Dis. [2022 Dec 19];75(12):2066–2075. doi: 10.1093/cid/ciac354
  • Galani I, Karaiskos I, Giamarellou H. Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel beta-lactam-beta-lactamase inhibitor combinations. Expert Rev Anti Infect Ther. 2021 Nov;19(11):1457–1468. doi: 10.1080/14787210.2021.1924674
  • Di Pilato V, Pollini S, Miriagou V, et al. Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge. Expert Rev Anti Infect Ther. 2024 Jan;22(1–3):25–43. doi: 10.1080/14787210.2024.2305854
  • Hobson CA, Cointe A, Jacquier H, et al. Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC beta-lactamase mutants and the inoculum effect. Clin Microbiol Infect. 2021 Aug;27(8):e1172 7–e1172 10. doi: 10.1016/j.cmi.2021.04.016
  • Di Pilato V, Principe L, Andriani L, et al. Deciphering variable resistance to novel carbapenem-based β-lactamase inhibitor combinations in a multi-clonal outbreak caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae resistant to ceftazidime/avibactam. Clinical Microbiology Infection. 2023 Apr;29(4):.e537.1–.e537.8. doi: 10.1016/j.cmi.2022.11.011

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.