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Review

Real-world clinical evidence on rivaroxaban, dabigatran, and apixaban compared with vitamin K antagonists in patients with nonvalvular atrial fibrillation: a systematic literature review

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Pages 27-36 | Received 02 Jul 2018, Accepted 28 Aug 2018, Published online: 19 Sep 2018

References

  • Fuster V, Rydén LE, Cannom DS, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American college of Cardiology/American heart association task force on practice guidelines and the European society of cardiology committee for practice guidelines (Writing committee to revise the 2001 guidelines for the management of patients with atrial fibrillation): developed in collaboration with the European heart rhythm association and the heart rhythm society. Circulation. 2006;114(7):e257–354.
  • Kannel WB, Benjamin EJ. Status of the epidemiology of atrial fibrillation. Med Clin North Am. 2008;92(1):17–40.
  • Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37(38):2893–2962.
  • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–891.
  • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139–1151.
  • Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981–992.
  • Centre for Reviews and Dissemination. Systematic Reviews. CRD’s guidance for undertaking reviews in health care. York: Univeristy of York; 2009. [ cited 2018 Apr 20] Available from: https://www.york.ac.uk/media/crd/Systematic_Reviews.pdf
  • Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0. 2011. cited. 2018 Apr 20. Available from. http://handbook-5-1.cochrane.org/
  • Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377–384.
  • Seeger JD, Bykov K, Bartels DB, et al. Safety and effectiveness of dabigatran and warfarin in routine care of patients with atrial fibrillation. Thromb Haemost. 2015;114(6):1277–1289.
  • Larsen TB, Skjøth F, Nielsen PB, et al. Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ. 2016;353:i3189.
  • Nelson WW, Song X, Coleman CI, et al. Medication persistence and discontinuation of rivaroxaban versus warfarin among patients with non-valvular atrial fibrillation. Curr Med Res Opin. 2014;30(12):2461–2469.
  • Chan YH, Kuo CT, Yeh YH, et al. Thromboembolic, bleeding, and mortality risks of rivaroxaban and dabigatran in Asians with nonvalvular atrial fibrillation. J Am Coll Cardiol. 2016;68(13):1389–1401.
  • Kodani E, Atarashi H, Inoue H, et al. Beneficial effect of non-vitamin k antagonist oral anticoagulants in patients with nonvalvular atrial fibrillation – results of the J-RHYTHM Registry 2. Circ J. 2016;80(4):843–851.
  • Charlton B, Adeboyeje G, Barron JJ, et al. Length of hospital stay and all-cause mortality among adults with atrial fibrillation hospitalized for bleeding during treatment with warfarin, dabigatran, or rivaroxaban. Circulation. 2015;132(Suppl 3):A11583.
  • Gorst-Rasmussen A, Lip GYH, Bjerregaard Larsen T. Rivaroxaban versus warfarin and dabigatran in atrial fibrillation: comparative effectiveness and safety in Danish routine care. Pharmacoepidemiol Drug Saf. 2016;25(11):1236–1244.
  • Laliberte F, Cloutier M, Nelson WW, et al. Real-world comparative effectiveness and safety of rivaroxaban and warfarin in nonvalvular atrial fibrillation patients. Curr Med Res Opin. 2014;30(7):1317–1325.
  • Yao X, Abraham NS, Sangaralingham LR, et al. Effectiveness and safety of dabigatran, rivaroxaban, and apixaban versus warfarin in nonvalvular atrial fibrillation. J Am Heart Assoc. 2016;5(6):e003725.
  • Coleman CI, Antz M, Bowrin K, et al. Real-world evidence of stroke prevention in patients with nonvalvular atrial fibrillation in the United States: the REVISIT-US study. Curr Med Res Opin. 2016;32(12):2047–2053.
  • Staerk L, Fosbøl EL, Lip GYH, et al. Ischaemic and haemorrhagic stroke associated with non-vitamin K antagonist oral anticoagulants and warfarin use in patients with atrial fibrillation: a nationwide cohort study. Eur Heart J. 2017;38(12):907–915.
  • Wong JM, Kennedy K, Shaw R. Comparing major bleeding risk in outpatients with atrial fibrillation by oral anticoagulant type: insights from the NCDR pinnacle registry. J Am Coll Cardiol. 2016;67(13 Suppl):666.
  • Nyman A, Collin JJKM, Borg N, et al. Safety of new anticoagulant treatments in Swedish patients with non-valvular atrial fibrillation. Pharmacoepidemiol Drug Saf. 2015;24:405.
  • Norby FL, Bengtson LG, Chen LY, et al. Comparative effectiveness of rivaroxaban versus warfarin for the treatment of patients with non-valvular atrial fibrillation. Circulation. 2016;133(Suppl 1):AP005 .
  • Halvorsen S, Ghanima W, Fride Tvete I, et al. A nationwide registry study to compare bleeding rates in patients with atrial fibrillation being prescribed oral anticoagulants. Eur Heart J Cardiovasc Pharmacother. 2017;3(1):28–36.
  • Coleman CI, Tangirala M, Evers T. Treatment persistence and discontinuation with rivaroxaban, dabigatran, and warfarin for stroke prevention in patients with non-valvular atrial fibrillation in the United States. PLoS One. 2016;11(6):e0157769.
  • Beyer-Westendorf J, Ehlken B, Evers T. Real-world persistence and adherence to oral anticoagulation for stroke risk reduction in patients with atrial fibrillation. Europace. 2016;18(8):1150–1157
  • Bengtson LGS, Lutsey PL, Chen LY, et al. Comparative effectiveness of dabigatran and rivaroxaban versus warfarin for the treatment of non-valvular atrial fibrillation. J Cardiol. 2017;69(6):868–876.
  • Chan YH, Yen KC, See LC, et al. Cardiovascular, bleeding, and mortality risks of dabigatran in Asians with nonvalvular atrial fibrillation. Stroke. 2016;47(2):441–449.
  • Chan PH, Huang D, Hai JJ, et al. Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation. Heart Rhythm. 2016;13(2):366–373.
  • Graham DJ, Reichman ME, Wernecke M, et al. Cardiovascular, bleeding, and mortality risks in elderly medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation. Circulation. 2015;131(2):157–164.
  • Ho CW, Ho MH, Chan PH, et al. Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control. Stroke. 2015;46(1):23–30.
  • Larsen TB, Rasmussen LH, Gorst-Rasmussen A, et al. Dabigatran and warfarin for secondary prevention of stroke in atrial fibrillation patients: a nationwide cohort study. Am J Med. 2014;127(12):1172–1178.
  • Li WH, Huang D, Chiang CE, et al. Efficacy and safety of dabigatran, rivaroxaban, and warfarin for stroke prevention in Chinese patients with atrial fibrillation: the Hong Kong atrial fibrillation project. Clin Cardiol. 2017;40(4):222–229.
  • Larsen TB, Rasmussen LH, Skjøth F, et al. Efficacy and safety of dabigatran etexilate and warfarin in “real-world” patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol. 2013;61(22):2264–2273.
  • Luger S, Hohmann C, Niemann D, et al. Adherence to oral anticoagulant therapy in secondary stroke prevention - impact of the novel oral anticoagulants. Patient Prefer Adherence. 2015;9:1695–1705.
  • Nishtala PS, Gnjidic D, Jamieson HA, et al. Real-world’ haemorrhagic rates for warfarin and dabigatran using population-level data in New Zealand. Int J Cardiol. 2016;203:746–752.
  • Tsadok MA, Jackevicius CA, Essebag V, et al. Comparative effectiveness and safety of dabigatran vs. warfarin in patients with atrial fibrillation - evidence from real world practice. Circulation. 2013;128(22 Suppl):A13884.
  • Vaughan Sarrazin MS, Jones M, Mazur A, et al. Bleeding rates in veterans affairs patients with atrial fibrillation who switch from warfarin to dabigatran. Am J Med. 2014;127(12):1179–1185.
  • Villines TC, Schnee J, Fraeman K, et al. A comparison of the safety and effectiveness of dabigatran and warfarin in non-valvular atrial fibrillation patients in a large healthcare system. Thromb Haemost. 2015;114(6):1290–1298.
  • Lauffenburger JC, Farley JF, Gehi AK, et al. Effectiveness and safety of dabigatran and warfarin in real-world US patients with non-valvular atrial fibrillation: a retrospective cohort study. J Am Heart Assoc. 2015;4(4):e001798.
  • Thelus R, Villines TC, Coster TS. Dabigatran versus warfarin among patients with atrial fibrillation: real-world post-market results. Circulation. 2012;126(Suppl 21):A14877.
  • Avgil Tsadok M, Jackevicius CA, Rahme E, et al. Sex differences in dabigatran use, safety, and effectiveness in a population-based cohort of patients with atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2015;8(6):593–599.
  • Alonso A, Chen LY, Maclehose RF, et al. Comparative effectiveness of dabigatran versus warfarin in patients with non-valvular atrial fibrillation. Circulation. 2013;128(Suppl 22):A14075.
  • Bengtson L, Chen L, Maclehose R, et al. Comparative effectiveness of dabigatran and rivaroxaban versus warfarin in patients with non-valvular atrial fibrillation. Circulation. 2014;130(Suppl 2):A20218.
  • Chan PH, Huang D, Lau CP, et al. Net clinical benefit of dabigatran over warfarin in patients with atrial fibrillation stratified by CHA2DS2-VASc and time in therapeutic range. Can J Cardiol. 2016;32(10):1247.e1215–1247.e1221.
  • Hernandez I, Baik SH, Pinera A, et al. Risk of bleeding with dabigatran in atrial fibrillation. JAMA Intern Med. 2015;175(1):18–24.
  • Larsen TB, Gorst-Rasmussen A, Rasmussen LH, et al. Bleeding events among new starters and switchers to dabigatran compared with warfarin in atrial fibrillation. Am J Med. 2014;127(7):650–656.e655.
  • Avgil-Tsadok M, Jackevicius CA, Essebag V, et al. Dabigatran use in elderly patients with atrial fibrillation. Thromb Haemost. 2016;115(1):152–160.
  • Agence Nationale de Sécurité du Médicament et des Produits de Santé. Study ‘in real life’ of the benefit/short-term risk of new oral anticoagulants (dabigatran, rivaroxaban) in patients starting treatment and not previously treated with oral anticoagulants. 2014. [ cited 2018 Apr 20] Available from: http://ansm.sante.fr/S-informer/Presse-Communiques-Points-presse/Surveillance-en-vie-reelle-des-anticoagulants-oraux-Communique. French.
  • Ellis MH, Neuman T, Bitterman H, et al. Bleeding in patients with atrial fibrillation treated with dabigatran, rivaroxaban or warfarin: a retrospective population-based cohort study. Eur J Intern Med. 2016;33:55–59.
  • Korenstra J, Wijtvliet EP, Veeger NJ, et al. Effectiveness and safety of dabigatran versus acenocoumarol in ‘real-world’ patients with atrial fibrillation. Europace. 2016;18(9):1319–1327.
  • Lip GY, Pan X, Kamble S, et al. Is major bleeding risk for oral anticoagulants similar among newly initiated non valvular atrial fibrillation patients? Circulation. 2015;132(Suppl 3):A19679.
  • Seeger JD, Bartels DB, Huybrechts K, et al. Safety and effectiveness of dabigatran relative to warfarin in routine clinical practice-new interim results of long-term study program. Circulation. 2015;132(Suppl 3):A17137.
  • Yavuz B, Ayturk M, Ozkan S, et al. A real world data of dabigatran etexilate: multicenter registry of oral anticoagulants in nonvalvular atrial fibrillation. J Thromb Thrombolysis. 2016;42(3):399–404.
  • Alpesh AN, Keshishian A, Xie L, et al. Early comparison of major bleeding, stroke and associated medical costs among treatment-naive non-valvular atrial fibrillation patients initiating apixaban, dabigatran, rivaroxaban or warfarin. Blood. 2015;126(23):745.
  • Amin A, Keshishian A, Xie L, et al. Comparison of major-bleeding risk and health care costs among treatment-naive non-valvular atrial fibrillation patients initiating apixaban, dabigatran, rivaroxaban or warfarin. Circulation. 2015;132(Suppl 3):A19672.
  • Choi JC, Dibonaventura MD, Kopenhafer L, et al. Survey of the use of warfarin and the newer anticoagulant dabigatran in patients with atrial fibrillation. Patient Prefer Adherence. 2014;8:167–177.
  • Lin I, Masseria C, Mardekian J, et al. Real-world bleeding risk among non-valvular atrial fibrillation (NVAF) patients prescribed apixaban, dabigatran, rivaroxaban and warfarin: analysis of electronic health records. Eur Heart J. 2015;36(Suppl 1):1084.
  • Sørensen R, Gislason G, Torp-Pedersen C, et al. Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study. BMJ Open. 2013;3(5):e002758.
  • Zalesak M, Siu K, Francis K, et al. Higher persistence in newly diagnosed nonvalvular atrial fibrillation patients treated with dabigatran versus warfarin. Circ Cardiovasc Qual Outcomes. 2013;6(5):567–574.
  • Johnson ME, Lefevre C, Collings SL, et al. Early real-world evidence of persistence on oral anticoagulants for stroke prevention in non-valvular atrial fibrillation: a cohort study in UK primary care. BMJ Open. 2016;6(9):e011471.
  • Lau WCY, Chan EW, Wong ICK. Persistence of dabigatran versus warfarin therapy in patients with non-valvular atrial fibrillation in the real-world clinical practice. Pharmacoepidemiol Drug Saf. 2015;24(S1):382.
  • Lip GYH, Pan X, Kamble S, et al. Real world comparison of major bleeding risk among non-valvular atrial fibrillation patients newly initiated on apixaban, dabigatran, rivaroxaban or warfarin. Eur Heart J. 2015;36(Suppl 1):1085.
  • Lip G, Keshishian A, Kamble S, et al. Real world comparison of major bleeding risk among non-valvular atrial fibrillation patients newly initiated on apixaban, warfarin, dabigatran or rivaroxaban: a 1:1 propensity-score matched analysis. J Am Coll Cardiol. 2016;67(13 Suppl 1):882.
  • Lamberts M, Harboe L, Lefevre C, et al. Comparison of bleeding and treatment persistence among new users of novel oral anticoagulants and warfarin in patients with non-valvular atrial fibrillation. J Am Coll Cardiol. 2016;67(13 Suppl 1):887.
  • Deitelzweig S, Gupta K, Ogbonnaya A, et al. Compare major bleeding risk and associated costs among NVAF patients with CHA2DS2-VASc score > 3 newly anticoagulated with apixaban versus warfarin. J Am Coll Cardiol. 2016;67(13 Suppl 1):876.

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