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Review

Current health and economic burden of chronic diabetic osteomyelitis

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Pages 279-286 | Received 06 Nov 2018, Accepted 07 Jan 2019, Published online: 21 Jan 2019

References

  • Center for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion. Division of Diabetes Translation. National diabetes statistics report 2017. Estimates of diabetes and its burden in the United States. 2018. p. 1–20.
  • Prompers L, Huijberts M, Apelqvist J, et al. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 2007;50:18–25.
  • Lavery LA, Peters EJG, Armstrong DG, et al. Risk factors for developing osteomyelitis in patients with diabetic foot wounds diabetes research and clinical practice. Diabetes Res Clin Pract. 2009;83:347–352.
  • Jeffcoate WJ, Lipsky BA. Controversies in diagnosing and managing osteomyelitis of the foot in diabetes. Clin Infect Dis. 2004;39(Supp2):S115–S122.
  • Berendt AR, Peters EJ, Bakker K, et al. Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment. Diabetes Metab Res Rev. 2008;24(Suppl1):S145–S161.
  • Aragón-Sánchez J, Lipsky BA. Modern management of diabetic foot osteomyelitis. The when, how and why of conservative approaches. Expert Rev Anti Infect Ther. 2018;16(1):35–50.
  • Dowd SE, Wolcott RD, Kennedy J, et al. Molecular diagnostics and personalised medicine in wound care: assessment of outcomes. J Wound Care. 2011;20(5):232–239.
  • Wolcott R. Economic aspects of biofilm-based wound care in diabetic foot ulcers. J Wound Care. 2015;24(5):189–194.
  • Jones CE, Kennedy JP. Treatment options to manage wound biofilm. Adv Wound Care (New Rochelle). 2012;1(3):120–126.
  • Reiber GE. Epidemiology of foot ulcers and amputations in the diabetic foot. In: Bowker JH, Pfeifer MA, editors. The diabetic foot. St Louis (MO): Mosby; 2001. p. 13–32.
  • International Working Group on the Diabetic Foot. Epidemiology of diabetic foot infections in a population-based cohort. Paper presented at: international Consensus on the Diabetic Foot; 2003 May 22–24; Noordwijkerhout, the Netherlands.
  • Reiber GE. The epidemiology of diabetic foot problems. Diabet Med. 1996;13(Suppl1):S6–S11.
  • Lavery LA, Armstrong DG, Wunderlich RP, et al. Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care. 2003;26:1435–1438.
  • Yang W, Dall TM, Beronjia K, et al. Economic costs of diabetes in the U.S. in 2017. Diabetes Care. 2018;41:917–928.
  • Nussbaum SR, Carter MJ, Fife CE, et al. An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds. ISPOR Value Health. 2018;21(1):27-32.
  • Boulton AJ, Kirsner RS, Vileikyte L. Clinical practice. Neuropathic diabetic foot ulcers. N Engl J Med. 2004;351:48–55.
  • Hicks CW, Selvarajah S, Mathioudakis N, et al. Trends and determinants of costs associated with the inpatient care of diabetic foot ulcers. Soc Clin Vasc Surg. 2014;60(5):1247–1254.
  • Harrington C, Zagari MJ, Corea J, et al. A cost analysis of diabetic lower-extremity ulcers. Diabetes Care 2000;23(9):1333–1338.
  • Rice JB, Desai U, Birnbaum HG, et al. Burden of diabetic foot ulcers for medicare and private insurers. Diabetes Care. 2014;37:651–658.
  • Prompers L, Huijberts M, Schaper N, et al. Resource utilisation and costs associated with the treatment of diabetic foot ulcers. Prospective data from the eurodiale study. Diabetologia. 2008;51(10):1826–1834.
  • Petrakis I, Kyriopoulos IJ, Ginis A, et al. Losing a foot versus losing a dollar; a systematic review of cost studies in diabetic foot complications. Expert Rev Pharmacoecon Outcomes Res. 2017;17(2):165–180.
  • American Diabetes Association. Economic costs of diabetes in the US 2007. Diabetes Care. 2008;31:596–615.
  • Hicks CW, Selvarajah S, Mathioudakis N, et al. Burden of infected diabetic foot ulcers on hospital admissions and costs. Ann Vasc Surg. 2016;33:149–158.
  • Gil J, Schiff AP, Pinzur MS. Cost comparison: limb salvage versus amputation in diabetic patients with charcot foot. Foot Ankle Int. 2013;34:1097–1099.
  • Gordois A, Scuffham P, Shearer A, et al. The health care costs of diabetic peripheral neuropathy in the. US Diabetes Care. 2003;26(6):1790–1795.
  • Tentolouris N, Jude EB, Smirnof I, et al. Methicillin-resistant staphylococcus aureus: an increasing problem in a diabetic foot clinic. Diabet Med. 1999;16:767–771.
  • Senneville E, Lombart A, Beltrand E, et al. Outcome of diabetic foot osteomyelitis treated nonsurgically: a retrospective cohort study. Diabetes Care. 2008;31(4):637–642.
  • Lesens O, Desbiez F, Vidal M, et al. Culture of per-wound bone specimens: a simplified approach for the medical management of diabetic foot osteomyelitis. Clin Microbiol Infect. 2011;17(2):285–291.
  • Kessler L, Piemont Y, Ortega F, et al. Comparison of microbiological results of needle puncture vs. superficial swab in infected diabetic foot ulcer with osteomyelitis. Diabet Med. 2006 Jan;23(1):99–102.
  • Ge Y, MacDonald D, Hait H, et al. Microbiological profile of infected diabetic foot ulcers. Diabet Med. 2002;19:1032–1034.
  • Tp E, Jagdish S, Kate V, et al. Role of bone biopsy specimen culture in the management of diabetic foot osteomyelitis. Int J Surg. 2011;9(3):214–216.
  • Senneville E, Morant H, Descamps D, et al. Needle puncture and transcutaneous bone biopsy cultures are inconsistent in patients with diabetes and suspected osteomyelitis of the foot. Clin Infect Dis. 2009;48(7):888–893.
  • Aragon-Sanchez J, Lipsky BA, Lazaro-Martinez JL. Gram-negative diabetic foot osteomyelitis: risk factors and clinical presentation. Int J Low Extrem Wounds. 2013;12(1):63–68.
  • Malone M, Fl B, Gannass A, et al. Deep wound cultures and bone biopsy in diabetic foot osteomyelitis. Diabetes Metab Res Rev. 2013;29(7):546–550.
  • Ertugrul MB, Baktiroglu S, Salman S, et al. The diagnosis of osteomyelitis of the foot in diabetes: microbiological examination vs. magnetic resonance imaging and labeled leucocyte scanning. Diabet Med. 2006;23(6):649–653.
  • Newman LG, Waller J, Palestro CJ, et al. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. Jama. 1991;266(9):1246–1251.
  • Senneville E, Melliez H, Beltrand E, et al. Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures. Clin Infect Dis. 2006;42(1):57–62.
  • Grigoropoulou P, Eleftheriadou I, Jude EB, et al. Diabetic foot infections: an update in diagnosis and management current diabetes reports. Curr Diab Rep. 2017;17(3):1–12.
  • Lazaro-Martinez JL, Aragon-Sanchez J, Garcia-Morales E. Antibiotics versus conservative surgery for treating diabetic foot osteomyelitis: a randomized comparative trial. Diabetes Care. 2014;37(3):789–795.
  • Conterno LO, da Silva Filho CR. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev. 2009;8(3):CD004439.
  • French G. Safety and tolerability of linezolid. J Antimicrob Chemother. 2003;51(Suppl 2):ii45–ii53.
  • Rubinstein E, Isturiz R, Standiford HC, et al. Worldwide assessment of linezolid’s clinical safety and tolerability: comparator-controlled phase III studies. Antimicrob Agents Chemother. 2003;47:1824–1831.
  • Nguyen S, Pasquet A, Legout L, et al. Efficacy and tolerance of rifampicin–linezolid compared with rifampicin–cotrimoxazole combinations in prolonged oral therapy for bone and joint infections. Clin Microbiol Infect. 2009;15:1163–1169.
  • Game FL, Jeffcoate WJ. Primarily non-surgical management of osteomyelitis of the foot in diabetes. Diabetologia. 2008;51(962–7).
  • Valabhji J, Oliver N, Samarasinghe D, et al. Conservative management of diabetic forefoot ulceration complicated by underlying osteomyelitis: the benefits of magnetic resonance imaging. Diabet Med. 2009;26(11):1127–1134.
  • Embil JM, Rose G, Trepman E, et al. Oral antimicrobial therapy for diabetic foot osteomyelitis. Foot Ankle Int. 2006;27(10):771–779.
  • Lew D, Waldvogel F. Osteomyelitis. Lancet. 2004;364(9431):369–379.
  • Spellberg B, Lipsky B. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2012;54(3):393–407.
  • Daver N, Shelburne S, Atmar R, et al. Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis. J Infect. 2007;54(6):539–544.
  • Roberts K. Oral antibiotics for the treatment of adult osteomyelitis: a tough pill to swallow. University of Texas at Austin College of Pharmacy Rounds. Seton Healthcare Family. 2014;1–20.
  • Lipsky B, Itani K, Norden C. Linezolid diabetic foot infections study group. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. Clin Infect Dis. 2004;38(1):17–24.
  • de Mesy Bentley KL, MacDonald A, Schwarz EM, et al. Chronic osteomyelitis with staphylococcus aureus deformation in submicron canaliculi of osteocytes. JBJS Case Connect. 2018;8(1):1–4.
  • Tice AD. Pharmacoeconomic considerations in the ambulatory use of parenteral cephalosporins. Drugs. 2000;59(Suppl 3):29–35.
  • Remington AC, Hernandez-Boussard T, Warstadt NM, et al. Analyzing treatment aggressiveness and identifying high-risk patients in diabetic foot ulcer return to care. Wound Repair Regen. 2016;24:731–736.
  • Holscher C, Hicks C, Canner J, et al. Unplanned 30-day readmission in patients with diabetic foot wounds treated in a multidisciplinary setting. Soc Clin Vasc Surg. 2017;67(3):876–886.
  • McPhee JT, Barshes NR, Ho KJ, et al. Predictive factors of 30-day unplanned readmission after lower extremity bypass. J Vasc Surg. 2013;57:955–962.
  • Ghanassia E, Villon L, Thuan Dit Dieudonne JF, et al. Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers. Diabetes Care. 2008;31:1288–1292.
  • Center for Disease Control and Prevention. national center for chronic disease prevention and health promotion. division of diabetes translation. National diabetes statistics report, 2014. Estimates of Diabetes and Its Burden in the United States; 2015. 1–8.
  • Brownrigg JRW, Apelqvist J, Bakker K, et al. Evidence-based management of PAD & the diabetic foot. Eur J Vasc Endovasc Surg. 2013;45(6):673–681.
  • Larsson J, Agardh CD, Apelqvist J. Long-term prognosis after healed amputation in patients with diabetes. Clin Orthop Relat Res. 1998;350:149–158.
  • Apelqvist J, Ragnarson-Tennvall G, Persson U, et al. Diabetic foot ulcers in a multidisciplinary setting. An economic analysis of primary healing and healing with amputation. J Intern Med. 1994;235:463–471.
  • Adiewere P, Gillis RB, Imran Jiwani S, et al. A systematic review and meta-analysis of patient education in preventing and reducing the incidence or recurrence of adult diabetes foot ulcers (DFU). Heliyon. 2018;4(5):1–20.
  • Ries Z, Rungprai C, Harpole B, et al. Incidence, risk factors, and causes for thirty-day unplanned readmissions following primary lower- extremity amputation in patients with diabetes. J Bone Joint Surg Am. 2015;97:1774–1780.

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