Economic evaluation of a multimodal intervention in pre-frail and frail older people with diabetes mellitus: the MID-FRAIL project

References

• International Diabetes Federation. IDF Diabetes Atlas. Upgrade. [Internet]. IDF Diabetes Atlas. 2019. 1–169 p. [cited 2019 Nov]. Available from: http://www.idf.org/sites/default/files/Atlas-poster-2014_ES.pd
   Google Scholar
• Sinclair AJ, Abdelhafiz AH, Forbes A, et al. Evidence-based diabetes care for older people with Type 2 diabetes: a critical re-view. Diabet Med. 2019;36(4):399–413.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). Diabetes data and statistics. Copenhagen, Denmark. Regional Office for Europe. 2017.
   Google Scholar
• Narayan KMV, Boyle JP, Geiss LS, et al. Impact of recent increase in incidence on future diabetes burden: U.S., 2005-2050. Diabetes Care. 2006;29:2114–2116.
   PubMed Web of Science ®Google Scholar
• Sinclair AJ, Dunning T, Rodriguez Mañas LR, et al. Diabetes in old age. John Wiley & Sons; 2017.
   Google Scholar
• Cacciatore F, Testa G, Galizia G, et al. Clinical frailty and long-term mortality in elderly subjects with diabetes. Acta Diabetol Heidelb. 2013;50:251–260.
   PubMed Web of Science ®Google Scholar
• Hubbard RE, Andrew MK, Fallah N, et al. Comparison of the prognostic importance of diagnosed diabetes, co-morbidity and frailty in older people. Diabet Med. 2010;27:603–606.
   PubMed Web of Science ®Google Scholar
• Castro-Rodríguez M, Carnicero JA, Garcia-Garcia FJ, et al. Frailty as a major factor in the increased risk of death and disability in older people with diabetes. J Am Med Dir Assoc. 2016;17:949–955.
   PubMed Web of Science ®Google Scholar
• Hayes A, Arima H, Woodward M, et al. Changes in quality of life associated with complications of diabetes: results from the ADVANCE study. Value Health. 2016;19(1):36–41.
   PubMed Web of Science ®Google Scholar
• Solli O, Stavem K, Kristiansen IS, et al. Health-related quality of life in diabetes: the associations of complications with EQ-5D scores. Health Qual Life Outcomes. 2010;8(1):18.
   PubMedGoogle Scholar
• Trikkalinou A, Papazafiropoulou AK, Melidonis A, et al. Type 2 diabetes and quality of life. World J Diabetes. 2017;8(4):120–129.
   PubMed Web of Science ®Google Scholar
• Gauvea GR, Silva M A U D, Possobon RD, et al. Quality of life and characteristics of diabetic patients. Cien Saude Colet. 2017;22(3):921–930.
   PubMed Web of Science ®Google Scholar
• Rwegerera GM, Moshomo T, Gaenamong M, et al. Health-related quality of life and associated factors among patients with diabetes mellitus in Botswana. Alexandria J Med. 2018;54(2):111–118.
   Web of Science ®Google Scholar
• Sinclair A, Dunning T, Rodriguez-Mañas L. Diabetes in older people: new insights and remaining challenges. Lancet Diabetes Endocrinol. 2015;3(4):275–285.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2012. Diabetes Care. 2013;36(4):1033–1046.
   PubMed Web of Science ®Google Scholar
• Seuring T, Archangelidi O, Suhrcke M. The economic costs of type 2 diabetes: a global systematic review. Pharmacoeconomics. 2015;33(8):811–831.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Sánchez B, Angelini V, Feenstra T, et al. J diabetes-associated factors as predictors of nursing home admission and costs in the elderly across Europe. Am Med Dir Assoc. 2017;18(1):74–82.
   PubMed Web of Science ®Google Scholar
• García-Nogueras I, Aranda-Reneo I, Peña-Longobardo LM, et al. Use of health resources and health care costs associated with frailty: the FRADEA study. J Nutr Health Aging. 2017;21:207–214.
   PubMed Web of Science ®Google Scholar
• Villarreal Ríos E, Paredes Cruz AG, Vargas Daza ER, et al. Costo de la atención médica de pacientes con síndrome de fragilidad vs. pacientes con pre-fragilidad [Cost of patients care with fragility syndrome vs. pre-frailty patients]. Revista Cubana de Medicina General Integral. 2015;31(1):61–68.
   Google Scholar
• Comans TA, Peel NM, Hubbard RE, et al. The increase in healthcare costs associated with frailty in older people discharged to a post-acute transition care program. Age Ageing. 2016;45(2):317–320.
   PubMed Web of Science ®Google Scholar
• Liotta G, Gilardi F, Orlando S, et al. Cost of hospital care for the older adults according to their level of frailty. A cohort study in the Lazio region, Italy. PLoS One. 2019;14(6):e0217829.
   PubMed Web of Science ®Google Scholar
• Bock JO, König HH, Brenner H, et al. Associations of frailty with health care costs–results of the ESTHER cohort study. BMC Health Serv Res. 2016;14(16):128.
   Google Scholar
• Sirven N, Rapp T. The cost of frailty in France. Eur J Health Econ. 2017;18(2):243–253.
   PubMed Web of Science ®Google Scholar
• Hajek A, Bock JO, Saum KU, et al. Frailty and healthcare costs-longitudinal results of a prospective cohort study. Age Ageing. 2018;47(2):233–241.
   PubMed Web of Science ®Google Scholar
• Kojima G. Increased healthcare costs associated with frailty among community-dwelling older people: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2019;5(84):103898.
   Google Scholar
• Ekdahl AW, Alwin J, Eckerblad J, et al. Long-term evaluation of the ambulatory geriatric assessment: a Frailty Intervention Trial (AGe-FIT): clinical outcomes and total costs after 36 months. J Am Med Dir Assoc. 2016;17:263–268.
   PubMed Web of Science ®Google Scholar
• Fairhall N, Sherrington C, Lord SR, et al. Effect of a multifactorial, interdisciplinary intervention on risk factors for falls and fall rate in frail older people: a randomised controlled trial. Age Ageing. 2014;43:616–622.
   PubMed Web of Science ®Google Scholar
• Farag I, Howard K, Hayes AJ, et al. Cost-effectiveness of a home-exercise program among older people after hospitalization. J Am Med Dir Assoc. 2015;16:490–496.
   PubMed Web of Science ®Google Scholar
• van Leeuwen KM, Bosmans JE, Jansen APD, et al. Cost-effectiveness of a chronic care model for frail older adults in primary care: economic evaluation alongside a stepped-wedge cluster-randomized trial. J Am Geriatr Soc. 2015;63:2494–2504.
   PubMed Web of Science ®Google Scholar
• Looman WM, Huijsman R, Bouwmans-Frijters CAM, et al. Cost-effectiveness of the “Walcheren Integrated Care Model” intervention for community-dwelling frail elderly. Fam Pract. 2016;33:154–160.
   PubMed Web of Science ®Google Scholar
• Melis RJF, Adang E, Teerenstra S, et al. Cost-effectiveness of a multidisciplinary intervention model for community-dwelling frail older people. J Gerontol A Biol Sci Med Sci. 2008;63:275–282.
   PubMed Web of Science ®Google Scholar
• Metzelthin SF, van Rossum E, Hendriks MRC, et al. Reducing disability in community-dwelling frail older people: cost-effectiveness study alongside a cluster randomised controlled trial. Age Ageing. 2015;44:390–396.
   PubMed Web of Science ®Google Scholar
• Sandberg M, Jakobsson U, Midlöv P, et al. Cost-utility analysis of case management for frail older people: effects of a randomised controlled trial. Health Econ Rev. 2015;5:51.
   PubMed Web of Science ®Google Scholar
• de Vries NM, Staal JB, van der Wees PJ, et al. Patient-centred physical therapy is (cost-) effective in increasing physical activity and reducing frailty in older adults with mobility problems: a randomized controlled trial with 6?months follow-up. J Cachexia Sarcopenia Muscle. 2016;7:422–435.
   PubMed Web of Science ®Google Scholar
• Yamada M, Arai H, Sonoda T, et al. Community-based exercise program is cost-effective by preventing care and disability in Japanese frail older adults. J Am Med Dir Assoc. 2012;13:507–511.
   PubMed Web of Science ®Google Scholar
• Fairhall N, Sherrington C, Cameron ID, et al. A multifactorial intervention for frail older people is more than twice as effective among those who are compliant: complier average causal effect analysis of a randomised trial. J Physiother. 2017;63:40–44.
   PubMed Web of Science ®Google Scholar
• Haider S, Dorner TE, Luger E, et al. Impact of a home-based physical and nutritional intervention program conducted by lay-volunteers on handgrip strength in prefrail and frail older adults: a randomized control trial. Plos One. 2017;12:e0169613.
   PubMed Web of Science ®Google Scholar
• Liu JY-W, Lai CK, Siu PM, et al. An individualized exercise programme with and without behavioural change enhancement strategies for managing fatigue among frail older people: a quasi-experimental pilot study. Clin Rehabil. 2017;31:521–531.
   PubMed Web of Science ®Google Scholar
• Luger E, Dorner TE, Haider S, et al. Effects of a home-based and volunteer-administered physical training, nutritional, and social support program on malnutrition and frailty in older persons: a randomized controlled trial. J Am Med Dir Assoc. 2016;17:671.e9-671.e16.
   PubMed Web of Science ®Google Scholar
• Serra-Prat M, Sist X, Domenich R, et al. Effectiveness of an intervention to prevent frailty in pre-frail community-dwelling older people consulting in primary care: a randomised controlled trial. Age Ageing. 2017;46(3):401–407.
   PubMed Web of Science ®Google Scholar
• Tarazona-Santabalbina FJ, Gómez-Cabrera MC, Pérez-Ros P, et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc. 2016;17:426–433.
   PubMed Web of Science ®Google Scholar
• Clegg A, Barber S, Young J, et al. The Home-based Older People’s Exercise (HOPE) trial: a pilot randomised controlled trial of a home-based exercise intervention for older people with frailty. Age Ageing. 2014;43:687–695.
   PubMed Web of Science ®Google Scholar
• Lammes E, Rydwik E, Akner G. Effects of nutritional intervention and physical training on energy intake, resting metabolic rate and body composition in frail elderly. a randomised, controlled pilot study. J Nutr Health Aging. 2012;16:162–167.
   PubMed Web of Science ®Google Scholar
• Ruikes FGH, Zuidema SU, Akkermans RP, et al. Multicomponent program to reduce functional decline in frail elderly people: a cluster controlled trial. J Am Board Fam Med JABFM. 2016;29:209–217.
   PubMed Web of Science ®Google Scholar
• Rydwik E, Frändin K, Akner G. Effects of a physical training and nutritional intervention program in frail elderly people regarding habitual physical activity level and activities of daily living–a randomized controlled pilot study. Arch Gerontol Geriatr. 2010;51:283–289.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Mañas L, Laosa O, Vellas B, et al. Sinclair & on behalf of the European MID-Frail Consortium. Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus. J Cachexia Sarcopenia Muscle. 2019. DOI:10.1002/jcsm.12432
   Web of Science ®Google Scholar
• Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–156.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Mañas L, Bayer AJ, Kelly M, et al. An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes - the MID-Frail study: study protocol for a randomised controlled trial. Trials. 2014;15:34.
   PubMed Web of Science ®Google Scholar
• Drummond MF, Sculpher MJ, Claxton K, et al. Methods for the economic evaluation of health care programmes. Oxford university press; 2015.
   Google Scholar
• Eurostat Database - Eurostat. Harmonized index of consumer prices. 2018. [cited 2019 Nov]. Available from: https://ec.europa.eu
   Google Scholar
• Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35:1095–1108.
   PubMed Web of Science ®Google Scholar
• EuroQol Value sets – EQ-5D. 2017
   Google Scholar
• Briggs AH, Claxton K, Sculpher MJ. Decision modelling for health economic evaluation. Oxford University Press; 2006.
   Google Scholar
• Mata-Cases M, Casajuana M, Franch-Nadal J, et al. Direct medical costs attributable to type 2 diabetes mellitus: a population-based study in Catalonia, Spain. Eur J Health Econ. 2016;17(8):1001–1010.
   PubMed Web of Science ®Google Scholar
• Ramzan S, Timmins P, Hasan SS, et al. Cost analysis of type 2 diabetes mellitus treatment in economically developed countries. Expert Rev Pharmacoecon Outcomes Res. 2019;19(1):5–14.
   PubMed Web of Science ®Google Scholar
• Afroz A, Alramadan MJ, Hossain MN, et al. Cost-of-illness of type 2 diabetes mellitus in low and lower-middle income countries: a systematic review. BMC Health Serv Res. 2018;18(1):972.
   PubMedGoogle Scholar
• Landi F, Abbatecola AM, Provinciali M, et al. Moving against frailty: does physical activity matter? Biogerontol Dordr. 2010;11:537–545.
   PubMed Web of Science ®Google Scholar
• Peterson MJ, Giuliani C, Morey MC, et al. Physical activity as a preventative factor for frailty: the health, aging, and body composition study. J Gerontol Ser A. 2009;64A:61–68.
   Web of Science ®Google Scholar
• Fairhall N, Sherrington C, Kurrle SE, et al. Economic evaluation of a multifactorial, interdisciplinary intervention versus usual care to reduce frailty in frail older people. J Am Med Dir Assoc. 2015;16:41–48.
   PubMed Web of Science ®Google Scholar
• Serra-Prat M, Sist X, Domenich R, et al. Effectiveness of an intervention to prevent frailty in pre-frail community-dwelling older people consulting in primary care: a randomised controlled trial. Age Ageing. 2017;46:401–407.
   PubMed Web of Science ®Google Scholar
• Windhaber T, Koula ML, Ntzani E, et al. Educational strategies to train health care professionals across the education continuum on the process of frailty prevention and frailty management: a systematic review. Aging Clin Exp Res. 2018;30(12):1409–1415.
   PubMed Web of Science ®Google Scholar
• Casas-Herrero A, Anton-Rodrigo I, Zambom-Ferraresi F, et al. Effect of a multicomponent exercise programme (VIVIFRAIL) on functional capacity in frail community elders with cognitive decline: study protocol for a randomized multicentre control trial. Trials. 2019;20(1):362.
   PubMedGoogle Scholar
• Patel A, Collaborative Group ADVANCE. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007;370(9590):829–840.
   PubMed Web of Science ®Google Scholar
• Ismail-Beigi F, Craven T, Banerji MA, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010;376(9739):419–430.
   PubMed Web of Science ®Google Scholar
• Nathan DM, Genuth S, Lachin J, et al. Diabetes control and complications trial research group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–986.
   PubMed Web of Science ®Google Scholar
• Turner RC. The U.K. prospective diabetes study. a review. Diabetes Care. 1998 Dec;21(Suppl 3):C35–8.
   PubMedGoogle Scholar
• Hemmingsen B, Gimenez-Perez G, Mauricio D, et al. Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus. Cochrane Database Syst Rev. 2017;12:Art. No.: CD003054.
   Web of Science ®Google Scholar
• Nield L, Moore H, Hooper L, et al. Dietary advice for treatment of type 2 diabetes mellitus in adults. Cochrane Database Syst Rev. 2007;3:Art. No.: CD004097.
   PubMed Web of Science ®Google Scholar
• ohansen MY, MacDonald CS, Hansen KB, et al. Effect of an intensive lifestyle intervention on glycemic control in patients with type 2 diabetes: a randomized clinical trial. JAMA. 2017 Aug 15;318(7):637–646.
   PubMed Web of Science ®Google Scholar