Elderly individuals with diabetes and foot ulcer have a probability for healing despite extensive comorbidity and dependency

References

• United Nations, Department of Economic and Social Affairs, Population Division (2015). World population ageing 2015 (ST/ESA/SER.A/390). [cited 2020 May 21]. Available from: https://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2015_Report.pdf
   Google Scholar
• Standl E, Khunti K, Hansen TB, et al. The global epidemics of diabetes in the 21st century: current situation and perspectives. Eur J Prev Cardiol. 2019;26(2S):7–14.
   PubMedGoogle Scholar
• Song P, Rudan D, Zhu Y, et al. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Glob Health. 2019;7(8):e1020–30.
   PubMed Web of Science ®Google Scholar
• Kähm K, Laxy M, Schneider U, et al. Health care costs associated with incident complications in patients with type 2 diabetes in Germany. Diabetes Care. 2018;41(5):971–978.
   PubMed Web of Science ®Google Scholar
• Sinclair A, Morley JE, Rodriguez-Manas L, et al. Diabetes mellitus in older people: position statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the international task force of experts in diabetes. J Am Med Dir Assoc. 2012;13(6):497–502.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. 11. Older Adults: standards of medical care in diabetes 2018. Diabetes Care. 2018;41(Suppl. 1):S119–S125.
   PubMedGoogle Scholar
• Swedish Council on Health Technology Assessment (SBU). Chronic ulcers in the elderly - prevention and treatment. SBU report no 226 (in Swedish). 2014;226.
   Google Scholar
• Schaper N, van Netten J, Apelqvist J, et al. IWGDF guidelines on the prevention and management of diabetic foot disease. [cited 2020 May 21]. Available from: https://iwgdfguidelines.org/wp-content/uploads/2019/05/IWGDF-Guidelines-2019.pdf.
   Google Scholar
• Rayman G, Vas P, Dhatariya K, et al. on behalf of the International Working Group on the Diabetic Foot (IWGDF) Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(S1):e3283.
   PubMedGoogle Scholar
• Gershater MA, Löndahl M, Nyberg P, et al. Complexity of factors related to outcome of neuropathic and neuroischaemic diabetic foot ulcers: a cohort study. Diabetologia. 2009; (52):398–407. DOI:10.1007/s00125-008-1226-2.
   PubMedGoogle Scholar
• Annersten Gershater M, Pilhammar E, Alm Roijer C. Documentation of diabetes care in home nursing service in a Swedish municipality: a cross-sectional study on nurses’ documentation. Scand J Caring Sci. 2011;25(2):220–226.
   PubMed Web of Science ®Google Scholar
• Annersten Gershater M, Pilhammar E, Alm Roijer C. Prevention of foot ulcers in patients with diabetes in home nursing: a qualitative interview study. Eur Diabetes Nurs. 2013 July;10(2):52–57.
   Google Scholar
• Apelqvist J, Larsson J, Agardh C. Long-term prognosis for diabetic patients with foot ulcers. J Intern Med. 1993;233:485–491. DOI:10.1111/j.1365-2796.1993.tb01003.x
   PubMedGoogle Scholar
• Wagner FW. The Dysvascular foot: A system for diagnosis and treatment. Foot Ankle. 1981 Feb;2(2):64–122.
   PubMedGoogle Scholar
• Larsson J, Agardh C, Apelqvist J, et al. Clinical characteristics in relation to final amputation level in diabetic patients with foot ulcers: a prospective study of healing below or above the ankle in 187 patients. Foot Ankle. 1995;16(2):69–74.
   PubMedGoogle Scholar
• van Netten J, Bus S, Apelqvist J, et al.Definitions and criteria for diabetic foot disease. Diabetes Metab Res Rev. 2020;36(Suppl_1)e3268. DOI:10.1002/dmrr.3268
   PubMed Web of Science ®Google Scholar
• Socialdepartementet. Hälso- och sjukvårdslagen (2017:30) . 2017.
   Google Scholar
• Distriktssköterskeföreningen i Sverige/Svensk sjuksköterskeförening. Kompetensbeskrivning legitimerad sjuksköterska med specialistsjuksköterskeexamen distriktssköterska. 2008. (In Swedish: Competency description for district nurses)
   Google Scholar
• Adolfsson ET, Smide B, Rosenblad A, et al. Does patient education facilitate diabetic patients’ possibilities to reach national treatment targets? A national survey in Swedish primary healthcare. Scand J Prim Health Care. 2009 June;27(2):91–96.
   PubMed Web of Science ®Google Scholar
• Janlöv A, Rahm Hallberg I, Pettersson K. Family members’ experience of participation in the needs of assessment when their older next of kin becomes in need of public home help: A qualitative interview study. Int J Nurs Stud. 2006;43(8):1033–1046.
   PubMed Web of Science ®Google Scholar
• Socialdepartementet. Socialtjänstlagen. 2001;453.
   Google Scholar
• Fahey T, Montgomery AA, Barnes J, et al. Quality of care for elderly residents in nursing homes and elderly people living at home: controlled observational study. BMJ. 2003 15;326(7389):580.
   PubMedGoogle Scholar
• Hjelm K, Rolfe M, Bryar RM, et al. Management of chronic leg ulcers by nurses working in the community in Sweden and the UK. J Wound Care. 2003;12(3):93–98.
   PubMedGoogle Scholar
• Munshi MN, Florez H, Huang ES, et al. Management of diabetes in long-term care and skilled nursing facilities: a position statement of the American Diabetes Association. Diabetes Care. 2016;39(2):308–318.
   PubMed Web of Science ®Google Scholar
• BØ K, Botten G, Gjevjon ER, et al. Quality work in long-term care: the role of first-line leaders. Int J Qual Health Care. 2010;22(5):351–357.
   PubMed Web of Science ®Google Scholar
• Rigby M, Roberts R, Williams J, et al. Integrated record keeping as an essential aspect of a primary care led health service. BMJ. 1998 29; 317(7158):579–582.
   PubMedGoogle Scholar
• Smith J. The changing face of community and district nursing. Aust Health Rev. 2002;25(3):131–133.
   PubMedGoogle Scholar
• Socialdepartementet. Lag om kommunernas betalningsansvar för viss hälso- och sjukvård. Stockholm: Socialdepartementet. 1990. p. 1404.
   Google Scholar
• Socialstyrelsen. Allmänna råd: grundläggande kunskaper hos personal som arbetar i socialtjänstens omsorg om äldre. 2011;SOSFS 2011:12 (S).
   Google Scholar
• Svensson H, Apelqvist J, Larsson J, et al. Minor amputation in patients with diabetes mellitus and severe foot ulcers achieves good outcomes. J Wound Care. 2011;20(6):261–262. 264, 266 passim.
   PubMed Web of Science ®Google Scholar
• Jeffcoate WJ, Chipchase SY, Ince P, et al. Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures. Diabetes Care. 2006;29(8):1784–1787.
   PubMed Web of Science ®Google Scholar
• Oyibo SO, Jude EB, Tarawneh I, et al. The effects of ulcer size and site, patient’s age, sex and type and duration of diabetes on the outcome of diabetic foot ulcers. Diabetic Med. 2001;18(2):133–138.
   PubMed Web of Science ®Google Scholar
• Gul A, Basit A, Ali SM, et al. Role of wound classification in predicting the outcome of diabetic foot ulcer. Jl Pak Med Assoc. 2006;56(10):444–447.
   PubMedGoogle Scholar
• Apelqvist J, Castenfors J, Stenström A, et al. Prognostic value of systolic ankle and toe pressure levels in outcome of diabetic foot ulcer. Diabetes Care. 1989;12(6):373–378.
   PubMed Web of Science ®Google Scholar
• Margolis DJ, Allen-Taylor L, Hoffstad O, et al. Diabetic neuropathic foot ulcers: the association of wound size, wound duration, and wound grade on healing. Diabetes Care. 2002;25(10):1835–1839.
   PubMed Web of Science ®Google Scholar
• Prompers L, Huijberts M, Apelqvist J, et al., High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 2007;50(1): 18–25.
   PubMed Web of Science ®Google Scholar
• Boyko EJ, Ahroni JH, Cohen V, et al. Prediction of diabetic foot ulcer occurrence using commonly available clinical information: the Seattle diabetic foot study. Diabetes Care. 2006;29(6):1202–1207.
   PubMed Web of Science ®Google Scholar
• Margolis DJ, Kantor J, Santanna J, et al. Risk factors for delayed healing of neuropathic diabetic foot ulcers: a pooled analysis. Arch Derm. 2000;136(12):1531–1535.
   PubMedGoogle Scholar
• Sheehan P, Jones P, Caselli A, et al. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes Care. 2003;26(6):1879–1882.
   PubMed Web of Science ®Google Scholar
• Tentolouris, N., Al-Sabbagh, S., Walker, M.G. et al. Mortality in diabetic and non-diabetic patients after amputations performed from 1990 to. a 5-year follow-up study. Diabetes Care. 2004;27(7):1598–1604.
   PubMed Web of Science ®Google Scholar
• Armstrong DG, Lavery LA, Frykberg RG, et al. Validation of a diabetic foot surgery classification. Int Wound J. 2006;3(3):240–246.
   PubMedGoogle Scholar
• Imran S, Ali R, Mahboob G. Frequency of lower extremity amputation in diabetics with reference to glycemic control and Wagner’s grades. J Coll Physicians Surg Pak. 2006;6(2):124–127.
   Google Scholar
• Izumi Y, Satterfield K, Lee S, et al. Risk of re-amputation in diabetic patients stratified by limb and level of amputation: a 10-year observation. Diabetes Care. 2006;29(3):566–570.
   PubMed Web of Science ®Google Scholar
• Pickwell K, Siersma V, Kars M, et al. Minor amputation does not negatively affect health-related quality of life as compared with conservative treatment in patients with a diabetic foot ulcer: an observational study. Diabetes Metab Res. 2017;33(3):e2867.
   Web of Science ®Google Scholar
• Peled S, Pollack R, Elishoov O, et al. Association of inpatient glucose measurements with amputations in patients hospitalized with acute diabetic foot. Jl Clin End Metab. 2019;104(11):5445–5452.
   PubMed Web of Science ®Google Scholar
• Behrendt C, Sigvant B, Szeberin Z, et al. International variations in amputation practice: A VASCUNET report. Eur J Vasc Endovascular Surg. 2018;56(3):391–399.
   PubMed Web of Science ®Google Scholar
• Larsson J, Agardh CD, Apelqvist J, et al. Longterm prognosis after healed amputation in patients with diabetes. Clin Orthop Relat Res. 1998;350:149–158.
   Google Scholar
• Apelqvist J, Agardh CD. The association between clinical risk factors and outcome of diabetic foot ulcers. Diabetes Res Clin Pract. 1992;18(1):43–53.
   PubMed Web of Science ®Google Scholar
• Beckert S, Witte M, Wicke C, et al. A new wound-based severity score for diabetic foot ulcers: a prospective analysis of 1,000 patients. Diabetes Care. 2006;29(5):988–992.
   PubMed Web of Science ®Google Scholar
• Margolis DJ, Kantor J, Santanna J, et al. Risk factors for delayed healing of neuropathic diabetic foot ulcers: a pooled analysis. Arch Dermatol. 2000;136(12):1531–1535.
   PubMedGoogle Scholar
• Armstrong D, Boulton A, Bus S. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–2375.
   PubMed Web of Science ®Google Scholar
• Statistiska centralbyrån (Statistics Sweden). Demografiska rapporter: livslängd och dödlighet i olika sociala grupper. 2016;2.
   Google Scholar
• Morbach S, Furchert H, Gröblinghoff U, et al. Long-term prognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade. Diabetes Care. 2012;35(10):2021–2027.
   PubMed Web of Science ®Google Scholar
• Xie Y, Zhang H, Ye T, et al. The geriatric nutritional risk index independently predicts mortality in diabetic foot ulcers patients undergoing amputations. J Diabetes Res. 2017;2017:5797194. DOI: 10.1155/2017/5797194
   PubMed Web of Science ®Google Scholar
• Boon MY, Chu BS, Lee P, et al. Perceptions of older people regarding their vision and incident causation. Optometry Vision Sci . 2015;92(10):995–1002.
   PubMed Web of Science ®Google Scholar
• Hausken MF, Graue M. Developing, implementing and evaluating diabetes care training for nurses and nursing aides in nursing homes and municipal home-based services. Eur Diabetes Nurs. 2013;10(1):19–24.
   Google Scholar
• Socialstyrelsen. Allmänna råd: Grundläggande kunskaper hos personal som arbetar i socialtjänstens omsorg om äldre. 2011;SOSFS 2011:12 (S).
   Google Scholar
• Titlestad I, Haugstvedt A, Igland J, et al. Patient safety culture in nursing homes - a cross-sectional study among nurses and nursing aides caring for residents with diabetes. BMC Nurs. 2018;17(1):36.
   PubMedGoogle Scholar
• National pressure ulcer advisory panel, european pressure ulcer advisory panel and pan pacific pressure injury alliance. In: HaeslerE, editor. Prevention and treatment of pressure ulcers: quick reference guide. 2014. Cambridge Media: Perth, Australia. Available from: https://www.epuap.org/wp-content/uploads/2010/10/Quick-Reference-Guide-DIGITAL-NPUAP-EPUAP-PPPIA-16Oct2014.pdf
   Google Scholar
• Munshi MN, Florez H, Huang ES, et al. Management of diabetes in long-term care and skilled nursing facilities: a position statement of the American Diabetes Association. Diabetes Care. 2016 Feb;39(2):308–318.
   PubMed Web of Science ®Google Scholar
• Pickwell K, Siersma V, Kars M, et al., on behalf of the Eurodiale consortium. Diabetic foot disease: impact of ulcer location on ulcer healing. Diabetes Metab Res Rev. 2013;29(5):377–383.
   PubMed Web of Science ®Google Scholar
• Wessman Y, Bahtsevani C. ‘Living with challenges in the shadow of diabetes’: an interview study among adults with diabetic peripheral neuropathy. Nord J Nurs Res. 2019:1–8.
   Google Scholar
• Ragnarson Tennvall G, Apelqvist J. Health-related quality of life in patients with diabetes mellitus and foot ulcers. J Diabetes Complications. 2000;14(5):235–241.
   PubMed Web of Science ®Google Scholar
• Haugstvedt A, Graue M, Aarflot M, et al. Challenges in maintaining satisfactory documentation routines and evidence based management in nursing homes. Int Diabetes Nurs. 2016;13(1–3):37–42.
   Google Scholar
• Jeffcoate W, Game F, Turtle-Savage V, et al. Evaluation of the effectiveness and cost-effectiveness of lightweight fibreglass heel casts in the management of ulcers of the heel in diabetes: a randomised controlled trial. Health Technol Assess. 2017;21(34):1–92.
   PubMed Web of Science ®Google Scholar
• Monami M, Scatena A, Zannoni S, et al. A randomized, open-label, controlled trial to evaluate the antimicrobial and surgical effect of CO2 laser treatment in diabetic infected foot ulcers: DULCIS (diabetic ulcer, CO2 laser, and infections) study. J Endocrinol Invest. 2017;40(9):985–989.
   PubMed Web of Science ®Google Scholar
• Lindholm E, Melander O, Almgren P, et al. Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. PLoS ONE. 2006.;20:1 e64
   Google Scholar
• Tivesten Å, Mellström D, Jutberger H, et al. Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men: the MrOS study in Sweden. J Am Coll Cardiol. 2007;50(11):1070–1076.
   PubMed Web of Science ®Google Scholar
• Hjelm K, Nyberg P, Apelqvist J. Gender influences beliefs about health and illness in diabetic subjects with severe foot lesions. J Adv Nurs. 2002;40(6):673–684.
   PubMed Web of Science ®Google Scholar