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Original Research

Cost-utility analysis of stereotactic body radiotherapy plus cetuximab in previously irradiated recurrent squamous cell carcinoma of the head and neck

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Pages 489-495 | Received 24 Oct 2020, Accepted 11 Feb 2021, Published online: 17 Mar 2021

References

  • Patel PR, Slama JK. Reirradiation for recurrent head and neck cancer. Expert Rev Anticancer Ther. 2012;12(12):1177–1189.
  • Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009;4(1):49–70.
  • Solomon B, Young RJ, Rischin D. Head and neck squamous cell carcinoma: genomics and emerging biomarkers for immunomodulatory cancer treatments. Semin Cancer Biol. 2018;52(Pt 2):228–240.
  • Fakhry C, Zhang Q, Nguyen-Tan PF, et al. Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. Journal of Clinical Oncology. 2014;32(30):3365–3373. .
  • Clavel M, Vermorken JB, Cognetti F, et al. Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck. A phase III study of the EORTC. Head and neck cancer cooperative group. AnnOncol. 1994;5:521–526.
  • Argiris A, Li Y, Forastiere A. Prognostic factors and long-term survivorship in patients with recurrent or metastatic carcinoma of the head and neck. Cancer. 2004;101(10):2222–2229.
  • Spencer SA, Harris J, Wheeler RH, et al. Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck. 2008;30(3):281–288. .
  • Langer CJ, Harris J, Horwitz EM, et al. Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of radiation therapy oncology group protocol 9911. Journal of Clinical Oncology. 2007;25(30):4800–4805. .
  • Sulman EP, Schwartz DL, Le TT, et al. IMRT reirradiation of head and neck cancer—disease control and morbidity outcomes. Int J Radiat Oncol Biol Phys. 2009;73(2):399–409. .
  • Salama JK, Vokes EE, Chmura SJ, et al. Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2006;64(2):382–391. .
  • Vargo JA, Ward MC, Caudell JJ. et al. A Multi-institutional Comparison of SBRT and IMRT for definitive reirradiation of recurrent or second primary head and neck cancer. Int J Radiat Oncol Biol Phys. 2018;100(3):595–605.
  • Heron DE, Ferris RL, Karamouzis M, et al. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys. 2009;75(5):1493–1500. .
  • Vargo JA, Ferris RL, Ohr J, et al. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. International Journal of Radiation Oncology*Biology*Physics. 2015;91(3):480–488. .
  • Comet B, Kramar A, Faivre-Pierret M, et al. stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility. J RadiatOncolBiol Phys 2012;84(1):203–209. study.Int
  • Vargo JA, Kubicek GJ, Ferris RL, et al. Adjuvant stereotactic body radiotherapy ± cetuximab following salvage surgery in previously irradiated head and neck cancer. The Laryngoscope. 2014;124(7):1579–1584. .
  • Lartigau EF, Tresch E, Thariat J, et al. Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer. RadiotherOncol. 2013;109(2):281–285.
  • Heron DE, Rwigema J-CM, Gibson MK, et al. Concurrent Cetuximab with stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck. Am J Clin Oncol. 2011;34(2):165–172. .
  • KEYSTROKE:a randomized phase ii study of pembrolizumab (KEYTRUDA®) plus stereotactic re-irradiation versus SBRT alone for locoregionally recurrent or second primary head and neck carcinoma. Clinical Trials.gov: https://clinicaltrials.gov/ct2/show/NCT03546582
  • Melero I, Berman DM, Aznar MA, et al. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer. 2015;15(8):457–472. .
  • Jie H-B, Srivastava RM, Argiris A, et al. Increased PD-1 + and TIM-3 + TILs during cetuximab therapy inversely correlate with response in head and neck cancer patients. Cancer Immunol Res. 2017;5(5):408–416. .
  • Taberna M, Oliva M, Mesía R. Cetuximab-containing combinations in locally advanced and recurrent or metastatic head and neck squamous cell carcinoma. Front Oncol. 2019;9:383.
  • Husereau D, Drummond M, Petrou S, et al. Consolidated health economic evaluation reporting standards (CHEERS) statement. Value Health. 2013;16(2):e1–5. .
  • Murray CJL, Evans DB, Acharya A, et al. Development of WHO guidelines on generalized cost-effectiveness analysis. Health Economics. 2000;9(3):235–251. .
  • International Monetary Fund. World economic outlook (April 2019) GDP current price. cited 2018 August 12. http://www.imf.org/external/datamapper/NGDPD@WEO/OEMDC/ADVEC/WEOWORLD
  • Diaby V, Adunlin G, Montero AJ. Survival modeling for the estimation of transition probabilities in model-based economic evaluations in the absence of individual patient data: a tutorial. Pharmacoeconomics. 2014;32(2):101–108.
  • Purmonen T, Martikainen JA, Soini EJO, et al. Economic evaluation of sunitinib malate in second-line treatment of metastatic renal cell carcinoma in Finland. Clin Ther. 2008;30(2):382–392. .
  • Kim H, Vargo JA, Beriwal S, et al. Cost-effectiveness analysis of salvage therapies in locoregional previously irradiated head and neck cancer. Head Neck. 2009;75(5):1743–1751. .
  • Brown B, Diamantopoulos A, Bernier J, et al. An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and Neck Cancer in Belgium, France, Italy, Switzerland, and the United Kingdom. Value Health. 2008;11(5):791–799. .
  • Drummond MF, Mj S, Gw T. Methods for the economic evaluation of health care programs. Oxford, UK: Oxford University Press; 2005.
  • Net benefits calculations, TreeAge Pro 2020 User’sManual. Chapter 33. TreeAge Software, Inc; 2020. p. 493.
  • Gray A, Clarke PM, Wolstenholme JL, et al. Applied methods of cost-effectiveness analysis in health care. Oxford University Press; 2010.
  • Sculpher Mark. The Use of a Probabilistic Sensitivity Analysis for Decision Making: the example of Drug Eluting Stents. 2008, Aug 17.
  • Gray LA, Alava MH, Wailoo AJ. Development of methods for the mapping of utilities using mixture models: mapping the AQLQ-S to the EQ-5D-5L and the HUI3 in Patients with Asthma. Value Health. 2018;21(6):748–757.
  • Mihaylova B, Briggs A, O’Hagan A, et al. Review of statistical methods for analysing healthcare resources and costs. Health Economics. 2011;20(8):897–916.
  • The beta-PERT Distribution RiskAMP. https://www.riskamp.com/beta-pert. cited 2020 Dec 18.
  • Shiroiwa T, Sung Y-K, Fukuda T, et al. International survey on willingness-to-pay (WTP) for one additional QALY gained: what is the threshold of cost effectiveness? Health Economics. 2010;19(4):422–437. .
  • Vallejo-Torres L, García-Lorenzo B, Castilla I, et al. On the estimation of the cost-effectiveness Threshold: why, what, how? Value Health. 2016;19(5):558–566. .
  • Vallejo-Torres L, García-Lorenzo B, Castilla I, et al. Cost-effectiveness thresholds: pros and cons. Bull World Health Organ 2016;94(12):925–930.
  • Value assessment framework - proposed changes, page ES3. Institute for Clinical and Economic Review; 2019.
  • Sun XS, Sire C, Tao Y, et al. A phase II randomized trial of pembrolizumab versus cetuximab, concomitant with radiotherapy (RT) in locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN): first results of the GORTEC 2015-01 “PembroRad” trial. J Clin Oncol. 2018;36(Suppl. 15_suppl):6018.
  • Levy A, Massard C, Soria J-C. Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: single centre subset analysis from a phase 1/2 trial. Eur J Cancer. 2016;68:156–162.
  • Powell SF, Gitau MM, Sumey CJ, et al. Safety of pembrolizumab with chemoradiation (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). J Clin Oncol. 2017;35(15_suppl):6011.
  • Gillison M, Ferris R, Zhang Q, et al. Safety evaluations of nivolumab (anti-pd1) added to chemoradiotherapy platformsfor patientswith intermediate and high-risk local-regionally advanced headand neck squamous cell carcinoma. In: Multidisciplinary Head and Neck Cancers Symposium (Scottsdale, AZ). 2018.
  • Wise-Draper TM, Old MO, Worden FP, et al. Phase II multi-site investigation of neoadjuvant pembrolizumab and adjuvant concurrent radiation and pembrolizumab with or without cisplatin in resected head and neck squamous cell carcinoma. J Clin Oncol. 2018;36(suppl. 15_suppl):6017.
  • McBride SM, Sherman EJ, Tsai CJ, et al. A phase II randomized trial of nivolumab with stereotactic body radiotherapy (SBRT) versus nivolumab alone in metastatic (M1) head and neck squamous cell carcinoma (HNSCC). J Clin Oncol. 2018;36(15_suppl):6009.
  • Campo C, Bai J, Keller LR. Comparing Markov and non-Markov alternatives for cost-effectiveness analysis: insights from a cervical cancer case. Oper Res Health Care. 2019;21:32–43.
  • Wong SJ, MachtayM M, Li Y. Locally recurrent, previously irradiated head and neck cancer: concurrent re-irradiation and chemotherapy, or chemotherapy alone? J Clin Oncol. 2006;24(17):2653–2658.
  • Tortochaux J, Tao Y, Tournay E, et al. Randomized phase III trial (GORTEC 98-03) comparing re-irradiation plus chemotherapy versus methotrexate in patients with recurrent or a second primary head and neck squamous cell carcinoma, treated with a palliative intent. Radiother Oncol. 2011;100(1):70–75.
  • Hannouf MB, Sehgal C, Cao JQ, et al. Cost-effectiveness of adding cetuximab to platinum-based chemotherapy for first-line treatment of recurrent or metastatic head and neck cancer. PLoS One. 2012;7(6):e38557.
  • Caudell JJ, Ward MC, Riaz N, et al. Volume, dose, and fractionation considerations for IMRT-based reirradiation in head and neck cancer: a multi-institution analysis. Int J Radiat Oncol Biol Phys. 2018;100(3):606–617.

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