Prevalence and direct costs of potentially inappropriate prescriptions in France: a population-based study

References

• He W, Goodkind D, Kowal P. Census bureau, international population reports, an aging world: 2015. Whashington DC: U.S. Government Publishing Office; 2016.
   Google Scholar
• Gallagher P, Barry P, O’Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32(2):113–121.
   PubMed Web of Science ®Google Scholar
• O’Connor MN, Gallagher P, O’Mahony D. Inappropriate prescribing: criteria, detection and prevention. Drugs Aging. 2012;29(6):437–452.
   PubMed Web of Science ®Google Scholar
• Clyne B, Fitzgerald C, Quinlan A, et al., Interventions to address potentially inappropriate prescribing in community-dwelling older adults: a systematic review of randomized controlled trials. J Am Geriatr Soc. 2016;64(6): 1210–1222.
   PubMed Web of Science ®Google Scholar
• Guaraldo L, Cano FG, Damasceno GS, et al. Inappropriate medication use among the elderly: a systematic review of administrative databases. BMC Geriatr. 2011;11(1):79.
   PubMedGoogle Scholar
• Xing XX, Zhu C, Liang HY, et al. Associations between potentially inappropriate medications and adverse health outcomes in the elderly: a systematic review and meta-analysis. Ann Pharmacother. 2019;53(10):1005–1019.
   PubMed Web of Science ®Google Scholar
• Cahir C, Fahey T, Teeling M, et al. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol. 2010;69(5):543–552.
   PubMed Web of Science ®Google Scholar
• Morgan SG, Hunt J, Rioux J, et al. Frequency and cost of potentially inappropriate prescribing for older adults: a cross-sectional study. CMAJ Open. 2016;4(2):E346–351.
   PubMedGoogle Scholar
• Bradley MC, Fahey T, Cahir C, et al. Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland enhanced prescribing database. Eur J Clin Pharmacol. 2012;68(10):1425–1433.
   PubMed Web of Science ®Google Scholar
• Moriarty F, Cahir C, Bennett K, et al. Economic impact of potentially inappropriate prescribing and related adverse events in older people: a cost-utility analysis using Markov models. BMJ Open. 2019;9(1):e021832.
   PubMed Web of Science ®Google Scholar
• Pohl-Dernick K, Meier F, Maas R, et al. Potentially inappropriate medication in the elderly in Germany: an economic appraisal of the PRISCUS list. BMC Health Serv Res. 2016;16(1):109.
   PubMedGoogle Scholar
• Leikola S, Dimitrow M, Lyles A, et al. Potentially inappropriate medication use among Finnish non-institutionalized people aged ≥65 years: a register-based, cross-sectional, national study. Drugs Aging. 2011;28(3):227–236.
   PubMed Web of Science ®Google Scholar
• Fralick M, Bartsch E, Ritchie CS, et al. Estimating the use of potentially inappropriate medications among older adults in the United States. J Am Geriatr Soc. 2020;68(12):2927–2930.
   PubMed Web of Science ®Google Scholar
• Clark CM, Shaver AL, Aurelio LA, et al., Potentially inappropriate medications are associated with increased healthcare utilization and costs. J Am Geriatr Soc. 2020;68(11): 2542–2550.
   PubMed Web of Science ®Google Scholar
• Jungo KT, Streit S, Lauffenburger JC. Utilization and spending on potentially inappropriate medications by US older adults with multiple chronic conditions using multiple medications. Arch Gerontol Geriatr. 2021;93:104326.
   PubMed Web of Science ®Google Scholar
• Moriarty F, Cahir C, Fahey T, et al. Potentially inappropriate medicines and potential prescribing omissions in older people and their association with health care utilization: a retrospective cohort study. Value Health. 2014;17(7):A520.
   PubMed Web of Science ®Google Scholar
• Bongue B, Laroche ML, Gutton S, et al. Potentially inappropriate drug prescription in the elderly in France: a population-based study from the French national insurance healthcare system. Eur J Clin Pharmacol. 2011;67(12):1291–1299.
   PubMed Web of Science ®Google Scholar
• Roux B, Berthou-Contreras J, Beuscart JB, et al. REview of potentially inappropriate MEDIcation pr[e]scribing in Seniors (REMEDI[e]S): French implicit and explicit criteria. Eur J Clin Pharmacol. 2021 Jun 11; https://doi.org/10.1007/s00228-021-03145-6. Online ahead of print.
   Google Scholar
• Direction de la recherche, des études, de l’évaluation et des statistiques (DRESS). Les dépenses de santé en 2017: les résultats des comptes de la santé. Edition 2018. https://dress.solidarities-sante.gouv.fr/IMG/pdf/cns18.pdf. 2020 Sept 20.
   Google Scholar
• Bezin J, Duong M, Lassalle R, et al. The national healthcare system claims databases in France, SNIIRAM and EGB: powerful tools for pharmacoepidemiology. Pharmacoepidemiol Drug Saf. 2017;26(8):954–962.
   PubMed Web of Science ®Google Scholar
• Tuppin P, De Roquefeuil L, Weill A, et al. French national health insurance information system and the permanent beneficiaries sample. Rev Epidemiol Sante Publique. 2010;58(4):286–290.
   PubMed Web of Science ®Google Scholar
• Tuppin P, Rudant J, Constantinou P, et al. Value of a national administrative database to guide public decisions: from the système national d’information interrégimes de l’Assurance maladie (SNIIRAM) to the système national des données de santé (SNDS) in France. Rev Epidemiol Sante Publique. 2017;65(Suppl 4):S149–67.
   PubMedGoogle Scholar
• Bezin J, Moore N, Mansiaux Y, et al. Benefits of statins for cardiovascular prevention in elderly subjects: a population-based cohort study. Am J Med. 2019;132(6):740–748.e7.
   PubMed Web of Science ®Google Scholar
• Bannay A, Chaignot C, P-o B, et al. The best use of the Charlson comorbidity index with electronic health care database to predict mortality. Med Care. 2016;54(2):188–194.
   PubMed Web of Science ®Google Scholar
• Roux B, Sirois C, Simard M, et al. Potentially inappropriate medications in older adults: a population-based cohort study. Fam Pract. 2020;37(2):173–179.
   PubMed Web of Science ®Google Scholar
• Caisse Nationale d’Assurance Maladie (CNAM). Méthodologie médicale de la cartographie et des dépenses, version G7 (années 2012 à 2018). Mars 2019. https://www.ameli.fr/fileadmin/user_upload/documents/Methodologie_medicale_cartographie.pdf. 2020 Jan 28.
   Google Scholar
• Hucteau E, Noize P, Pariente A, et al. ADL-dependent older adults were identified in medico-administrative databases. J Clin Epidemiol. 2021Jun21;S0895-4356(21)00192-X. https://doi.org/10.1016/j.jclinepi.2021.06.014 Online ahead of print
   Google Scholar
• Institut national de la statistique et des études économiques (INSEE). Tableaux de l’économie française 2017. https://www.insee.fr/fr/information/2655532. 2021 Jun 06.
   Google Scholar
• Herr M, Sirven N, Grondin H, et al. Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population. Eur J Clin Pharmacol. 2017;73(9):1165–1172.
   PubMed Web of Science ®Google Scholar
• Martinot P, Landré B, Zins M, et al. Association Between Potentially Inappropriate Medications and Frailty in the Early Old Age: a Longitudinal Study in the GAZEL Cohort. J Am Med Dir Assoc. 2018;19(11):967–973.e3.
   PubMed Web of Science ®Google Scholar
• Beuscart J-B, Dupont C, Defebvre M-M PF. Potentially inappropriate medications (PIMs) and anticholinergic levels in the elderly: a population based study in a French region. Arch Gerontol Geriatr. 2014;59(3):630–635.
   PubMed Web of Science ®Google Scholar
• Laroche M-L, Charmes J-P ML. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol. 2007;63(8):725–731.
   PubMed Web of Science ®Google Scholar
• Tommelein E, Mehuys E, Petrovic M, et al. Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review. Eur J Clin Pharmacol. 2015;71(12):1415–1427.
   PubMed Web of Science ®Google Scholar
• Guillot J, Maumus-Robert S, Marceron A, et al. The burden of potentially inappropriate medications in chronic polypharmacy. J Clin Med. 2020;9(11):11.
   Web of Science ®Google Scholar
• Huon J-F, Lenain E, LeGuen J, et al. Use by French elderly patients has changed during the last decade. Drugs Real World Outcomes. 2015;2(4):327–333.
   PubMedGoogle Scholar
• Moriarty F, Bennett K, Cahir C, et al. Characterizing potentially inappropriate prescribing of proton pump inhibitors in older people in primary care in Ireland from 1997 to 2012. J Am Geriatr Soc. 2016;64(12):e291–e296.
   PubMed Web of Science ®Google Scholar
• Beuscart J-B, Genin M, Dupont C, et al. Potentially inappropriate medication prescribing is associated with socioeconomic factors: a spatial analysis in the French nord-pas-de-calais region. Age Ageing. 2017;46(4):607–613.
   PubMed Web of Science ®Google Scholar
• Re T, Bc T. A systematic review of studies of the STOPP/START 2015 and American geriatric society beers 2015 criteria in patients ≥ 65 Years. Curr Aging Sci. 2019;12(2):121–154.
   PubMedGoogle Scholar
• Morin L, Laroche M-L. Medication use in adults aged 60 years and older in France: a population-level study using national health insurance data. Rev Geriatr. 2016;41(6):335-49.
   Google Scholar
• Roux B, Sirois C, Simard M, et al. One-year persistence of potentially inappropriate medication use in older adults: a population-based study. Br J Clin Pharmacol. 2020;86(6):1062–1080.
   PubMed Web of Science ®Google Scholar
• Bénard-Laribière A, Noize P, Pambrun E, et al. Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study. Pharmacoepidemiol Drug Saf. 2017;26(2):162–169.
   PubMed Web of Science ®Google Scholar
• Mathieu C, Joly P, Jacqmin-Gadda H, et al. Patterns of benzodiazepine use and excess risk of all-cause mortality in the elderly: a nationwide cohort study. Drug Saf. 2021;44(1):53–62.
   PubMed Web of Science ®Google Scholar
• Ikeji C, Williams A, Hennawi G, et al. Patient and provider perspectives on deprescribing proton pump inhibitors. J Gerontol Nurs. 2019;45(10):9–17.
   PubMed Web of Science ®Google Scholar
• Jaynes M, Kumar AB. The risks of long-term use of proton pump inhibitors: a critical review. Ther Adv Drug Saf. 2019;10:2042098618809927.
   Web of Science ®Google Scholar
• Pandraud-Riguet I, Bonnet-Zamponi D, Bourcier E, et al. Monitoring of potentially inappropriate prescriptions in older inpatients: a French multicenter study. J Am Geriatr Soc. 2017;65(12):2713–2719.
   PubMed Web of Science ®Google Scholar
• Pohontsch NJ, Heser K, Löffler A, et al. General practitioners’ views on (long-term) prescription and use of problematic and potentially inappropriate medication for oldest-old patients-A qualitative interview study with GPs (C IM-TRIAD study). BMC Fam Pract. 2017;18(1):22.
   PubMedGoogle Scholar
• Heser K, Pohontsch NJ, Scherer M, et al., Perspective of elderly patients on chronic use of potentially inappropriate medication - Results of the qualitative CIM-TRIAD study. PLoS ONE. 2018;13(9): e0202068.
   PubMed Web of Science ®Google Scholar
• Cullinan S, O’Mahony D, Fleming A, et al. A meta-synthesis of potentially inappropriate prescribing in older patients. Drugs Aging. 2014;31(8):631–638.
   PubMed Web of Science ®Google Scholar
• Black CD, Thavorn K, Coyle D, et al. The health system costs of potentially inappropriate prescribing: a population-based, retrospective cohort study using linked health administrative databases in Ontario, Canada. Pharmacoecon Open. 2020;4(1):27–36.
   PubMed Web of Science ®Google Scholar
• Panneman MJM, Goettsch WG, Kramarz P, et al. The costs of benzodiazepine-associated hospital-treated fall Injuries in the EU: a Pharmo study. Drugs Aging. 2003;20(11):833–839.
   PubMed Web of Science ®Google Scholar
• Tannenbaum C, Martin P, Tamblyn R, et al. Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial. JAMA Intern Med. 2014;174(6):890–898.
   PubMed Web of Science ®Google Scholar
• Martin P, Tamblyn R, Benedetti A, et al. Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: the D-PRESCRIBE randomized clinical trial. JAMA. 2018;320(18):1889–1898.
   PubMed Web of Science ®Google Scholar
• Sanyal C, Turner JP, Martin P, et al. Cost-effectiveness of pharmacist-led deprescribing of NSAIDs in community-dwelling older adults. J Am Geriatr Soc. 2020;68(5):1090–1097.
   PubMed Web of Science ®Google Scholar
• Noize P, Bazin F, Dufouil C, et al. Comparison of health insurance claims and patient interviews in assessing drug use: data from the Three-City (3C) Study. Pharmacoepidemiol Drug Saf. 2009;18(4):310–319.
   PubMed Web of Science ®Google Scholar