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Review

Anti N-methyl-D-aspartate receptor encephalitis: a game-changer?

, , , , , , , & show all
Pages 849-859 | Received 08 Mar 2016, Accepted 26 Apr 2016, Published online: 17 May 2016

References

  • Scull A. Hysteria: the biography. Oxford (UK): Oxford University Press; 2009.
  • Putnam J. Relation of infectious processes to diseases of the nervous system. Pathology and etiology. Am J Med Sci. 1895;109(3):254–277.
  • Dalmau J, Tuzun E, Wu HY, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61(1):25–36.
  • Day GS, Tang-Wai DF, Shamy MCF. A case study in the history of neurology. Neurohospitalist. Forthcoming 2016.
  • Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12(2):157–165.
  • Barry H, Hardiman O, Healy DG, et al. Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis. Br J Psychiatry. 2011 Dec;199(6):508–509.
  • Chang HS, Chen PM, Lu T, et al. Anti-N-methyl-D-aspartate receptor encephalitis: should psychiatrists shoulder the responsibility for a non-psychiatric disorder? J Neurol Sci. 2015 Jun;353(1–2):189–190.
  • Kuppuswamy PS, Takala CR, Sola CL. Management of psychiatric symptoms in anti-NMDAR encephalitis: a case series, literature review and future directions. Gen Hosp Psychiatry. 2014 Jul–Aug;36(4):388–391.
  • Maneta E, Garcia G. Psychiatric manifestations of anti-NMDA receptor encephalitis: neurobiological underpinnings and differential diagnostic implications. Psychosomatics. 2014 Jan–Feb;55(1):37–44.
  • Ryan SA, Costello DJ, Cassidy EM, et al. Anti-NMDA receptor encephalitis: a cause of acute psychosis and catatonia. J Psychiatr Pract. 2013 Mar;19(2):157–161.
  • Tidswell J, Kleinig T, Ash D, et al. Early recognition of anti-N-methyl D-aspartate (NMDA) receptor encephalitis presenting as acute psychosis. Australas Psychiatry. 2013 Dec;21(6):596–599.
  • Kayser MS, Titulaer MJ, Gresa-Arribas N, et al. Frequency and characteristics of isolated psychiatric episodes in anti-N-methyl-D-aspartate receptor encephalitis. JAMA Neurol. 2013 Sep;70(9):1133–1139.
  • Titulaer MJ, Kayser MS, Dalmau J. Prevalence and treatment of anti-NMDA receptor encephalitis reply. Lancet Neurol. 2013 May;12(5):425–426.
  • Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7(12):1091–1098.
  • DeSena AD, Greenberg BM, Graves D. “Light Switch” mental status changes and irritable insomnia are two particularly salient features of anti-NMDA receptor antibody encephalitis. Pediatr Neurol. 2014 Jul;51(1):151–153.
  • Scott O, Richer L, Forbes K, et al. Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis an unusual cause of autistic regression in a toddler. J Child Neurol. 2014 Jul;29(5):691–694.
  • Mechelhoff D, Van Noort BM, Weschke B, et al. Anti-NMDA receptor encephalitis presenting as atypical anorexia nervosa: an adolescent case report. Eur Child Adolesc Psychiatry. 2015 Nov;24(11):1321–1324.
  • Marques IB, Teotonio R, Cunha C, et al. Anti-NMDA receptor encephalitis presenting with total insomnia - a case report. J Neurol Sci. 2014 Jan;336(1–2):276–280.
  • Vitaliani R, Mason W, Ances B, et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005 Oct;58(4):594–604.
  • Viaccoz A, Desestret V, Ducray F, et al. Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology. 2014 Feb 18;82(7):556–563.
  • Novillo-Lopez ME, Rossi JE, Dalmau J, et al. Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man. Neurology. 2008 Feb;70(9):728–729.
  • Day GS, High SM, Cot B, et al. Anti-NMDA-receptor encephalitis: case report and literature review of an under-recognized condition. J Gen Intern Med. 2011 Jul;26(7):811–816.
  • Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013 Feb;12(2):157–165.
  • Irani SR, Bera K, Waters P, et al. N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 2010;133:1655–1667.
  • Dalmau J, Lancaster E, Martinez-Hernandez E, et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10(1):63–74.
  • Hsu MH, Huang CC, Hung PL, et al. Paraneoplastic neurological disorders in children with benign ovarian tumors. Brain Dev. 2014 Mar;36(3):248–253.
  • Nijmeijer S, Bontemps S, Naeije L, et al. Anti-N-methyl-D-aspartate receptor encephalitis in a pre-teenage girl: a case report. Eur J Pediatr. 2014 May;173(5):681–683.
  • Eker A, Saka E, Dalmau J, et al. Testicular teratoma and anti-N-methyl-D-aspartate receptor-associated encephalitis. J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1082–1083.
  • Gable MS, Sheriff H, Dalmau J, et al. The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis. 2012 Apr;54(7):899–904.
  • Pillai SC, Hacohen Y, Tantsis E, et al. Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. Pediatrics. 2015 Apr;135(4):e974–984.
  • Ambrose HE, Granerod J, Clewley JP, et al. Diagnostic strategy used to establish etiologies of encephalitis in a prospective cohort of patients in England. J Clin Microbiol. 2011 Oct;49(10):3576–3583.
  • Davies G, Irani SR, Coltart C, et al. Anti-N-methyl-D-aspartate receptor antibodies: a potentially treatable cause of encephalitis in the intensive care unit. Crit Care Med. 2010 Feb;38(2):679–682.
  • Zandi MS, Irani SR, Lang B, et al. Disease-relevant autoantibodies in first episode schizophrenia. J Neurol. 2011 Apr;258(4):686–688.
  • Steiner J, Walter M, Glanz W, et al. Increased prevalence of diverse N-Methyl-D-Aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia specific relevance of IgG NR1a antibodies for distinction from N-Methyl-D-Aspartate glutamate receptor encephalitis. JAMA Psychiatry. 2013 Mar;70(3):271–278.
  • Tsutsui K, Kanbayashi T, Tanaka K, et al. Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features. BMC Psychiatry. 2012;12:37.
  • Rhoads J, Guirgis H, McKnight C, et al. Lack of anti-NMDA receptor autoantibodies in the serum of subjects with schizophrenia. Schizophr Res. 2011 Jul;129(2–3):213–214.
  • Masdeu JC, Gonzalez-Pinto A, Matute C, et al. Serum IgG antibodies against the NR1 subunit of the NMDA receptor not detected in schizophrenia. Am J Psychiatry. 2012 Oct;169(10):1120–1121.
  • Lancelot E, Beal MF. Glutamate toxicity in chronic neurodegenerative disease. Prog Brain Res. 1998;116:331–347.
  • Gunduz-Bruce H. The acute effects of NMDA antagonism: from the rodent to the human brain. Brain Res Rev. 2009 May;60(2):279–286.
  • Coyle JT, Tsai G, Goff D. Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Ann N Y Acad Sci. 2003 Nov;1003:318–327.
  • Leon-Caballero J, Pacchiarotti I, Murru A, et al. Bipolar disorder and antibodies against the N-methyl-D-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. Neurosci Biobehav Rev. 2015;55:403–412.
  • Levite M. Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren’s syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. J Neural Transm (Vienna). 2014 Aug;121(8):1029–1075.
  • Mikasova L, De Rossi P, Bouchet D, et al. Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain. 2012 May;135(Pt 5):1606–1621.
  • Moghaddam B, Adams B, Verma A, et al. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997 Apr 15;17(8):2921–2927.
  • Kjaerby C, Bundgaard C, Fejgin K, et al. Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment. Neuropharmacology. 2013 Sep;72:157–168.
  • Moscato EH, Peng X, Jain A, et al. Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2014 Jul;76(1):108–119.
  • Wurdemann T, Kersten M, Tokay T, et al. Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Res. 2016 Feb 15;1633:10–18.
  • Day GS, Laiq S, Tang-Wai DF, et al. Abnormal neurons in teratomas in NMDAR encephalitis. JAMA Neurol. 2014 Jun;71(6):717–724.
  • Dabner M, McCluggage WG, Bundell C, et al. Ovarian teratoma associated with anti-N-methyl D-aspartate receptor encephalitis: a report of 5 cases documenting prominent intratumoral lymphoid infiltrates. Int J Gynecological Pathol. 2012 Sep;31(5):429–437.
  • Tuzun E, Zhou L, Baehring JM, et al. Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol. 2009 Dec;118(6):737–743.
  • Peery HE, Day GS, Dunn S, et al. Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmun Rev. 2012 Oct;11(12):863–872.
  • Adang LA, Lynch DR, Panzer JA. Pediatric anti-NMDA receptor encephalitis is seasonal. Ann Clin Transl Neurol. 2014 Nov;1(11):921–925.
  • Desena A, Graves D, Warnack W, et al. Herpes simplex encephalitis as a potential cause of anti-N-methyl-D-aspartate receptor antibody encephalitis: report of 2 cases. JAMA Neurol. 2014 Mar;71(3):344–346.
  • Armangue T, Moris G, Cantarin-Extremera V, et al. Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology. 2015 Nov;85(20):1736–1743.
  • Leypoldt F, Titulaer MJ, Aguilar E, et al. Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report. Neurology. 2013 Oct;81(18):1637–1639.
  • Pruss H, Finke C, Holtje M, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol. 2012 Dec;72(6):902–911.
  • Schabitz WR, Rogalewski A, Hagemeister C, et al. VZV brainstem encephalitis triggers NMDA receptor immunoreaction. Neurology. 2014 Dec;83(24):2309–2311.
  • Day GS, Pruss H, Benseler SM, et al. GRIN1 polymorphisms do not affect susceptibility or phenotype in NMDA receptor encephalitis. Neuro Neuroimmunol Neuroinflamm. 2015 Oct;2(5):e153.
  • Byun JI, Lee ST, Moon J, et al. Cardiac sympathetic dysfunction in anti-NMDA receptor encephalitis. Auton Neurosci. 2015;193:142–146.
  • Ziaeian B, Shamsa K. Dazed, confused, and asystolic: possible signs of anti-N-Methyl-D-Aspartate receptor encephalitis. Tex Heart Inst J. 2014 Apr;42(2):175–177.
  • Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009 Jul;66(1):11–18.
  • Armangue T, Titulaer MJ, Malaga I, et al. Pediatric anti-N-methyl-D-aspartate receptor encephalitis-clinical analysis and novel findings in a series of 20 patients. J Pediatr. 2013 Apr;162(4):850–856, e852.
  • Jones KC, Benseler SM, Moharir M. Anti-NMDA receptor encephalitis. Neuroimaging Clin N Am. 2013 May;23(2):309–320.
  • Irani SR, Bera K, Waters P, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 2010 Jun;133(Pt 6):1655–1667.
  • Deiva K, Pera MC, Maurey H, et al. Sudden and isolated Broca’s aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children. Eur J Paediatr Neurol. 2014 Nov;18(6):790–792.
  • Titulaer MJ, Dalmau J. Seizures as first symptom of anti-NMDA receptor encephalitis are more common in men. Neurology. 2014 Feb;82(7):550–551.
  • Gresa-Arribas N, Titulaer MJ, Torrents A, et al. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol. 2014 Feb;13(2):167–177.
  • Wang R, Guan HZ, Ren HT, et al. CSF findings in patients with anti-N-methyl-D-aspartate receptor-encephalitis. Seizure. 2015 Jul;29:137–142.
  • Jones SV, Breakey RW, Lockwood BM A case of anti-NMDA receptor encephalitis with the highest reported CSF white cells to date. J Neuropsychiatry Clin Neurosci. Fal 2014;26(4):E10–E11.
  • Veciana M, Becerra JL, Fossas P, et al. EEG extreme delta brush: an ictal pattern in patients with anti-NMDA receptor encephalitis. Epilepsy Behav. 2015;49:280–285.
  • Schmitt SE, Pargeon K, Frechette ES, et al. Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology. 2012 Sep 11;79(11):1094–1100.
  • Veciana M, Becerra JL, Fossas P, et al. EEG extreme delta brush: an ictal pattern in patients with anti-NMDA receptor encephalitis. Epilepsy Behav. 2015;49:280–285.
  • Finke C, Kopp UA, Pajkert A, et al. Structural hippocampal damage following anti-N-methyl-D-aspartate receptor encephalitis. Biol Psychiatry. 2015 Feb;79(9):727–734..
  • Llorens V, Gabilondo I, Gomez-Esteban JC, et al. Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis. J Neurol. 2010 Sep;257(9):1568–1569.
  • Gunther A, Brodoehl S, Witte OW, et al. Atypical posthypoxic MRI changes in hypermetabolic regions in anti-NMDA-receptor encephalitis. Neurology. 2012 Aug 14;79(7):720–721.
  • Padma S, Sundaram PS, Marmattom BV. PET/CT in the evaluation of anti-NMDA-receptor encephalitis: what we need to know as a NM physician. Indian J Nucl Med. 2011 Apr;26(2):99–101.
  • Chanson JB, Diaconu M, Honnorat J, et al. PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis. Epileptic Disord. 2012 Mar;14(1):90–93.
  • Finke C, Kopp UA, Scheel M, et al. Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2013 Aug;74(2):284–296.
  • Brier MR, Day GS, Snyder AZ, et al. N-methyl-D-aspartate receptor encephalitis mediates loss of intrinsic activity measured by functional MRI. J Neurol. Forthcoming 2016. PMID: 27025853.
  • Rosenfeld MR, Dalmau J. Anti-NMDA-receptor encephalitis and other synaptic autoimmune disorders. Curr Treat Options Neurol. 2011 Jun;13(3):324–332.
  • Bataller L, Galiano R, Garcia-Escrig M, et al. Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor. Neurology. 2010 Jan 19;74(3):265–267.
  • Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009 Apr;65(4):424–434.
  • Lancaster E, Lai M, Peng X, et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010 Jan;9(1):67–76.
  • Boronat A, Gelfand JM, Gresa-Arribas N, et al. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol. 2013 Jan;73(1):120–128.
  • Lai M, Huijbers MG, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010 Aug;9(8):776–785.
  • Andrade DM, Tai P, Dalmau J, et al. Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis? Neurology. 2011 Apr 12;76(15):1355–1357.
  • Flanagan EP, Kotsenas AL, Britton JW, et al. Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures. Neurol Neuroimmunol Neuroinflamm. 2015 Dec;2(6):e161.
  • Desestret V, Chefdeville A, Viaccoz A, et al. CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis. Neurol Neuroimmunol Neuroinflamm. 2015 Dec;2(6):e166.
  • DeSena AD, Noland DK, Matevosyan K, et al. Intravenous methylprednisolone versus therapeutic plasma exchange for treatment of anti-N-methyl-D-aspartate receptor antibody encephalitis: a retrospective review. J Clin Apher. 2015 Aug;30(4):212–216.
  • Batra R, Pang YH, Friedman MT. Therapeutic plasma exchange in anti-N-methyl-D-aspartate-receptor (anti-NMDA-R) encephalitis associated with benign ovarian teratoma. J Clin Apher. 2012;27(4):227–228.
  • Pham HP, Daniel-Johnson JA, Stotler BA, et al. Therapeutic plasma exchange for the treatment of anti-NMDA receptor encephalitis. J Clin Apher. 2011;26(6):320–325.
  • Mann A, Machado NM, Liu N, et al. A multidisciplinary approach to the treatment of anti-NMDA-receptor antibody encephalitis: a case and review of the literature. J Neuropsychiatry Clin Neurosci Spring. 2012;24(2):247–254.
  • Finke C, Kopp UA, Pruss H, et al. Cognitive deficits following anti-NMDA receptor encephalitis. J Neurol Neurosurg Psychiatry. 2012 Feb;83(2):195–198.
  • Gabilondo I, Saiz A, Galan L, et al. Analysis of relapses in anti-NMDAR encephalitis. Neurology. 2011 Sep 6;77(10):996–999.
  • Titulaer MJ, McCracken L, Gabilondo I, et al. Late-onset anti-NMDA receptor encephalitis. Neurology. 2013 Sep;81(12):1058–1063.
  • Chapman MR, Vause HE. Anti-NMDA receptor encephalitis: diagnosis, psychiatric presentation, and treatment. Am J Psychiatry. 2011 Mar;168(3):245–251.
  • Tan A, Shuey N, Bladin C. A modern perspective on the differential diagnosis between encephalitis lethargica or anti-NMDA-receptor encephalitis. J Clin Neurosci. 2010 Sep;17(9):1204–1206.
  • Byrne S, McCoy B, Lynch B, et al. Does early treatment improve outcomes in N-methyl-D-aspartate receptor encephalitis? Dev Med Child Neurol. 2014 Aug;56(8):794–796.
  • Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016 Feb 19;15(4):391–404.
  • Caroff SN, Campbell EC. Risk of neuroleptic malignant syndrome in patients with NMDAR encephalitis. Neurol Sci. 2015 Mar;36(3):479–480.
  • Braakman HM, Moers-Hornikx VM, Arts BM, et al. Pearls & Oy-sters: electroconvulsive therapy in anti-NMDA receptor encephalitis. Neurology. 2010 Sep 7;75(10):e44–46.
  • Consoli A, Ronen K, An-Gourfinkel I, et al. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report. Child Adolesc Psychiatry Ment Health. 2011;5(1):15.
  • Florance-Ryan N, Dalmau J. Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr. 2010 Dec;22(6):739–744.
  • Gulyayeva NA, Massie MJ, Duhamel KN. Anti-NMDA receptor encephalitis: psychiatric presentation and diagnostic challenges from psychosomatic medicine perspective. Palliat Support Care. 2014 Apr;12(2):159–163.
  • Tham SL, Kong KH. A case of anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis: a rehabilitation perspective. Neurorehabilitation. 2012;30(2):109–112.
  • Houtrow AJ, Bhandal M, Pratini NR, et al. The rehabilitation of children with anti-N-methyl-D-aspartate-receptor encephalitis: a case series. Am J Phys Med Rehabil. 2012 May;91(5):435–441.
  • Bradley L. Rehabilitation following anti-NMDA encephalitis. Brain Inj. 2015;29(6):785–788.
  • Bartolini L. How do you treat anti-NMDA receptor encephalitis? Neurol Clin Pract. 2016;6(1):69–72.
  • Zekeridou A, Karantoni E, Viaccoz A, et al. Treatment and outcome of children and adolescents with N-methyl-D-aspartate receptor encephalitis. J Neurol. 2015 Aug;262(8):1859–1866.
  • Gronseth GS, Woodroffe LM, Getchius TS. Clinical Practice Guideline Process Manual. St. Paul (MN): American Academy of Neurology; 2011.
  • Lee WJ, Lee ST, Byun JI, et al. Rituximab treatment for autoimmune limbic encephalitis in an institutional cohort. Neurology. 2016 Apr 1;86(18):1683–1691.
  • Chugh S, Darvish-Kazem S, Lim W, et al. Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol. 2015 Feb;2(2):e75–81.
  • Laribi K, Bolle D, Ghnaya H, et al. Rituximab is an effective and safe treatment of relapse in elderly patients with resistant warm AIHA. Ann Hematol. 2016 Apr;95(5):765–769.
  • Dale RC, Brilot F, Duffy LV, et al. Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. Neurology. 2014 Jul 8;83(2):142–150.
  • Rommer PS, Dorner T, Freivogel K, et al. Safety and clinical outcomes of rituximab treatment in patients with multiple sclerosis and neuromyelitis optica: experience from a national online registry (GRAID). J Neuroimmune Pharmacol. 2016 Mar;11(1):1–8.
  • Twilt M, Benseler SM. Childhood inflammatory brain diseases: pathogenesis, diagnosis and therapy. Rheumatology (Oxford). 2014 Aug;53(8):1359–1368.
  • Ikeguchi R, Shibuya K, Akiyama S, et al. Rituximab Used successfully in the treatment of anti-NMDA receptor encephalitis. Intern Med. 2012;51(12):1585–1589.
  • Ishiura H, Matsuda S, Higashihara M, et al. Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology. 2008 Dec 2;71(23):1921–1923.
  • Tanyi JL, Marsh EB, Dalmau J, et al. Reversible paraneoplastic encephalitis in three patients with ovarian neoplasms. Acta Obstet Gynecol Scand. 2012 May;91(5):630–634.
  • Boeck AL, Logemann F, Krauss T, et al. Ovarectomy despite negative imaging in anti-NMDA receptor encephalitis: effective even late. Case Rep Neurol Med. 2013;2013:843192.
  • Van Swieten JC, Koudstaal PJ, Visser MC, et al. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19(5):604–607.
  • Leypoldt F, Gelderblom M, Schottle D, et al. Recovery from severe frontotemporal dysfunction at 3 years after N-methyl-D-aspartic acid (NMDA) receptor antibody encephalitis. J Clin Neurosci. 2013 Apr;20(4):611–613.
  • Sarkis RA, Nehme R, Chemali ZN. Neuropsychiatric and seizure outcomes in nonparaneoplastic autoimmune limbic encephalitis. Epilepsy Behav. 2014 Oct;39:21–25.
  • Lebon S, Mayor-Dubois C, Popea I, et al. Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis mimicking a primary psychiatric disorder in an adolescent. J Child Neurol. 2012 Dec;27(12):1607–1610.
  • Leypoldt F, Hoftberger R, Titulaer MJ, et al. Investigations on CXCL13 in anti-N-methyl-D-aspartate receptor encephalitis: a potential biomarker of treatment response. JAMA Neurol. 2015 Feb;72(2):180–186.
  • Finke C, Kopp UA, Scheel M, et al. Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2013 Aug;74(2):284–296.
  • Planaguma J, Leypoldt F, Mannara F, et al. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice. Brain. 2015;138:94–109.
  • Li Y, Tanaka K, Wang L, et al. Induction of memory deficit in mice with chronic exposure to cerebrospinal fluid from patients with anti-N-methyl-D-aspartate receptor encephalitis. Tohoku J Exp Med. 2015;237(4):329–338.
  • Ransohoff RM. Gathering thunder. Neurol Neuroimmunol Neuroinflamm. 2014 Jun;1(1):e15.
  • The Anti-NMDA Receptor Encephalitis Foundation. 2016. Available from: http://www.antinmdafoundation.org/.
  • Autoimmune Encephalitis Alliance. 2016. Available from: https://aealliance.org/.
  • The Encephalitis Society. 2016. Available from: http://www.encephalitis.info/.
  • Cahalan S. Brain on fire: my month of madness. New York (NY): Simon and Shuster; 2012.

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