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Editorial

Modulating the immune response in spinal cord injury

, , &
Pages 1127-1129 | Received 18 Apr 2016, Accepted 27 Jun 2016, Published online: 11 Jul 2016

References

  • Baptiste DC, Fehlings MG. Pharmacological approaches to repair the injured spinal cord. J Neurotrauma. 2006;23(3–4):318–334.
  • Ankeny DP, Guan Z, Popovich PG. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest. 2009;119(10):2990–2999.
  • Riegger T, Conrad S, Liu K, et al. Spinal cord injury-induced immune depression syndrome (SCI-IDS). Eur J Neurosci. 2007;25(6):1743–1747.
  • Lee J-M, Yan P, Xiao Q, et al. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci. 2008;28(12):3141–3149.
  • Fehlings MG, Wilson JR, Cho N. Methylprednisolone for the treatment of acute spinal cord injury: counterpoint. Neurosurgery. 2014;Suppl 61:36–42.
  • Wells JEA, Hurlbert RJ, Fehlings MG, et al. Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain J Neurol. 2003;126(Pt 7):1628–1637.
  • Casha S, Zygun D, McGowan MD, et al. Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain J Neurol. 2012;135(Pt 4):1224–1236.
  • US National Institutes of Health. ClinicalTrials.gov. 2016 [cited 2016 Mar]. Available from: https://clinicaltrials.gov/
  • Gok B, Sciubba DM, Okutan O, et al. Immunomodulation of acute experimental spinal cord injury with human immunoglobulin G. J Clin Neurosci Off J Neurosurg Soc Australas. 2009;16(4):549–553.
  • Nguyen DH, Cho N, Satkunendrarajah K, et al. Immunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury. J Neuroinflammation. 2012;9:224.
  • Gris D, Marsh DR, Oatway MA, et al. Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. J Neurosci. 2004;24(16):4043–4051.
  • Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012;13(4):267–278.
  • Dietrich WD, Atkins CM, Bramlett HM. Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. J Neurotrauma. 2009;26(3):301–312.
  • Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med. 2001;344(8):556–563.
  • Hutchison JS, Ward RE, Lacroix J, et al. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008;358(23):2447–2456.
  • Levi AD, Green BA, Wang MY, et al. Clinical application of modest hypothermia after spinal cord injury. J Neurotrauma. 2009;26(3):407–415.
  • Vawda R, Fehlings MG. Mesenchymal cells in the treatment of spinal cord injury: current & future perspectives. Curr Stem Cell Res Ther. 2013;8(1):25–38.
  • Martino G, Pluchino S. The therapeutic potential of neural stem cells. Nat Rev Neurosci. 2006;7(5):395–406.
  • Fainstein N, Einstein O, Cohen ME, et al. Time limited immunomodulatory functions of transplanted neural precursor cells. Glia. 2013;61(2):140–149.
  • Rapalino O, Lazarov-Spiegler O, Agranov E, et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med. 1998;4(7):814–821.
  • Bomstein Y, Marder JB, Vitner K, et al. Features of skin-coincubated macrophages that promote recovery from spinal cord injury. J Neuroimmunol. 2003;142(1–2):10–16.
  • Kigerl KA, Gensel JC, Ankeny DP, et al. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci. 2009;29(43):13435–13444.
  • Kliesch WF, Cruse JM, Lewis RE, et al. Restoration of depressed immune function in spinal cord injury patients receiving rehabilitation therapy. Paraplegia. 1996;34(2):82–90.
  • Maldonado-Bouchard S, Peters K, Woller SA, et al. Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury. Brain Behav Immun. 2016;51:176–195.
  • Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014;34(33):10989–11006.
  • The National Spinal Cord Injury Statistical Center. Spinal cord injury: facts and figures at a glance. 2015 [cited 2016 Mar]. Available from: https://www.nscisc.uab.edu/

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