The effect of L-dopa in Parkinson’s disease as revealed by neurophysiological studies of motor and sensory functions

References

• Braak H, Del Tredici K, Rüb U, et al. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24(2):197–211.
   PubMed Web of Science ®Google Scholar
• Dickson DW, Braak H, Duda JE, et al. Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol. 2009;8(12):1150–1157.
   PubMed Web of Science ®Google Scholar
• Lees AJ, Hardy J, Revesz T. Parkinson’s disease. Lancet. 2009 Jun 13;373(9680):2055–2066.
   PubMed Web of Science ®Google Scholar
• DeLong MR, Wichmann T. Circuits and circuit disorders of the basal ganglia. Arch Neurol. 2007;64:20–24.
   PubMedGoogle Scholar
• Creese I, Sibley DR, Leff S, et al. Dopamine receptors: subtypes, localization and regulation. Fed Proc. 1981;40(2):147–152.
   PubMedGoogle Scholar
• Redgrave P, Rodriguez M, Smith Y, et al. Goal-directed and habitual control in the basal ganglia: implications for Parkinson’s disease. Nat Rev Neurosci. 2010;11(11):760–772.
   PubMed Web of Science ®Google Scholar
• Calabresi P, Ghiglieri V, Mazzocchetti P, et al. Levodopa-induced plasticity: a double-edged sword in Parkinson’s disease?. Philos Trans R Soc Lond B Biol Sci. 2015;370(1672). pii:20140184.
   PubMed Web of Science ®Google Scholar
• Calabresi P, Picconi B, Tozzi A, et al. Direct and indirect pathways of basal ganglia: a critical reappraisal. Nat Neurosci. 2014;17(8):1022–1030.
   PubMed Web of Science ®Google Scholar
• Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson’s disease. New Engl J Med. 2004;351(24):2498–2508.
   PubMed Web of Science ®Google Scholar
• Chen R, Cros D, Currà A, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol. 2008;119:504–532.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Abbruzzese G, Chen R, et al. Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders. Brain Stim. 2008;1:183–191.
   PubMed Web of Science ®Google Scholar
• Suppa S, Huang YZ, Funke K, et al. Ten years of theta burst stimulation in humans: established knowledge, unknown and prospects. Brain Stimul. 2016;9:323–335.
   PubMed Web of Science ®Google Scholar
• Currà A, Modugno N, Inghilleri M, et al. Transcranial magnetic stimulation techniques in clinical investigation. Neurology. 2002 24;59(12):1851–1859.
   PubMed Web of Science ®Google Scholar
• Conte A, Khan N, Defazio G, et al. Pathophysiology of somatosensory abnormalities in Parkinson disease. Nat Rev Neurol. 2013;9:687–697.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Rothwell JC, Thompson PD, et al. Pathophysiology of bradykinesia in Parkinson’s disease. Brain. 2001;124:2131–2146.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Hallett M, Rothwell JC, et al. Single-joint rapid arm movements in normal subjects and in patients with motor disorders. Brain. 1996;119(Pt 2):661–674.
   PubMed Web of Science ®Google Scholar
• Vaillancourt DE, Prodoehl J, VerhagenMetman L, et al. Effects of deep brain stimulation and medication on bradykinesia and muscle activation in Parkinson’s disease. Brain. 2004;127(Pt 3):491–504.
   PubMed Web of Science ®Google Scholar
• Rafal RD, Friedman JH, Lannon MC. Preparation of manual movements in hemiparkinsonism. J Neurol Neurosurg Psychiatry. 1989;52:399–40.
   PubMed Web of Science ®Google Scholar
• Jackson GM, Jackson SR, Hindle JV. The control of bimanual reach-to-grasp movements in hemiparkinsonian patients. Exp Brain Res. 2000;132:390–398.
   PubMed Web of Science ®Google Scholar
• Castiello U, Bennett KM, Bonfiglioli C, et al. The reach-to-grasp movement in Parkinson’s disease before and after dopaminergic medication. Neuropsychologia. 2000;38(1):46–59.
   PubMed Web of Science ®Google Scholar
• Doana JB, Melvinc KG, Whishaw IQ, et al. Bilateral impairments of skilled reach-to-eat in early Parkinson’s disease patients presenting with unilateral or asymmetrical symptoms. Behavioural Brain Research. 2008;194:207–213.
   PubMed Web of Science ®Google Scholar
• Bastian AJ, Kelly VE, Perlmutter JS, et al. Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson’s disease. Mov Disord. 2003;18(9):1008–1017.
   PubMed Web of Science ®Google Scholar
• Benecke R, Rothwell JC, Dick JP, et al. Disturbance of sequential movements in patients with Parkinson’s disease. Brain. 1987;110:361–379.
   PubMed Web of Science ®Google Scholar
• Stelmach GE, Worringham CJ. The control of bimanual aiming movements in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988;51(2):223–231.
   PubMed Web of Science ®Google Scholar
• Castiello U, Bennett KM. The bilateral reach-to-grasp movement of Parkinson’s disease subjects. Brain. 1997;120(Pt 4):593–604.
   PubMed Web of Science ®Google Scholar
• Agostino R, Berardelli A, Formica A, et al. Sequential arm movements in patients with Parkinson’s disease, Huntington’s disease and dystonia. Brain. 1992;115:1481–1495.
   PubMed Web of Science ®Google Scholar
• Agostino R, Berardelli A, Formica A, et al. Analysis of repetitive and nonrepetitive sequential arm movements in patients with Parkinson’s disease. Mov Disord. 1994;9(3):311–314.
   PubMed Web of Science ®Google Scholar
• Kang SY, Wasaka T, Shamim EA. Characteristics of the sequence effect in Parkinson’s disease. Mov Disord. 2010;25(13):2148–2155.
   PubMed Web of Science ®Google Scholar
• Lee E, Lee JE, Yoo K, et al. Neural correlates of progressive reduction of bradykinesia in de novo Parkinson’s disease. Parkinsonism Relat Disord. 2014;20:1376–1381.
   PubMed Web of Science ®Google Scholar
• Wu T, Zhang J, Hallett M, et al. Neural correlates underlying micrographia in Parkinson’s disease. Brain. 2016;139:144–160.
   PubMed Web of Science ®Google Scholar
• Kelly VE, Bastian AJ. Antiparkinson medications improve agonist activation but not antagonist inhibition during sequential reaching movements. Mov Disord. 2005;20:694–704.
   PubMed Web of Science ®Google Scholar
• Agostino R, Berardelli A, Currà A, et al. Clinical impairment of sequential finger movements in Parkinson’s disease. Mov Disord. 1998;13(3):418–421.
   PubMed Web of Science ®Google Scholar
• Goetz CG, Fahn S, Martinez-Martin P, et al. Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord. 2007;22:41–47.
   PubMed Web of Science ®Google Scholar
• Goetz CG, Tilley BC, Shaftman SR, et al. Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23:2129–2170.
   PubMed Web of Science ®Google Scholar
• Agostino R, Currà A, Giovannelli M, et al. Impairment of individual finger movements in Parkinson’s disease. Mov Disord. 2003;18(5):560–565.
   PubMed Web of Science ®Google Scholar
• Espay AJ, Beaton DE, Morgante F, et al. Impairments of speed and amplitude of movement in Parkinson’s disease: a pilot study. Mov Disord. 2009;24(7):1001–1008.
   PubMed Web of Science ®Google Scholar
• Espay AJ, Giuffrida JP, Chen R, et al. Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson’s disease. Mov Disord. 2011;26(14):2504–2508.
   PubMed Web of Science ®Google Scholar
• Teo WP, Rodrigues JP, Mastaglia FL, et al. Comparing kinematic changes between a finger-tapping task and unconstrained finger flexion-extension task in patients with Parkinson’s disease. Exp Brain Res. 2013;227(3):323–331.
   PubMed Web of Science ®Google Scholar
• Bologna M, Fabbrini G, Marsili L, et al. Facial bradykinesia. J Neurol Neurosurg Psychiatry. 2013;84(6):681–685.
   PubMed Web of Science ®Google Scholar
• Karson CN. Spontaneous eye-blink rates and dopaminergic systems. Brain. 1983;106:643–653.
   PubMed Web of Science ®Google Scholar
• Deuschl G, Goddemeier C. Spontaneous and reflex activity of facial muscles in dystonia, Parkinson’s disease, and in normal subjects. J NeurolNeurosurgPsychiatry. 1998;64:320–324.
   PubMed Web of Science ®Google Scholar
• Altiparmak UE, Eggenberger E, Coleman A, et al. The ratio of square wave jerk rates to blink rates distinguishes progressive supranuclear palsy from Parkinson disease. J Neuroophthalmol. 2006;26:257–259.
   PubMed Web of Science ®Google Scholar
• Korosec M, Zidar I, Reits D, et al. Eyelid movements during blinking in patients with Parkinson’s disease. Mov Disord. 2006;21:1248–1251.
   PubMed Web of Science ®Google Scholar
• Kimber TE, Thompson PD. Increased blink rate in advanced Parkinson’s disease: a form of ‘off’-period dystonia? Mov Disord. 2000;15(5):982–985.
   PubMed Web of Science ®Google Scholar
• Agostino R, Bologna M, Dinapoli L, et al. Voluntary, spontaneous, and reflex blinking in Parkinson’s disease. Mov Disord. 2008;15:669–675.
   Web of Science ®Google Scholar
• Bologna M, Fasano A, Modugno N, et al. Effects of subthalamic nucleus deep brain stimulation and L-DOPA on blinking in Parkinson’s disease. Exp Neurol. 2012;235(1):265–272.
   PubMed Web of Science ®Google Scholar
• Marsili L, Agostino R, Bologna M, et al. Bradykinesia of posed smiling and voluntary movement of the lower face in Parkinson’s disease. Parkinsonism Relat Disord. 2014;20(4):370–375.
   PubMed Web of Science ®Google Scholar
• Caligiuri MP. Labial kinematics during speech in patients with parkinsonian rigidity. Brain. 1987;110:1033–1044.
   PubMed Web of Science ®Google Scholar
• Connor NP, Abbs JH, Cole KJ, et al. Parkinsonian deficits in serial multiarticulate movements for speech. Brain. 1989;112:997–1009.
   PubMed Web of Science ®Google Scholar
• Cruccu G, Deuschl G. The clinical use of brainstem reflexes and hand-muscle reflexes. Clin Neurophysiol. 2000;111:371–387.
   PubMed Web of Science ®Google Scholar
• Valls-Sole J. Assessment of excitability in brainstem circuits mediating the blink reflex and the startle reaction. Clin Neurophysiol. 2012 Jan;123(1):13–20.
   PubMed Web of Science ®Google Scholar
• Kimura J, Rodnitzky RL, Van Allen MW. Electrodiagnostic study of trigeminal nerve. Orbicularis oculi reflex and masseter reflex in trigeminal neuralgia, paratrigeminal syndrome, and other lesions of the trigeminal nerve. Neurology. 1970;20(6):574–583.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Accornero N, Cruccu G, et al. The orbicularis oculi response after hemispheral damage. J Neurol Neurosurg Psychiatry. 1983;46(9):837–843.
   PubMed Web of Science ®Google Scholar
• Aramideh M, Ongerboer de Visser BW. Brainstem reflexes: electrodiagnostic techniques, physiology, normative data, and clinical applications. Muscle Nerve. 2002 Jul;26(1):14–30.
   PubMed Web of Science ®Google Scholar
• Cruccu G, Iannetti GD, Marx JJ, et al. Brainstem reflex circuits revisited. Brain. 2005;128(Pt 2):386–394.
   PubMed Web of Science ®Google Scholar
• Basso MA, Evinger C. An explanation for reflex blink hyperexcitability in Parkinson’s disease. II. Nucleus raphe magnus. J Neurosci. 1996;16(22):7318–7330.
   PubMed Web of Science ®Google Scholar
• Basso MA, Powers AS, Evinger C. An explanation for reflex blink hyperexcitability in Parkinson’s disease. I. Superior colliculus. J Neurosci. 1996;16(22):7308–7317.
   PubMed Web of Science ®Google Scholar
• Agostino R, Bologna M, Dinapoli L, et al. Voluntary, spontaneous, and reflex blinking in Parkinson’s disease. Mov Disord. 2008 Apr 15;23(5):669–675.
   PubMed Web of Science ®Google Scholar
• Rocchi L, Chiari L, Horak FB. Effects of deep brain stimulation and levodopa on postural sway in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73(3):267–274.
   PubMed Web of Science ®Google Scholar
• Gago MF, Fernandes V, Ferreira J, et al. The effect of levodopa on postural stability evaluated by wearable inertial measurement units for idiopathic and vascular Parkinson’s disease. Gait Posture. 2015;41(2):459–464.
   PubMed Web of Science ®Google Scholar
• Benninger F, Khlebtovsky A, Roditi Y, et al. Beneficial effect of levodopa therapy on stooped posture in Parkinson’s disease. Gait Posture. 2015;42(3):263–268.
   PubMed Web of Science ®Google Scholar
• Morris M, Iansek R, McGinley J, et al. Three-dimensional gait biomechanics in Parkinson’s disease: evidence for a centrally mediated amplitude regulation disorder. Mov Disord. 2005;20(1):40–50.
   PubMed Web of Science ®Google Scholar
• Iansek R, Huxham F, McGinley J. The sequence effect and gait festination in Parkinson disease: contributors to freezing of gait? Mov Disord. 2006;21(9):1419–1424.
   PubMed Web of Science ®Google Scholar
• Grajić M, Stanković I, Radovanović S, et al. Gait in drug naïve patients with de novo Parkinson’s disease–altered but symmetric. Neurol Res. 2015;37(8):712–716.
   PubMed Web of Science ®Google Scholar
• Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol. 2011;10:734–744.
   PubMed Web of Science ®Google Scholar
• Giladi N, McMahon D, Przedborski S, et al. Motor blocks in Parkinson’s disease. Neurology. 1992;42(2):333–339.
   PubMed Web of Science ®Google Scholar
• Kerr GK, Worringham CJ, Cole MH, et al. Predictors of future falls in Parkinson disease. Neurology. 2010;75:116–124.
   PubMed Web of Science ®Google Scholar
• Ferrarin M, Rizzone M, Lopiano L, et al. Effects of subthalamic nucleus stimulation and L-dopa in trunk kinematics of patients with Parkinson’s disease. Gait Posture. 2004;19(2):164–171.
   PubMed Web of Science ®Google Scholar
• Morris ME, Iansek R, Matyas TA, et al. Stride length regulation in Parkinson’s disease. Normalization strategies and underlying mechanism. Brain. 1996;119:551–568.
   PubMed Web of Science ®Google Scholar
• Ridding MC, Inzelberg R, Rothwell JC. Changes in excitability of motor cortical circuitry in patients with Parkinson’s disease. Ann Neurol. 1995;37(2):181–188.
   PubMed Web of Science ®Google Scholar
• Strafella AP, Valzania F, Nassetti SA, et al. Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson’s disease: a transcranial magnetic stimulation study. Clin Neurophysiol. 2000;111(7):1198–1202.
   PubMed Web of Science ®Google Scholar
• Bares M, Kanovský P, Klajblová H, et al. Intracortical inhibition and facilitation are impaired in patients with early Parkinson’s disease: a paired TMS study. Eur J Neurol. 2003;10(4):385–389.
   PubMed Web of Science ®Google Scholar
• MacKinnon CD, Gilley EA, Weis-McNulty A, et al. Pathways mediating abnormal intracortical inhibition in Parkinson’s disease. Ann Neurol. 2005;58:516–524.
   PubMed Web of Science ®Google Scholar
• Ni Z, Bahl N, Gunraj CA, et al. Increased motor cortical facilitation and decreased inhibition in Parkinson disease. Neurology. 2013;80:1746–1753.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Rona S, Inghilleri M, et al. Cortical inhibition in Parkinson’s disease. A study with paired magnetic stimulation. Brain. 1996;119(Pt 1):71–77.
   PubMed Web of Science ®Google Scholar
• Civardi C, Cantello R, Asselman P, et al. Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans. Neuroimage. 2001;14:1444–1453.
   PubMed Web of Science ®Google Scholar
• Koch G, Fernandez Del Olmo M, Cheeran B, et al. Focal stimulation of the posterior parietal cortex increases the excitability of the ipsilateral motor cortex. J Neurosci. 2007;27:6815–6822.
   PubMed Web of Science ®Google Scholar
• Koch G, Franca M, Mochizuki H, et al. Interactions between pairs of transcranial magnetic stimuli over the human left dorsal premotor cortex differ from those seen in primary motor cortex. J Physiol. 2007;578:551–562.
   PubMed Web of Science ®Google Scholar
• Buhmann C, Gorsler A, Bäumer T, et al. Abnormal excitability of premotor-motor connections in de novo Parkinson’s disease. Brain. 2004;127:2732–2746.
   PubMed Web of Science ®Google Scholar
• Mir P, Matsunaga K, Gilio F, et al. Dopaminergic drugs restore facilitatory premotor–motor interactions in Parkinson’s disease. Neurology. 2005;64:1906–1912.
   PubMed Web of Science ®Google Scholar
• Zittel S, Heinbokel C, van der Vegt JP, et al. Effects of dopaminergic treatment on functional cortico-cortical connectivity in Parkinson’s disease. Exp Brain Res. 2015;233:329–337.
   PubMed Web of Science ®Google Scholar
• Carrillo F, Palomar FJ, Conde V, et al. Study of cerebello-thalamocortical pathway by transcranial magnetic stimulation in Parkinson’s disease. Brain Stimul. 2013;6:582–589.
   PubMed Web of Science ®Google Scholar
• Pascual-Leone A, Valls-Solé J, Wassermann EM, et al. Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain. 1994;117:847–858.
   PubMed Web of Science ®Google Scholar
• Jennum P, Winkel H, Fuglsang-Frederiksen A. Repetitive magnetic stimulation and motor evoked potentials. Electroencephalogr Clin Neurophysiol. 1995;97:96–101.
   PubMedGoogle Scholar
• Suppa A, Bologna M, Gilio F, et al. Preconditioning rTMS of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex. J Neurophysiol. 2008;99:564–570.
   PubMed Web of Science ®Google Scholar
• Gilio F, Curra A, Inghilleri M, et al. Repetitive magnetic stimulation of cortical motor areas in Parkinson’s disease: implications for the pathophysiology of cortical function. Mov Disord. 2002;17:467–473.
   PubMed Web of Science ®Google Scholar
• Suppa A, Iezzi E, Conte A, et al. Dopamine influences primary motor cortex plasticity and dorsal premotor-to-motor connectivity in Parkinson’s disease. Cereb Cortex. 2010;20:2224–2233.
   PubMed Web of Science ®Google Scholar
• Ueki Y, Mima T, Ali Kotb M, et al. Altered plasticity of the human motor cortex in Parkinson’s disease. Ann Neurol. 2006;59:60–71.
   PubMed Web of Science ®Google Scholar
• Morgante F, Espay AJ, Gunraj C, et al. Motor cortex plasticity in Parkinson’s disease and levodopa-induced dyskinesias. Brain. 2006;129:1059–1069.
   PubMed Web of Science ®Google Scholar
• Kawashima S, Ueki Y, Mima T, et al. Differences in dopaminergic modulation to motor cortical plasticity between Parkinson’s disease and multiple system atrophy. PLoS ONE. 2013;8:e62515.
   PubMed Web of Science ®Google Scholar
• Bagnato S, Agostino R, Modugno N, et al. Plasticity of the motor cortex in Parkinson’s disease patients on and off therapy. Mov Disord. 2006;21:639–645.
   PubMed Web of Science ®Google Scholar
• Kojovic M, Bologna M, Kassavetis P, et al. Functional reorganization of sensorimotor cortex in early Parkinson disease. Neurology. 2012;78:1441–1448.
   PubMed Web of Science ®Google Scholar
• Kojovic M, Kassavetis P, Bologna M, et al. Transcranial magnetic stimulation follow-up study in early Parkinson’s disease: a decline in compensation with disease progression? Mov Disord. 2015;30:1098–1106.
   PubMed Web of Science ®Google Scholar
• Huang YZ, Edwards MJ, Rounis E, et al. Theta burst stimulation of the human motor cortex. Neuron. 2005;45:201–206.
   PubMed Web of Science ®Google Scholar
• Eggers C, Fink GR, Nowak DA. Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease. J Neurol. 2010;257:1669–1674.
   PubMed Web of Science ®Google Scholar
• Suppa A, Marsili L, Belvisi D, et al. Lack of LTP-like plasticity in primary motor cortex in Parkinson’s disease. Exp Neurol. 2011;227:296–301.
   PubMed Web of Science ®Google Scholar
• Kishore A, Joseph T, Velayudhan B, et al. Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson’s disease. Clin Neurophysiol. 2012;123:822–828.
   PubMed Web of Science ®Google Scholar
• Zamir O, Gunraj C, Ni Z, et al. Effects of theta burst stimulation on motor cortex excitability in Parkinson’s disease. Clin Neurophysiol. 2012;123:815–821.
   PubMed Web of Science ®Google Scholar
• Huang YZ, Rothwell JC, Lu CS, et al. Abnormal bidirectional plasticity-like effects in Parkinson’s disease. Brain. 2011;134:2312–2320.
   PubMed Web of Science ®Google Scholar
• Brown P, Eusebio A. Paradoxes of functional neurosurgery: clues from basal ganglia recordings. Mov Disord. 2008;23(1):12–20.
   PubMed Web of Science ®Google Scholar
• Little S, Brown P. The functional role of beta oscillations in Parkinson’s disease. Parkinsonism Relat Disord. 2014;20(Suppl 1):S44–S48.
   PubMedGoogle Scholar
• Quiroga-Varela A, Walters JR, Brazhnik E, et al. What basal ganglia changes underlie the parkinsonian state? The significance of neuronal oscillatory activity. Neurobiol Dis. 2013;58:242–248.
   PubMed Web of Science ®Google Scholar
• Bergman H, Wichmann T, Karmon B, et al. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol. 1994;72:507–520.
   PubMed Web of Science ®Google Scholar
• Nini A, Feingold A, Slovin H, et al. Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appearin the MPTP model of parkinsonism. J Neurophysiol. 1995;74:1800–1805.
   PubMed Web of Science ®Google Scholar
• Brown P, Oliviero A, Mazzone P, et al. Dopaminedependency of oscillations between subthalamic nucleus and pallidum inParkinson’s disease. J Neurosci. 2001;21:1033–1038.
   PubMed Web of Science ®Google Scholar
• Priori A, Foffani G, Pesenti A, et al. Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson’s disease. Exp Neurol. 2004;189:369–379.
   PubMed Web of Science ®Google Scholar
• Weinberger MMN, Hutchison WD, Lozano AM, et al. Beta oscillatory activity in the subthalamic nucleus and its relation todopaminergic response in Parkinson’s disease. J Neurophysiol. 2006;96:3248–3256.
   PubMed Web of Science ®Google Scholar
• Kuhn AA, Tsui A, Aziz T, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson’s disease relates to both bradykinesia and rigidity. Exp Neurol. 2009;215:380–387.
   PubMed Web of Science ®Google Scholar
• Kuhn AA, Kupsch A, Schneider GH, et al. Reduction in subthalamic 8–35 Hzoscillatory activity correlates with clinical improvement in Parkinson’s disease. Eur JNeurosci. 2006;23:1956–1960.
   PubMed Web of Science ®Google Scholar
• Chen CC, Litvak V, Gilbertson T, et al. Excessive synchronization of basal ganglianeurons at 20 Hz slows movement in Parkinson’s disease. Exp Neurol. 2007;205:214–221.
   PubMed Web of Science ®Google Scholar
• Eusebio A, Chen CC, Lu CS, et al. Effects of low-frequency stimulation of the subthalamic nucleus on movement inParkinson’s disease. Exp Neurol. 2008;209(1):125–130.
   PubMed Web of Science ®Google Scholar
• Artieda J, Pastor MA, Lacruz F, et al. Temporal discrimination is abnormal in Parkinson’s disease. Brain. 1992;115:199–210.
   PubMed Web of Science ®Google Scholar
• Conte A, Modugno N, Lena F, et al. Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson’s disease. Brain. 2010;133(9):2656–2663.
   PubMed Web of Science ®Google Scholar
• Rocchi L, Conte A, Nardella A, et al. Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients with Parkinson’s disease. Eur J Neurol. 2013;20(4):714–719.
   PubMed Web of Science ®Google Scholar
• Lyoo CH, Lee SY, Song TJ, et al. Abnormal temporal discrimination threshold in patients with multiple system atrophy. Mov Disord. 2007 Mar 15;22(4):556–559.
   PubMed Web of Science ®Google Scholar
• Lyoo CH, Ryu YH, Lee MJ, et al. Striatal dopamine loss and discriminative sensory dysfunction in Parkinson’s disease. Acta Neurol Scand. 2012;126:344–349.
   PubMed Web of Science ®Google Scholar
• Lee MS, Lyoo CH, Lee MJ, et al. Impaired finger dexterity in patients with Parkinson’s disease correlates with discriminative cutaneous sensory dysfunction. Mov Disord. 2010;25:2531–2535.
   PubMed Web of Science ®Google Scholar
• Patel N, Jankovic J, Hallett M. Sensory aspects of movement disorders. Lancet Neurol. 2014 Jan;13(1):100–112.
   PubMed Web of Science ®Google Scholar
• Lee MS, Kim HS, Lyoo CH. “Off” gait freezing and temporal discrimination threshold in patients with Parkinson disease. Neurology. 2005 22;64(4):670–674.
   PubMed Web of Science ®Google Scholar
• Djaldetti R, Shifrin A, Rogowski Z, et al. Quantitative measurement of pain sensation in patients with Parkinson disease. Neurology. 2004;62:2171–2175.
   PubMed Web of Science ®Google Scholar
• Brefel-Courbon C, Payoux P, Thalamas C, et al. Effect of levodopa on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord. 2005;20:1557–1563.
   PubMed Web of Science ®Google Scholar
• Nolano M, Provitera V, Estraneo A, et al. Sensory deficit in Parkinson’s disease: evidence of a cutaneous denervation. Brain. 2008;131:1903–1911.
   PubMed Web of Science ®Google Scholar
• Lim SY, Farrell MJ, Gibson SJ, et al. Do dyskinesia and pain share common pathophysiological mechanisms in Parkinson’s disease? Mov Disord. 2008(23):1689–1695.
   PubMed Web of Science ®Google Scholar
• Jensen TS, Smith DF. Dopaminergic effects on tail-flick response in spinal rats. Eur J Pharmacol. 1982;79:129–133.
   PubMed Web of Science ®Google Scholar
• Jensen TS, Yaksh TL. Effects of an intrathecal dopamine agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. Brain Res. 1984;296:285–293.
   PubMed Web of Science ®Google Scholar
• Fleetwood-Walker SM, Hope PJ, Mitchell R. Antinociceptive actions of descending dopaminergic tracts on cat and rat dorsal horn somatosensory neurones. J Physiol. 1998;399:335–348.
   Google Scholar
• Liu QS, Qiao JT, Dafny N. D2 dopamine receptor involvement in spinal dopamine-produced antinociception. Life Sci. 1992;51:1485–1492.
   PubMed Web of Science ®Google Scholar
• Ben-Sreti MM, Gonzalez JP, Sewell RD. Differential effects of SKF 38393 and LY 141865 on nociception and morphine analgesia. Life Sci. 1983;33(Suppl 1):665–668.
   PubMed Web of Science ®Google Scholar
• Altier N, Stewart J. Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine. J Pharmaco Lexpther. 1998;285:208–215.
   Google Scholar
• Magnusson JE, Fisher K. The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum. Brain Res. 2000;855:260–266.
   PubMed Web of Science ®Google Scholar
• Hagelberg N, Martikainen IK, Mansikka H, et al. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. Pain. 2002;99:273–279.
   PubMed Web of Science ®Google Scholar
• Pertovaara A, Martikainen IK, Hagelberg N, et al. Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain. Eur J Neurosci. 2004;20:1587–1592.
   PubMed Web of Science ®Google Scholar
• Martikainen IK, Hagelberg N, Mansikka H, et al. Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia. Neurosci Lett. 2005;376:149–153.
   PubMed Web of Science ®Google Scholar
• Scott DJ, Heitzeg MM, Koeppe RA, et al. Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity. J Neurosci. 2006;26:10789–10795.
   PubMed Web of Science ®Google Scholar
• Scott DJ, Stohler CS, Koeppe RA, et al. Timecourse of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge. Synapse. 2007;61:707–714.
   PubMed Web of Science ®Google Scholar
• Tinazzi M, Del Vesco C, Defazio G, et al. Abnormal processing of the nociceptive input in Parkinson’s disease: a study with CO2 laser evoked potentials. Pain. 2008;136:117–124.
   PubMed Web of Science ®Google Scholar
• Abbruzzese G, Berardelli A. Sensorimotorintegration in movementdisorders. Mov Disord. 2003 Mar;18(3):231–240.
   PubMed Web of Science ®Google Scholar
• Di Lazzaro V, Oliviero A, Saturno E, et al. Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans. J Physiol. 2005;564:661–668.
   PubMed Web of Science ®Google Scholar
• Sailer A, Molnar GF, Paradiso G, et al. Short and long latency afferent inhibition in Parkinson’s disease. Brain. 2003;126:1883–1894.
   PubMed Web of Science ®Google Scholar
• Berardelli A, Dick JP, Rothwell JC, et al. Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1986;49:1273–1279.
   PubMed Web of Science ®Google Scholar
• Michely J, Volz LJ, Barbe MT, et al. Dopaminergic modulation of motor network dynamics in Parkinson’s disease. Brain. 2015;138(Pt 3):664–678.
   PubMed Web of Science ®Google Scholar
• Nachev P, Kennard C, Husain M. Functional role of the supplementary and pre-supplementary motor areas. Nat Rev Neurosci. 2008;9:856–869.
   PubMed Web of Science ®Google Scholar
• D’Angelo E. Neural circuits of the cerebellum: hypothesis for function. J Integr Neurosci. 2011;10:317–52.31.
   PubMed Web of Science ®Google Scholar
• Bologna M, Suppa A, Conte A, et al. Are studies of motor cortex plasticity relevant in human patients with Parkinson’s disease?. Clin Neurophysiol. 2016;127(1):50–59.
   PubMed Web of Science ®Google Scholar
• Wang J, O’Donnell P. D1 dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb Cortex. 2001;11:452–462.
   PubMed Web of Science ®Google Scholar
• Molina-Luna K, Pekanovic A, Röhrich S, et al. Dopamine in motor cortex is necessary for skill learning and synaptic plasticity. PLoS One. 2009;4:e7082.
   PubMed Web of Science ®Google Scholar
• Hosp JA, Luft AR. Dopaminergic meso-cortical projections to M1: role in motor learning and motor cortex plasticity. Front Neurol. 2013;4:145.
   PubMed Web of Science ®Google Scholar
• Harrington DL, Haaland KY, Hermanowicz N. Temporal processing in the basal ganglia. Neuropsychology. 1998;12(1):3–12.
   PubMed Web of Science ®Google Scholar
• Harrington DL, Haaland KY, Knight RT. Cortical networks underlying mechanisms of time perception. J Neurosci. 1998 1;18(3):1085–1095.
   PubMed Web of Science ®Google Scholar
• Ivry RB. The representation of temporal information in perception and motor control. Curr Opin Neurobiol. 1996;6(6):851–857.
   PubMed Web of Science ®Google Scholar
• Appel-Cresswell S, De La Fuente-Fernandez R, Galley S, et al. Imaging of compensatory mechanisms in Parkinson’s disease. Curr Opin Neurol. 2010;23(4):407–412.
   PubMed Web of Science ®Google Scholar
• Obeso JA, Rodriguez-Oroz M, Marin C, et al. The origin of motor fluctuations in Parkinson’s disease: importance of dopaminergic innervation and basal ganglia circuits. Neurology. 2004 13;62(1 Suppl 1):S17–S30.
   PubMed Web of Science ®Google Scholar
• Sabatini U, Boulanouar K, Fabre N, et al. Cortical motor reorganization in akinetic patients with Parkinson’s disease: a functional MRI study. Brain. 2000;123(Pt 2):394–403.
   PubMed Web of Science ®Google Scholar
• van Nuenen BF, van Eimeren T, van der Vegt JP, et al. Mapping preclinical compensation in Parkinson’s disease: an imaging genomics approach. Mov Disord. 2009;24(Suppl 2):S703–S710.
   PubMed Web of Science ®Google Scholar
• Zigmond MJ. Do compensatory processes underlie the preclinical phase of neurodegenerative disease? Insights from an animal model of parkinsonism. Neurobiol Dis. 1997;4(3–4):247–253.
   PubMed Web of Science ®Google Scholar
• Defazio G, Tinazzi M, Berardelli A. How pain arises in Parkinson’s disease? Eur J Neurol. 2013 Dec;20(12):1517–1523.
   PubMed Web of Science ®Google Scholar
• Fabbrini G, Latorre A, Suppa A, et al. Fatigue in Parkinson’s disease: motor or non-motor symptom? Parkinsonism Relat Disord. 2013;19:148–152.
   PubMed Web of Science ®Google Scholar
• Cury RG, Galhardoni R, Fonoff ET, et al. Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms. Eur J Pain. 2016;20(2):151–165.
   PubMed Web of Science ®Google Scholar
• Becker S, Gandhi W, Elfassy NM, et al. The role of dopamine in the perceptual modulation of nociceptive stimuli by monetary wins or losses. Eur J Neurosci. 2013;38:3080–3088.
   PubMed Web of Science ®Google Scholar