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Special Report

Omega-3 fatty acids (ῳ-3 fatty acids) in epilepsy: animal models and human clinical trials

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Pages 1141-1145 | Received 01 Jun 2016, Accepted 16 Aug 2016, Published online: 06 Sep 2016

References

  • Martin K, Jackson CF, Levy RG, et al. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2016 Feb 9;2:CD001903.
  • Friedman D, Devinsky O. Cannabinoids in epilepsy. N Engl J Med. 2015;373:1048–1058.
  • Riediger ND, Othman RA, Suh M, et al. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009;109:668–679.
  • Leaf A, Xiao YF, Kang JX, et al. Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias. J Membr Biol. 2005;206:129–139.
  • De Caterina R. n–3 Fatty acids in cardiovascular disease. N Engl J Med. 2011;364:2439–2450.
  • Kelley DS, Siegel D, Vemuri M, et al. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr. 2007;86:324–333.
  • GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI Prevenzione trial. Lancet. 1999;354:447–455.
  • Wen YT, Dai JH, Gao Q. Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2014;24:470–475.
  • Rizos EC, Ntzani EE, Bika E, et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308:1024–1033.
  • Helland IB, Smith L, Saarem K, et al. Maternal supplementation with very-long-chain ῳ-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age. Pediatrics. 2003;111:e39–e44.
  • Makrides M, Gibson RA, McPhee AJ, et al. DOMInO Investigative Team, authors. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010;304:1675–1683.
  • Taha AY, Burnham WM, Auvin S. Polyunsaturated fatty acids and epilepsy. Epilepsia. 2010;51:1348–1358.
  • Calder P. Mechanisms of action of (n-3) fatty acids. J Nutr. 2012;142:592S–599S.
  • Innis SM. Dietary omega 3 fatty acids and the developing brain. Brain Res. 2008;1237:35–43.
  • Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience. 2006;139:991–997.
  • Jernerén F, Elshorbagy AK, Oulhaj A, et al. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015;102:215–221.
  • Quinn JF, Raman R, Thomas RG, et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA. 2010;304:1903–1911.
  • Witte AV, Kerti L, Hermannstädter HM, et al. Long-chain omega-3 fatty acids improve brain function and structure in older adults. Cereb Cortex. 2014;24:3059–3068.
  • Xiao YF, Kang J, Morgan J, et al. Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes. Proc Natl Acad Sci. 1995;92:11000–11004.
  • Kang JX, Leaf A. Evidence that free polyunsaturated fatty acids modify Na_channels by directly binding to the channel proteins. Proc Natl Acad Sci. 1996;93:3542–3546.
  • Xiao YF, Gomez AM, Morgan JP, et al. Suppression of voltage gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc Natl Acad Sci. 1997;94:4182–4187.
  • Leaf A, Kang J, Xiao Y, et al. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003;107:2646–2652.
  • Xiao Y, Li X. Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Res. 1999;846:112–121.
  • Taha AY, Huot PS, Reza-Lopez S, et al. Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. J Neurochem. 2008;105:380–388.
  • Willis S, Samala R, Rosenberger TA, et al. Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia. 2009;50:138–142.
  • El-Mowafy AM, Abdel-Dayem MA, Abdel-Aziz A, et al. Eicosapentaenoic acid ablates valproate-induced liver oxidative stress and cellular derangement without altering its clearance rate: dynamic synergy and therapeutic utility. Biochim Biophys Acta. 2011;1811:460–467.
  • Abdel-Dayem MA, Elmarakby AA, Abdel-Aziz AA, et al. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. Drugs R D. 2014;14:85–94.
  • Musto AE, Walker CP, Petasis NA, et al. Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. PLoS One. 2015;10:e0116543.
  • Climax J, Sewell RD. Modification of convulsive behaviour and body temperature in mice by intracerebroventricular administration of prostaglandins, arachidonic acid and the soluble acetylsalicylic acid salt lysine acetylsalicylate. Arch Int Pharmacodyn Ther. 1981;250:254–265.
  • Bandero CR, Salvadori MG, Gomes AT, et al. Fish-oil attenuates methylmalonate-induced seizures. Epilepsy Res. 2013;105:69–76.
  • Flores-Mancilla LE, Hernandez-Gonzalez M, Guevara MA, et al. Long-term fish-oil supplementation attenuates seizure activity in the amygdala induced by 3-mercaptopropionic acid in adult male rats. Epilepsy Behav. 2014;33:126–134.
  • Gilby KL, Jans J, McIntyre DC. Chronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary tale. Neuroscience. 2009;163:750–758.
  • Chen CC, Chaung HC, Chung MY, et al. Menhaden fish-oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures. Epilepsy Behav. 2006;8:516–521.
  • Curatolo N, Lecointe C, Bordet R, et al. Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. Pediatr Res. 2011;70:584–588.
  • Taha AY, Trepanie37r MO, Ciobanu FA, et al. A minimum of 3 months of dietary fish-oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats–implications for treating complex partial seizures. Epilepsy Behav. 2013;27:49–58.
  • Voskuyl RA, Vreugdenhil M, Kang JX, et al. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol. 1998;341:145–152.
  • Taha AY, Jeffrey MA, Taha NM, et al. Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats. Epilepsy Behav. 2010;17:336–343.
  • Musto AE, Gjorstrup P, Bazan NG. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia. 2011;52:1601–1608.
  • Trepanier MO, Taha AY, Mantha RL, et al. Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. Epilepsy Res. 2012;99:225–232.
  • Scorza FA, Cavalheiro EA, Arida RM, et al. Positive impact of omega-3 fatty acid supplementation in a dog with drug-resistant epilepsy: a case study. Epilepsy Behav. 2009;15:527–528.
  • Matthews H, Granger N, Wood J, et al. Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial. Vet J. 2012;191:396–398.
  • Pages N, Maurois P, Delplanque B, et al. Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions. PLEFA. 2012;87:63–70.
  • Abdel-Wahab BA, Shaikh IA, Khateeb MM, et al. Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. Pharmacol Biochem Behav. 2015;135:105–113.
  • DeGiorgio CM, Miller PR, Harper R, et al. Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomized placebo-controlled crossover study. J Neurol Neurosurg Psychiatry. 2015;86:65–70.
  • Chaddha A, Eagle K. Omega-3 fatty acids and heart health. Circulation. 2015;132:e350–e352.
  • Di Stasi D, Bernasconi R, Marchioli R, et al. Early modification of fatty acid composition in plasma phospholipids, platelets, and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids. Eur J Clin Pharmacol. 2004;60:183–190.
  • Product review: fish oil and omega-3 fatty acid supplements review (including Krill, Algae, Calamari, Green-lipped Mussel Oil). Available from: Consumerlab.com.
  • Yuen AW, Flugel D, Poepel A, et al. Non-randomized open trial of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in ten people with chronic epilepsy. Epilepsy Behav. 2012;23:370–372.
  • Yuen AW, Sander JW, Fluegel D, et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav. 2005;7:253–258.
  • Bromfield E, Dworetzky B, Hurwitz S, et al. A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav. 2008;12:187–190.

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