Radiologically isolated syndrome: watchful waiting vs. active treatment

References

• Lebrun C, Cohen M, Chaussenot A, et al. A prospective study of patients with brain MRI showing incidental t2 hyperintensities addressed as multiple sclerosis: a lot of work to do before treating. Neurol Ther. 2014;3(2):123–132.
   PubMedGoogle Scholar
• Granberg T, Martola J, Kristoffersen-Wiberg M, et al. Radiologically isolated syndrome–incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler. 2013;19(3):271–280.
   PubMed Web of Science ®Google Scholar
• “Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis.” [Online]. Available from: http://www.bmj.com/content/bmj/339/bmj.b3016.full.pdf. [ cited 2015 11 Dec].
   Google Scholar
• Rolak LA, Fleming JO. The differential diagnosis of multiple sclerosis. Neurologist. 2007 Mar;13(2):57–72.
   PubMed Web of Science ®Google Scholar
• McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001 Jul;50(1):121–127.
   PubMed Web of Science ®Google Scholar
• Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 Feb;69(2):292–302.
   PubMed Web of Science ®Google Scholar
• Bourdette D, Yadav V. The radiologically isolated syndrome revisited: when is it presymptomatic multiple sclerosis? Neurology. 2011;76(8):680–681.
   PubMed Web of Science ®Google Scholar
• Traboulsee AL, Li DKB. The role of MRI in the diagnosis of multiple sclerosis. Adv Neurol. 2006 Jan;98:125–146.
   PubMedGoogle Scholar
• Nielsen JM, Korteweg T, Barkhof F, et al. Overdiagnosis of multiple sclerosis and magnetic resonance imaging criteria. Ann Neurol. 2005;58(5):781–783.
   PubMed Web of Science ®Google Scholar
• Fazekas F, Offenbacher H, Fuchs S, et al. Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology. 1988 Dec;38(12):1822–1825.
   PubMed Web of Science ®Google Scholar
• Okuda DT, Mowry EM, Beheshtian A, et al. Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology. 2009;72(9):800–805.
   PubMed Web of Science ®Google Scholar
• Okuda DT, Siva A, Kantarci O, et al. Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS One. 2014;9(3):e90509.
   PubMed Web of Science ®Google Scholar
• Tur C, Tintoré M, Rovira A, et al. Very early scans for demonstrating dissemination in time in multiple sclerosis. Mult Scler. 2008;14(5):631–635.
   PubMed Web of Science ®Google Scholar
• Swanton JK, Fernando K, Dalton CM, et al. Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes. J Neurol Neurosurg Psychiatry. 2006;77(7):830–833.
   PubMed Web of Science ®Google Scholar
• Sellner J, Schirmer L, Hemmer B, et al. The radiologically isolated syndrome: take action when the unexpected is uncovered? J Neurol. 2010;257:1602–1611.
   PubMed Web of Science ®Google Scholar
• Filippi M, Rocca MA, Ciccarelli O, et al. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol. 2016;15(March):292–303.
   PubMed Web of Science ®Google Scholar
• Filippi M, Rocca MA, Ciccarelli O, et al., “MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines,” Lancet Neurol, vol. 15, no. Mar, pp. 292–303, 2016.
   PubMed Web of Science ®Google Scholar
• Lana-Peixoto MA. How much radiologically isolated syndrome suggestive of multiple sclerosis is multiple sclerosis? Arq Neuropsiquiatr. 2012 Jan;70(1):2–4.
   PubMed Web of Science ®Google Scholar
• Macmanus DG, Kendall BE, Kingsley DPE, et al. Breakdown of the Blood-Brain Barrier Precedes Symptoms and Other MRI Signs of New Lesions in Multiple Sclerosis. Brain. 1990;113(Pt 5):1477-1489.
   Google Scholar
• Brassat D. When does multiple sclerosis start? Three case reports and a review of the literature. Rev Neurol (Paris). 2012;168(11):846–851.
   PubMed Web of Science ®Google Scholar
• Eter P, Rex AB, Lga O, et al. A longitudinal study of abnormalities on mri and disability from multiple sclerosis. N Engl J Med. 2002;346(3):158–164.
   PubMed Web of Science ®Google Scholar
• Predominant HE, Hered- OFL. The 5-year risk of MS after opticneuritis. Experience of the optic neuritis treatment trial. Neurology. 1997;49(5):1404-1413.
   Google Scholar
• McDonnell GV, Cabrera-Gomez J, Calne DB, et al. Clinical presentation of primary progressive multiple sclerosis 10 years after the incidental finding of typical magnetic resonance imaging brain lesions: the subclinical stage of primary progressive multiple sclerosis may last 10 years. Mult Scler. 2003;9(2):204–209.
   PubMed Web of Science ®Google Scholar
• Rao SM. Neuropsychology of multiple sclerosis. Curr Opin Neurol. 1995 Jun;8(3):216–220.
   PubMed Web of Science ®Google Scholar
• Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 2008 Dec;7(12):1139–1151.
   PubMed Web of Science ®Google Scholar
• Hoffmann S, Tittgemeyer M, Von Cramon DY. Cognitive impairment in multiple sclerosis. Curr Opin Neurol. 2007 Jun;20(3):275–280.
   PubMed Web of Science ®Google Scholar
• Zipoli V, Goretti B, Hakiki B, et al. Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Mult Scler. 2010 Jan;16(1):62–67.
   PubMed Web of Science ®Google Scholar
• Lebrun C, Blanc F, Brassat D, et al. Cognitive function in radiologically isolated syndrome. Mult Scler. 2010;16(8):919–925.
   PubMed Web of Science ®Google Scholar
• Glanz BI, Healy BC, Rintell DJ, et al. The association between cognitive impairment and quality of life in patients with early multiple sclerosis. J Neurol Sci. 2010 Mar;290(1–2):75–79.
   PubMed Web of Science ®Google Scholar
• Amato MP, Langdon D, Montalban X, et al. Treatment of cognitive impairment in multiple sclerosis: position paper. J Neurol. 2013 Jun;260(6):1452–1468.
   PubMed Web of Science ®Google Scholar
• Gold R, Wolinsky JS, Amato MP, et al. Evolving expectations around early management of multiple sclerosis. Ther Adv Neurol Disord. 2010 Nov;3(6):351–367.
   PubMedGoogle Scholar
• Kantarci OH, Lebrun C, Siva A, et al. Primary Progressive MS evolvingfrom Radiologically Isolated Syndrome. Ann Neurol. 2015;79(2):288-294.
   Google Scholar
• Kappos SR, Polman L, Freedman CH, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology. 2006;67(7):1242-1249.
   Google Scholar
• Noyes K, Weinstock-Guttman B. Impact of diagnosis and early treatment on the course of multiple sclerosis. Am J Manag Care. 2013;19:321–331.
   PubMed Web of Science ®Google Scholar
• Jacobs LD, Beck RW, Simon JH, et al., the CHAMPS Study Group. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N Engl, Am J Ophthalmol. 2001 Jan; 131(1):154–155.
   Google Scholar
• Comi G, Filippi M, Barkhof F, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet (London, England). 2001 May;357(9268):1576–1582.
   PubMed Web of Science ®Google Scholar
• Comi G, Martinelli V, Rodegher M, et al. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet (London, England). 2009 Oct;374(9700):1503–1511.
   PubMed Web of Science ®Google Scholar
• Kappos L, Radue E-W, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010 Feb;362(5):387–401.
   PubMed Web of Science ®Google Scholar
• O’Connor PW, Li D, Freedman MS, et al. A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology. 2006 Mar;66(6):894–900.
   PubMed Web of Science ®Google Scholar
• Okuda DT, Mowry EM, Cree BAC, et al. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology. 2011 Mar;76(8):686–692.
   PubMed Web of Science ®Google Scholar
• Tintore M, Rovira A, Arrambide G, et al. Brainstem lesions in clinically isolated syndromes. Neurology. 2010 Nov;75(21):1933–1938.
   PubMed Web of Science ®Google Scholar
• Lebrun C, Bensa C, Debouverie M, et al. Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients. Arch Neurol. 2009;66(7):841–846.
   PubMedGoogle Scholar
• Bielekova B, Richert N, Herman ML, et al. Intrathecal effects of daclizumab treatment of multiple sclerosis. Neurology. 2011 Nov;77(21):1877–1886.
   PubMed Web of Science ®Google Scholar
• Bielekova B, Komori M, Xu Q, et al. Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation. PLoS One. 2012 Jan;7(11):e48370.
   PubMed Web of Science ®Google Scholar
• Rossi S, Motta C, Studer V, et al. Subclinical central inflammation is risk for RIS and CIS conversion to MS. Mult Scler J. 2015;21(11):1443-1452.
   Google Scholar
• Giorgio A, Stromillo ML, Rossi F, et al. Cortical lesions in radiologically isolated syndrome. Neurology. 2011;77(21):1896–1899.
   PubMed Web of Science ®Google Scholar
• Barkhof F, Filippi M, Miller DH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain. 1997;120:2059–2069.
   PubMed Web of Science ®Google Scholar
• Phadke JG, Best PV. Atypical and clinically silent multiple sclerosis: a report of 12 cases discovered unexpectedly at necropsy. J Neurol Neurosurg Psychiatry. 1983 May;46(5):414–420.
   PubMed Web of Science ®Google Scholar
• Rovira À, Wattjes MP, Tintoré M, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process. Nat Rev Neurol. 2015;11(Aug):1–12.
   PubMedGoogle Scholar
• Lebrun C, Bensa C, Debouverie M, et al. Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile. J Neurol Neurosurg Psychiatry. 2008;79(2):195–198.
   PubMed Web of Science ®Google Scholar
• Kappos L, Moeri D, Radue EW, et al. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: A meta-analysis. Lancet. 1999;353:964–969.
   PubMed Web of Science ®Google Scholar
• Koudriavtseva T, Thompson AJ, Fiorelli M, et al. Gadolinium enhanced MRI predicts clinical and MRI disease activity in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry. 1997;62(3):285–287.
   PubMed Web of Science ®Google Scholar
• Gabelic T, Ramasamy DP, Weinstock-Guttman B, et al. Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis. AJNR Am J Neuroradiol. 2014 Jan;35(1):106–112.
   PubMed Web of Science ®Google Scholar
• De Stefano N, Cocco E, Lai M, et al. Imaging brain damage in first-degree relatives of sporadic and familial multiple sclerosis. Ann Neurol. 2006 May;59(4):634–639.
   PubMed Web of Science ®Google Scholar
• Freedman MS, Comi G, De Stefano N, et al. Moving toward earlier treatment of multiple sclerosis: findings from a decade of clinical trials and implications for clinical practice. Mult Scler Relat Disord. 2014;3(2):147–155.
   PubMed Web of Science ®Google Scholar
• Kieseier BC. The mechanism of action of interferon-β in relapsing multiple sclerosis. CNS Drugs. 2011 Jun;25(6):491–502.
   PubMed Web of Science ®Google Scholar
• Wolinsky JS, Narayana PA, O’Connor P, et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol. 2007 Jan;61(1):14–24.
   PubMed Web of Science ®Google Scholar