A review of cognitive remediation approaches for schizophrenia: from top-down to bottom-up, brain training to psychotherapy

References

• Goldstein G, Zubin J. Neuropsychological differences between young and old schizophrenics with and without associated neurological dysfunction. Schizophr Res. 1990;3(2):117–126.
   PubMed Web of Science ®Google Scholar
• Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull. 1993;19(2):233–259.
   PubMed Web of Science ®Google Scholar
• Green M, Walker E. Neuropsychological performance and positive and negative symptoms in schizophrenia. J Abnorm Psychol. 1985;94(4):460–469.
   PubMed Web of Science ®Google Scholar
• Crawford JR, Obonsawin MC, Bremner M. Frontal lobe impairment in schizophrenia: relationship to intellectual functioning. Psychol Med. 1993;23(3):787–790.
   PubMed Web of Science ®Google Scholar
• Paulsen JS, Heaton RK, Sadek JR, et al. The nature of learning and memory impairments in schizophrenia. J Int Neuropsychol Soc. 1995;1(1):88–99.
   PubMedGoogle Scholar
• Heinrichs RW. Variables associated with Wisconsin Card Sorting Test performance in neuropsychiatric patients referred for assessment. Cogn Behav Neurol. 1990;3(2):107–112.
   Google Scholar
• Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12(3):426–445.
   PubMed Web of Science ®Google Scholar
• Mesholam-Gately RI, Giuliano AJ, Goff KP, et al. Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology. 2009;23(3):313–336.
   Web of Science ®Google Scholar
• Lencz T, Smith CW, McLaughlin D, et al. Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatry. 2006;59(9):863–871.
   PubMed Web of Science ®Google Scholar
• Fervaha G, Zakzanis KK, Foussias G, et al. Motivational deficits and cognitive test performance in schizophrenia. JAMA Psychiatry. 2014;71(9):1058–1065.
   PubMed Web of Science ®Google Scholar
• Bramon E, Rabe-Hesketh S, Sham P, et al. Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr Res. 2004;70(2–3):315–329.
   PubMed Web of Science ®Google Scholar
• Brockhaus-Dumke A, Schultze-Lutter F, Mueller R, et al. Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients. Biol Psychiatry. 2008;64(5):376–384.
   PubMed Web of Science ®Google Scholar
• Kasai K, Nakagome K, Itoh K, et al. Impaired cortical network for preattentive detection of change in speech sounds in schizophrenia: a high-resolution event-related potential study. Am J Psychiatry. 2002;159(4):546–553.
   PubMed Web of Science ®Google Scholar
• Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Rev. 1999;29(2–3):169–195. .
   PubMed Web of Science ®Google Scholar
• Basar-Eroglu C, Schmiedt-Fehr C, Marbach S, et al. Altered oscillatory alpha and theta networks in schizophrenia. Brain Res. 2008;1235:143–152.
   PubMed Web of Science ®Google Scholar
• Shenton ME, Dickey CC, Frumin M, et al. A review of MRI findings in schizophrenia. Schizophr Res. 2001;49(1–2):1–52. .
   PubMed Web of Science ®Google Scholar
• Manoach DS, Press DZ, Thangaraj V, et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry. 1999;45(9):1128–1137.
   PubMed Web of Science ®Google Scholar
• Manoach DS, Gollub RL, Benson ES, et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry. 2000;48(2):99–109.
   PubMed Web of Science ®Google Scholar
• Aleman A, Hijman R, de Haan EH, et al. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry. 1999;156(9):1358–1366.
   PubMed Web of Science ®Google Scholar
• Keefe RSE, Bilder RM, Harvey PD, et al. Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology. 2006;31(9):2033–2046.
   PubMed Web of Science ®Google Scholar
• Perkins DO, Gu H, Boteva K, et al. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry. 2005;162:1785–1804.
   PubMed Web of Science ®Google Scholar
• Lincoln TM, Lüllmann E, Rief W. Correlates and long-term consequences of poor insight in patients with schizophrenia. A systematic review. Schizophr Bull. 2007;33(6):1324–1342.
   PubMed Web of Science ®Google Scholar
• Emsley R, Chiliza B, Schoeman R. Predictors of long-term outcome in schizophrenia. Curr Opin Psychiatry. 2008;21(2):173–177.
   PubMed Web of Science ®Google Scholar
• Milev P, Ho B-C, Arndt S, et al. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. Am J Psychiatry. 2005;162(3):495–506.
   PubMed Web of Science ®Google Scholar
• Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996;153(3):321–330.
   PubMed Web of Science ®Google Scholar
• Bowie CR, Reichenberg A, Patterson TL, et al. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am J Psychiatry. 2006;163(3):418–425.
   PubMed Web of Science ®Google Scholar
• Bowie CR, Leung WW, Reichenberg A, et al. Predicting schizophrenia patients’ real-world behavior with specific neuropsychological and functional capacity measures. Biol Psychiatry. 2008;63(5):505–511.
   PubMed Web of Science ®Google Scholar
• Bowie CR, Depp C, McGrath JA, et al. Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry. 2010;167(9):1116–1124.
   PubMed Web of Science ®Google Scholar
• McGurk SR, Meltzer HY. The role of cognition in vocational functioning in schizophrenia. Schizophr Res. 2000;45(3):175–184.
   PubMed Web of Science ®Google Scholar
• Light GA, Braff DL. Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch Gen Psychiatry. 2005;62(2):127–136.
   PubMed Web of Science ®Google Scholar
• Wynn JK, Sugar C, Horan WP, et al. Mismatch negativity, social cognition, and functioning in schizophrenia patients. Biol Psychiatry. 2010;67(10):940–947.
   PubMed Web of Science ®Google Scholar
• Thomas ML, Green MF, Hellemann G, et al. Modeling deficits from early auditory information processing to psychosocial functioning in schizophrenia.. JAMA Psychiatry. 2017;74(1):37–46.
   PubMed Web of Science ®Google Scholar
• Lee S-H, Sung K, Lee K-S, et al. Mismatch negativity is a stronger indicator of functional outcomes than neurocognition or theory of mind in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:213–219.
   PubMed Web of Science ®Google Scholar
• Medalia A, Choi J. Cognitive remediation in schizophrenia. Neuropsychol Rev. 2009;19(3):353–364.
   PubMed Web of Science ®Google Scholar
• Rohling ML, Faust ME, Beverly B, et al. Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al.’s (2000, 2005) systematic reviews. Neuropsychology. 2009;23(1):20–39.
   PubMed Web of Science ®Google Scholar
• Lewis DA, Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci. 2002;25(1):409–432.
   PubMed Web of Science ®Google Scholar
• Fisher M, Holland C, Merzenich MM, et al. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am J Psychiatry. 2009;166(7):805–811. .
   PubMed Web of Science ®Google Scholar
• Medalia A, Freilich B. The neuropsychological educational approach to cognitive remediation (NEAR) model: practice principles and outcome studies. Am J Psychiatr Rehabil. 2008;11(2):123–143.
   Google Scholar
• Bowie CR, Medalia A. Bridging groups. In: Medalia A, Bowie CR, editors. Cognitive remediation to improve functional outcomes. New York (NY): Oxford University Press; 2016. p. 66–87.
   Google Scholar
• McGurk SR, Twamley EW, Sitzer DI, et al. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry. 2007;164(12):1791–1802. .
   PubMed Web of Science ®Google Scholar
• Wykes T, Huddy V, Cellard C, et al. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011;168(5):472–485.
   PubMed Web of Science ®Google Scholar
• Delahunty A, Morice R. Rehabilitation of frontal/executive impairments in schizophrenia. Aust N Z J Psychiatry. 1996;30(6):760–767.
   PubMed Web of Science ®Google Scholar
• Lindenmayer J-P, McGurk SR, Mueser KT, et al. A randomized controlled trial of cognitive remediation among inpatients with persistent mental illness. Psychiatr Serv. 2008;59(3):241–247.
   PubMed Web of Science ®Google Scholar
• Eack SM, Greenwald DP, Hogarty SS, et al. Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial. Psychiatr Serv. 2009;60(11):1468–1476.
   PubMed Web of Science ®Google Scholar
• Medalia A, Lim R. Treatment of cognitive dysfunction in psychiatric disorders. J Psychiatr Pract. 2004;10(1):17–25.
   PubMedGoogle Scholar
• Winterer G, Ziller M, Dorn H, et al. Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing. Clin Neurophysiol. 2000;111(5):837–849.
   PubMed Web of Science ®Google Scholar
• Leitman DI, Hoptman MJ, Foxe JJ, et al. The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. Am J Psychiatry. 2007;164(3):474–482.
   PubMed Web of Science ®Google Scholar
• Kawakubo Y, Kasai K, Kudo N, et al. Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia. Neuroreport. 2006;17(10):1043–1046.
   PubMed Web of Science ®Google Scholar
• Kawakubo Y, Kamio S, Nose T, et al. Phonetic mismatch negativity predicts social skills acquisition in schizophrenia. Psychiatry Res. 2007;152(2–3):261–265.
   PubMed Web of Science ®Google Scholar
• Popov T, Jordanov T, Rockstroh B, et al. Specific cognitive training normalizes auditory sensory gating in schizophrenia: a randomized trial. Biol Psychiatry. 2011;69(5):465–471.
   PubMed Web of Science ®Google Scholar
• Mahncke HW, Bronstone A, Merzenich MM. Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Prog Brain Res. 2006;157:81–109.
   PubMed Web of Science ®Google Scholar
• Merzenich MM. Cortical plasticity contributing to child development. In: McClelland JL, Siegler RS, editors. Mechanisms of cognitive development: behavioral and neural perspectives. Mahwah (NJ): Lawrence Erlbaum Associates; 2001. p. 67–95.
   Google Scholar
• Fisher M, Holland C, Subramaniam K, et al. Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months later. Schizophr Bull. 2010;36(4):869–879.
   PubMed Web of Science ®Google Scholar
• Adcock RA, Dale C, Fisher M, et al. When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia. Schizophr Bull. 2009;35(6):1132–1141.
   PubMed Web of Science ®Google Scholar
• Popov TG, Carolus A, Schubring D, et al. Targeted training modifies oscillatory brain activity in schizophrenia patients. Neuroimage Clin. 2015;7:807–814.
   PubMed Web of Science ®Google Scholar
• Russo-Neustadt A, Beard RC, Cotman CW. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999;21(5):679–682.
   PubMed Web of Science ®Google Scholar
• Young D, Lawlor PA, Leone P, et al. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med. 1999;5(4):448–453.
   PubMed Web of Science ®Google Scholar
• Popova P, Popov TG, Wienbruch C, et al. Changing facial affect recognition in schizophrenia: effects of training on brain dynamics. Neuroimage Clin. 2014;6:156–165.
   PubMed Web of Science ®Google Scholar
• Medalia A, Aluma M, Tryon W, et al. Effectiveness of attention training in schizophrenia. Schizophr Bull. 1998;24(1):147–152.
   PubMed Web of Science ®Google Scholar
• Silverstein SM, Hatashita-Wong M, Solak BA, et al. Effectiveness of a two-phase cognitive rehabilitation intervention for severely impaired schizophrenia patients. Psychol Med. 2005;35(6):829–837.
   PubMed Web of Science ®Google Scholar
• Benedict RH, Harris AE, Markow T, et al. Effects of attention training on information processing in schizophrenia. Schizophr Bull. 1994;20(3):537–546.
   PubMed Web of Science ®Google Scholar
• López-Luengo B, Vázquez C. Effects of attention process training on cognitive functioning of schizophrenic patients. Psychiatry Res. 2003;119(1–2):41–53.
   PubMed Web of Science ®Google Scholar
• Ingvar DH, Franzén G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand. 1974;50(4):425–462.
   PubMed Web of Science ®Google Scholar
• Minzenberg MJ, Laird AR, Thelen S, et al. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry. 2009;66(8):811–822.
   PubMed Web of Science ®Google Scholar
• Griesmayr B, Berger B, Stelzig-Schoeler R, et al. EEG theta phase coupling during executive control of visual working memory investigated in individuals with schizophrenia and in healthy controls. Cogn Affect Behav Neurosci. 2014;14(4):1340–1355.
   PubMed Web of Science ®Google Scholar
• Andreasen NC, O’Leary DS, Flaum M, et al. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients.. Lancet. 1997;349(9067):1730–1734.
   PubMed Web of Science ®Google Scholar
• Medalia A, Dorn H, Watras-Gans S. Treating problem-solving deficits on an acute care psychiatric inpatient unit. Psychiatr Res. 2000;97(1):79–88.
   PubMed Web of Science ®Google Scholar
• Choi J, Kurtz MM. A comparison of remediation techniques on the Wisconsin Card Sorting Test in schizophrenia. Schizophr Res. 2009;107(1):76–82.
   PubMed Web of Science ®Google Scholar
• Medalia A, Revheim N, Casey M. Remediation of problem-solving skills in schizophrenia: evidence of a persistent effect. Schizophr Res. 2002;57(2–3):165–171.
   PubMed Web of Science ®Google Scholar
• Penadés R, Catalán R, Salamero M, et al. Cognitive remediation therapy for outpatients with chronic schizophrenia: a controlled and randomized study. Schizophr Res. 2006;87(1–3):323–331.
   PubMed Web of Science ®Google Scholar
• Wykes T, Brammer M, Mellers J. Effects on the brain of a psychological treatment: cognitive remediation therapy functional magnetic resonance imaging in schizophrenia. Br J Psychiatry. 2002;181(2):144–152.
   PubMed Web of Science ®Google Scholar
• Eack SM, Hogarty GE, Cho RY, et al. Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial. Arch Gen Psychiatry. 2010;67(7):674–682.
   PubMed Web of Science ®Google Scholar
• Penadés R, Pujol N, Catalán R, et al. Brain effects of cognitive remediation therapy in schizophrenia: a structural and functional neuroimaging study. Biol Psychiatry. 2013;73(10):1015–1023.
   PubMed Web of Science ®Google Scholar
• Edwards BG, Barch DM, Braver TS. Improving prefrontal cortex function in schizophrenia through focused training of cognitive control. Front Hum Neurosci. 2010;4(32):1–12.
   PubMedGoogle Scholar
• Thorsen AL, Johansson K, Løberg EM. Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review. Front Psychiatry. 2014;5(103):1–9.
   PubMed Web of Science ®Google Scholar
• Puig O, Penadés R, Baeza I, et al. Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2014;53(8):859–868.
   PubMed Web of Science ®Google Scholar
• Tan S, Zou Y, Wykes T, et al. Group cognitive remediation therapy for chronic schizophrenia: a randomized controlled trial. Neurosci Lett. 2016;626:106–111.
   PubMed Web of Science ®Google Scholar
• Medalia A, Revheim N, Casey M. The remediation of problem-solving skills in schizophrenia. Schizophr Bull. 2001;27(2):259–267.
   PubMed Web of Science ®Google Scholar
• Rodewald K, Rentrop M, Holt DV, et al. Planning and problem-solving training for patients with schizophrenia: a randomized controlled trial. BMC Psychiatry. 2011;11(73):1–11.
   PubMed Web of Science ®Google Scholar
• Hogarty GE, Flesher S, Ulrich R, et al. Cognitive enhancement therapy for schizophrenia: effects of a 2-year randomized trial on cognition and behavior. Arch Gen Psychiatry. 2004;61(9):866–876.
   PubMed Web of Science ®Google Scholar
• McGurk SR, Mueser KT, Xie H, et al. Cognitive enhancement treatment for people with mental illness who do not respond to supported employment: a randomized controlled trial. Am J Psychiatry. 2015;172(9):852–861.
   PubMed Web of Science ®Google Scholar
• Bell MD, Zito W, Greig T, et al. Neurocognitive enhancement therapy with vocational services: work outcomes at two-year follow-up. Schizophr Res. 2008;105(1–3):18–29.
   PubMed Web of Science ®Google Scholar
• Hodge MAR, Siciliano D, Withey P, et al. A randomized controlled trial of cognitive remediation in schizophrenia. Schizophr Bull. 2010;36(2):419–427.
   PubMed Web of Science ®Google Scholar
• Kidd SA, Kaur J, Virdee G, et al. Cognitive remediation for individuals with psychosis in a supported education setting: a randomized controlled trial. Schizophr Res. 2014;157(1–3):90–98.
   PubMed Web of Science ®Google Scholar
• Cavallaro R, Anselmetti S, Poletti S, et al. Computer-aided neurocognitive remediation as an enhancing strategy for schizophrenia rehabilitation. Psychiatr Res. 2009;169(3):191–196.
   PubMed Web of Science ®Google Scholar
• Bowie CR, McGurk SR, Mausbach B, et al. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry. 2012;169(7):710–718.
   PubMed Web of Science ®Google Scholar
• Wykes T, Newton E, Landau S, et al. Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Schizophr Res. 2007;94(1–3):221–230.
   PubMed Web of Science ®Google Scholar
• Gomar JJ, Valls E, Radua J, et al. A multisite, randomized controlled clinical trial of computerized cognitive remediation therapy for schizophrenia. Schizophr Bull. 2015;41(6):1387–1396.
   PubMed Web of Science ®Google Scholar
• Twamley EW, Vella L, Burton CZ, et al. Compensatory cognitive training for psychosis: effects in a randomized controlled trial. J Clin Psychiatry. 2012;73(9):1212–1219.
   PubMed Web of Science ®Google Scholar
• Velligan DI, Mahurin RK, True JE, et al. Preliminary evaluation of cognitive adaptation training to compensate for cognitive deficits in schizophrenia. Psychiatr Serv. 1996;47(4):415–417.
   PubMed Web of Science ®Google Scholar
• Barch DM, Carter CS, Braver TS, et al. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry. 2001;58(3):280–288.
   PubMed Web of Science ®Google Scholar
• Medalia A, Saperstein AM, Hansen MC, et al. Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders. Neuropsychol Rehabil. 2016;1–12.
   PubMedGoogle Scholar
• Choi J, Medalia A. Factors associated with a positive response to cognitive remediation in a community psychiatric sample. Psychiatr Serv. 2005;56(5):602–604.
   PubMed Web of Science ®Google Scholar
• Bowie CR, Grossman M, Gupta M, et al. Cognitive remediation in schizophrenia: efficacy and effectiveness in patients with early versus long‐term course of illness. Early Interv Psychiatry. 2014;8(1):32–38.
   PubMed Web of Science ®Google Scholar
• Fiszdon JM, Choi J, Bryson GJ, et al. Impact of intellectual status on response to cognitive task training in patients with schizophrenia. Schizophr Res. 2006;87(1–3):261–269.
   PubMed Web of Science ®Google Scholar
• Franck N, Duboc C, Sundby C, et al. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013;147(1):68–74.
   PubMed Web of Science ®Google Scholar
• Benedict RH, Harris AE. Remediation of attention deficits in chronic schizophrenic patients: a preliminary study. Br J Clin Psychol. 1989;28(2):187–188.
   PubMed Web of Science ®Google Scholar
• Hermanutz M, Gestrich J. Computer-assisted attention training in schizophrenics. A comparative study. Eur Arch Psychiatry Clin Neurosci. 1991;240(4–5):282–287.
   PubMed Web of Science ®Google Scholar
• Olbrich R, Mussgay L. Reduction of schizophrenic deficits by cognitive training: an evaluative study. Eur Arch Psychiatry Neurol Sci. 1990;239(6):366–369.
   PubMedGoogle Scholar
• Kurtz MM, Seltzer JC, Shagan DS, et al. Computer-assisted cognitive remediation in schizophrenia: what is the active ingredient? Schizophr Res. 2007;89(1–3):251–260.
   PubMed Web of Science ®Google Scholar
• Burda PC, Starkey TW, Dominguez F, et al. Computer-assisted cognitive rehabilitation of chronic psychiatric inpatients. Comput Human Behav. 1994;10(3):359–368.
   Web of Science ®Google Scholar
• Sartory G, Zorn C, Groetzinger G, et al. Computerized cognitive remediation improves verbal learning and processing speed in schizophrenia. Schizophr Res. 2005;75(2–3):219–223.
   PubMed Web of Science ®Google Scholar
• McGurk SR, Mueser KT, Pascaris A. Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophr Bull. 2005;31(4):898–909.
   PubMed Web of Science ®Google Scholar
• Schunk DH. Self-efficacy, motivation, and performance. J Appl Sport Psychol. 1995;7(2):112–137.
   Web of Science ®Google Scholar
• Cordova DI, Lepper MR. Intrinsic motivation and the process of learning: beneficial effects of contextualization, personalization, and choice. J Educ Psychol. 1996;88(4):715–730.
   Web of Science ®Google Scholar
• Wykes T, Reeder C, Corner J, et al. The effects of neurocognitive remediation on executive processing in patients with schizophrenia. Schizophr Bull. 1999;25(2):291–307.
   PubMed Web of Science ®Google Scholar
• Hadas-Lidor N, Katz N, Tyano S, et al. Effectiveness of dynamic cognitive intervention in rehabilitation of clients with schizophrenia. Clin Rehabil. 2001;15(4):349–359.
   PubMed Web of Science ®Google Scholar
• Van Der Gaag M, Kern RS, Van Den Bosch RJ, et al. A controlled trial of cognitive remediation in schizophrenia. Schizophr Bull. 2002;28(1):167–176.
   PubMed Web of Science ®Google Scholar
• Twamley EW, Savla GN, Zurhellen CH, et al. Development and pilot testing of a novel compensatory cognitive training intervention for people with psychosis. Am J Psychiatr Rehabil. 2008;11(2):144–163.
   PubMedGoogle Scholar
• Bowie CR, Grossman M, Gupta M, et al. Action-based cognitive remediation for individuals with serious mental illnesses: effects of real-world simulations and goal setting on functional and vocational outcomes. Psychiatr Rehabil J. 2017 Mar;40(1):53-60. doi: 10.1037/prj0000189.
   Google Scholar
• Vauth R, Corrigan PW, Clauss M, et al. Cognitive strategies versus self-management skills as adjunct to vocational rehabilitation. Schizophr Bull. 2005;31(1):55–66.
   PubMed Web of Science ®Google Scholar
• Leucht S, Corves C, Arbter D, et al. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373(9657):31–41.
   PubMed Web of Science ®Google Scholar
• Jauhar S, McKenna PJ, Radua J, et al. Cognitive-behavioural therapy for the symptoms of schizophrenia: systematic review and meta-analysis with examination of potential bias. Br J Psychiatry. 2014;204(1):20–29.
   PubMed Web of Science ®Google Scholar
• Owen AM, Hampshire A, Grahn JA, et al. Putting brain training to the test. Nature. 2010;465(7299):775–778.
   PubMed Web of Science ®Google Scholar
• Rose D, Wykes T, Farrier D, et al. What do clients think of cognitive remediation therapy? A consumer-led investigation of satisfaction and side effects. Am J Psychiatr Rehabil. 2008;11(2):181–204.
   Google Scholar
• Klingberg S, Herrlich J, Wiedemann G, et al. Adverse effects of cognitive behavioral therapy and cognitive remediation in schizophrenia: results of the treatment of negative symptoms study. J Nerv Ment Dis. 2012;200(7):569–576.
   PubMed Web of Science ®Google Scholar
• Vinogradov S, Fisher M, Warm H, et al. The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia. Am J Psychiatry. 2009;166:1055–1062.
   PubMed Web of Science ®Google Scholar
• Cain CK, McCue M, Bello I, et al. D-Cycloserine augmentation of cognitive remediation in schizophrenia. Schizophr Res. 2014;153:177–183.
   PubMed Web of Science ®Google Scholar
• Michalopoulou PG, Lewis SW, Drake RJ, et al. Modafinil combined with cognitive training: pharmacological augmentation of cognitive training in schizophrenia. Eur Neuropsychopharmacol. 2015;25:1178–1189.
   PubMed Web of Science ®Google Scholar