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Review

Treatment options for severe traumatic brain injuries in children: current therapies, challenges, and future prospects

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Pages 1145-1155 | Received 13 Jun 2017, Accepted 13 Sep 2017, Published online: 22 Sep 2017

References

  • Taylor CA, Bell JM, Breiding MJ, et al. Traumatic brain injury – related emergency department visits, hospitalizations, and deaths – United States, 2007 and 2013. MMWR Surveill Summ. 2017;66:1–16.
  • Thurman D. The epidemiology of traumatic brain injury in children and youths: a review of research since 1990. J Child Neurol. 2016;3:20–27.
  • Traumatic Brain Injury and Concussion. Centers for Disease Control (CDC). 2017 Mar 28. [cited 2017 May 23]. Available from: www.cdc.gov/traumaticbraininjury
  • Dewan MC, Mummareddy N, Wellons JC, et al. Epidemiology of global pediatric traumatic brain injury: qualitative review. World Neurosurg. 2016;91:497–509.
  • Teasdale G, Jennet B, Murray L, et al. Glasgow Coma Scale: to sum or not to sum? Lancet. 1983;2:678.
  • Kochanek PM, Bell MJ, Bayir H, et al. Severe traumatic brain injury in infants and children. In: Fuhrman BP, Zimmerman JJ, editors. Pediatric critical care. 4th ed. Philadelphia, PA:Elsevier Health Sciences; 2011. p. 849–870.
  • Beauchamp MH, Anderson V Cognitive and psychopathological sequelae of pediatric traumatic brain injury. In: Dulac O, Lassonde M, Sarnat HB, editors. Handbook of clinical neurology. 3rd series. Amsterdam, The Netherlands: Elsevier B.V.; 2013. p. 913–920.
  • Shaklai S, Peretz R, Spasser R, et al. Long-term functional outcome after moderate-to-severe-paediatric traumatic brain injury. Brain Inj. 2014;28:916–921.
  • Babikian T, Merkley T, Savage RC, et al. Chronic aspects of pediatric traumatic brain injury: review of the literature. J Neurotrauma. 2015;32:1849–1860.
  • Catroppa C, Godfrey C, Rosenfeld JV, et al. Functional recovery ten years after pediatric traumatic brain injury: outcomes and predictors. J Neurotrauma. 2012;29:2539–2547.
  • Anderson V, Godfrey C, Rosenfeld J, et al. Predictors of cognitive function and recovery 10 years after traumatic brain injury in young children. Pediatrics. 2012;129:e254–61.
  • McCauley SR, Wilde EA, Anderson VA, et al. Recommendations for the use of common outcome measures in pediatric traumatic brain injury research. J Neurotrauma. 2012;29:678–705.
  • Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology. 2001;56:1746–1748.
  • Kadhim HJ, Duchateau J, Seblic G. Cytokines and brain injury. J Intensive Care Med. 2008;23:236–249.
  • Bramlett HM, Dietrich WD. Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes. J Neurotrauma. 2015;32:1834–1848.
  • Ferreira LC, Ragner A, Miotto KD, et al. Increased levels of interleukin-6, −8, and −10 are associated with fatal outcomes following severe traumatic brain injury. Brain Inj. 2014;28:1311–1316.
  • Kumar RG, Boles JA, Wagner AK. Chronic inflammation after severe traumatic brain injury: characterization and associations with outcome at 6 and 12 months post-injury. J Head Trauma Rehabil. 2015;30:369–381.
  • Udomphorn Y, Armstead WM, Vavilala MS. Cerebral blood flow and autoregulation after pediatric traumatic brain injury. Pediatr Neurol. 2008;38:225–234.
  • Kochanek PM, Carney N, Adelson PD, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents – second edition. Pediatr Crit Care Med. 2012;13(suppl 1):S1–S82.
  • Carney N, Totten AM, O’Reilly C, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 2016;0:1–10.
  • Boone MD, Oren-Grinberg A, Robinson TM, et al. Mannitol or hypertonic saline in the setting of traumatic brain injury: what have we learned? Surg Neurol Int. 2015;23:177.
  • Kamel H, Navi BB, Nakagawa K, et al. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials. Crit Care Med. 2011;39:554–559.
  • Gonda DD, Meltzer HS, Crawford JR, et al. Complications associated with prolonged hypertonic saline therapy in children with elevated intracranial pressure. Pediatr Crit Care Med. 2013;14:610–620.
  • Berger-Pelleiter E, Emond M, Lauzier F, et al. Hypertonic saline in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. CJEM. 2016;18:112–120.
  • Burgess S, Abu-Laban RB, Slavik RS, et al. A systematic review of randomized controlled trials comparing hypertonic saline solutions and mannitol for traumatic brain injury: implications for emergency department management. Ann Pharmacother. 2016;50:291–300.
  • Mangat HS, Chiu YL, Gerber LM, et al. Hypertonic saline reduces cumulative and daily intracranial pressure burdens after severe traumatic brain injury. J Neurosurg. 2015;122:202–210.
  • Oddo M, Crippa IA, Mehta S, et al. Optimizing sedation in paitents with acute brain injury. Crit Care. 2016;20:128.
  • Welch TP, Wallendorf MJ, Kharasch ED, et al. Fentanyl and midazolam are ineffective in reducing episodic intracranial hypertension in severe traumatic brain injury. Crit Care Med. 2016;44:809–818.
  • Roberts I, Sydeham E. Barbiturates for acute traumatic brain injury. Cochrane Database Syst Rev. 2012;12:CD000033.
  • Mellion SA, Bennet KS, Ellsworth GL, et al. High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury. Pediatr Crit Care Med. 2013;14:239–247.
  • Andrews PJ, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med. 2015;373:2403–2412.
  • Hutchinson JS, Ward RE, Lacroix J, et al. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008;358:2447–2456.
  • Adelson PD, Wisniewski SR, Beca J, et al. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial. Lancet Neurol. 2013;12:546–553.
  • Beca J, McSharry B, Erickson S, et al. Pediatric Study Group of the Australia and New Zealand Intensive Care Society Clinical Trials Group: hypothermia for traumatic brain injury in children—A phase II randomized controlled trial. Crit Care Med. 2015;43:1458–1466.
  • Tasker RC, Vonberg FW, Ulano ED, et al. Updating evidence for using hypothermia in pediatric severe traumatic brain injury: conventional and Bayesian meta-analytic perspectives. Pediatr Crit Care Med. 2017;18:355–362.
  • Crompton EM, Lubomirova I, Cotlarciuc I, et al. Meta-analysis of therapeutic hypothermia for traumatic brain injury in adult and pediatric patients. Crit Care Med. 2017;45:575–583.
  • Peterson K, Carson S, Carney N. Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis. J Neurotrauma. 2003;25:62–71.
  • Li P, Yang C. Moderate hypothermia treatment in adult patients with severe traumatic brain injury: a meta-analysis. Brain Inj. 2014;28:1036–1041.
  • Cooper DJ, Rosenfeld JV, Murray L, et al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011;364:1493–1502.
  • Hutchinson PJ, Kolias AG, Timofeev EA, et al. Trial of decompressive craniectomy for traumatic intracranial hypertension. N Engl J Med. 2016;375:1119–1130.
  • Taylor A, Butt W, Rosenfeld J, et al. A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertension. Childs Nerv Syst. 2001;17:154–162.
  • Wang R, Li M, Gao WW, et al. Outcomes of early decompressive craniectomy versus conventional medical management after severe traumatic brain injury: a systematic review and meta-analysis. Medicine (Baltimore). 2015;94:e1733.
  • Bennett KS, DeWitt PE, Harlarr N, et al. Seizures in children with severe traumatic brain injury. Pediatr Crit Care Med. 2017;18:54–63.
  • Ruzas CM, DeWitt PE, Bennett KS, et al. EEG monitoring and antiepileptic drugs in children with severe TBI. Neurocrit Care. 2017;26:256–266.
  • Tanaka T, Litofsky NS. Anti-epileptic drugs in pediatric traumatic brain injury. Expert Rev Neurother. 2016;16:1229–1234.
  • Kurz JE, Poloyac SM, Abend NS, et al. Variation in anticonvulsant selection and electroencephalographic monitoring following severe traumatic brain injury in children—understanding resource availability in sites participating in a comparative effectiveness study. Pediatr Crit Care Med. 2016;17:649–657.
  • Mass AIR, Murray GD, Roosenbeek B, et al. Advancing the care for traumatic brain injury: summary results from the IMPACT studies and perspectives on future research. Lancet Neurol. 2013;12:1200–1210.
  • IMPACT: International Mission for Prognosis and Analysis of Clinical Trials in TBI. IMPACT investigators. [cited 2017 May 23]. Available from: www.tbi-impact.org
  • McConeghy KW, Hatton J, Hughes L, et al. A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury. CNS Drugs. 2012;26:613–636.
  • Gruenbaum SE, Zlotnik A, Gruenbaum BF, et al. Pharmacologic neuroprotection for functional outcomes after traumatic brain injury: a systematic review of the clinical literature. CNS Drugs. 2016;30:791–806.
  • Prasanna KL, Mittal RS, Gandhi A. Neuroendocrine dysfunction in acute phase of moderate-to-severe traumatic brain injury: a prospective study. Brain Inj. 2015;29:336–342.
  • Moreau OK, Cortet-Rudelli C, Yollin E, et al. Growth hormone replacement therapy in patients with traumatic brain injury. J Neurotrauma. 2013;30:988–1006.
  • Takala J, Ruokonen E, Webster NR, et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 1999;341:785–792.
  • Gardner CJ, Mattsson AF, Daousi C, et al. GH deficiency after traumatic brain injury: improvement in quality of life with GH therapy: analysis of the KIMS database. Eur J Endocrinol. 2015;172:371–381.
  • Corwin HL, Gettinger A, Fabian TC, et al. Efficacy and safety of epotein alfa in critically ill patients. N Engl J Med. 2007;357:965–976.
  • Napolitano LM, Fabian TC, Kelly KM, et al. Improved survival of critically ill trauma patients treated with recombinant human erythropoietin. J Trauma. 2008;65:285–297.
  • Juul SE, Pet GC. Erythropoietin and neonatal neuroprotection. Clin Perinatol. 2016;42:469–481.
  • Aloizos S, Evodia E, Gourgiotis S, et al. Neuroprotective effects of erythropoietin in patients with severe close brain injury. Turk Neurosurg. 2015;25:552–558.
  • Robertson CS, Hannay J, Yamal JM, et al. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA. 2014;312:36–47.
  • Nichol A, French C, Little L, et al. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blinded randomised controlled trial. Lancet. 2015;386:2499–2506.
  • Ehrenreich H, Weissenborn K, Prange H, et al. Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke. 2009;40:e647–e656.
  • Robertson CL, Fidan E, Stanley RM, et al. Progesterone for neuroprotection in pediatric traumatic brain injury. Pediatr Crit Care Med. 2015;16:236–244.
  • Stein DG. Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev. 2008;57:386–397.
  • Roof RL, Duvdevani R, Stein DG. Gender influences outcome of brain injury: progesterone plays a protective role. Brain Res. 1993;607:333–336.
  • Skolnick BE, Mass AI, Narayan RK, et al. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014;371:2467–2476.
  • Wright DW, Yeatts SD, Silbergleit R, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371:2457–2466.
  • Xiao G, Wei J, Yan W, et al. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care. 2008;12:R61.
  • Feng Y, Zheng X, Fang Z. Treatment progress of paroxysmal sympathetic hyperactivity after acquired brain injury. Pediatr Neurosurg. 2014–2015;50:301–309.
  • Alali AS, McCredie VA, Golan E, et al. Beta blockers for acute traumatic brain injury: a systematic review and meta-analysis. Neurocrit Care. 2014;20:514–523.
  • Mohseni S, Talving P, Thelin E, et al. The effect of β-blockade on survival after isolated severe traumatic brain injury. World J Surg. 2015;39:2076–2083.
  • Sawyer E, Mauro LS, Ohlinger MJ. Amantadine enhancement of arousal and cognition after traumatic brain injury. Ann Pharmacother. 2008;42:247–252.
  • Giancio JT, Whyte J, Bagiella E, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012;366:819–826.
  • Schwarzmaier SM, Terpolilli NA, Dienel A, et al. Endothelial nitric oxide synthase mediates arteriolar vasodilation after traumatic brain injury in mice. J Neurotrauma. 2015;32:731–738.
  • Stover JF, Belli A, Boret H, et al. Nitric oxide synthase with antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo controlled randomized phase IIa trial (NOSTRA). J Neurotrauma. 2014;31:1599–1606.
  • Efficacy of VAS203 (Ronopterin) in patients with moderate and severe traumatic brain injury (NOSTRA-III). ClinicalTrials.gov. 2017 Apr 19. [cited 2017 May 23]. Available from: www.clinicaltrials.gov/ct2/show/NCT02794168
  • Maas A, Steyerberg EW, Marmarou A, et al. IMPACT recommendations for improving the design and analysis of clinical trials in moderate to severe traumatic brain injury. J Neurotherapeutics. 2010;7:127–134.
  • Kochanek PM, Bramlett HM, Shear DA, et al. Synthesis of findings, current investigations, and future directions: operation brain trauma therapy. J Neurotrauma. 2016;33:606–614.
  • NINDS common data elements: traumatic brain injury. National Institute of Health/National Institute of Neurological Disorders and Stroke. 2017 Jul 27. [cited 2017 Aug 23]. Available from: www.commondataelements.ninds.nih.gov/tbi.aspx#tab=data_standards
  • Bennet TD, Dixon RR, Kartchner C, et al. Functional status scale in children with traumatic brain injury: a prospective cohort study. Pediatr Crit Care Med. 2016;17:1147–1156.

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