Cerebrolysin: a multi-target drug for recovery after stroke

References

• Neuhaus A, Couch Y, Hadley G, et al. Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain. 2017;140:2079–2092.
   PubMed Web of Science ®Google Scholar
• Ladurner G, Kalvach P, Moessler H. Cerebrolysin study group. Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neural Transm (Vienna). 2005;112:415–428.
   PubMed Web of Science ®Google Scholar
• Lang W, Ch S, Poljakovic Z, et al. Lyse study group. A prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy of combined treatment with alteplase (rt-pa) and Cerebrolysin in acute ischaemic hemispheric stroke. Int J Stroke. 2013;8:95–104.
   PubMed Web of Science ®Google Scholar
• Bornstein NM, Guekht A, Vester J, et al. Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials. Neurol Sci. 2018;39:629–640.
   PubMed Web of Science ®Google Scholar
• Hong Z, Moessler H, Bornstein N, et al. A double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin in patients with acute ischaemic stroke in Asia – CASTA. Stroke. 2009;4:406–412.
   PubMed Web of Science ®Google Scholar
• Heiss WD, Brainin M, Bornstein NM, et al. Cerebrolysin in patients with acute ischemic stroke in Asia. Results of a double-blind, placebo controlled randomized trial. Stroke. 2012;43:630–636.
   PubMed Web of Science ®Google Scholar
• Windholz E, Gschanes A, Windisch M, et al. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 6-week-old rats. Histochem J. 2000;32:79–84.
   PubMedGoogle Scholar
• Baskys A, Wojtowicz JM. Effects of brain tissue hydrolysate on synaptic transmission in the hippocampus. Pharmacol Biochem Behav. 1994;49:1105–1107.
   PubMed Web of Science ®Google Scholar
• Satou T, Itoh T, Tamai Y, et al. Neurotrophic effects of FPF-1070 (Cerebrolysin) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm. 2000;107:1253–1262.
   PubMed Web of Science ®Google Scholar
• Juárez I, González DJ, Mena R, et al. The chronic administration of cerebrolysin induces plastic changes in the prefrontal cortex and dentate gyrus in aged mice. Synapse. 2011;65:1128–1135.
   PubMed Web of Science ®Google Scholar
• Alcántara-González F, Mendoza-Perez CR, Zaragoza N, et al. Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice. Synapse. 2012;66:938–949.
   PubMed Web of Science ®Google Scholar
• Solis-Gaspar C, Vazquez-Roque R, De Jesús Gómez-Villalobos M, et al. Cerebrolysin improves memory and ameliorates neuronal atrophy in spontaneously hypertensive, aged rats. Synapse. 2016;70:378–389.
   PubMed Web of Science ®Google Scholar
• Lucas B, Pinkernelle J, Fansa H, et al. Effects of cerebrolysin on rat Schwann cells in vitro. Acta Histochem. 2014;116:820–830.
   PubMed Web of Science ®Google Scholar
• Tatebayashi Y, Lee MH, Li L, et al. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer’s disease. Acta Neuropathol. 2003;105:225–232.
   PubMed Web of Science ®Google Scholar
• Rockenstein E, Mante M, Adame A, et al. Effects of cerebrolysin on neurogenesis in APP transgenic model of Alzheimer’s disease. Acta Neuropathol. 2007;113:265–275.
   PubMed Web of Science ®Google Scholar
• Zhang C, Chopp M. Cui Yet al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res. 2010;88:3275–3281.
   Google Scholar
• Rockenstein E, Mallory M, Mante M, et al. Effects of Cerebrolysin on amyloid-beta deposition in a transgenic model of Alzheimer’s disease. J Neural Transm Suppl. 2002;62:327–336.
   Google Scholar
• Reinprecht I, Gschanes A, Windisch M, et al. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J. 1999;31:395–401.
   PubMedGoogle Scholar
• Zhang L, Chopp M, Meier DH, et al. Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke. Stroke. 2013;44:1965–1972.
   PubMed Web of Science ®Google Scholar
• Teasell R, Pereira S, Cotoi A.Evidence-based review of stroke rehabilitation. Evidence Reviews: Chapter 22 The rehabilitation of severe stroke. Last updated September 2016. http://www.ebrsr.com/evidence-review/22-rehabilitation-severe-stroke. Accessed 2018 May 24.
   Google Scholar
• Ward NS, Cohen LG. Mechanisms underlying recovery of motor function after stroke. Arch Neurol. 2004;61:1844–1848.
   PubMed Web of Science ®Google Scholar
• Miltner WH, Bauder H, Sommer M, et al. Effects of constraint-induced movement therapy on patients with chronic motor deficits after stroke: a replication. Stroke. 1999;30:586–592.
   PubMed Web of Science ®Google Scholar
• Hesse S, Bertelt C, Schaffrin A, et al. Restoration of gait in nonambulatory hemiparetic patients by treadmill training with partial body-weight support. Arch Phys Med Rehabil. 1994;75:1087–1093.
   PubMed Web of Science ®Google Scholar
• Frassinetti F, Angeli V, Meneghello F, et al. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–623.
   PubMed Web of Science ®Google Scholar
• Muresanu DF, Heiss WD, Hoemberg V, et al. Cerebrolysin and recovery after stroke (cars): a randomized, placebo-controlled, double-blind, multicenter trial. Stroke. 2016;47:151–159.
   PubMed Web of Science ®Google Scholar
• Guekht A, Vester J, Heiss WD, et al. Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials. Neurol Sci. 2017;38:1761–1769.
   PubMed Web of Science ®Google Scholar
• Kerr DM, Fulton RL, Lees KR. Seven-day NIHSS is a sensitive outcome measure for exploratory clinical trials in acute stroke: evidence from the Virtual International Stroke Trials Archive. Stroke. 2012;43:1401–1403.
   PubMed Web of Science ®Google Scholar
• Chang WH, Park CH, Kim DY, et al. Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke. BMC Neurol. 2016;16:31.
   PubMed Web of Science ®Google Scholar
• DeGraba T, Hallenbeck J, Pettigrew K, et al. Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials. Stroke. 1999;30:1208–1212.
   PubMed Web of Science ®Google Scholar
• National Institute of Neurological Disorders and Stroke.Post-stroke rehabilitation fact sheet. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Post-Stroke-Rehabilitation-Fact-Sheet. Accessed May 24th, 2018.
   Google Scholar
• Sundseth A, Thommessen B, Ronning OM. Outcome after mobilization within 24 hours of acute stroke: a randomized controlled trial. Stroke. 2012;43:2389–2394.
   PubMed Web of Science ®Google Scholar
• Bindawas SM, Vennu BS. Stroke rehabilitation: A call to action in Saudi Arabia. Neurosciences (Riyadh). 2016;21:297–305.
   PubMed Web of Science ®Google Scholar