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Review

Traditional Ayurvedic and herbal remedies for Alzheimer’s disease: from bench to bedside

, , , , &
Pages 359-374 | Received 25 Dec 2018, Accepted 14 Mar 2019, Published online: 10 Apr 2019

References

  • Blennow K, de Leon MJ, Zetterberg H. Alzheimer’s disease. Lancet. 2006;368(9533):387–403.
  • Shinohara M, Fujioka S, Murray ME, et al. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease. Brain. 2014;137(Pt 5):1533e1549.
  • Fratiglioni L, De Ronchi D, Aguero-Torres H. Worldwide prevalence and incidence of dementia. Drugs Aging. 1999;15;36575.
  • Wimo A, Prince M The global economic impact of dementia, 2010. Alzheimer’s disease International, World Alzheimer Report
  • Patwardhan B. Ayurveda: the ‘designer’ medicine: a review of ethno pharmacology and bioprospecting research. Indian Drugs. 2000;37:213–227.
  • Lakhotia SC. Neurodegeneration disorders need holistic care and treatment – can Ayurveda meet the challenge? Ann Neurosci. 2013;20(1):1–2.
  • Rauk A. The chemistry of Alzheimer s disease. Chem Soc Rev. 2009;38:2698–2715.
  • Farías G, Cornejo A, Jimenez J, et al. Mechanisms of tau self-aggregation and neurotoxicity. Curr Alzheimer Res. 2011;8(6):608e614.
  • Paula-Lima AC, Brito-Moreira J, Ferreira ST. Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer’s disease. J Neurochem. 2013;126(2):191e202.
  • Tu S, Okamoto S, Lipton SA, et al. Oligomeric ab-induced synaptic dysfunction in Alzheimer’s disease. Mol Neurodegener. 2014;9:48.
  • Soldano A, Hassan BA. Beyond pathology: APP, brain development and Alzheimer’s disease. Curr Opin Neurobiol. 2014;27:61e67.
  • Nhan HS, Chiang K, Koo EH. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol. 2015;129:1–19.
  • Cai Z, Wang C, Yang W. Role of berberine in Alzheimer’s disease. Neuropsychiatr Dis Treat. 2016;12:2509–2520.
  • Kwon J, Seo YH, Lee JE, et al. Spiroindole alkaloids and spiroditerpenoids from aspergillus duricaulis and their potential neuroprotective effects. J Nat Prod. 2015;78(11):2572–2579.
  • Mattson MP. Pathways towards and away from Alzheimer’s disease. Nature. 2004;430(7000):631–639.
  • Ryoo SR, Jeong HK, Radnaabazar C, et al. DYRK1A-mediated hyper-phosphorylation of Tau A functional link between down syndrome and Alzheimer disease. J Biol Chem. 2007;282(48):34850e34857.
  • Stancu IC, Vasconcelos B, Terwel D, et al. Models of b-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism. Mol Neurodegener. 2014;9:51.
  • Lloret A, Fuchsberger T, Giraldo E, et al. Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease. Free Radic Biol Med. 2015;83:186e191.
  • West S, Bhugra P. Emerging drug targets for Ab and tau in Alzheimer’s disease: a systematic review. J Clin Pharmacol. 2015;80(2):221e234.
  • Blasko I, Stampfer-Kountchev M, Robatscher P, et al. How chronic inflammation can affect the brain and support the development of Alzheimer’s disease in old age: the role of microglia and astrocytes. Aging Cell. 2004;3(4):169e176.
  • Agostinho P, Cunha RA, Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer’s disease. Curr Pharm Des. 2010;16:(25):2766e2778.
  • Morales I, Guzman-Martínez L, Cerda-Troncoso C, et al. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 2014;8:112.
  • Trepanier CH, Milgram NW. Neuroinflammation in Alzheimer’s disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy? J Alzheimers Dis. 2010;21(4):1089e1099.
  • Francis PT, Palmer AM, Snape M. The cholinergic hypothesis of Alzheimer’s disease: A review of progress. J Neurol Neurosurg Psychiatry. 1999;54:137–147.
  • Misane I, Ogren SO. Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacol. 2003;28(2):253–264.
  • Ballard CG, Greig NH, Guillozet-Bongaarts AL, et al. Cholinesterases: roles in the brain during health and disease. Curr Alzheimer Res. 2005;2(3):307–318.
  • Bejar C, Wang RH, Weinstock M. Effect of rivastigmine on scopolamine-induced memory impairment in rats. Eur J Pharmacol. 1999;383(3):231–240.
  • Bartus RT, Dean RL, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science. 1982;217(4558):408–414.
  • Mallet PE, Beninger RJ, Flesher SN, et al. Nucleus basalis lesions: implication of basoamygdaloid cholinergic pathways in memory. Brain Res Bull. 1995;36(1):5156.
  • Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003;75(3):547–555.
  • McGaughy J, Decker MW, Sarter M. Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacol. 1999;144(2):175–182.
  • Bassett CN, Montine TJ. Lipoproteins and lipid peroxidation in Alzheimer’s disease. J Nutr Health Aging. 2003;7(1):24–29.
  • El-Sherbiny DA, Khalifa AE, Attia AS, et al. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacol Biochem Behav. 2003;76(3–4):525–533.
  • Gilgun-Sherki Y, Melamed E, Offen D. Antioxidant treatment in Alzheimer’s disease: current state. J Mol Neurosci. 2003;21(1):1–11.
  • Bullock R. Drug treatment in dementia. Curr Opin Psychiatry. 2001;14:349–353.
  • Bullock R. New drugs for Alzheimer’s disease and other dementias. Br J Psychiatry. 2002;180:135–139.
  • Keltner NL, Beth Williams SN. Memantine- A new approach to Alzheimer’s disease. Perspect Psychiatric Care. 2004;40:123–124.
  • Allgaier M, Allgaier C. An update on drug treatment options of Alzheimer’s disease. Front Biosci. 2014;19:1345e1354.
  • Akhondzadeh S, Noroozian M. Alzheimer’s disease: pathophysiology and pharmacotherapy. I Drugs. 2002;4:11671172.
  • Mayeux R, Sano M. Treatment of Alzheimer’s disease. N Engl J Med. 1999;34:1670–1679.
  • Growdon GH. Treatment for Alzheimer disease? N Engl J Med. 1992;327:1306–1308.
  • Ashford WJ, Mahoney L, Burkett T. A role for complementary and integrative medicine in Alzheimer’s disease prevention. J Alzheimers Dis. 2015;48:13–14.
  • McCaffrey R, Park J, Newman D, et al. The effect of chair yoga in older adults with moderate and severe Alzheimer’s disease. Res Gerontol Nurs. 2014;7:171–177.
  • Hügel HM. Brain food for Alzheimer-free ageing: focus on herbal medicines. Adv Exp Med Biol. 2015;863:95–116.
  • Li N, Zhou L, Li W, et al. Protective effects of ginsenosides Rg1 and Rb1 on an Alzheimer’s disease mouse model: a metabolomics study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;985:54–61.
  • Yan S, Li Z, Li H, et al. Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. Sci Rep. 2014;4:6352.
  • Malve HO. Management of Alzheimer’s disease: role of existing therapies, traditional medicines and new treatment targets. Ind J Pharm Sci. 2017;79(1):2–15.
  • Shadlen MF, Larson EB. What’s new in Alzheimer’s disease treatment? reasons for optimism about future pharmacologic options. Postgrad Med. 1999;105:109–118.
  • Bush AL. Therapeutic targets in the biology of Alzheimer’s disease. Curr Opin Psychiatry. 2001;14:341–348.
  • Shareera Sthaana A. chapter 1, verse 22-23. In: Trikamji Y, editor. Charaka Samhita. Reprint Varanasi: Chaukamba Orientalia; 2011.
  • ShareeraSthaana A. chapter 4, verse 34. In: Trikamji Y, editor. Charaka Samhita. Reprint Varanasi; 2011. Chaukamba Orientalia.
  • Chaudhuri K, Samarakoon SM, Chandola HM, et al. Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study. Ayu. 2011;32:171‑6.
  • Madhavi A, Savitha HP. Depression-an Ayurvedic outlook. J Ayu Holistic Med. 2017;5(2):12–23.
  • Amin H, Sharma R. Nootropic efficacy of Satvavajaya Chikitsa and ayurvedic drug therapy: A comparative clinical exposition. Int J Yoga. 2015;8:109–116.
  • Yadavji T, Charaka samhitha of Charaka, Sutra Sthana. chapter 1, verse no.58. 2nd ed, editor. Varanasi: Chaukamba Prakashan; 1992.
  • Sharma R, Rasayana Therapy: AH. Ayurvedic contribution to improve quality of life. World J Pharmacol Res Tech. 2015;4(1):23–33.
  • Vagbhata. Ashtanga Hridaya with the commentaries Sarvangasundara of Arundatta & Ayurveda Rasayana of Hemadri. Varanasi: Chaukhamba Surbharati Prakashan; 2010. (Chapter 4, verse 36, reprint ed).
  • Pandey SK, Jangra MK, Yadav AK. Herbal and synthetic approaches for the treatment of epilepsy. Intern J Nutr Pharmacol Neurol Dis. 2014;4:43–52.
  • Perry EK, Pickering AT, Wang WW, et al. Medicinal plants and Alzheimer’s disease: integrating ethnobotanical and contemporary scientific evidence. J Altern Complement Med. 1998;4(4):419–428.
  • Wang YH, Du GH. Ginsenoside Rg1 inhibits beta-secretase activity in vitro and protects against abeta-induced cytotoxicity in PC12 cells. J Asian Nat Prod Res. 2009;11:604–612.
  • Yang L, Hao J, Zhang J, et al. Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin. J Pharm Pharmacol. 2009;61:375–380.
  • Baurle P, Suter A, Wormstall H. Safety and effectiveness of a traditional ginkgo fresh plant extract – results from a clinical trial. Forsch Komplementmed. 2009;16:156–161.
  • Zhou YQ, Yang ZL, Xu L, et al. Akebia saponin D, a saponin component from dipsacus asper wall, protects PC 12 cells against amyloid-beta induced cytotoxicity. Cell Biol. 2009;33:1102–1110.
  • Fujiwara H, Tabuchi M, Yamaguchi T, et al. A traditional medicinal herb paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-ogalloyl-beta-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid beta proteins in vitro and in vivo. J Neurochem. 2009;109:1648–1657.
  • Lv J, Jia H, Jiang Y, et al. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro. Acta Physiol. 2009;196:419–425.
  • Yin Y, Huang L, Liu Y, et al. Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer’s disease rat model. Clin Invest Med. 2008;31:E248–E257.
  • Qian YF, Wang H, Yao WB, et al. Aqueous extract of the Chinese medicine, Danggui-Shaoyao San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell Biol Int. 2008;32:304–311.
  • Lee CL, Kuo TF, Wang JJ, et al. Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation. J Neurosci Res. 2007;85:3171–3182.
  • Fujiwara H, Iwasaki K, Furukawa K, et al. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer’s beta-amyloid proteins. J Neurosci Res. 2006;84:427–433.
  • Tohda C, Tamura T, Komatsu K. Repair of amyloid beta (25– 35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Brain Res. 2003;990:141–147.
  • Tabuchi M, Yamaguchi T, Iizuka S, et al. Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and noncognitive disturbances in the Tg2576 mouse model of Alzheimer’s disease. J Ethnopharmacol. 2009;122:157–162.
  • Uabundit N, Wattanathorn J, Mucimapura S, et al. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol. 2010;127:26–31.
  • Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebocontrolled trial. J Clin Pharm Ther. 2003;28:53–59.
  • Akhondzadeh S, Shafiee SM, Harirchian MH, et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacol. 2010;207:637–643.
  • Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatr. 2003;74:863–866.
  • Vasudevan M, Parle M. Antiamnesic potential of Murraya koenigii leaves. Phytother Res. 2009;23:308–316.
  • Kim DH, Hyun SK, Yoon BH, et al. Gluco-obtusifolin and its aglycon, obtusifolin, attenuate scopolamine-induced memory impairment. J Pharmacol Sci. 2009;111:110–116.
  • Dhanasekaran M, Holcomb LA, Hitt AR, et al. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer’s disease animal model. Phytother Res. 2009;23:14–19.
  • Lai CS, Yu MS, Yuen WH, et al. Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res. 2008;1190:215–224.
  • Joshi H, Parle M. Antiamnesic effects of Desmodium gangeticum in mice. Yakugaku Zasshi. 2006;126:795–804.
  • Yu MS, Leung SK, Lai SW, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against betaamyloid peptide neurotoxicity. Exp Gerontol. 2005;40:716–727.
  • Meyers RA. Encyclopedia of physical science and technology- alkaloids. 3rd ed. Academic Press: Cambridge, United States; 2002.
  • Lu JJ, Pan W, Hu YJ, et al. Multi-target drugs: the trend of drug research and development. PLoS One. 2012;7(6):e40262.
  • Hu Y, Zhang J, Chandrashankra O, et al. Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Bioorg Med Chem. 2013;21(3):676e683.
  • Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Clin Ther. 1998;20(4):634–647.
  • Razay G, Wilcock GK. Galantamine in Alzheimer’s disease. Expert Rev Neurother. 2008;8(1):9–17.
  • Maelicke A, Hoeffle-Maas A, Ludwig J, et al. Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy. J Mol Neurosci. 2010;40(1–2):135–137.
  • Williams P, Sorribasa A, Howes MJ. Natural products as a source of Alzheimer’s drug leads. Nat Prod Rep. 2011;28(1):48–77.
  • Karuppagounder SS, Pinto JT, Xu H, et al. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int. 2009;54(2):111–118.
  • Ha GT, Wong RK, Zhang Y. Huperzine a as potential treatment of Alzheimer’s disease: an assessment on chemistry, pharmacology, and clinical studies. Chem Biodivers. 2011;8(7):1189–1204.
  • Rajakrishnan V, Viswanathan P, Rajasekharan KN, et al. Neuroprotective role of curcumin from curcuma longa on ethanol- induced brain damage. Phytother Res. 1999;13(7):571–574.
  • Imenshahidi M, Qaredashi R, Hashemzaei M, et al. Inhibitory effect of Berberis vulgaris aqueous extract on acquisition and reinstatement effects of morphine in conditioned place preferences (CPP) in mice. Jundishapur. J Nat Pharm Prod. 2014;9(3):e16145.
  • Jin Y, Khadka DB, Cho W-J. Pharmacological effects of berberine and its derivatives: a patent update. Expert Opin Ther Pat. 2016;26(2):229–243.
  • Jiang WX, Li SH, Li XJ. Therapeutic potential of berberine against neurodegenerative diseases. Sci China Life Sci. 2015;58(6):564–569.
  • Jiang W, Wei W, Gaertig MA, et al. Therapeutic effect of berberine on Huntington’s disease transgenic mouse model. PLoS One. 2015;10(7):e0134142.
  • Cushnie TPT, Cushnie B, Lamb AJ. Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. Int J Antimicrob Agents. 2014;44(5):377–386.
  • Zhu HL, Wan JB, Wang YT, et al. Medicinal compounds with antiepileptic/anticonvulsant activities. Epilepsia. 2014;55:3–16.
  • Acqua SD. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer’s disease. Bot Targets Ther. 2013;3:19–28.
  • Choudhury B, Saytode P, ShahV, et al. Neurodegenerative Disorders: Past, Present and Future. Int J Appl Pharm Biotechnol. 2014;5(2):14–28.
  • Kumar A, Singh A. A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacol Rep. 2015;67:195–203.
  • Hritcu L, Noumedem JA, Cioanca O, et al. Methanolic extract of piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta(1–42) rat model of Alzheimer’s disease. Cell Mol Neurobiol. 2014;34(3):437–449.
  • Xing S, Zhu C, Zhang R, et al. Huperzine A in the treatment of Alzheimer’s disease and vascular dementia: a meta-analysis. Evid Based Complement Altern Med. 2014;2014:1–10.
  • Xian YF, Lin ZX, Mao QQ, et al. Protective effect of isorhynchophylline against b-amyloid-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol. 2012;32(3):353e360.
  • Xian YF, Lin ZX, Mao QQ, et al. Bioassay-guided Isolation of neuroprotective compounds from uncaria rhynchophylla against beta-amyloid-induced neurotoxicity. Evid Based Complement Altern Med. 2012;2012:802625.
  • Jiang X, Jia LW, Li XH, et al. Capsaicin ameliorates stress-induced Alzheimer’s disease-like pathological and cognitive impairments in rats. J Alzheimers Dis. 2013;35(1):91e105.
  • Ding Y, Qiao A, Fan GH. Indirubin-3ʹ-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease. Neurobiol Dis. 2010;39(2):156e168.
  • Nishteswar K, Joshi H, Karra RD. Role of indigenous herbs in the management of Alzheimer’s disease. Anc Sci Life. 2014;34:3–7.
  • Agnivesh. Chikitsa Sthaanachapter 1|3 × 31. Yadavaji Trikamji. Samhita C,editor. Reprint Varanasi: Chaukamba Orientalia; 2011.
  • Amin H, Sharma R, Vyas M, et al. Shankhapushpi (Convolvulus pluricaulis Choisy): validationof the ayurvedic therapeutic claims through contemporary studies. Int J Green Pharm. 2014;8(4):193–200.
  • Amin H, Sharma R, Vyas H, et al. Nootropic (medhya) effect of Bhavita Śaṇkhapuṣpi tablets: A clinical appraisal. Anc Sci Life. 2014;34(2):109–112.
  • Gujran S, Singh SP, Pal R, et al. An extract of Commiphora whighitti with lipid lowering properties, has protective effects against streptozotocin induced memory deficits in mice. Pharmacol Biochem Behav. 2007;8:797–805.
  • Gharibi A, Khalili M, Kiasalari Z, et al. The effect of Zingiber officinalis Lon learning and memory in rats. J Bas Clin Pathophysiol. 2013;2:2013–2014.
  • Mani V, Milind P. Memory enhancing activity of Emblica officinalis Gaertn: an ayurvedic preparation. Physiol Behav. 2007;91(1):46–54.
  • Kulkarni SK, Dhir A. Withania somnifera: an Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1093‑105.
  • Singh HK, Dhawan BN. Neuropsychopharmacological effects of the ayurvedic nootropic Bacopa monniera Linn(Brahmi). Ind J Pharmacol. 1997;29(5):359–365.
  • Sharma R, Amin H, Prajapati P, et al. Therapeutic Vistas of Guduchi (Tinospora cordifolia): A medico-historical memoir. J Res Edu Ind Med. 2014;XX(2):113–128.
  • Obulesu M, Rao D. Effect of plant extracts on Alzheimer’s disease: an insight into therapeutic avenues. J Neurosci Rural Pract. 2011;2:56–61.
  • Karkada G, Shenoy K, Halahalli H, et al. Nardostachys jatamansi extract prevents chronic restraint stress-induced learning and memory deficits in a radial arm maze task. J Nat Sci Biol Med. 2012;3:125132.
  • Bhanumathy M, Harish MS, Shivaprasad HN, et al. Nootropic activity of Celastrus paniculatus seed. Pharm Biol. 2010;48:324327.
  • Parle M, Dhingra D, Kulkarni S. Improvement of mouse memory by Myristica fragrans seeds. J Med Food. 2004;7:157–1661.
  • Vasudevan M, Milind P. Memory enhancing activity of Coriandrum sativum in rats. Pharmacologyonline. 2009;2:827–839.
  • Papandreou MA, Kanakis CD, Polissiou MG, et al. Inhibitory activity on amyloid aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem. 2006;54:8762–8768.
  • Saxena V, Ahmad H, Gupta R. Memory enhancing effects of Ficus carica leaves in hexane extract on interoceptive behavioral models Asian. J Pharm Clin Res. 2013;6:109–113.
  • Pramodinee D, Mahesh M, Niranjan D, et al. Memory enhancing activity of Cissampelos papiera in mice. Int J Pharm Sci. 2011;3:206–211.
  • Roy C, Ghosh T, Guha D. The antioxidative role of Benincasa hispida on colchicine induced experimental rat model of Alzheimer’s disease. Biog Amines. 2007;21(1):42–55.
  • Veerendra KMH, Gupta YK. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J Ethnophamacol. 2002;79:253–260.
  • Jyothi P, Sarala KD. Central nervous system protection by Catharanthus roseus leaf extract on Streptozotocin-induced diabetes in rat brain. J Pharmacog. 2012;3(2):63–66.
  • Houghton PJ, Seth P. Plants and the central nervous system. Pharmacol Biochem Behav. 2003;75(3):497–499.
  • Dhingra D, Kumar V. Pharmacological evaluation for antidepressant-like activity of Asparagus racemosus willd. In Mice Pharmacologyonline. 2007;3:133–152.
  • Perry NSL, Houghton PJ, Theobald A, et al. In-vitro inhibition of erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol. 2000;52(7):1347–1356.
  • Vohora SB, Shah SA, Dandiya PC. Central nervous system studies on an ethanol extract of Acorus calamus rhizomes. J Ethnopharmacol. 1990;28:53–62.
  • Chakravarthi KK, Avadhani R. Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: an experimental study. J Nat Sci Biol Med. 2013;4(2):420–425.
  • Rai KS, Murthy KD, Karanth KS, et al. Clitoria ternatea root extract enhances acetylcholine content in rat hippocampus. Fitoterapia. 2002;73:685–689.
  • Cambay Z, Baydas G, Tuzcu M. Pomegranate (Punica granatum L.) flowers improves learning and memory performances impaired by diabetes mellitus in rats. Acta Physiol Hung. 2011;98:409–420.
  • Dileep K, Sarvesh K, Murthy K, et al. Ayurvedic formulations for the management of psychotic disorders. Int J Res Ayur Pharm. 2012;3(5):655–658.
  • Bhattacharya SK, Kumar A, Jaiswal AK. Effect of mentat, a herbal formulation, on experimental models of Alzheimer’s disease and central cholinergic markers in rats. Fitoterapia. 1995;56:216–222.
  • Perry EK, Pickering AT, Wang WW, et al. Medicinal plants and Alzheimer’s disease: from ethnobotany to phytotherapy. J pharm pharmacol. 1999;51:527–534.
  • Bhattacharya SK. Effect of Trasina®, an ayurvedic herbal formulation, on experimental models of Alzheimer’s disease and central cholinergic markers in rats. J Altern Complement Med. 1998;3:327–367.
  • Manyam BV. Dementia in Ayurveda. J Altern Complement Med. 1999;5(1):81–88.
  • Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: concept of Ayurveda. Pharmacogn Rev. 2014;8:73–80.
  • Pathak N. Reverse pharmacology of Ayurvedic drugs includes mechanisms of molecular actions. J Ayurveda Integ Med. 2011;2(2):49–50.
  • Sharma R, Kabra A, Rao MM, et al. Herbal and Holistic solutions for Neurodegenerative and depressive disorders: leads from ayurveda. Curr Pharm Des. 2018;24(22):2597–2608.
  • Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer’s disease: an overview. Ann Indian Acad Neurol. 2008;11(1):13–19.
  • Cox KHM, Pipingas A, Scholey AB. Investigation of the efects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642–651.
  • Rainey-Smith SR, Brown BM, Sohrabi HR, et al. Curcumin and cognition: A randomised, placebo-controlled, doubleblind study of community-dwelling older adults. Br J Nutri. 2016;115(12):2106–2113.
  • Chengappa KNR, Bowie CR, Schlicht PJ, et al. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013;74(11):1076–1083.
  • Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacol. 2001;156(4):481–484.
  • Stough C, Downey LA, Lloyd J, et al. Examining the nootropic efects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebocontrolled randomized trial. Phytother Res. 2008;22(12):1629–1634.
  • Calabrese C, Gregory WL, Leo M, et al. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707–713.
  • Morgan A, Stevens J. Does bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med. 2010;16(7):753–759.
  • Roodenrys S, Booth D, Bulzomi S, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacol. 2002;27(2):279–281.
  • Dev RDO. Comparison on cognitive effects of Centella asiatica in healthy middle age female and male volunteers. Annals Nutri Metabol. 2009;55:709.
  • Wattanathorn J, Mator L, Muchimapura S, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008;116(2):325–332.
  • Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2007;18(2):CD003120.
  • Mazza M, Capuano A, Bria P, et al. Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer’s dementia in a randomized placebo-controlled double-blind study. Eur J Neurol. 2006;13:981–985.
  • Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003;28:53–59.
  • Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo-controlled trial. J Neurol Neurosurg Psychiatr. 2003;74:863–866.
  • Iwasaki K, Satoh-Nakagawa T, Maruyama M, et al. Tomita N e cols A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatr. 2005;66:248–252.
  • Iwasaki K, Kobayashi S, Chimura Y, et al. Cho S e cols A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine ‘Ba Wei Huang Wan’ in the treatment of dementia. J Am Geriatr Soc. 1994;52:1518–1521.
  • Fu LM, Li JT. A systematic review of single Chinese herbs for Alzheimer’s disease treatment. Evid Based Complement Alternat Med. 2011;2011:640284.
  • Gohil KJ, Patel AJ. A review on Bacopa monniera: current research and future prospects. Int J Green Pharm. 2010;4(1):1–9.
  • Alavala RR, Katahala P, Thipparapu G, et al. Study of in vivo pharmacokinetic drug interactions of curcumin on tacrine. Asian J Pharmaceut Clin Res. 2018;11(9):337–343.
  • Fang J, Wang L, Wu T, et al. Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment. J Ethnopharmacol. 2017;196:281–292.
  • Cai H, Luo Y, Yan X, et al. The mechanisms of Bushen-Yizhi formula as a therapeutic agent against Alzheimer’s disease. Sci Rep. 2018;8(1):3104.
  • Brahma SK, Debnath PK. Therapeutic importance of Rasayana drugs with special reference to their multi-dimensional actions. Aryavaidyan. 2003;16:160–163.
  • Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in ayurvedic medicine. Phytother Res. 1999;13(4):275–291.
  • Schlebusch L, Bosch BA, Polglase G, et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J. 2000;90(12):1216–1223.
  • Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of “Rasayana” herbs of Ayurveda. J Ethnopharmacol. 2005;99(2):165–178.
  • Joy J. The Ayurvedic perspective on the Etiopathogenesis of Neurodegeneration. J Health Edu Res Dev. 2015;3:137.

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