Microbiota-gut brain axis involvement in neuropsychiatric disorders

References

• Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2018;16(1):35–56.
   Web of Science ®Google Scholar
• Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474:1823–1836.
   PubMed Web of Science ®Google Scholar
• Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65.
   PubMed Web of Science ®Google Scholar
• Lynch SV, Pedersen O. The human intestinal microbiome in health and disease Phimister E G editor.. N Engl J Med. 2016;375 2369–2379.
   PubMed Web of Science ®Google Scholar
• Maier L, Pruteanu M, Kuhn M, et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018;555:623–628.
   PubMed Web of Science ®Google Scholar
• Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541–546.
   PubMed Web of Science ®Google Scholar
• Fischbach MA. Microbiome: focus on causation and mechanism. Cell. 2018;174:785–790.
   PubMed Web of Science ®Google Scholar
• van de Guchte M, Blottière HM, Doré J. Humans as holobionts: implications for prevention and therapy. Microbiome. 2018;6:81.
   PubMed Web of Science ®Google Scholar
• Berni Canani R, Paparo L, Nocerino R, et al. Gut microbiome as target for innovative strategies against food allergy. Front Immunol. 2019;10:191.
   PubMed Web of Science ®Google Scholar
• Huang YJ, Marsland BJ, Bunyavanich S, et al. The microbiome in allergic disease: current understanding and future opportunities—2017 PRACTALL document of the American academy of allergy, asthma & immunology and the European academy of allergy and clinical immunology. J Allergy Clin Immunol. 2017;139:1099–1110.
   PubMed Web of Science ®Google Scholar
• Mancuso C, Santangelo R. Alzheimer’s disease and gut microbiota modifications: the long way between preclinical studies and clinical evidence. Pharmacol Res. 2018;129:329–336.
   PubMed Web of Science ®Google Scholar
• Liu F, Li J, Wu F, et al. Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review. Transl Psychiatry. 2019;9:43.
   PubMed Web of Science ®Google Scholar
• Wen C, Zheng Z, Shao T, et al. Correction to: quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. Genome Biol. 2017;18:214.
   PubMed Web of Science ®Google Scholar
• Breban M, Tap J, Leboime A, et al. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann Rheum Dis. 2017;76:1614–1622.
   PubMed Web of Science ®Google Scholar
• Tang WHW, Hazen SL. The Gut Microbiome and Its Role in Cardiovascular Diseases. Circulation. 2017;135:1008–1010.
   PubMed Web of Science ®Google Scholar
• Li J, Zhao F, Wang Y, et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017;5:14.
   PubMed Web of Science ®Google Scholar
• D’Argenio V, Casaburi G, Precone V, et al. No change in the mucosal gut microbiome is associated with celiac disease-specific microbiome alteration in adult patients. Am J Gastroenterol. 2016;111:1659–1661.
   PubMed Web of Science ®Google Scholar
• Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015;148:1244–1260.e16.
   PubMed Web of Science ®Google Scholar
• Kang M, Martin A. Microbiome and colorectal cancer: unraveling host-microbiota interactions in colitis-associated colorectal cancer development. Semin Immunol. 2017;32:3–13.
   PubMed Web of Science ®Google Scholar
• Franzosa EA, Sirota-Madi A, Avila-Pacheco J, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019;4:293–305.
   PubMed Web of Science ®Google Scholar
• Pei L, Ke Y, Zhao H, et al. Role of colonic microbiota in the pathogenesis of ulcerative colitis. BMC Gastroenterol. 2019;19:10.
   PubMed Web of Science ®Google Scholar
• Peng J, Pang N, Wang Y, et al. Next-generation sequencing improves treatment efficacy and reduces hospitalization in children with drug-resistant epilepsy. CNS Neurosci Ther. 2018;25(1):14–20.
   Web of Science ®Google Scholar
• Staffas A, Burgos Da Silva M, van Den Brink MRM. The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease. Blood. 2017;129:927–933.
   PubMed Web of Science ®Google Scholar
• Yoshioka K, Kakihana K, Doki N, et al. Gut microbiota and acute graft-versus-host disease. Pharmacol Res. 2017;122:90–95.
   PubMed Web of Science ®Google Scholar
• Tap J, Derrien M, Törnblom H, et al. Identification of an intestinal microbiota signature associated with severity of irritable bowel syndrome. Gastroenterology. 2017;152:111–123.e8.
   PubMed Web of Science ®Google Scholar
• Xu D, Chen VL, Steiner CA, et al. Efficacy of Fecal Microbiota Transplantation in Irritable Bowel Syndrome. Am J Gastroenterol. 2019;114(7):1043–1050.
   Google Scholar
• Nallu A, Sharma S, Ramezani A, et al. Gut microbiome in chronic kidney disease: challenges and opportunities. Transl Res. 2017;179:24–37.
   PubMed Web of Science ®Google Scholar
• Qin N, Yang F, Li A, et al. Alterations of the human gut microbiome in liver cirrhosis. Nature. 2014;513:59–64.
   PubMed Web of Science ®Google Scholar
• Ma J, Zhou Q, Li H. Gut microbiota and nonalcoholic fatty liver disease: insights on mechanisms and therapy. Nutrients. 2017;9:1124.
   PubMed Web of Science ®Google Scholar
• Cekanaviciute E, Yoo BB, Runia TF, et al. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114:10713–10718.
   PubMed Web of Science ®Google Scholar
• Berer K, Gerdes LA, Cekanaviciute E, et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017;114:10719–10724.
   PubMed Web of Science ®Google Scholar
• Bouter KE, van Raalte DH, Groen AK, et al. Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology. 2017;152:1671–1678.
   PubMed Web of Science ®Google Scholar
• Maruvada P, Leone V, Kaplan LM, et al. The human microbiome and obesity: moving beyond associations. Cell Host Microbe. 2017;22:589–599.
   PubMed Web of Science ®Google Scholar
• Campos-Acuña J, Elgueta D, Pacheco R. T-cell-driven inflammation as a mediator of the gut-brain axis involved in Parkinson’s disease. Front Immunol. 2019;10:239.
   PubMed Web of Science ®Google Scholar
• Kostic AD, Gevers D, Siljander H, et al. The dynamics of the human infant gut microbiome in development and in progression toward Type 1 diabetes. Cell Host Microbe. 2015;17:260–273.
   PubMed Web of Science ®Google Scholar
• Forslund K, Hildebrand F, Nielsen T, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 2015;528:262–266.
   PubMed Web of Science ®Google Scholar
• Komaroff AL. The microbiome and risk for obesity and diabetes. JAMA. 2017;317:355.
   PubMed Web of Science ®Google Scholar
• Sherwin E, Dinan TG, Cryan JF. Recent developments in understanding the role of the gut microbiota in brain health and disease. Ann N Y Acad Sci. 2018;1420:5–25.
   PubMed Web of Science ®Google Scholar
• Blander JM, Longman RS, Iliev ID, et al. Regulation of inflammation by microbiota interactions with the host. Nat Immunol. 2017;18:851–860.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13:701–712.
   PubMed Web of Science ®Google Scholar
• Lin L, Zhang J. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol. 2017;18:2.
   PubMed Web of Science ®Google Scholar
• Farzi A, Fröhlich EE, Holzer P. Gut microbiota and the neuroendocrine system. Neurotherapeutics. 2018;15:5–22.
   PubMed Web of Science ®Google Scholar
• Dinan TG, Cryan JF. The microbiome-gut-brain axis in health and disease. Gastroenterol Clin North Am. 2017;46:77–89.
   PubMed Web of Science ®Google Scholar
• Bonaz B, Bazin T, Pellissier S. The vagus nerve at the interface of the microbiota-gut-brain axis. Front Neurosci. 2018;12:1–9.
   PubMed Web of Science ®Google Scholar
• Anderson G, Seo M, Berk M, et al. Gut permeability and microbiota in Parkinson’s disease: role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatonergic pathways. Curr Pharm Des. 2016;22:6142–6151.
   PubMed Web of Science ®Google Scholar
• Fülling C, Dinan TG, Cryan JF. Gut Microbe to Brain Signaling: What Happens in Vagus. Neuron. 2019;101(6):998–1002.
   Google Scholar
• Bravo JA, Forsythe P, M V C, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108:16050–16055.
   PubMed Web of Science ®Google Scholar
• De Vadder F, Grasset E, Mannerås Holm L, et al. Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Proc Natl Acad Sci U S A. 2018;115:6458–6463.
   PubMed Web of Science ®Google Scholar
• Sharon G, Sampson TR, Geschwind DH, et al. The central nervous system and the gut microbiome. Cell. 2016;167:915–932.
   PubMed Web of Science ®Google Scholar
• Montiel-Castro AJ, González-Cervantes RM, Bravo-Ruiseco G, et al. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality. Front Integr Neurosci. 2013;7:70.
   PubMedGoogle Scholar
• Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci. 2011;108:16050–16055.
   PubMed Web of Science ®Google Scholar
• Erny D, Hrabě de Angelis AL, Jaitin D, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18:965–977.
   PubMed Web of Science ®Google Scholar
• Stilling RM, van de Wouw M, Clarke G, et al. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?. Neurochem Int. 2016;99:110–132.
   PubMed Web of Science ®Google Scholar
• Obrenovich M. Leaky Gut, Leaky Brain? Microorganisms. 2018;6:107.
   Web of Science ®Google Scholar
• Quigley EMM. Microbiota-brain-gut axis and neurodegenerative diseases. Curr Neurol Neurosci Rep. 2017;17(12):94.
   PubMed Web of Science ®Google Scholar
• Yarandi SS, Peterson DA, Treisman GJ, et al. Modulatory effects of gut microbiota on the central nervous system: how gut could play a role in neuropsychiatric health and diseases. J Neurogastroenterol Motil. 2016;22:201–212.
   PubMed Web of Science ®Google Scholar
• van Den Elsen LW, Poyntz HC, Weyrich LS, et al. Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases. Clin Transl Immunol. 2017;6:e125.
   PubMed Web of Science ®Google Scholar
• Lau JT, Whelan FJ, Herath I, et al. Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling. Genome Med. 2016;8:72.
   PubMed Web of Science ®Google Scholar
• Mark Welch JL, Hasegawa Y, McNulty NP, et al. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proc Natl Acad Sci U S A. 2017;114:E9105–E9114.
   PubMed Web of Science ®Google Scholar
• Whitaker WR, Shepherd ES, Sonnenburg JL. Tunable expression tools enable single-cell strain distinction in the gut microbiome. Cell. 2017;169:538–546.e12.
   PubMed Web of Science ®Google Scholar
• Hollywood K, Brison DR, Metabolomics: GR. Current technologies and future trends. Proteomics. 2006;6:4716–4723.
   PubMed Web of Science ®Google Scholar
• Zimmermann J, Hübschmann T, Schattenberg F, et al. High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition. Eur J Immunol. 2016;46:1300–1303.
   PubMed Web of Science ®Google Scholar
• Uchimura Y, Fuhrer T, Li H, et al. Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response. Immunity. 2018;49:545–559.e5.
   PubMed Web of Science ®Google Scholar
• Uchimura Y, Wyss M, Brugiroux S, et al. Complete genome sequences of 12 species of stable defined moderately diverse mouse microbiota 2: TABLE 1. Genome Announc. 2016;4(5):e00951–16.
   PubMedGoogle Scholar
• Browne HP, Forster SC, Anonye BO, et al. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature. 2016;533:543–546.
   PubMed Web of Science ®Google Scholar
• Sjöberg F, Nowrouzian F, Rangel I, et al. Comparison between terminal-restriction fragment length polymorphism (T-RFLP) and quantitative culture for analysis of infants’ gut microbiota. J Microbiol Methods. 2013;94:37–46.
   PubMed Web of Science ®Google Scholar
• Hoyles L, Clear JA, McCartney AL. Use of denaturing gradient gel electrophoresis to detect Actinobacteria associated with the human faecal microbiota. Anaerobe. 2013;22:90–96.
   PubMed Web of Science ®Google Scholar
• Filleron A, Simon M, Hantova S, et al. tuf-PCR-temporal temperature gradient gel electrophoresis for molecular detection and identification of staphylococci: application to breast milk and neonate gut microbiota. J Microbiol Methods. 2014;98:67–75.
   PubMed Web of Science ®Google Scholar
• Khan F, Oloketuyi SF. A future perspective on neurodegenerative diseases: nasopharyngeal and gut microbiota. J Appl Microbiol. 2017;122:306–320.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Dinan TG. Talking about a microbiome revolution. Nat Microbiol. 2019;4:552–553.
   PubMed Web of Science ®Google Scholar
• Pellegrini C, Antonioli L, Colucci R, et al. Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? Acta Neuropathol. 2018;136:345–361.
   PubMed Web of Science ®Google Scholar
• Hecht G, Bar-Nathan C, Milite G, et al. A simple cage-autonomous method for the maintenance of the barrier status of germ-free mice during experimentation. Lab Anim. 2014;48:292–297.
   PubMedGoogle Scholar
• Lundberg R, Bahl MI, Licht TR, et al. Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime. Sci Rep. 2017;7:42245.
   PubMed Web of Science ®Google Scholar
• Hufeldt MR, Nielsen DS, Vogensen FK, et al. Variation in the gut microbiota of laboratory mice is related to both genetic and environmental factors. Comp Med. 2010;60:336–347.
   PubMed Web of Science ®Google Scholar
• Wullaert A, Lamkanfi M, McCoy KD. Defining the impact of host genotypes on microbiota composition requires meticulous control of experimental variables. Immunity. 2018;48:605–607.
   PubMed Web of Science ®Google Scholar
• Lemire P, Robertson SJ, Maughan H, et al. The NLR protein NLRP6 does not impact gut microbiota composition. Cell Rep. 2017;21:3653–3661.
   PubMed Web of Science ®Google Scholar
• Mamantopoulos M, Ronchi F, McCoy KD, et al. Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions. Gut Microbes. 2018;9:1–8.
   PubMed Web of Science ®Google Scholar
• Macpherson AJ, McCoy KD. Standardised animal models of host microbial mutualism. Mucosal Immunol. 2015;8:476–486.
   PubMed Web of Science ®Google Scholar
• Smith K, McCoy KD, Macpherson AJ. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol. 2007;19:59–69.
   PubMed Web of Science ®Google Scholar
• Mooser C, Gomez de Agüero M, Ganal-Vonarburg SC. Standardization in host–microbiota interaction studies: challenges, gnotobiology as a tool, and perspective. Curr Opin Microbiol. 2018;44:50–60.
   PubMed Web of Science ®Google Scholar
• Carraro S, Giordano G, Reniero F, et al. Metabolomics: A new Frontier for research in pediatrics. J Pediatr. 2009;154:638–644.
   PubMed Web of Science ®Google Scholar
• Dettmer K, Aronov PA, Hammock BD. Mass spectrometry-based metabolomics. Mass Spectrom Rev. 2007;26:51–78.
   PubMed Web of Science ®Google Scholar
• Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B. Environmental pollutants as risk factors for neurodegenerative disorders: alzheimer and Parkinson diseases. Front Cell Neurosci. 2015;9:124.
   PubMed Web of Science ®Google Scholar
• Landgrave-Gómez J, Mercado-Gómez O, Guevara-Guzmán R. Epigenetic mechanisms in neurological and neurodegenerative diseases. Front Cell Neurosci. 2015;9:58.
   PubMed Web of Science ®Google Scholar
• Uher R. Gene–environment interactions in severe mental illness. Front Psychiatry. 2014;5:48.
   PubMed Web of Science ®Google Scholar
• Tordjman S, Somogyi E, Coulon N, et al. Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms. Front Psychiatry. 2014;5:53.
   PubMed Web of Science ®Google Scholar
• Morris G, Fernandes BS, Puri BK, et al. Leaky brain in neurological and psychiatric disorders: drivers and consequences. Aust N Z J Psychiatry. 2018;52:924–948.
   PubMed Web of Science ®Google Scholar
• Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121–141.
   PubMed Web of Science ®Google Scholar
• Simeonova D, Ivanovska M, Murdjeva M, et al. Recognizing the leaky gut as a trans-diagnostic target for neuro-immune disorders using clinical chemistry and molecular immunology assays. Curr Top Med Chem. 2018;18(19):1641–1655.
   Web of Science ®Google Scholar
• Cheung SG, Goldenthal AR, Uhlemann A-C, et al. Systematic review of gut microbiota and major depression. Front Psychiatry. 2019;10:34.
   PubMed Web of Science ®Google Scholar
• Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017;20:145–155.
   PubMed Web of Science ®Google Scholar
• Cenit MC, Sanz Y, Codoñer-Franch P. Influence of gut microbiota on neuropsychiatric disorders. World J Gastroenterol. 2017;23:5486–5498.
   PubMed Web of Science ®Google Scholar
• Fattorusso A, Di Genova L, Dell’Isola G, et al. Autism spectrum disorders and the gut microbiota. Nutrients. 2019;11:521.
   PubMed Web of Science ®Google Scholar
• Severance EG, Yolken RH, Eaton WW. Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr Res. 2016;176:23–35.
   PubMed Web of Science ®Google Scholar
• Kang D-W, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5:10.
   PubMed Web of Science ®Google Scholar
• Sanctuary MR, Kain JN, Chen SY, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. van Wouwe JP, editor. PLoS One. 2019;14, e0210064.
   PubMed Web of Science ®Google Scholar
• Holingue C, Newill C, Lee L-C, et al. Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Res. 2018;11:24–36.
   PubMed Web of Science ®Google Scholar
• Prosperi M, Santocchi E, Balboni G, et al. Behavioral phenotype of ASD preschoolers with gastrointestinal symptoms or food selectivity. J Autism Dev Disord. 2017;47:3574–3588.
   PubMed Web of Science ®Google Scholar
• Adams JB, Johansen LJ, Powell LD, et al. Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity. BMC Gastroenterol. 2011;11:22.
   PubMed Web of Science ®Google Scholar
• Rose DR, Yang H, Serena G, et al. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018;70:354–368.
   PubMed Web of Science ®Google Scholar
• de Magistris L, Familiari V, Pascotto A, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51:418–424.
   PubMed Web of Science ®Google Scholar
• Kelly JR, Minuto C, Cryan JF, et al. Cross Talk: the Microbiota and Neurodevelopmental Disorders. Front Neurosci. 2017;11:490.
   PubMed Web of Science ®Google Scholar
• Kang D-W, Park JG, Ilhan ZE, et al. Reduced incidence of prevotella and other fermenters in intestinal microflora of autistic children. Gilbert JA, editor. PLoS One. 2013;8, e68322.
   PubMed Web of Science ®Google Scholar
• Shaaban SY, El Gendy YG, Mehanna NS, et al. The role of probiotics in children with autism spectrum disorder: A prospective, open-label study. Nutr Neurosci. 2018;21:676–681.
   PubMed Web of Science ®Google Scholar
• Patusco R, Ziegler J. Role of probiotics in managing gastrointestinal dysfunction in children with autism spectrum disorder: an update for practitioners. Adv Nutr. 2018;9:637–650.
   PubMed Web of Science ®Google Scholar
• Millward C, Ferriter M, Calver S, et al. Gluten- and casein-free diets for autistic spectrum disorder. Cochrane Database Syst Rev. 2008;4:CD003498.
   PubMed Web of Science ®Google Scholar
• Sichel J, Roberts E, Sichel LS, et al. Improvements in gastrointestinal symptoms among children with autism spectrum disorder receiving the delpro� probiotic and immunomodulator formulation. J Probiotics Heal. 2013;01:1–6.
   Google Scholar
• Tomova A, Husarova V, Lakatosova S, et al. Gastrointestinal microbiota in children with autism in Slovakia. Physiol Behav. 2015;138:179–187.
   PubMed Web of Science ®Google Scholar
• Messias EL, Chen C-Y, Eaton WW. Epidemiology of schizophrenia: review of findings and myths. Psychiatr Clin North Am. 2007;30:323–338.
   PubMed Web of Science ®Google Scholar
• Severance EG, Prandovszky E, Castiglione J, et al. Gastroenterology issues in schizophrenia: why the gut matters. Curr Psychiatry Rep. 2015;17:27.
   PubMed Web of Science ®Google Scholar
• Dickerson FB, Stallings C, Origoni A, et al. Effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning. Prim Care Companion CNS Disord. 2014;16(1).
   PubMedGoogle Scholar
• Szeto JYY, Lewis SJG. Current treatment options for alzheimer’s disease and parkinson’s disease dementia. Curr Neuropharmacol. 2016;14:326–338.
   PubMed Web of Science ®Google Scholar
• Westfall S, Lomis N, Kahouli I, et al. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci. 2017;74:3769–3787.
   PubMed Web of Science ®Google Scholar
• Silva de Lima AL, Hahn T, de Vries NM, et al. Large-scale wearable sensor deployment in parkinson’s patients: the parkinson@home study protocol. JMIR Res Protoc. 2016;5:e172.
   PubMedGoogle Scholar
• Sampson TR, Debelius JW, Thron T, et al. Gut Microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease. Cell. 2016;167:1469–1480.e12.
   PubMed Web of Science ®Google Scholar
• Radisavljevic N, Cirstea M, Finlay BB. Bottoms up: the role of gut microbiota in brain health. Environ Microbiol. 2018;1462–2920.14506.
   Google Scholar
• Scheperjans F, Aho V, Pereira PAB, et al. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Mov Disord. 2015;30:350–358.
   PubMed Web of Science ®Google Scholar
• Qian Y, Yang X, Xu S, et al. Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease. Brain Behav Immun. 2018;70:194–202.
   PubMed Web of Science ®Google Scholar
• Bedarf JR, Hildebrand F, Coelho LP, et al. Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients. Genome Med. 2017;9:39.
   PubMed Web of Science ®Google Scholar
• Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16:358–372.
   PubMed Web of Science ®Google Scholar
• El Aidy S, Dinan TG, Cryan JF. Gut Microbiota: the Conductor in the Orchestra of Immune–neuroendocrine Communication. Clin Ther. 2015;37:954–967.
   PubMed Web of Science ®Google Scholar
• Logsdon AF, Erickson MA, Rhea EM, et al. Gut reactions: how the blood–brain barrier connects the microbiome and the brain. Exp Biol Med. 2018;243:159–165.
   Web of Science ®Google Scholar
• Kumar DKV, Choi SH, Washicosky KJ, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci Transl Med. 2016;8:340ra72–340ra72.
   PubMed Web of Science ®Google Scholar
• Harach T, Marungruang N, Duthilleul N, et al. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep. 2017;7:41802.
   PubMed Web of Science ®Google Scholar
• Minter MR, Zhang C, Leone V, et al. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease. Sci Rep. 2016;6:30028.
   PubMed Web of Science ®Google Scholar
• Vogt NM, Kerby RL, Dill-McFarland KA, et al. Gut microbiome alterations in Alzheimer’s disease. Sci Rep. 2017;7:13537.
   PubMedGoogle Scholar
• Cattaneo A, Cattane N, Galluzzi S, et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging. 2017;49:60–68.
   PubMed Web of Science ®Google Scholar
• He Z, Cui BT, Zhang T, et al. Fecal microbiota transplantation cured epilepsy in a case with Crohn’s Disease: the first report. World J Gastroenterol. 2017;23:3565–3568.
   PubMed Web of Science ®Google Scholar
• Peng A, Qiu X, Lai W, et al. Altered composition of the gut microbiome in patients with drug-resistant epilepsy. Epilepsy Res. 2018;147:102–107.
   PubMed Web of Science ®Google Scholar
• Gómez-Eguílaz M, Ramón-Trapero JL, Pérez-Martínez L, et al. The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study. Benef Microbes. 2018;9:875–881.
   PubMed Web of Science ®Google Scholar
• Axisa -P-P, Hafler DA. Multiple sclerosis. Curr Opin Neurol. 2016;29:345–353.
   PubMed Web of Science ®Google Scholar
• Miyake S, Kim S, Suda W, et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV Clusters. Wilson BA, editor. PLoS One. 2015;10, e0137429.
   PubMed Web of Science ®Google Scholar
• Cekanaviciute E, A-K P, Thomann A, et al. Multiple sclerosis-associated changes in the composition and immune functions of spore-forming bacteria. mSystems. 2018;3(6):e00083–18.
   PubMed Web of Science ®Google Scholar
• Chen J, Chia N, Kalari KR, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484.
   PubMed Web of Science ®Google Scholar
• Cantarel BL, Waubant E, Chehoud C, et al. Gut microbiota in multiple sclerosis. J Investig Med. 2015;63:729–734.
   PubMed Web of Science ®Google Scholar
• Jangi S, Gandhi R, Cox LM, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016;7:12015.
   PubMed Web of Science ®Google Scholar
• Kwon H-K, Kim G-C, Kim Y, et al. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 2013;146:217–227.
   PubMed Web of Science ®Google Scholar
• Shen T-CD. Diet and gut microbiota in health and disease. Nestle Nutr Inst Workshop Ser. 2017;88:117–126.
   PubMedGoogle Scholar
• David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505:559–563.
   PubMed Web of Science ®Google Scholar
• Proctor C, Thiennimitr P, Chattipakorn N, et al. Diet, gut microbiota and cognition. Metab Brain Dis. 2017;32:1–17.
   PubMed Web of Science ®Google Scholar
• Mörkl S, Wagner-Skacel J, Lahousen T, et al. The role of nutrition and the gut-brain axis in psychiatry: a review of the literature. Neuropsychobiology. 2018;17:1–9.
   Google Scholar
• Sánchez-Villegas A, Delgado-Rodríguez M, Alonso A, et al. Association of the mediterranean dietary pattern with the incidence of depression: the seguimiento universidad de navarra/university of navarra follow-up (SUN) cohort. Arch Gen Psychiatry. 2009;66:1090–1098.
   PubMed Web of Science ®Google Scholar
• Jacka FN. Nutritional Psychiatry: where to Next? EBioMedicine. 2017;17:24–29.
   PubMed Web of Science ®Google Scholar
• Marx W, Moseley G, Berk M, et al. Nutritional psychiatry: the present state of the evidence. Proc Nutr Soc. 2017;76:427–436.
   PubMed Web of Science ®Google Scholar
• Firth J, Stubbs B, Sarris J, et al. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychol Med. 2017;47:1515–1527.
   PubMed Web of Science ®Google Scholar
• Sarris J, Murphy J, Mischoulon D, et al. Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry. 2016;173:575–587.
   PubMed Web of Science ®Google Scholar
• Heintz C, Mair W. You are what you host: microbiome modulation of the aging process. Cell. 2014;156:408–411.
   PubMed Web of Science ®Google Scholar
• Bersani FS, Biondi M, Coviello M, et al. Psychoeducational intervention focused on healthy living improves psychopathological severity and lifestyle quality in psychiatric patients: preliminary findings from a controlled study. J Ment Health. 2017;26:271–275.
   PubMed Web of Science ®Google Scholar
• Jacka FN, O’Neil A, Opie R, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Med. 2017;15:23.
   PubMed Web of Science ®Google Scholar
• Boison D. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017;30:187–192.
   PubMed Web of Science ®Google Scholar
• Wheless JW. History of the ketogenic diet. Epilepsia. 2008;49:3–5.
   PubMed Web of Science ®Google Scholar
• Verrotti A, Iapadre G, Pisano S, et al. Ketogenic diet and childhood neurological disorders other than epilepsy: an overview. Expert Rev Neurother. 2017;17:461–473.
   PubMed Web of Science ®Google Scholar
• Martin K, Jackson CF, Levy RG, et al. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2016;2:CD001903.
   PubMedGoogle Scholar
• Olson CA, Vuong HE, Yano JM, et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell. 2018;173:1728–1741.e13.
   PubMed Web of Science ®Google Scholar
• Swidsinski A, Dörffel Y, Loening-Baucke V, et al. Reduced mass and diversity of the colonic microbiome in patients with multiple sclerosis and their improvement with ketogenic diet. Front Microbiol. 2017;8:1141.
   PubMed Web of Science ®Google Scholar
• Xie G, Zhou Q, Qiu C-Z, et al. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J Gastroenterol. 2017;23:6164–6171.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhou S, Zhou Y, et al. Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet. Epilepsy Res. 2018;145:163–168.
   PubMed Web of Science ®Google Scholar
• Tagliabue A, Ferraris C, Uggeri F, et al. Short-term impact of a classical ketogenic diet on gut microbiota in GLUT1 Deficiency Syndrome: A 3-month prospective observational study. Clin Nutr ESPEN. 2017;17:33–37.
   PubMed Web of Science ®Google Scholar
• Lindefeldt M, Eng A, Darban H, et al. The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy. Npj Biofilms Microbiomes. 2019;5:5.
   PubMed Web of Science ®Google Scholar
• Morelli L, Capurso L. FAO/WHO guidelines on probiotics. J Clin Gastroenterol. 2012;46:S1–S2.
   PubMed Web of Science ®Google Scholar
• Ford AC, Quigley EMM, Lacy BE, et al. Efficacy of prebiotics, probiotics and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014;109:1547–1561.
   PubMed Web of Science ®Google Scholar
• Liu X, Cao S, Zhang X. Modulation of gut microbiota–brain axis by probiotics, prebiotics, and diet. J Agric Food Chem. 2015;63:7885–7895.
   PubMed Web of Science ®Google Scholar
• Gareau MG, Jury J, MacQueen G, et al. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut. 2007;56:1522–1528.
   PubMed Web of Science ®Google Scholar
• Wang H, Lee I-S, Braun C, et al. Effect of probiotics on central nervous system functions in animals and humans: a systematic review. J Neurogastroenterol Motil. 2016;22:589–605.
   PubMed Web of Science ®Google Scholar
• Akbari E, Asemi Z, Daneshvar Kakhaki R, et al. Effect of probiotic supplementation on cognitive function and metabolic status in alzheimer’s disease: a randomized, double-blind and controlled trial. Front Aging Neurosci. 2016;8:256.
   PubMed Web of Science ®Google Scholar
• Pärtty A, Kalliomäki M, Wacklin P, et al. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatr Res. 2015;77:823–828.
   PubMed Web of Science ®Google Scholar
• Hill C, Guarner F, Reid G, et al. The International scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514.
   PubMed Web of Science ®Google Scholar
• Burokas A, Arboleya S, Moloney RD, et al. Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol Psychiatry. 2017;82:472–487.
   PubMed Web of Science ®Google Scholar
• Ghanizadeh A, Moghimi-Sarani E. A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disorders. BMC Psychiatry. 2013;13:196.
   PubMed Web of Science ®Google Scholar
• Grimaldi R, Cela D, Swann JR, et al. In vitro fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children. Marchesi J, editor. FEMS Microbiol Ecol. 2017;93:fiw233.
   PubMed Web of Science ®Google Scholar
• Borody TJ, Campbell J. Fecal microbiota transplantation. gastroenterol. Clin North Am. 2012;41:781–803.
   Google Scholar
• Xu M-Q, Cao H-L, Wang W-Q, et al. Fecal microbiota transplantation broadening its application beyond intestinal disorders. World J Gastroenterol. 2015;21:102.
   PubMed Web of Science ®Google Scholar
• Sampson TR, Debelius JW, Thron T, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease. Cell. 2016;167:1469–1480.e12.
   PubMed Web of Science ®Google Scholar
• Borody TJ, Brandt LJ, Paramsothy S. Therapeutic faecal microbiota transplantation: current status and future developments. Curr Opin Gastroenterol. 2014;30:97–105.
   PubMed Web of Science ®Google Scholar
• Kang D-W, Adams JB, Gregory AC, et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5:10.
   PubMed Web of Science ®Google Scholar
• Saad MJA, Santos A, Prada PO. Linking gut microbiota and inflammation to obesity and insulin resistance. Physiology. 2016;31:283–293.
   PubMed Web of Science ®Google Scholar
• Boulangé CL, Neves AL, Chilloux J, et al. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016;8:42.
   PubMed Web of Science ®Google Scholar
• Rana A, Musto AE. The role of inflammation in the development of epilepsy. J Neuroinflammation. 2018;15:144.
   PubMed Web of Science ®Google Scholar
• French JA, Koepp M, Naegelin Y, et al. Clinical studies and anti-inflammatory mechanisms of treatments. Epilepsia. 2017;58:69–82.
   PubMed Web of Science ®Google Scholar
• Aronica E, Bauer S, Bozzi Y, et al. Neuroinflammatory targets and treatments for epilepsy validated in experimental models. Epilepsia. 2017;58:27–38.
   PubMed Web of Science ®Google Scholar
• Morís G. Inflammatory bowel disease: an increased risk factor for neurologic complications. World J Gastroenterol. 2014;20:1228–1237.
   PubMed Web of Science ®Google Scholar
• Ma Q, Xing C, Long W, et al. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. J Neuroinflammation. 2019;16:53.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Dinan TG. Microbiota and neuroimmune signalling—metchnikoff to microglia. Nat Rev Gastroenterol Hepatol. 2015;12:494–496.
   PubMed Web of Science ®Google Scholar
• Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13:321–335.
   PubMed Web of Science ®Google Scholar
• Vindigni SM, Surawicz CM. Fecal microbiota transplantation. gastroenterol. Clin North Am. 2017;46:171–185.
   Google Scholar