What role should spinal cord MRI take in the future of multiple sclerosis surveillance?

References

• Gilmore CP, Bo L, Owens T, et al. Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology. Brain Pathol. 2006 Jul;16(3):202–208. PubMed PMID: 16911477.
   PubMed Web of Science ®Google Scholar
• Gilmore CP, Donaldson I, Bo L, et al. Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):182–187. PubMed PMID: 18829630.
   PubMed Web of Science ®Google Scholar
• Lovas G, Szilagyi N, Majtenyi K, et al. Axonal changes in chronic demyelinated cervical spinal cord plaques. Brain. 2000 Feb;123(Pt 2):308–317. PubMed PMID: 10648438.
   PubMedGoogle Scholar
• DeLuca GC, Ebers GC, Esiri MM. Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts. Brain. 2004 May;127(Pt 5):1009–1018. PubMed PMID: 15047586.
   PubMedGoogle Scholar
• Tallantyre EC, Bo L, Al-Rawashdeh O, et al. Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis. Mult Scler. 2010 Apr;16(4):406–411. PubMed PMID: 20215480.
   PubMed Web of Science ®Google Scholar
• Ganter P, Prince C, Esiri MM. Spinal cord axonal loss in multiple sclerosis: a post-mortem study. Neuropathol Appl Neurobiol. 1999 Dec;25(6):459–467. PubMed PMID: 10632896.
   PubMed Web of Science ®Google Scholar
• Bjartmar C, Kidd G, Mork S, et al. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol. 2000 Dec;48(6):893–901. PubMed PMID: 11117546.
   PubMed Web of Science ®Google Scholar
• Petrova N, Carassiti D, Altmann DR, et al. Axonal loss in the multiple sclerosis spinal cord revisited. Brain Pathol. 2018 May;28(3):334–348. PubMed PMID: 28401686.
   PubMed Web of Science ®Google Scholar
• Bican O, Minagar A, Pruitt AA. The spinal cord: a review of functional neuroanatomy. Neurol Clin. 2013 Feb;31(1):1–18. PubMed PMID: 23186894.
   PubMed Web of Science ®Google Scholar
• Stroman PW, Wheeler-Kingshott C, Bacon M, et al. The current state-of-the-art of spinal cord imaging: methods. Neuroimage. 2014 Jan;1(84):1070–1081. PubMed PMID: 23685159.
   PubMed Web of Science ®Google Scholar
• Wheeler-Kingshott CA, Stroman PW, Schwab JM, et al. The current state-of-the-art of spinal cord imaging: applications. Neuroimage. 2014 Jan;1(84):1082–1093. PubMed PMID: 23859923.
   PubMed Web of Science ®Google Scholar
• Lassmann H. Multiple Sclerosis Pathology. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3). PubMed PMID: 29358320. DOI:10.1101/cshperspect.a028936
   Web of Science ®Google Scholar
• Gilmore CP, Geurts JJ, Evangelou N, et al. Spinal cord grey matter lesions in multiple sclerosis detected by post-mortem high field MR imaging. Mult Scler. 2009 Feb;15(2):180–188. PubMed PMID: 18845658.
   PubMed Web of Science ®Google Scholar
• Gilmore CP, DeLuca GC, Bo L, et al. Spinal cord neuronal pathology in multiple sclerosis. Brain Pathol. 2009 Oct;19(4):642–649. PubMed PMID: 19170682.
   PubMed Web of Science ®Google Scholar
• Ciccarelli O, Cohen JA, Reingold SC, et al. Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. Lancet Neurol. 2019 Feb;18(2):185–197. PubMed PMID: 30663608.
   PubMed Web of Science ®Google Scholar
• Rovira A, Wattjes MP, Tintore M, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process. Nat Rev Neurol. 2015 Aug;11(8):471–482. PubMed PMID: 26149978.
   PubMed Web of Science ®Google Scholar
• Traboulsee A, Simon JH, Stone L, et al. Revised recommendations of the consortium of MS centers task force for a standardized MRI protocol and clinical guidelines for the diagnosis and follow-up of multiple sclerosis. AJNR Am J Neuroradiol. 2016 Mar;37(3):394–401. PubMed PMID: 26564433.
   PubMed Web of Science ®Google Scholar
• Wattjes MP, Rovira A, Miller D, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis–establishing disease prognosis and monitoring patients. Nat Rev Neurol. 2015 Oct;11(10):597–606. PubMed PMID: 26369511.
   PubMed Web of Science ®Google Scholar
• Filippi M, Preziosa P, Banwell BL, et al. Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines. Brain. 2019 Jul 1;142(7):1858–1875. PubMed PMID: 31209474.
   PubMed Web of Science ®Google Scholar
• Phalke VV, Gujar S, Quint DJ. Comparison of 3.0 T versus 1.5 T MR: imaging of the spine. Neuroimaging Clin N Am. 2006 May;16(2): 241–248. ix.
   PubMed Web of Science ®Google Scholar
• Stankiewicz JM, Neema M, Alsop DC, et al. Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study. J Neurol Sci. 2009 Apr 15;279(1–2):99–105. PubMed PMID: 19178916.
   PubMed Web of Science ®Google Scholar
• Hittmair K, Mallek R, Prayer D, et al. Spinal cord lesions in patients with multiple sclerosis: comparison of MR pulse sequences. AJNR Am J Neuroradiol. 1996 Sep;17(8):1555–1565. PubMed PMID: 8883656.
   PubMed Web of Science ®Google Scholar
• Rocca MA, Mastronardo G, Horsfield MA, et al. Comparison of three MR sequences for the detection of cervical cord lesions in patients with multiple sclerosis. AJNR Am J Neuroradiol. 1999 Oct;20(9):1710–1716. PubMed PMID: 10543646.
   PubMed Web of Science ®Google Scholar
• Campi A, Pontesilli S, Gerevini S, et al. Comparison of MRI pulse sequences for investigation of lesions of the cervical spinal cord. Neuroradiology. 2000 Sep;42(9):669–675. PubMed PMID: 11071441.
   PubMed Web of Science ®Google Scholar
• Bot JC, Barkhof F, Lycklama a Nijeholt GJ, et al. Comparison of a conventional cardiac-triggered dual spin-echo and a fast STIR sequence in detection of spinal cord lesions in multiple sclerosis. Eur Radiol. 2000;10(5):753–758. PubMed PMID: 10823627.
   PubMed Web of Science ®Google Scholar
• Philpott C, Brotchie P. Comparison of MRI sequences for evaluation of multiple sclerosis of the cervical spinal cord at 3 T. Eur J Radiol. 2011 Dec;80(3):780–785. PubMed PMID: 21041051.
   PubMed Web of Science ®Google Scholar
• Chong AL, Chandra RV, Chuah KC, et al. Proton density MRI increases detection of cervical spinal cord multiple sclerosis lesions compared with t2-weighted fast spin-echo. AJNR Am J Neuroradiol. 2016 Jan;37(1):180–184. PubMed PMID: 26427838.
   PubMed Web of Science ®Google Scholar
• Alcaide-Leon P, Pauranik A, Alshafai L, et al. Comparison of sagittal FSE T2, STIR, and T1-weighted phase-sensitive inversion recovery in the detection of spinal cord lesions in MS at 3T. AJNR Am J Neuroradiol. 2016 May;37(5):970–975. PubMed PMID: 26797141.
   PubMed Web of Science ®Google Scholar
• Nair G, Absinta M, Reich DS. Optimized T1-MPRAGE sequence for better visualization of spinal cord multiple sclerosis lesions at 3T. AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2215–2222. PubMed PMID: 23764721
   PubMed Web of Science ®Google Scholar
• Weier K, Mazraeh J, Naegelin Y, et al. Biplanar MRI for the assessment of the spinal cord in multiple sclerosis. Mult Scler. 2012 Nov;18(11):1560–1569. PubMed PMID: 22539086.
   PubMed Web of Science ®Google Scholar
• Lycklama G, Thompson A, Filippi M, et al. Spinal-cord MRI in multiple sclerosis. Lancet Neurol. 2003 Sep;2(9):555–562. PubMed PMID: 12941578
   PubMed Web of Science ®Google Scholar
• Bot JC, Barkhof F, Polman CH, et al. Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination. Neurology. 2004 Jan 27;62(2):226–233. PubMed PMID: 14745058
   PubMed Web of Science ®Google Scholar
• Gass A, MA R, Agosta F, et al. MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis. Lancet Neurol. 2015 Apr;14(4):443–454. PubMed PMID: 25748099.
   PubMed Web of Science ®Google Scholar
• Kearney H, Miszkiel KA, Yiannakas MC, et al. Grey matter involvement by focal cervical spinal cord lesions is associated with progressive multiple sclerosis. Mult Scler. 2016 Jun;22(7):910–920. PubMed PMID: 26432854.
   PubMed Web of Science ®Google Scholar
• Eden D, Gros C, Badji A, et al. Spatial distribution of multiple sclerosis lesions in the cervical spinal cord. Brain. 2019 Mar 1;142(3):633–646. PubMed PMID: 30715195.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Aboulwafa M, Preziosa P, et al. Cervical cord T1-weighted hypointense lesions at MR imaging in multiple sclerosis: relationship to cord atrophy and disability. Radiology. 2018 Jul;288(1):234–244. PubMed PMID: 29664341.
   PubMed Web of Science ®Google Scholar
• Thorpe JW, Kidd D, Moseley IF, et al. Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology. 1996 Feb;46(2):373–378. PubMed PMID: 8614497.
   PubMed Web of Science ®Google Scholar
• Ruggieri S, Logoteta A, Tinelli E, et al. Measuring disease activity in multiple sclerosis: the essential role of spinal cord MRI monitoring. In ECTRIMS online library; 2018 [cited 2019 Dec 10]. https://onlinelibraryectrims-congresseu/ectrims/2018/ectrims-2018/228465/serenaruggierimeasuringdiseaseactivityinmultiplesclerosistheessentialhtml.
   Google Scholar
• Pyle W, Dastur K, Rahman M, et al. Open-ring peripherally enhancing lesion of the cervical spine. Neurology. 2009 Jan 27;72(4):381. PubMed PMID: 19171840.
   PubMed Web of Science ®Google Scholar
• Klawiter EC, Benzinger T, Roy A, et al. Spinal cord ring enhancement in multiple sclerosis. Arch Neurol. 2010 Nov;67(11):1395–1398. PubMed PMID: 21060017.
   PubMedGoogle Scholar
• Okuda DT, Mowry EM, Cree BA, et al. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology. 2011 Feb 22;76(8):686–692. PubMed PMID: 21270417.
   PubMed Web of Science ®Google Scholar
• Kantarci OH, Lebrun C, Siva A, et al. Primary progressive multiple sclerosis evolving from radiologically isolated syndrome. Ann Neurol. 2016 Feb;79(2):288–294. PubMed PMID: 26599831.
   PubMed Web of Science ®Google Scholar
• Sombekke MH, Wattjes MP, Balk LJ, et al. Spinal cord lesions in patients with clinically isolated syndrome: a powerful tool in diagnosis and prognosis. Neurology. 2013 Jan 1;80(1):69–75. PubMed PMID: 23243070.
   PubMed Web of Science ®Google Scholar
• McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001 Jul;50(1):121–127. PubMed PMID: 11456302.
   PubMed Web of Science ®Google Scholar
• Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 Feb;69(2):292–302. PubMed PMID: 21387374.
   PubMed Web of Science ®Google Scholar
• Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005 Dec;58(6):840–846. PubMed PMID: 16283615.
   PubMed Web of Science ®Google Scholar
• Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018 Feb;17(2):162–173. PubMed PMID: 29275977.
   PubMed Web of Science ®Google Scholar
• Nijeholt GJ, van Walderveen MA, Castelijns JA, et al. Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain. 1998 Apr;121(Pt 4):687–697. PubMed PMID: 9577394.
   PubMed Web of Science ®Google Scholar
• Geraldes R, Ciccarelli O, Barkhof F, et al. The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nat Rev Neurol. 2018 Apr;14(4):199–213. PubMed PMID: 29521337.
   PubMed Web of Science ®Google Scholar
• Zalewski NL, Flanagan EP, Keegan BM. Evaluation of idiopathic transverse myelitis revealing specific myelopathy diagnoses. Neurology. 2018 Jan 9;90(2):e96–e102. PubMed PMID: 29247071.
   PubMed Web of Science ®Google Scholar
• Flanagan EP, Weinshenker BG, Krecke KN, et al. Short myelitis lesions in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders. JAMA Neurol. 2015 Jan;72(1):81–87. PubMed PMID: 25384099.
   PubMed Web of Science ®Google Scholar
• Hyun JW, Kim SH, Jeong IH, et al. Bright spotty lesions on the spinal cord: an additional MRI indicator of neuromyelitis optica spectrum disorder? J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1280–1282. PubMed PMID: 25575845.
   PubMed Web of Science ®Google Scholar
• Sato DK, Callegaro D, Lana-Peixoto MA, et al. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology. 2014 Feb 11;82(6):474–481. PubMed PMID: 24415568.
   PubMed Web of Science ®Google Scholar
• Dubey D, Pittock SJ, Krecke KN, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol. 2018 Dec 21. DOI:10.1001/jamaneurol.2018.4053. PubMed PMID: 30575890.
   PubMed Web of Science ®Google Scholar
• Deneve M, Biotti D, Patsoura S, et al. MRI features of demyelinating disease associated with anti-MOG antibodies in adults. J Neuroradiol. 2019 Sep;46(5):312–318. PubMed PMID: 31228536.
   PubMed Web of Science ®Google Scholar
• Pohl D, Alper G, Van Haren K, et al. Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome. Neurology. 2016 Aug 30;87(9 Suppl 2):S38–45. PubMed PMID: 27572859.
   PubMed Web of Science ®Google Scholar
• Flanagan EP, Kaufmann TJ, Krecke KN, et al. Discriminating long myelitis of neuromyelitis optica from sarcoidosis. Ann Neurol. 2016 Mar;79(3):437–447. PubMed PMID: 26677112.
   PubMed Web of Science ®Google Scholar
• Al-Araji A, Kidd DP. Neuro-behcet’s disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009 Feb;8(2):192–204. PubMed PMID: 19161910
   PubMed Web of Science ®Google Scholar
• Uygunoglu U, Zeydan B, Ozguler Y, et al. Myelopathy in behcet’s disease: the bagel sign. Ann Neurol. 2017 Aug;82(2):288–298. PubMed PMID: 28749553.
   PubMed Web of Science ®Google Scholar
• Arrambide G, Rovira A, Sastre-Garriga J, et al. Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor. Mult Scler. 2018 Mar;24(3):301–312. PubMed PMID: 28301287.
   PubMed Web of Science ®Google Scholar
• Brownlee WJ, Altmann DR, Alves Da Mota P, et al. Association of asymptomatic spinal cord lesions and atrophy with disability 5 years after a clinically isolated syndrome. Mult Scler. 2017 Apr;23(5):665–674. PubMed PMID: 27481210.
   PubMed Web of Science ®Google Scholar
• WJ B, DR A, Prados F, et al. Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis. Brain. 2019 Aug 1;142(8):2276–2287. PubMed PMID: 31342055.
   PubMedGoogle Scholar
• Kearney H, Altmann DR, Samson RS, et al. Cervical cord lesion load is associated with disability independently from atrophy in MS. Neurology. 2015 Jan 27;84(4):367–373. PubMed PMID: 25540312.
   PubMed Web of Science ®Google Scholar
• MA R, Valsasina P, Meani A, et al. Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS. Neurology. 2019 Nov 12;93(20):e1852–e1866. PubMed PMID: 31611336.
   PubMed Web of Science ®Google Scholar
• D’Amico E, Patti F, Leone C, et al. Negative prognostic impact of MRI spinal lesions in the early stages of relapsing-remitting multiple sclerosis. Mult Scler J Exp Transl Clin. 2016 Jan-Dec;2:2055217316631565. PubMed PMID: 28607716.
   Google Scholar
• Keegan BM, Kaufmann TJ, Weinshenker BG, et al. Progressive solitary sclerosis: gradual motor impairment from a single CNS demyelinating lesion. Neurology. 2016 Oct 18;87(16):1713–1719. PubMed PMID: 27638926.
   PubMed Web of Science ®Google Scholar
• Casserly C, Seyman EE, Alcaide-Leon P, et al. Spinal cord atrophy in multiple sclerosis: a systematic review and meta-analysis. J Neuroimaging. 2018 Nov;28(6):556–586. PubMed PMID: 30102003.
   PubMed Web of Science ®Google Scholar
• Brex PA, Leary SM, O’Riordan JI, et al. Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2001 Apr;70(4):544–547. PubMed PMID: 11254786.
   PubMed Web of Science ®Google Scholar
• Biberacher V, Boucard CC, Schmidt P, et al. Atrophy and structural variability of the upper cervical cord in early multiple sclerosis. Mult Scler. 2015 Jun;21(7):875–884. PubMed PMID: 25139943.
   PubMed Web of Science ®Google Scholar
• Hagstrom IT, Schneider R, Bellenberg B, et al. Relevance of early cervical cord volume loss in the disease evolution of clinically isolated syndrome and early multiple sclerosis: a 2-year follow-up study. J Neurol. 2017 Jul;264(7):1402–1412. PubMed PMID: 28600596.
   PubMed Web of Science ®Google Scholar
• Moccia M, Prados F, Filippi M, et al. Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral. Ann Neurol. 2019 Nov;86(5):704–713. PubMed PMID: 31385358.
   PubMed Web of Science ®Google Scholar
• Rocca MA, Horsfield MA, Sala S, et al. A multicenter assessment of cervical cord atrophy among MS clinical phenotypes. Neurology. 2011 Jun 14;76(24):2096–2102. PubMed PMID: 21670439.
   PubMed Web of Science ®Google Scholar
• Klein JP, Arora A, Neema M, et al. A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):1138–1142. PubMed PMID: 21527570.
   PubMed Web of Science ®Google Scholar
• Filippi M, Campi A, Colombo B, et al. A spinal cord MRI study of benign and secondary progressive multiple sclerosis. J Neurol. 1996 Jul;243(7):502–505. PubMed PMID: 8836938.
   PubMed Web of Science ®Google Scholar
• Lukas C, Knol DL, Sombekke MH, et al. Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):410–418. PubMed PMID: 24973341.
   PubMed Web of Science ®Google Scholar
• Lukas C, Sombekke MH, Bellenberg B, et al. Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients. Radiology. 2013 Nov;269(2):542–552. PubMed PMID: 23737540.
   PubMed Web of Science ®Google Scholar
• Tsagkas C, Magon S, Gaetano L, et al. Spinal cord volume loss: A marker of disease progression in multiple sclerosis. Neurology. 2018 Jul 24;91(4):e349–e358. PubMed PMID: 29950437.
   PubMed Web of Science ®Google Scholar
• Andelova M, Uher T, Krasensky J, et al. Additive effect of spinal cord volume, diffuse and focal cord pathology on disability in multiple sclerosis. Front Neurol. 2019;10:820. PubMed PMID: 31447759.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Rocca MA, Horsfield MA, et al. A longitudinal MRI study of cervical cord atrophy in multiple sclerosis. J Neurol. 2015 Jul;262(7):1622–1628. PubMed PMID: 25929665.
   PubMed Web of Science ®Google Scholar
• Cawley N, Tur C, Prados F, et al. Spinal cord atrophy as a primary outcome measure in phase II trials of progressive multiple sclerosis. Mult Scler. 2018 Jun;24(7):932–941. PubMed PMID: 28516804.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Horsfield MA, Rocca MA, et al. Spatial normalization and regional assessment of cord atrophy: voxel-based analysis of cervical cord 3D T1-weighted images. AJNR Am J Neuroradiol. 2012 Dec;33(11):2195–2200. PubMed PMID: 22678848.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Rocca MA, Horsfield MA, et al. Regional cervical cord atrophy and disability in multiple sclerosis: a voxel-based analysis. Radiology. 2013 Mar;266(3):853–861. PubMed PMID: 23192778.
   PubMed Web of Science ®Google Scholar
• Rocca MA, Valsasina P, Damjanovic D, et al. Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypes. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):35–41. PubMed PMID: 23064100.
   PubMed Web of Science ®Google Scholar
• Pravata E, Valsasina P, Gobbi C, et al. Influence of CNS T2-focal lesions on cervical cord atrophy and disability in multiple sclerosis. Mult Scler. 2019 Jul 26:1352458519865989. PubMed PMID: 31347448. DOI:10.1177/1352458519865989
   Google Scholar
• Schlaeger R, Papinutto N, Panara V, et al. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct;76(4):568–580. PubMed PMID: 25087920.
   PubMed Web of Science ®Google Scholar
• Schlaeger R, Papinutto N, Zhu AH, et al. Association between thoracic spinal cord gray matter atrophy and disability in multiple sclerosis. JAMA Neurol. 2015 Aug;72(8):897–904. PubMed PMID: 26053119.
   PubMed Web of Science ®Google Scholar
• Clark CA, Werring DJ, Miller DH. Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis. Magn Reson Med. 2000 Jan;43(1):133–138. PubMed PMID: 10642740.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Rocca MA, Agosta F, et al. Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients. Neuroimage. 2005 Jul 1;26(3):822–828. PubMed PMID: 15955492.
   PubMed Web of Science ®Google Scholar
• Benedetti B, Rocca MA, Rovaris M, et al. A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients. J Neurol Neurosurg Psychiatry. 2010 Jan;81(1):26–30. PubMed PMID: 19546104.
   PubMed Web of Science ®Google Scholar
• Ohgiya Y, Oka M, Hiwatashi A, et al. Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis. Eur Radiol. 2007 Oct;17(10):2499–2504. PubMed PMID: 17505830.
   PubMed Web of Science ®Google Scholar
• Cruz LC Jr., Domingues RC, Gasparetto EL. Diffusion tensor imaging of the cervical spinal cord of patients with relapsing-remising multiple sclerosis: a study of 41 cases. Arq Neuropsiquiatr. 2009 Jun;67(2B):391–395. PubMed PMID: 19623432.
   PubMed Web of Science ®Google Scholar
• Ciccarelli O, Wheeler-Kingshott CA, McLean MA, et al. Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain. 2007 Aug;130(Pt 8):2220–2231. PubMed PMID: 17664178.
   PubMedGoogle Scholar
• Oh J, Saidha S, Chen M, et al. Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis. Neurology. 2013 Feb 5;80(6):540–547. PubMed PMID: 23325903.
   PubMed Web of Science ®Google Scholar
• Oh J, Zackowski K, Chen M, et al. Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis. Mult Scler. 2013 Apr;19(4):427–435. PubMed PMID: 22891033.
   PubMed Web of Science ®Google Scholar
• Toosy AT, Kou N, Altmann D, et al. Voxel-based cervical spinal cord mapping of diffusion abnormalities in MS-related myelitis. Neurology. 2014 Oct 7;83(15):1321–1325. PubMed PMID: 25186861.
   PubMed Web of Science ®Google Scholar
• Agosta F, Pagani E, Caputo D, et al. Associations between cervical cord gray matter damage and disability in patients with multiple sclerosis. Arch Neurol. 2007 Sep;64(9):1302–1305. PubMed PMID: 17846269.
   PubMedGoogle Scholar
• Kearney H, Schneider T, Yiannakas MC, et al. Spinal cord grey matter abnormalities are associated with secondary progression and physical disability in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):608–614. PubMed PMID: 25097217.
   PubMed Web of Science ®Google Scholar
• Grussu F, Schneider T, Tur C, et al. Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology? Ann Clin Transl Neurol. 2017 Sep;4(9):663–679. PubMed PMID: 28904988.
   PubMed Web of Science ®Google Scholar
• By S, Xu J, Box BA, et al. Application and evaluation of NODDI in the cervical spinal cord of multiple sclerosis patients. Neuroimage Clin. 2017;15:333–342. PubMed PMID: 28560158.
   PubMed Web of Science ®Google Scholar
• Collorone S, Cawley N, Grussu F, et al. Reduced neurite density in the brain and cervical spinal cord in relapsing-remitting multiple sclerosis: A NODDI study. Mult Scler. 2019 Nov 4:1352458519885107. PubMed PMID: 31682198. DOI:10.1177/1352458519885107
   Google Scholar
• Rovaris M, Gallo A, Riva R, et al. An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS. Neurology. 2004 Aug 10;63(3):584–585. PubMed PMID: 15304603.
   PubMed Web of Science ®Google Scholar
• Rovaris M, Judica E, Ceccarelli A, et al. Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: a preliminary study. Mult Scler. 2008 Jul;14(6):853–856. PubMed PMID: 18611991.
   PubMedGoogle Scholar
• Mezzapesa DM, Rocca MA, Falini A, et al. A preliminary diffusion tensor and magnetization transfer magnetic resonance imaging study of early-onset multiple sclerosis. Arch Neurol. 2004 Mar;61(3):366–368. PubMed PMID: 15023813.
   PubMedGoogle Scholar
• Combes B, Kerbrat A, Ferre JC, et al. Focal and diffuse cervical spinal cord damage in patients with early relapsing-remitting MS: A multicentre magnetisation transfer ratio study. Mult Scler. 2019 Jul;25(8):1113–1123. PubMed PMID: 29909771.
   PubMed Web of Science ®Google Scholar
• Bozzali M, Rocca MA, Iannucci G, et al. Magnetization-transfer histogram analysis of the cervical cord in patients with multiple sclerosis. AJNR Am J Neuroradiol. 1999 Nov-Dec;20(10):1803–1808. PubMed PMID: 10588100.
   PubMed Web of Science ®Google Scholar
• Charil A, Caputo D, Cavarretta R, et al. Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study. Mult Scler. 2006 Oct;12(5):662–665. PubMed PMID: 17086915.
   PubMed Web of Science ®Google Scholar
• Hickman SJ, Hadjiprocopis A, Coulon O, et al. Cervical spinal cord MTR histogram analysis in multiple sclerosis using a 3D acquisition and a B-spline active surface segmentation technique. Magn Reson Imaging. 2004 Jul;22(6):891–895. PubMed PMID: 15234459.
   PubMed Web of Science ®Google Scholar
• Filippi M, Bozzali M, Horsfield MA, et al. A conventional and magnetization transfer MRI study of the cervical cord in patients with MS. Neurology. 2000 Jan 11;54(1):207–213. PubMed PMID: 10636149.
   PubMed Web of Science ®Google Scholar
• Rovaris M, Bozzali M, Santuccio G, et al. In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis. Brain. 2001 Dec;124(Pt 12):2540–2549. PubMed PMID: 11701606.
   PubMedGoogle Scholar
• Lycklama a Nijeholt GJ, Castelijns JA, Lazeron RH, et al. Magnetization transfer ratio of the spinal cord in multiple sclerosis: relationship to atrophy and neurologic disability. J Neuroimaging. 2000 Apr;10(2):67–72. PubMed PMID: 10800258.
   PubMed Web of Science ®Google Scholar
• Zackowski KM, Smith SA, Reich DS, et al. Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord. Brain. 2009 May;132(Pt 5):1200–1209. PubMed PMID: 19297508.
   PubMedGoogle Scholar
• Kearney H, Yiannakas MC, Samson RS, et al. Investigation of magnetization transfer ratio-derived pial and subpial abnormalities in the multiple sclerosis spinal cord. Brain. 2014 Sep;137(Pt 9):2456–2468. PubMed PMID: 24966048.
   PubMed Web of Science ®Google Scholar
• MacKay A, Whittall K, Adler J, et al. In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med. 1994 Jun;31(6):673–677. PubMed PMID: 8057820.
   PubMed Web of Science ®Google Scholar
• Laule C, Moore GRW. Myelin water imaging to detect demyelination and remyelination and its validation in pathology. Brain Pathol. 2018 Sep;28(5):750–764. PubMed PMID: 30375119
   PubMed Web of Science ®Google Scholar
• Laule C, Yung A, Pavolva V, et al. High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report. Mult Scler. 2016 Oct;22(11):1485–1489. PubMed PMID: 26819263.
   PubMed Web of Science ®Google Scholar
• Laule C, Kozlowski P, Leung E, et al. Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology. Neuroimage. 2008 May 1;40(4):1575–1580. PubMed PMID: 18321730.
   PubMed Web of Science ®Google Scholar
• Kolind S, Seddigh A, Combes A, et al. Brain and cord myelin water imaging: a progressive multiple sclerosis biomarker. Neuroimage Clin. 2015;9:574–580. PubMed PMID: 26594633
   PubMed Web of Science ®Google Scholar
• Laule C, Vavasour IM, Zhao Y, et al. Two-year study of cervical cord volume and myelin water in primary progressive multiple sclerosis. Mult Scler. 2010 Jun;16(6):670–677. PubMed PMID: 20558500.
   PubMed Web of Science ®Google Scholar
• Blamire AM, Cader S, Lee M, et al. Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy. Magn Reson Med. 2007 Nov;58(5):880–885. PubMed PMID: 17969113.
   PubMed Web of Science ®Google Scholar
• Marliani AF, Clementi V, Albini Riccioli L, et al. Quantitative cervical spinal cord 3T proton MR spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol. 2010 Jan;31(1):180–184. PubMed PMID: 19729541.
   PubMed Web of Science ®Google Scholar
• Abdel-Aziz K, Schneider T, Solanky BS, et al. Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis. Brain. 2015 Jun;138(Pt 6):1568–1582. PubMed PMID: 25863355.
   PubMedGoogle Scholar
• Kendi AT, Tan FU, Kendi M, et al. MR spectroscopy of cervical spinal cord in patients with multiple sclerosis. Neuroradiology. 2004 Sep;46(9):764–769. PubMed PMID: 15258708.
   PubMed Web of Science ®Google Scholar
• Ciccarelli O, Altmann DR, McLean MA, et al. Spinal cord repair in MS: does mitochondrial metabolism play a role? Neurology. 2010 Mar 2;74(9):721–727. PubMed PMID: 20107138.
   PubMed Web of Science ®Google Scholar
• Absinta M, Rocca MA, Valsasina P, et al. Cervical cord fMRI abnormalities differ between the progressive forms of multiple sclerosis. J Neurol. 2011 May;258:220–221. PubMed PMID: WOS:000289992800631
   Web of Science ®Google Scholar
• Agosta F, Valsasina P, Caputo D, et al. Tactile-associated recruitment of the cervical cord is altered in patients with multiple sclerosis. Neuroimage. 2008 Feb 15;39(4):1542–1548. PubMed PMID: 18061484.
   PubMed Web of Science ®Google Scholar
• Agosta F, Valsasina P, Rocca MA, et al. Evidence for enhanced functional activity of cervical cord in relapsing multiple sclerosis. Magn Reson Med. 2008 May;59(5):1035–1042. PubMed PMID: 18429010.
   PubMed Web of Science ®Google Scholar
• Rocca MA, Absinta M, Valsasina P, et al. Abnormal cervical cord function contributes to fatigue in multiple sclerosis. Mult Scler. 2012 Nov;18(11):1552–1559. PubMed PMID: 22389415.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Agosta F, Absinta M, et al. Cervical cord functional MRI changes in relapse-onset MS patients. J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):405–408. PubMed PMID: 19965858.
   PubMed Web of Science ®Google Scholar
• Valsasina P, Rocca MA, Absinta M, et al. Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis. Hum Brain Mapp. 2012 Sep;33(9):2072–2080. PubMed PMID: 22887824.
   PubMed Web of Science ®Google Scholar
• Conrad BN, Barry RL, Rogers BP, et al. Multiple sclerosis lesions affect intrinsic functional connectivity of the spinal cord. Brain. 2018 Jun 1;141(6):1650–1664. PubMed PMID: 29648581.
   PubMedGoogle Scholar
• Zecca C, Disanto G, Sormani MP, et al. Relevance of asymptomatic spinal MRI lesions in patients with multiple sclerosis. Mult Scler. 2016 May;22(6):782–791. PubMed PMID: 26459149.
   PubMed Web of Science ®Google Scholar
• Lin X, Tench CR, Turner B, et al. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1090–1094. PubMed PMID: 12876240
   PubMed Web of Science ®Google Scholar
• Dupuy SL, Khalid F, Healy BC, et al. The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis. BMC Med Imaging. 2016 Oct 5;16(1):56. PubMed PMID: 27716096.
   PubMed Web of Science ®Google Scholar
• Singhal T, Tauhid S, Hurwitz S, et al. The effect of glatiramer acetate on spinal cord volume in relapsing-remitting multiple sclerosis. J Neuroimaging. 2017 Jan;27(1):33–36. PubMed PMID: 27466943.
   PubMed Web of Science ®Google Scholar
• Leary SM, Miller DH, Stevenson VL, et al. Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial. Neurology. 2003 Jan 14;60(1):44–51. PubMed PMID: 12525716
   PubMed Web of Science ®Google Scholar
• Montalban X, Sastre-Garriga J, Tintore M, et al. A single-center, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis. Mult Scler. 2009 Oct;15(10):1195–1205. PubMed PMID: 19797261.
   PubMed Web of Science ®Google Scholar
• Kalkers NF, Barkhof F, Bergers E, et al. The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study. Mult Scler. 2002 Dec;8(6):532–533. PubMed PMID: 12474997.
   PubMedGoogle Scholar
• Kapoor R, Furby J, Hayton T, et al. Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial. Lancet Neurol. 2010 Jul;9(7):681–688. PubMed PMID: 20621711.
   PubMed Web of Science ®Google Scholar
• Rovira A, de Stefano N. MRI monitoring of spinal cord changes in patients with multiple sclerosis. Curr Opin Neurol. 2016 Aug;29(4):445–452. PubMed PMID: 27175890
   PubMed Web of Science ®Google Scholar
• Swanton JK, Fernando KT, Dalton CM, et al. Early MRI in optic neuritis: the risk for disability. Neurology. 2009 Feb 10;72(6):542–550. PubMed PMID: 19204264.
   PubMed Web of Science ®Google Scholar
• Filippi M, Rocca MA, Calabrese M, et al. Intracortical lesions: relevance for new MRI diagnostic criteria for multiple sclerosis. Neurology. 2010 Nov 30;75(22):1988–1994. PubMed PMID: 21115953.
   PubMed Web of Science ®Google Scholar
• Dekker I, Sombekke MH, Witte BI, et al. Asymptomatic spinal cord lesions do not predict the time to disability in patients with early multiple sclerosis. Mult Scler. 2018 Apr;24(4):481–490. PubMed PMID: 29106327.
   PubMed Web of Science ®Google Scholar
• Yaldizli Ö, MacManus D, Stutters J, et al. Brain and cervical spinal cord atrophy in primary progressive multiple sclerosis: results from a placebo-controlled phase III trial (INFORMS). In ECTRIMS online library; 2015. [cited 2019 Dec 10]. https://onlinelibraryectrims-congresseu/ectrims/2015/31st/116684/oezgueryaldizlibrainandcervicalspinalcordatrophyinprimaryprogressivehtml.
   Google Scholar