Developments in treating the nonmotor symptoms of stroke

References

• Carrozzino D, Patierno C, Fava GA, et al. The hamilton rating scales for depression: a critical review of clinimetric properties of different versions. Psychother Psychosom. 2020;89:133–150.
   PubMed Web of Science ®Google Scholar
• King RB. Quality of life after stroke. Stroke. 1996;27:1467–1472.
   PubMed Web of Science ®Google Scholar
• Vose A, Nonnenmacher J, Singer ML, et al. Dysphagia management in acute and sub-acute stroke. Curr Phys Med Rehabil Rep. 2014;2:197–206.
   PubMedGoogle Scholar
• Graff-Radford J. Vascular cognitive impairment. Continuum. 2019;25:147–164.
   PubMedGoogle Scholar
• Burvill PW, Johnson GA, Jamrozik KD, et al. Prevalence of depression after stroke: the Perth community stroke study. Br J Psychiatry. 1995;166:320–327.
   PubMed Web of Science ®Google Scholar
• Whyte EM, Mulsant BH. Post stroke depression: epidemiology, pathophysiology, and biological treatment. Biol Psychiatry. 2002;52:253–264.
   PubMed Web of Science ®Google Scholar
• Robinson RG, Starr LB, Lipsey JR, et al. A two-year longitudinal study of post-stroke mood disorders: dynamic changes in associated variables over the first six months of follow-up. Stroke. 1984;15:510–517.
   PubMed Web of Science ®Google Scholar
• Downhill JE Jr, Robinson RG. Longitudinal assessment of depression and cognitive impairment following stroke. J Nerv Ment Dis. 1994;182:425–431.
   PubMed Web of Science ®Google Scholar
• Löwe B, Kroenke K, Herzog W, et al. Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9). J Affect Disord. 2004;81:61–66.
   PubMed Web of Science ®Google Scholar
• Robinson RG, Jorge RE, Moser DJ, et al. Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA. 2008;299:2391–2400.
   PubMed Web of Science ®Google Scholar
• Mikami K, Jorge RE, Moser DJ, et al. Increased frequency of first-episode poststroke depression after discontinuation of escitalopram. Stroke. 2011;42:3281–3283.
   PubMed Web of Science ®Google Scholar
• Hackett ML, Anderson CS, House A, et al. Interventions for treating depression after stroke. Cochrane Database Syst Rev. 2008; 4.
   Google Scholar
• Lipsey J, Pearlson G, Robinson R, et al. Nortriptyline treatment of post-stroke depression: a double-blind study. Lancet. 1984;323:297–300.
   Google Scholar
• Gabaldon L, Fuentes B, Frank-Garcia A, et al. Poststroke depression: importance of its detection and treatment. Cerebrovasc Dis. 2007;24(Suppl 1):181–188.
   PubMedGoogle Scholar
• Chen Y, Guo JJ, Zhan S, et al. Treatment effects of antidepressants in patients with post-stroke depression: a meta-analysis. Ann Pharmacother. 2006;40:2115–2122.
   PubMed Web of Science ®Google Scholar
• Gu J, Huang H, Chen K, et al. Are they necessary? Preventive therapies for post-stroke depression: a meta-analysis of RCTs. Psychiatry Res. 2020;284:112670.
   PubMed Web of Science ®Google Scholar
• Chollet F, Tardy J, Albucher J, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10:123–130.
   PubMed Web of Science ®Google Scholar
• Schneider CL, Majewska AK, Busza A, et al. Selective serotonin reuptake inhibitors for functional recovery after stroke: similarities with the critical period and the role of experience-dependent plasticity. J Neurol. 2019;1–7.
   Web of Science ®Google Scholar
• Mortensen JK, Andersen G. Potential role of selective serotonin reuptake inhibitors in improving functional outcome after stroke. CNS Drugs. 2018;32:895–903.
   PubMed Web of Science ®Google Scholar
• Legg LA, Tilney R, Hsieh C, et al. Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. Cochrane Database Syst Rev. 2019;11.
   Google Scholar
• Jorge RE, Acion L, Moser D, et al. Escitalopram and enhancement of cognitive recovery following stroke. Arch Gen Psychiatry. 2010;67:187–196.
   PubMed Web of Science ®Google Scholar
• Dennis M, Mead G, Forbes J, et al. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet. 2019;393(10168):265–267.
   PubMed Web of Science ®Google Scholar
• Gu S, Wang C. Early selective serotonin reuptake inhibitors for recovery after stroke: a meta-analysis and trial sequential analysis. J Stroke Cerebrovascular Dis. 2018;27:1178–1189.
   PubMed Web of Science ®Google Scholar
• Valiengo LC, Goulart AC, de Oliveira JF, et al. Transcranial direct current stimulation for the treatment of post-stroke depression: results from a randomised, sham-controlled, double-blinded trial. J Neurol Neurosurg Psychiatr. 2017;88:170–175.
   PubMed Web of Science ®Google Scholar
• Fregni F, Boggio PS, Nitsche MA, et al. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord. 2006;8:203–204.
   PubMed Web of Science ®Google Scholar
• Frank E, Eichhammer P, Burger J, et al. Transcranial magnetic stimulation for the treatment of depression: feasibility and results under naturalistic conditions: a retrospective analysis. Eur Arch Psychiatry Clin Neurosci. 2011;261:261–266.
   PubMed Web of Science ®Google Scholar
• Lai S, Studenski S, Richards L, et al. Therapeutic exercise and depressive symptoms after stroke. J Am Geriatr Soc. 2006;54:240–247.
   PubMed Web of Science ®Google Scholar
• VanDerwerker CJ, Ross RE, Stimpson KH, et al. Combining therapeutic approaches: rTMS and aerobic exercise in post-stroke depression: a case series. Top Stroke Rehabil. 2018;25:61–67.
   PubMed Web of Science ®Google Scholar
• Alexopoulos GS. Mechanisms and treatment of late-life depression. Transl Psychiatry. 2019;9:1–16.
   PubMed Web of Science ®Google Scholar
• Bella R, Pennisi G, Cantone M, et al. Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. Gerontology. 2010;56:298–302.
   PubMed Web of Science ®Google Scholar
• Morris PL, Raphael B, Robinson RG. Clinical depression is associated with impaired recovery from stroke. Med J Aust. 1992;157:239–242.
   PubMed Web of Science ®Google Scholar
• Santos CO, Caeiro L, Ferro JM, et al. Mania and stroke: a systematic review. Cerebrovascular Dis. 2011;32:11–21.
   PubMed Web of Science ®Google Scholar
• Ferro JM, Caeiro L, Figueira ML. Neuropsychiatric sequelae of stroke. Nat Rev Neurol. 2016;12:269.
   PubMed Web of Science ®Google Scholar
• Evans DL, Byerly MJ, Greer RA. Secondary mania: diagnosis and treatment. J Clin Psychiatry. 1995;56(Suppl 3):31–37.
   PubMedGoogle Scholar
• Barker-Collo SL. Depression and anxiety 3 months post stroke: prevalence and correlates. Arch Clini Neuropsychol. 2007;22:519–531.
   PubMed Web of Science ®Google Scholar
• West A, Simonsen SA, Zielinski A, et al. An exploratory investigation of the effect of naturalistic light on depression, anxiety, and cognitive outcomes in stroke patients during admission for rehabilitation: a randomized controlled trial. NeuroRehabilitation. 2019;1–11.
   Web of Science ®Google Scholar
• Starkstein SE, Fedoroff JP, Price TR, et al. Apathy following cerebrovascular lesions. Stroke. 1993 Nov;24(11):1625–1630.
   PubMed Web of Science ®Google Scholar
• Kortte KB, Hillis AE. Recent trends in rehabilitation interventions for visual neglect and anosognosia for hemiplegia following right hemisphere stroke. Future Neurol. 2011;6:33–43.
   PubMedGoogle Scholar
• Kim EH, Chien JH, Liu CC, et al. Stroke of bad luck? Neurocase. 2017;23:70–78.
   PubMed Web of Science ®Google Scholar
• Ingles JL, Eskes GA, Phillips SJ. Fatigue after stroke. Arch Phys Med Rehabil. 1999;80:173–178.
   PubMed Web of Science ®Google Scholar
• Glader E, Stegmayr B, Asplund K. Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke. 2002;33:1327–1333.
   PubMed Web of Science ®Google Scholar
• Annoni J, Staub F, Bogousslavsky J, et al. Frequency, characterisation and therapies of fatigue after stroke. Neurol Sci. 2008;29:244–246.
   PubMed Web of Science ®Google Scholar
• Acciarresi M, Bogousslavsky J, Paciaroni M. Post-stroke fatigue: epidemiology, clinical characteristics and treatment. Eur Neurol. 2014;72:255–261.
   PubMed Web of Science ®Google Scholar
• Celnik P, Hillis AE. Reconnecting the dots after stroke. Brain. 2009;66:570–571.
   PubMedGoogle Scholar
• McGeough E, Pollock A, Smith LN, et al. Interventions for post‐stroke fatigue. Cochrane Database Syst Rev. 2009;3.
   Google Scholar
• Ma HM, Zafonte RD. Amantadine and memantine: a comprehensive review for acquired brain injury. Brain Inj. 2020;34:299–315.
   PubMed Web of Science ®Google Scholar
• Bhogal SK, Teasell R, Speechley M. Intensity of aphasia therapy, impact on recovery. Stroke. 2003;34:987–993.
   PubMed Web of Science ®Google Scholar
• Saxena S, Hillis AE. An update on medications and noninvasive brain stimulation to augment language rehabilitation in post-stroke aphasia. Expert Rev Neurother. 2017;17:1091–1107.
   PubMed Web of Science ®Google Scholar
• Berube S, Hillis AE. Advances and innovations in aphasia treatment trials. Stroke. 2019;50:2977–2984.
   PubMed Web of Science ®Google Scholar
• Fridriksson J, Rorden C, Elm J, et al. Transcranial direct current stimulation vs sham stimulation to treat aphasia after stroke: a randomized clinical trial. JAMA Neurol. 2018;75:1470–1476.
   PubMed Web of Science ®Google Scholar
• Fridriksson J, Elm J, Stark BC, et al. BDNF genotype and tDCS interaction in aphasia treatment. Brain Stimul. 2018;11:1276–1281.
   PubMed Web of Science ®Google Scholar
• Khedr E, El-Fetoh NA, Ali A, et al. Dual-hemisphere repetitive transcranial magnetic stimulation for rehabilitation of poststroke aphasia: a randomized, double-blind clinical trial. Neurorehabil Neural Repair. 2014;28:740–750.
   PubMed Web of Science ®Google Scholar
• Berthier ML, Green C, Higueras C, et al. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Neurology. 2006;67:1687–1689.
   PubMed Web of Science ®Google Scholar
• Berthier ML, Green C, Lara JP, et al. Memantine and constraint‐induced aphasia therapy in chronic poststroke aphasia. Ann Neurol. 2009;65:577–585.
   PubMed Web of Science ®Google Scholar
• Kleinman JT, Newhart M, Davis C, et al. Right hemispatial neglect: frequency and characterization following acute left hemisphere stroke. Brain Cogn. 2007;64:50–59.
   PubMed Web of Science ®Google Scholar
• Barrett AM, Buxbaum LJ, Coslett HB, et al. Cognitive rehabilitation interventions for neglect and related disorders: moving from bench to bedside in stroke patients. J Cogn Neurosci. 2006;18:1223–1236.
   PubMed Web of Science ®Google Scholar
• Rossi PW, Kheyfets S, Reding MJ. Fresnel prisms improve visual perception in stroke patients with homonymous hemianopia or unilateral visual neglect. Neurology. 1990;40:1597–1599.
   PubMed Web of Science ®Google Scholar
• Frassinetti F, Angeli V, Meneghello F, et al. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–623.
   PubMed Web of Science ®Google Scholar
• Barrett AM, Goedert KM, Basso JC. Prism adaptation for spatial neglect after stroke: translational practice gaps. Nat Rev Neurol. 2012;8:567–577.
   PubMed Web of Science ®Google Scholar
• Müri RM, Cazzoli D, Nef T, et al. Non-invasive brain stimulation in neglect rehabilitation: an update. Front Hum Neurosci. 2013;7:248.
   PubMedGoogle Scholar
• Làdavas E, Giulietti S, Avenanti A, et al. a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect. Restor Neurol Neurosci. 2015;33:647–662.
   PubMed Web of Science ®Google Scholar
• Kashiwagi FT, El Dib R, Gomaa H, et al. Noninvasive brain stimulations for unilateral spatial neglect after stroke: a systematic review and meta-analysis of randomized and nonrandomized controlled trials. Neural Plast. 2018;2018:Article ID 1638763.
   Web of Science ®Google Scholar
• Dara C, Bang J, Gottesman RF, et al. Right hemisphere dysfunction is better predicted by emotional prosody impairments as compared to neglect. J Neurol Transl Neurosci. 2014;2:1037.
   PubMedGoogle Scholar
• Cantone M, Lanza G, Bella R, et al. Fear and disgust: case report of two uncommon emotional disturbances evoked by visual disperceptions after a right temporal-insular stroke. BMC Neurol. 2019;19:1–4.
   PubMed Web of Science ®Google Scholar
• Sheppard SM, Keator LM, Breining BL, et al. Right hemisphere ventral stream for emotional prosody identification: evidence from acute stroke. Neurology. 2020;94:e1013–20.
   PubMed Web of Science ®Google Scholar
• Rosenbek JC, Rodriguez AD, Hieber B, et al. Effects of two treatments for aprosodia secondary to acquired brain injury. J Rehabil Res Dev. 2006;43:379.
   PubMed Web of Science ®Google Scholar
• Sheppard SM, Patel S, Parra D, et al. Cues to improve emotional prosody after right frontal strokes. Ann Neurol. 2019;86:S129–S130.
   PubMed Web of Science ®Google Scholar
• Hillis AE, Tippett DC. Stroke recovery: surprising influences and residual consequences. Adv Med. 2014;2014:Article ID 378263.
   Google Scholar
• Leigh R, Oishi K, Hsu J, et al. Acute lesions that impair affective empathy. Brain. 2013;136:2539–2549.
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory S, Tomer R, Berger B, et al. Characterization of empathy deficits following prefrontal brain damage: the role of the right ventromedial prefrontal cortex. J Cogn Neurosci. 2003;15:324–337.
   PubMed Web of Science ®Google Scholar
• Hillis AE. Inability to empathize: brain lesions that disrupt sharing and understanding another’s emotions. Brain. 2014;137:981–997.
   PubMed Web of Science ®Google Scholar
• Rankin KP, Kramer JH, Miller BL. Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol. 2005;18:28–36.
   PubMed Web of Science ®Google Scholar
• Jesso S, Morlog D, Ross S, et al. The effects of oxytocin on social cognition and behaviour in frontotemporal dementia. Brain. 2011;134:2493–2501.
   PubMed Web of Science ®Google Scholar
• Long C, Hillis AE. Oxytocin as a treatment option in right hemisphere stroke. In: Edwards C, editor. Psychology of empathy: new research. New York (NY): Nova Science Publishers; 2016. p. 151–172.
   Google Scholar
• Finger E, Berry S, Cummings J, et al. Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY). Alzheimer’s Res Ther. 2018;10:102.
   PubMed Web of Science ®Google Scholar
• Gottesman RF, Hillis AE. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurol. 2010;9:895–905.
   PubMed Web of Science ®Google Scholar
• Van Der Flier WM, Skoog I, Schneider JA, et al. Vascular cognitive impairment. Nat Rev Dis Primers. 2018;4:1–16.
   PubMed Web of Science ®Google Scholar
• Black S, Roman GC, Geldmacher DS, et al. Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. Stroke. 2003;34:2323–2330.
   PubMed Web of Science ®Google Scholar
• Bordet R, Ihl R, Korczyn AD, et al. Towards the concept of disease-modifier in post-stroke or vascular cognitive impairment: a consensus report. BMC Med. 2017;15:107.
   PubMed Web of Science ®Google Scholar
• Pasinska P, Kowalska K, Klimiec E, et al. Poststroke delirium clinical motor subtypes: the prospective observational polish study (PROPOLIS). J Neuropsychiatry Clin Neurosci. 2019;31:104–111.
   PubMed Web of Science ®Google Scholar
• Hillis AE. For a theory of rehabilitation: progress in the decade of the brain. In: Halligan P, Wade D, editors. Effectiveness of rehabilitation of cognitive deficits. Oxford (UK): Oxford University Press; 2005. p. 271–280.
   Google Scholar
• Olsen TS. Post-stroke epilepsy. Curr Atheroscler Rep. 2001;3:340–344.
   PubMedGoogle Scholar
• Consoli D, Bosco D, Postorino P, et al. Levetiracetam versus carbamazepine in patients with late poststroke seizures: a multicenter prospective randomized open-label study (EpIC Project). Cerebrovascular Dis. 2012;34:282–289.
   PubMed Web of Science ®Google Scholar
• Brigo F, Lattanzi S, Zelano J, et al. Randomized controlled trials of antiepileptic drugs for the treatment of post-stroke seizures: a systematic review with network meta-analysis. Seizure. 2018;61:57–62.
   PubMed Web of Science ®Google Scholar
• Hermann DM, Schmidt MH, Bassetti CL. Sleep disorders associated with stroke. In S Overeem & P Reading, editors. Sleep disorders in neurology: A practical approach. Hoboken, NJ: John Wiley & Sons. 2018;301-318.
   Google Scholar
• Jehan S, Farag M, Zizi F, et al. Obstructive sleep apnea and stroke. Sleep Med Disord. 2018;2:120.
   PubMedGoogle Scholar
• Paolucci S, Iosa M, Toni D, et al. Prevalence and time course of post-stroke pain: a multicenter prospective hospital-based study. Pain Med. 2016;17:924–930.
   PubMed Web of Science ®Google Scholar
• Lindgren I, Brogårdh C, Gard G. Pain management strategies among persons with long-term shoulder pain after stroke–a qualitative study. Clin Rehabil. 2019;33:357–364.
   PubMed Web of Science ®Google Scholar
• Fink E. Central pain syndromes. In: Pain. New York (NY): Springer; 2019. p. 927–929.
   Google Scholar
• Kumar P. Hemiplegic shoulder pain in people with stroke: present and the future. Future Med. 2019;9:107–110.
   Google Scholar
• Yochelson M, Creamer M, Cloud G, et al. Intrathecal baclofen therapy versus conventional medical management in post-stroke spasticity: assessment of patient-reported outcome: quality of life, pain and satisfaction (SISTERS). Ann Phys Rehabil Med. 2018;61:e356.
   Google Scholar
• Shu Y, Qin Y. Advances in research on acupuncture combined with rehabilitation training for the treatment of Shoulder-hand syndrome after stroke. Classical Chin Med Res. 2019;2:63–66.
   Google Scholar
• Elsner B, Kugler J, Pohl M, et al. Transcranial direct current stimulation (tDCS) for improving aphasia in adults with aphasia after stroke. Cochrane Database Syst Rev. 2019(5). DOI:10.1002/14651858.CD009760.pub4
   PubMed Web of Science ®Google Scholar
• Fisicaro F, Lanza G, Grasso AA, et al. Repetitive transcranial magnetic stimulation in stroke rehabilitation: review of the current evidence and pitfalls. Ther Adv Neurol Disord. 2019;12:1756286419878317.
   Web of Science ®Google Scholar
• Fisicaro F, Lanza G, Bella R, et al. “Self-neuroenhancement”: the last frontier of noninvasive brain stimulation? J Clin Neurol. 2020;16:158–159.
   PubMed Web of Science ®Google Scholar
• Schabitz WR, Berger C, Kollmar R, et al. Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke. 2004;35:992–997.
   PubMed Web of Science ®Google Scholar
• Hillis AE, Beh JY, Sebastian R, et al. Predicting recovery in acute post-stroke aphasia. Ann Neurol. 2018;83:612–622.
   PubMed Web of Science ®Google Scholar
• Wright A, Tippett D, Saxena S, et al. Leukoaraiosis is independently associated with naming outcome in poststroke aphasia. Neurology. 2018;91:e526–32.
   PubMed Web of Science ®Google Scholar
• Bahrainwala ZS, Hillis AE, Dearborn J, et al. Neglect performance in acute stroke is related to severity of white matter hyperintensities. Cerebrovasc Dis. 2014;37:223–230.
   PubMed Web of Science ®Google Scholar
• Zeiler SR, Krakauer JW. The interaction between training and plasticity in the poststroke brain. Curr Opin Neurol. 2013;26:609–616.
   PubMed Web of Science ®Google Scholar
• Harris AD, Wang Z, Ficek B, et al. Reductions in GABA following a tDCS-language intervention for primary progressive aphasia. Neurobiol Aging. 2019;79:75–82.
   PubMed Web of Science ®Google Scholar
• Sebastian R, Saxena S, Tsapkini K, et al. Cerebellar tDCS: a novel approach to augment language treatment post-stroke. Front Hum Neurosci. 2017;10:695.
   PubMed Web of Science ®Google Scholar
• Keser Z, Breining B, Hillis AE. Improved integrity of left arcuate fasciculus after naming therapy is associated with gains in naming accuracy in post stroke aphasia. Stroke. 2019;30:119.
   Google Scholar