482
Views
13
CrossRef citations to date
0
Altmetric
Review

Emerging pharmacological strategies for the management of chemotherapy-induced peripheral neurotoxicity (CIPN), based on novel CIPN mechanisms

ORCID Icon, , & ORCID Icon
Pages 1005-1016 | Received 07 May 2020, Accepted 14 Jul 2020, Published online: 06 Aug 2020

References

  • Miller KD, Nogueira L, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 2019;69:363–385.
  • Cavaletti G, Alberti P, Argyriou AA, et al.; Toxic Neuropathy Consortium of the Peripheral Nerve Society. Chemotherapy-induced peripheral neurotoxicity: a multifaceted, still unsolved issue. J Peripher Nerv Syst. 2019;24(Suppl 2):S6–12.
  • Cavaletti G, Cornblath DR, Merkies ISJ, et al. Patients’ and physicians’ interpretation of chemotherapy-induced peripheral neurotoxicity. J Peripher Nerv Syst. 2019;24:111–119.
  • Dorsey SG, Kleckner IR, Barton D, et al. The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy. J Natl Cancer Inst. 2019;111:531–537.
  • Seretny M, Currie GL, Sena ES, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Pain. 2014;155:2461–2470.
  • Argyriou AA, Park SB, Islam B, et al.; Toxic Neuropathy Consortium (TNC). Neurophysiological, nerve imaging and other techniques to assess chemotherapy-induced peripheral neurotoxicity in the clinical and research settings. J Neurol Neurosurg Psychiatry. 2019;90:1361–1369.
  • Song X, Wilson KL, Kagan J, et al. Cost of peripheral neuropathy in patients receiving treatment for multiple myeloma: a US administrative claims analysis. Ther Adv Hematol. 2019;10:2040620719839025.
  • Tamburin S, Park SB, Alberti P, et al. Taxane and epothilone-induced peripheral neurotoxicity: from pathogenesis to treatment. J Peripher Nerv Syst. 2019;24(Suppl2):S40–51.
  • Islam B, Lustberg M, Staff NP, et al. Vinca alkaloids, thalidomide and eribulin-induced peripheral neurotoxicity: from pathogenesis to treatment. J Peripher Nerv Syst. 2019;24(Suppl2):S63–73.
  • Bechakra M, Nieuwenhoff MD, van Rosmalen J, et al. Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain. Mol Pain. 2018;14:1744806918797042.
  • Colvin LA. Chemotherapy-induced peripheral neuropathy: where are we now? Pain. 2019;160(Suppl1):S1–10.
  • Staff NP, Cavaletti G, Islam B, et al. Platinum-induced peripheral neurotoxicity: from pathogenesis to treatment. J Peripher Nerv Syst. 2019;24(Suppl2):S26–39.
  • Robertson J, Raizer J, Hodges JS, et al. Risk factors for the development of paclitaxel-induced neuropathy in breast cancer patients. J Peripher Nerv Syst. 2018;23:129–133.
  • Hershman DL, Till C, Wright JD, et al. Comorbidities and risk of chemotherapy-induced peripheral neuropathy among participants 65 years or older in southwest oncology group clinical trials. J Clin Oncol. 2016;34:3014–3022.
  • Greenwald MK, Ruterbusch JJ, Beebe-Dimmer JL, et al. Risk of incident claims for chemotherapy-induced peripheral neuropathy among women with breast cancer in a medicare population. Cancer. 2019;125:269–277.
  • Argyriou AA, Bruna J, Genazzani AA, et al. Chemotherapy-induced peripheral neurotoxicity: management informed by pharmacogenetics. Nat Rev Neurol. 2017;13:492–504.
  • Park SB, Alberti P, Kolb NA, et al. Overview and critical revision of clinical assessment tools in chemotherapy-induced peripheral neurotoxicity. J Peripher Nerv Syst. 2019;24(Suppl2):S13–25.
  • Calls A, Carozzi V, Navarro X, et al. Pathogenesis of platinum-induced peripheral neurotoxicity: insights from preclinical studies. Exp Neurol. 2020;325:113141.
  • Staff NP, Fehrenbacher JC, Caillaud M, et al. Pathogenesis of paclitaxel-induced peripheral neuropathy: a current review of in vitro and in vivo findings using rodent and human model systems. Exp Neurol. 2020;324:113121.
  • Kober KM, Olshen A, Conley YP, et al. Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors. Mol Pain. 2018;14:1744806918816462.
  • Trecarichi A, Flatters SJL. Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheral neuropathy. Int Rev Neurobiol. 2019;145:83–126.
  • Makker PG, Duffy SS, Lees JG, et al. Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy. PLoS One. 2017;12:e0170814.
  • Geisler S, Doan RA, Strickland A, et al. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain. 2016;139:3092–3108.
  • Pease-Raissi SE, Pazyra-Murphy MF, Li Y, et al. Paclitaxel reduces axonal bclw to initiate IP3R1-dependent axon degeneration. Neuron. 2017;96:373–386.
  • Bruna J, Velasco R. Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy. Neural Regen Res. 2018;13:775–778.
  • Bruna J, Videla S, Argyriou AA, et al. Efficacy of a novel sigma-1 receptor antagonist for oxaliplatin-induced neuropathy: a randomized, double-blind, placebo-controlled phase IIa clinical trial. Neurotherapeutics. 2018;15:178–189.
  • Lisse TS, Middleton LJ, Pellegrini AD, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016;113:E2189‐98.
  • Janes K, Little JW, Li C, et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014;289:21082–21097.
  • Stockstill K, Doyle TM, Yan X, et al. Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. J Exp Med. 2018;215:1301–1313.
  • Alé A, Bruna J, Morell M, et al. Treatment with anti-TNF alpha protects against the neuropathy induced by the proteasome inhibitor bortezomib in a mouse model. Exp Neurol. 2014;253:165–173.
  • Meregalli C, Marjanovic I, Scali C, et al. High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats. J Neuroinflammation. 2018;15:232.
  • Chua KC, Xiong C, Ho C, et al. Genome-wide meta-analysis validates a role for S1PR1 in microtubule targeting agent-induced sensory peripheral neuropathy. Clin Pharmacol Ther. 2020. DOI:10.1002/cpt.1958
  • Sprowl JA, Ong SS, Gibson AA, et al. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016;7:10880.
  • Stojanovska V, McQuade R, Rybalka E, et al. Neurotoxicity associated with platinum-based anti-cancer agents: what are the implications of copper transporters? Curr Med Chem. 2017;24:1520–1536.
  • Fujita S, Hirota T, Sakiyama R, et al. Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy. J Neurochem. 2019;148:373–385.
  • Leblanc AF, Sprowl JA, Alberti P, et al. OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity. J Clin Invest. 2018;128:816–825.
  • Stage TB, Mortensen C, Khalaf S, et al. P-glycoprotein inhibition exacerbates paclitaxel neurotoxicity in neurons and cancer patients. Clin Pharmacol Ther. 2020 Apr 10. DOI:10.1002/cpt.1847
  • Grube M, Ameling S, Noutsias M, et al. Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy. Am J Pathol. 2011;178:2547–2559.
  • Fu C, Gombos DS, Lee J, et al. Ocular toxicities associated with targeted anticancer agents: an analysis of clinical data with management suggestions. Oncotarget. 2017;8:58709–58727.
  • Ferdousi M, Azmi S, Petropoulos IN, et al. Corneal confocal microscopy detects small fibre neuropathy in patients with upper gastrointestinal cancer and nerve regeneration in chemotherapy induced peripheral neuropathy. PLoS One. 2015;10:e0139394.
  • Kim HS, Guo C, Thompson EL, et al. APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER. Mutat Res. 2015;779:96–104.
  • Kelley MR, Wikel JH, Guo C, et al. Identification and characterization of new chemical entities targeting apurinic/apyrimidinic endonuclease 1 for the prevention of chemotherapy-induced peripheral neuropathy. J Pharmacol Exp Ther. 2016;359(2):300–309.
  • Glimelius B, Manojlovic N, Pfeiffer P, et al. Persistent prevention of oxaliplatin-induced peripheral neuropathy using calmangafodipir (PledOx(®)): a placebo-controlled randomised phase II study (PLIANT). Acta Oncol. 2018;57:393–402.
  • Areti A, Komirishetty P, Kumar A. Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy. Toxicol Appl Pharmacol. 2017;322:97–103.
  • Bordet T, Berna P, Abitbol JL, et al. Olesoxime (TRO19622): a novel mitochondrial-targeted neuroprotective compound. Pharmaceuticals (Basel). 2010;3:345–368.
  • Aureli M, Mauri L, Ciampa MG, et al. GM1 ganglioside: past studies and future potential. Mol Neurobiol. 2016;53:1824–1842.
  • Ferrari G, Anderson BL, Stephens RM, et al. Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. J Biol Chem. 1995;270:3074–3080.
  • San Gil R, Ooi L, Yerbury JJ, et al. The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Mol Neurodegener. 2017;12:65.
  • Zhu J, Chen W, Mi R, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013;74:893–904.
  • Zhu J, Carozzi VA, Reed N, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016;6:28861.
  • Mendillo ML, Santagata S, Koeva M, et al. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 2012;150:549–562.
  • Shevtsov M, Multhoff G, Mikhaylova E, et al. Combination of anti-cancer drugs with molecular chaperone inhibitors. Int J Mol Sci. 2019;20:5284.
  • Hershman DL, Lacchetti C, Dworkin RH, et al.; American Society of Clinical Oncology. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American society of clinical oncology clinical practice guideline. J Clin Oncol. 2014;32:1941–1967.
  • Smith EM, Pang H, Cirrincione C, et al.; Alliance for Clinical Trials in Oncology. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309:1359–1367.
  • Barton DL, Wos EJ, Qin R, et al. A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Support Care Cancer. 2011;19:833–841.
  • Karlsson JOG, Jynge P. Is it possible to draw firm conclusions from the PLIANT trial? Acta Oncol. 2018;57:862–864.
  • Su Y, Huang J, Wang S, et al. The effects of ganglioside-monosialic acid in taxane-induced peripheral neurotoxicity in patients with breast cancer: a randomized trial. J Natl Cancer Inst. 2020;112:55–62.
  • Wang DS, Wang ZQ, Chen G, et al. Phase III randomized, placebo-controlled, double-blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin-induced peripheral neurotoxicity in stage II/III colorectal cancer. Cancer Med. 2020;9:151–159.
  • Vela JM, Merlos M, Almansa C. Investigational sigma-1 receptor antagonists for the treatment of pain. Expert Opin Investig Drugs. 2015;24:883–896.
  • Aghili M, Zare M, Mousavi N, et al. Efficacy of gabapentin for the prevention of paclitaxel induced peripheral neuropathy: a randomized placebo controlled clinical trial. Breast J. 2019;25:226–231.
  • Shinde SS, Seisler D, Soori G, et al. Can pregabalin prevent paclitaxel-associated neuropathy?-An ACCRU pilot trial. Support Care Cancer. 2016;24:547–553.
  • Salehifar E, Janbabaei G, Hendouei N, et al. Comparison of the efficacy and safety of pregabalin and duloxetine in taxane-induced sensory neuropathy: a randomized controlled trial. Clin Drug Investig. 2020;40:249–257.
  • Kim BS, Jin JY, Kwon JH, et al. Efficacy and safety of oxycodone/naloxone as add-on therapy to gabapentin or pregabalin for the management of chemotherapy-induced peripheral neuropathy in Korea. Asia Pac J Clin Oncol. 2018;14:e448–54.
  • Song SY, Ko YB, Kim H, et al. Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: a meta-analysis. Medicine (Baltimore). 2020;99:e18653.
  • Farshchian N, Alavi A, Heydarheydari S, et al. Comparative study of the effects of venlafaxine and duloxetine on chemotherapy-induced peripheral neuropathy. Cancer Chemother Pharmacol. 2018;82:787–793.
  • Argyriou AA, Kalofonou F, Litsardopoulos P, et al. Real world, open label experience with lacosamide against acute painful oxaliplatin-induced peripheral neurotoxicity. J Peripher Nerv Syst. 2020;25:178–183.
  • Pfeiffer P, Qvortrup C, Muro K, et al. The Global POLAR program: calmangafodipir used on top of modified FOLFOX6 (5-FU/FA and oxaliplatin) to prevent chemotherapy induced peripheral neuropathy. J Clin Oncol. 2018;37(4suppl):TPS722.
  • PLEDPharma Media Release, STO: PLED. [ cited 2020 July 10]. Available from: https://www.pledpharma.com/mfn_news/pledpharma-to-close-polar-phase-3-program-in-the-third-quarter/
  • Geisler S, Doan RA, Cheng GC, et al. Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. JCI Insight. 2019;4(17):e129920.
  • Hamity MV, White SR, Walder RY, et al. Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats. Pain. 2017;158:962–972.
  • Angeli A, Di Cesare Mannelli L, Ghelardini C, et al. Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur J Med Chem. 2019;177:188–197.
  • van den Heuvel SAS, van der Wal SEI, Smedes LA, et al. Intravenous lidocaine: old-school drug, new purpose-reduction of intractable pain in patients with chemotherapy induced peripheral neuropathy. Pain Res Manag. 2017;2017:8053474.
  • Favre-Guilmard C, Auguet M, Chabrier PE. Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models. Eur J Pharmacol. 2009;617:48–53.
  • Lynch ME, Cesar-Rittenberg P, Hohmann AG. A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. J Pain Symptom Manage. 2014;47:166–173.
  • Fallon MT, Storey DJ, Krishan A, et al. Cancer treatment-related neuropathic pain: proof of concept study with menthol-a TRPM8 agonist. Support Care Cancer. 2015;23:2769–2777.
  • Thompson T, Whiter F, Gallop K, et al. NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials. Neurology. 2019;92:e1652–62.
  • Park BY, Park SH, Kim WM, et al. Antinociceptive effect of memantine and morphine on vincristine-induced peripheral neuropathy in rats. Korean J Pain. 2010;23:179–185.
  • Cavaletti G, Marmiroli P. Pharmacotherapy options for managing chemotherapy-induced peripheral neurotoxicity. Expert Opin Pharmacother. 2018;19:113–121.
  • Gewandter JS, Brell J, Cavaletti G, et al. Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations. Neurology. 2018;91:403–413.
  • Frigeni B, Piatti M, Lanzani F, et al. Chemotherapy-induced peripheral neurotoxicity can be misdiagnosed by the national cancer institute common toxicity scale. J Peripher Nerv Syst. 2011;16:228–236.
  • Gewandter JS, Dworkin RH, Finnerup NB, et al. Painful chemotherapy-induced peripheral neuropathy: lack of treatment efficacy or the wrong clinical trial methodology? Pain. 2017;158:30–33.
  • Alvarez P, Levine JD. Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain. Neuroscience. 2015;311:499–507.
  • Kumar R, Ryan D. Lorcaserin departs, leaving more questions than answers. Obesity. 2020;28(7):1167.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.