Developments in combined analgesic regimens for improved safety in postoperative pain management

References

• Unsal A, Karakurt P, Bahceli A. Exploring factors that affected pain severity in postoperative period. Int J Caring Sci. 2019;12:501–510.
   Google Scholar
• Pozek JP, Beausang D, Baratta JL, et al. The acute to chronic pain transition: can chronic pain be prevented? Med Clin North Am. 2016 Jan;100(1):17–30.
   PubMed Web of Science ®Google Scholar
• Sharrock N, Cazan M, Hargett M, et al. Changes in mortality after total hip and knee arthroplasty over a ten-year period. Anesth Analg. 1995;80, p. 244.
   Web of Science ®Google Scholar
• Pergolizzi JV, Joseph VP, Raffa RB, et al. Continuous multimechanistic postoperative Analgesia: a rationale for transitioning from intravenous acetaminophen and opioids to oral formulations (Report). Pain Pract. 2012 Feb;12(2):159.
   PubMed Web of Science ®Google Scholar
• Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain–United States, 2016. J Am Med Assoc. 2016;19(15):1624–1645.
   Google Scholar
• Chou R, Gordon DB, de Leon-casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the american pain society, the American society of regional Anesthesia and pain medicine, and the American society of anesthesiologists’ committee on regional Anesthesia, executive committee, and administrative council. J Pain. 2016 Feb;17(2):131–157.
   PubMed Web of Science ®Google Scholar
• Morlion B, Coluzzi F, Aldington D, et al. Pain chronification: what should a non-pain medicine specialist know? Curr Med Res Opin. 2018 Jul;34(7):1169–1178.
   PubMed Web of Science ®Google Scholar
• Varrassi G, Hanna M, Macheras G, et al. Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol. Curr Med Res Opin. 2017 Jun;33(6):1165–1173.
   PubMed Web of Science ®Google Scholar
• Sutters KA, Miaskowski C, Taiwo YO, et al. Analgesic synergy and improved motor function produced by combinations of mu-delta- and mu-kappa-opioids. Brain Res. 1990 Oct;22(530):290–294.
   Google Scholar
• White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg. 2005 Nov;101(5 Suppl):S5–22.
   PubMed Web of Science ®Google Scholar
• Liu B, Liu R, Wang L. A meta-analysis of the preoperative use of gabapentinoids for the treatment of acute postoperative pain following spinal surgery. Medicine (Baltimore). 2017 Sep;96(37):e8031.
   PubMed Web of Science ®Google Scholar
• Gabriel RA, Swisher MW, Sztain JF, et al. State of the art opioid-sparing strategies for post-operative pain in adult surgical patients. Expert Opin Pharmacother. 2019 Jun;20(8):949–961.
   PubMed Web of Science ®Google Scholar
• Kumar AH, Habib AS. The role of gabapentinoids in acute and chronic pain after surgery. Curr Opin Anaesthesiol. 2019 Oct;32(5):629–634.
   PubMed Web of Science ®Google Scholar
• Malan TP Jr., Marsh G, Hakki SI, et al. Parecoxib sodium, a parenteral cyclooxygenase 2 selective inhibitor, improves morphine analgesia and is opioid-sparing following total hip arthroplasty. Anesthesiology. 2003 Apr;98(4):950–956.
   PubMed Web of Science ®Google Scholar
• Lewis SC, Langman MJ, Laporte JR, et al. Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data. Br J Clin Pharmacol. 2002 Sep;54(3):320–326.
   PubMed Web of Science ®Google Scholar
• Patrono C, Baigent C. Coxibs, traditional NSAIDs, and cardiovascular safety post-PRECISION: what we thought we knew then and what we think we know now. Clin Pharmacol Ther. 2017 Aug;102(2):238–245.
   PubMed Web of Science ®Google Scholar
• Aminoshariae A, Khan A. Acetaminophen: old drug, new issues. J Endod. 2015 May;41(5):588–593.
   PubMed Web of Science ®Google Scholar
• Thennarasu P, Rani NV, Ragesh G, et al. Study on safety and efficacy of different modalities in the postoperative pain management in a tertiary care teaching hospital. Int J Pharm Sci Res. 2018;9:2999.
   Web of Science ®Google Scholar
• Daniels SE, Atkinson HC, Stanescu I, et al. Analgesic efficacy of an acetaminophen/ibuprofen fixed-dose combination in moderate to severe postoperative dental pain: a randomized, double-blind, parallel-group, placebo-controlled trial. Clin Ther. 2018;40(10):1765–1766.
   PubMed Web of Science ®Google Scholar
• Singla N, Margulis R, Kostenbader K, et al. Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. Phys Sportsmed. 2015;43(2):126–137.
   PubMed Web of Science ®Google Scholar
• Cho C-H, Song K-S, Min B-W, et al. Multimodal approach to postoperative pain control in patients undergoing rotator cuff repair. Knee surgery, sports traumatology, arthroscopy. Off J ESSKA. 2011;19:1744–1748.
   Google Scholar
• Coluzzi F, Bragazzi L, Di Bussolo E, et al. Determinants of patient satisfaction in postoperative pain management following hand ambulatory day-surgery. Minerva Med. 2011 Jun;102(3):177–186.
   PubMed Web of Science ®Google Scholar
• Mattia C, Coluzzi F. A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy. Eur Rev Med Pharmacol Sci. 2015;19(3):507–516.
   PubMed Web of Science ®Google Scholar
• Habibi M, Kim PY. Hydrocodone and Acetaminophen. StatPearls. 2020 April. PMID: 30860765.
   Google Scholar
• Oldfield V, Perry CM. Oxycodone/Ibuprofen combination tablet: a review of its use in the management of acute pain. Drugs. 2005;65(16):2337–2354.
   PubMed Web of Science ®Google Scholar
• Derry S, Derry CJ, Moore RA. Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults. Cochrane Database Syst Rev. 2013;6:CD010289.
   Google Scholar
• Munafo MR, Stevenson J. Anxiety and surgical recovery. Reinterpreting the literature. J Psychosom Res. 2001 Oct;51(4):589–596.
   PubMed Web of Science ®Google Scholar
• Caumo W, Schmidt AP, Schneider CN, et al. Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery. Acta Anaesthesiol Scand. 2002 Nov;46(10):1265–1271.
   PubMed Web of Science ®Google Scholar
• Kalkman CJ, Visser K, Moen J, et al. Preoperative prediction of severe postoperative pain. Pain. 2003 Oct;105(3):415–423.
   PubMed Web of Science ®Google Scholar
• Pavlin DJ, Sullivan MJ, Freund PR, et al. Catastrophizing: a risk factor for postsurgical pain. Clin J Pain. 2005 Jan-Feb;21(1):83–90.
   PubMed Web of Science ®Google Scholar
• Granot M, Ferber SG. The roles of pain catastrophizing and anxiety in the prediction of postoperative pain intensity: a prospective study. Clin J Pain. 2005 Sep-Oct;21(5):439–445.
   PubMed Web of Science ®Google Scholar
• Aubrun F, Valade N, Coriat P, et al. Predictive factors of severe postoperative pain in the postanesthesia care unit. Anesth Analg. 2008 May;106(5):1535–1541.
   PubMed Web of Science ®Google Scholar
• Ip HY, Abrishami A, Peng PW, et al. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology. 2009 Sep;111(3):657–677.
   PubMed Web of Science ®Google Scholar
• Rago R, Forfori F, Materazzi G, et al. Evaluation of a preoperative pain score in response to pressure as a marker of postoperative pain and drugs consumption in surgical thyroidectomy. Clin J Pain. 2012 Jun;28(5):382–386.
   PubMed Web of Science ®Google Scholar
• Ahn ST, Kim JH, Park JY, et al. Acute postoperative pain after ureteroscopic removal of stone: incidence and risk factors. Korean J Urol. 2012 Jan;53(1):34–39.
   PubMedGoogle Scholar
• Sommer M, de Rijke JM, van Kleef M, et al. The prevalence of postoperative pain in a sample of 1490 surgical inpatients. Eur J Anaesthesiol. 2008 Apr;25(4):267–274.
   PubMed Web of Science ®Google Scholar
• Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007 Apr;89(4):780–785.
   PubMed Web of Science ®Google Scholar
• National Quality Forum. Surgery 2015-2017 final report Washington, DC: National Quality Forum; 2017 cited 2019 Nov 9. Available from: https://www.qualityforum.org/Publications/2017/04/Surgery_2015-2017_Final_Report.aspx
   Google Scholar
• Hall M, Schwartzman A, Zhang J, et al. Ambulatory surgeyr data from hospitals and ambulatory surgical centers: united States, 2010 Washington, DC: U.S. Department of Health and Human Services; 2017 cited 2019 Nov 9. Available from: https://www.cdc.gov/nchs/data/nhsr/nhsr102.pdf
   Google Scholar
• Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017;10:2287–2298.
   PubMed Web of Science ®Google Scholar
• Shang AB, Gan TJ. Optimising postoperative pain management in the ambulatory patient. Drugs. 2003;63(9):855–867.
   PubMed Web of Science ®Google Scholar
• Beloeil H, Albaladejo P, Sion A, et al. Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study. Br J Anaesth. 2019;122(6):e98–e106.
   PubMed Web of Science ®Google Scholar
• Dahl JB, Nielsen RV, Wetterslev J, et al. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. Acta Anaesthesiol Scand. 2014 Nov;58(10):1165–1181.
   PubMed Web of Science ®Google Scholar
• Maund E, McDaid C, Rice S, et al. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011 Mar;106(3):292–297.
   PubMed Web of Science ®Google Scholar
• Chen LC, Elliott RA, Ashcroft DM. Systematic review of the analgesic efficacy and tolerability of COX‐2 inhibitors in post‐operative pain control. J Clin Pharm Ther. 2004;29(3):215–229.
   PubMed Web of Science ®Google Scholar
• Varrassi G, Pergolizzi JV, Dowling P, et al. Ibuprofen safety at the golden anniversary: are all NSAIDs the same? A narrative review. Adv Ther. 2019;37(1): 61–82.
   PubMed Web of Science ®Google Scholar
• Cooper C, Chapurlat R, Al-Daghri N, et al. Safety of oral non-selective non-steroidal anti-inflammatory drugs in osteoarthritis: what does the literature say? Drugs Aging. 2019;36(Suppl 1):15–24.
   PubMed Web of Science ®Google Scholar
• Harbin M, Turgeon RD, Kolber MR. Cardiovascular safety of NSAIDs. Cana Family Physician Med Famille Canadien. 2014;60(3):e166–e166.
   PubMed Web of Science ®Google Scholar
• Radi ZA, Khan KN. Cardio-renal safety of non-steroidal anti-inflammatory drugs. J Toxicol Sci. 2019;44(6):373–391.
   PubMed Web of Science ®Google Scholar
• Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16(5):821–847.
   PubMed Web of Science ®Google Scholar
• Weir MR. Renal effects of nonselective NSAIDs and coxibs. Cleve Clin J Med. 2002;69(Suppl 1):Si53–8.
   PubMedGoogle Scholar
• Solomon DH, Husni ME, Libby PA, et al. The risk of major NSAID toxicity with celecoxib, ibuprofen, or naproxen: a secondary analysis of the PRECISION trial. Am J Med. 2017 Dec;130(12):1415–1422.
   PubMed Web of Science ®Google Scholar
• Antman EM, Bennett JS, Daugherty A, et al. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115(12):1634–1642.
   PubMed Web of Science ®Google Scholar
• Teerawattananon C, Tantayakom P, Suwanawiboon B, et al. Risk of perioperative bleeding related to highly selective cyclooxygenase-2 inhibitors: A systematic review and meta-analysis. Semin Arthritis Rheum. 2017 Feb;46(4):520–528.
   PubMed Web of Science ®Google Scholar
• Maslin B, Lipana L, Roth B, et al. Safety considerations in the use of ketorolac for postoperative pain. Curr Drug Saf. 2017;12(1):67–73.
   PubMed Web of Science ®Google Scholar
• McQuay H, Edwards J. Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. Eur J Anaesthesiol Suppl. 2003;28:19–22.
   PubMedGoogle Scholar
• Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010 Jul;26(7):1715–1731.
   PubMed Web of Science ®Google Scholar
• Raffa RB, Friderichs E, Reimann W, et al. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an ‘atypical’ opioid analgesic. J Pharmacol Exp Ther. 1992 Jan;260(1):275–285.
   PubMed Web of Science ®Google Scholar
• Jung Y-S, Kim DK, Kim M-K, et al. Onset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: A single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain model. Clin Ther. 2004;26(7):1037–1045.
   PubMed Web of Science ®Google Scholar
• Rawal N, Macquaire V, Catala E, et al. Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial. J Pain Res. 2011 Apr;8(4):103–110.
   Google Scholar
• Dogar AS, Khan AF. Tramadol-paracetamol combination for postoperative pain relief in elective single-level microdisectomy surgery. J Neurosurg Anesthesiol. 2017;29(2):157–160.
   PubMed Web of Science ®Google Scholar
• Wei W, Zhao T, Li Y. Efficacy and safety of parecoxib sodium for acute postoperative pain: a meta-analysis. Exp Ther Med. 2013;6(2):525–531.
   PubMed Web of Science ®Google Scholar
• McQuay HJ, Moore RA, Berta A, et al. Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty. Br J Anaesth. 2016 Feb;116(2):269–276.
   PubMed Web of Science ®Google Scholar
• Varrassi G, Coaccioli S, De-Andres J, et al. Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study. Adv Ther. 2019 Nov;36(11):3174–3185.
   PubMed Web of Science ®Google Scholar
• GroenewaldCB. Combining morphine and ibuprofen does not improve pain control compared with using either drug alone following musculoskeletal injury in children. Evid Based Nurs. 2018 Oct;21:107.
   Google Scholar
• Hubbard RC, Naumann TM, Traylor L, et al. Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia. Br J Anaesth. 2003 Feb;90(2):166–172.
   PubMed Web of Science ®Google Scholar
• Tang J, Li S, White PF, et al. Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control. Anesthesiology. 2002 Jun;96(6):1305–1309.
   PubMed Web of Science ®Google Scholar
• Diaz-Borjon E, Torres-Gomez A, Essex MN, et al. Parecoxib provides analgesic and opioid-sparing effects following major orthopedic surgery: a subset analysis of a randomized, placebo-controlled clinical trial. Pain Ther. 2017;6(1):61–72.
   PubMed Web of Science ®Google Scholar
• Legeby M, Sandelin K, Wickman M, et al. Analgesic efficacy of diclofenac in combination with morphine and paracetamol after mastectomy and immediate breast reconstruction. Acta Anaesthesiol Scand. 2005 Oct;49(9):1360–1366.
   PubMed Web of Science ®Google Scholar
• Fayaz MK, Abel RJ, Pugh SC, et al. Opioid-sparing effects of diclofenac and paracetamol lead to improved outcomes after cardiac surgery. J Cardiothorac Vasc Anesth. 2004 Dec;18(6):742–747.
   PubMed Web of Science ®Google Scholar
• McDaid C, Maund E, Rice S, et al. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review. Health Technol Assess. 2010 Mar;14(17):1–153,iii–iv.
   PubMed Web of Science ®Google Scholar
• Lee YW, Kim YJ, Kim JM, et al. Efficacy and safety of transdermal fentanyl in the control of postoperative pain after photorefractive keratectomy. J Ocul Pharmacol Ther. 2014 Nov 01;30(9):783–789.
   PubMed Web of Science ®Google Scholar
• Karam JA, Zmistowski B, Restrepo C, et al. Fewer postoperative fevers: an unexpected benefit of multimodal pain management? Clin Orthop Relat Res. 2014 May;472(5):1489–1495.
   PubMed Web of Science ®Google Scholar
• Ross F, Wallis S, Smith MA. Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain. 2000;84(2):421–428.
   PubMed Web of Science ®Google Scholar
• Mizoguchi H, Spaulding A, Leitermann R, et al. Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse. J Pharmacol Exp Ther. 2003 Jul;306(1):394–400.
   PubMed Web of Science ®Google Scholar
• Morgan D, Cook CD, Smith MA, et al. An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensity. Anesth Analg. 1999 Feb;88(2):407–413.
   PubMed Web of Science ®Google Scholar
• Pergolizzi J, Aloisi AM, Dahan A, et al. Current knowledge of buprenorphine and its unique pharmacological profile. Pain Pract. 2010 Sep-Oct;10(5):428–450.
   PubMed Web of Science ®Google Scholar
• Oifa S, Sydoruk T, White I, et al. Effects of intravenous patient-controlled analgesia with buprenorphine and morphine alone and in combination during the first 12 postoperative hours: A randomized, double-blind, four-arm trial in adults undergoing abdominal surgery. Clin Ther: Int Peer-Rev J Drug Ther. 2009;31(3):527–541.
   Google Scholar
• Richards P, Gimbel JS, Minkowitz HS, et al. Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. Clin Ther. 2013;35(4):498–511.
   PubMed Web of Science ®Google Scholar
• Richards P, Riff D, Kelen R, et al. Analgesic and adverse effects of a fixed-ratio morphine-oxycodone combination (MoxDuo) in the treatment of postoperative pain. J Opioid Manag. 2011;7(3):217–228.
   PubMedGoogle Scholar
• Richards P, Riff D, Kelen R, et al. A phase 3, randomized, double‐blind comparison of analgesic efficacy and tolerability of Q8003 vs oxycodone or morphine for moderate‐to‐severe postoperative pain following bunionectomy surgery. Pain Med. 2013 Aug;14(8):1230–1289.
   PubMed Web of Science ®Google Scholar
• Pergolizzi J. Orphengesic Forte: a multimodal opioid alternative for the treatment of mild to moderate musculoskeletal pain 2019 cited 2019 Nov 30. Available from: https://www.painmedicinenews.com/Monographs-Whitepapers/Article/10-19/Orphengesic-Forte-A-Multimodal-Opioid-Alternative-for-the-Treatment-of-Mild-to-Moderate-Musculoskeletal-Pain/56298
   Google Scholar
• Orphenadrine. LiverTox: clinical and research information on drug-induced liver injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
   Google Scholar
• Bedwell JR, Pierce M, Levy M, et al. Ibuprofen with acetaminophen for postoperative pain control following tonsillectomy does not increase emergency department utilization. Otolaryngol Head Neck Surg. 2014;151(6):963–966.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. FDA drug safety communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women Rockville, Maryland: Food and Drug Administration; 2017 cited 2019 Dec 9. Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-restricts-use-prescription-codeine-pain-and-cough-medicines-and
   Google Scholar
• European Medicines Agency. Codeine-containing medicinal products for the treatment of cough or cold in pediatric patients Amsterdam, The Netherlands: European Medicines Agency; 2015 cited 2019 Dec 9. Available from: https://www.ema.europa.eu/en/about-us/contacts-european-medicines-agency
   Google Scholar
• Heintze K, Fuchs W. Codeine ultra-rapid metabolizers: age appears to be a key factor in adverse effects of codeine. Drug Res (Stuttg). 2015 Dec;65(12):640–644.
   PubMed Web of Science ®Google Scholar
• Freedman-Weiss MR, Chiu AS, Worhunsky D, et al. An evidence-based guideline supporting restricted opioid prescription after pediatric appendectomy. J Pediatr Surg. 2020;55(1):106–111.
   PubMed Web of Science ®Google Scholar
• Park SJ, Shin S, Kim SH, et al. Comparison of dexmedetomidine and fentanyl as an adjuvant to ropivacaine for postoperative epidural analgesia in pediatric orthopedic surgery. Yonsei Med J. 2017 May;58(3):650–657.
   PubMed Web of Science ®Google Scholar
• Pollak U, Bronicki RA, Achuff BJ, et al. Postoperative pain management in pediatric patients undergoing cardiac surgery: where are we heading? J Intensive Care Med. 2019Aug;25:885066619871432.
   Google Scholar
• Eerdekens M, Beuter C, Lefeber C, et al. The challenge of developing pain medications for children: therapeutic needs and future perspectives. J Pain Res. 2019;12:1649–1664.
   PubMed Web of Science ®Google Scholar