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Perspective

The insidious impact of under-diagnosed proximal weakness induced by statins

Pages 267-275 | Received 06 Sep 2020, Accepted 17 Dec 2020, Published online: 24 Dec 2020

References

  • Fabiana R, Santos RD. The role of statins in current guidelines. Curr Atheroscler Rep. 2020;22:50.
  • Amarenco P, Bogousslavsky J, Callahan A, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355:549–559.
  • Chou R, Dana T, Blazina I, et al. Statins for prevention of cardiovascular disease in adults: evidence report and systematic review for the US preventive services task force. JAMA. 2016;316:2008–2024.
  • Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact of statin therapy – European atherosclerosis society consensus panel statement on assessment, aetiology and management. Eur Heart J. 2015;36:1012–1022.
  • Newman CB, Preiss D, Tobert JA, et al. Statin safety and associated adverse events: a scientific statement from the American heart association. Arterioscler Thromb Vasc Biol. 2019;39:e38–81.
  • Rosenson RS, Baker SK, Jacobson TA, et al. The National Lipid Association’s Muscle Safety Expert Panel. An assessment by the statin muscle safety task force: 2014 update. J Clin Lipidol. 2014;8(Suppl):S58–S71.
  • Abdullah K, Rohatgi A. Statins: practical considerations – a review. Eur Cardiol Rev. 2014;9: 71–75.
  • Lemstra M, Blackburn D, Crawley A, et al. Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis. Can J Cardiol. 2012;28:574–580.
  • Cohen JD, Brinton EA, Ito MK, et al. Understanding statin use in America and gaps in patient education (USAGE): an internet-based survey of 10,138 current and former statin users. J Clin Lipidol. 2012;6:208–215.
  • Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients–the PRIMO study. Cardiovasc Drugs Ther. 2005;19:403–414.
  • Lowenstern A, Navar AM, Li S, et al. Association of clinician knowledge and statin beliefs with statin therapy use and lipid levels (a survey of US practice in the PALM registry). Am J Cardiol. 2019;123:1011–1018.
  • Bradley CK, Wang TY, Li S, et al. Patient-reported reasons for declining or discontinuing statin therapy: insights from the PALM registry. J Am Heart Assoc. 2019;8:e011765.
  • Nelson AJ, Puri R, Nissen SE. Statins in a distorted mirror of media. Curr Atheroscler Rep. 2020;22:37.
  • Nissen SE, Stroes E, Dent-Acosta RE, et al.; GAUSS-3 Investigators. Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial. JAMA. 2016;315:1580–1590.
  • Wood FA, Howard JP, Finegold JA, et al. N-of-1 trial of a statin, placebo, or no treatment to assess side effects. N Eng J Med. 2020 Nov 15;383(22):2182–2184.
  • Dobkin BH. Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments. Neurorehabil Neural Repair. 2008;22:105–110.
  • Dobkin BH. Underappreciated statin-induced myopathic weakness causes disability. Neurorehabil Neural Repair. 2005;19(3):259–263.
  • Gras-Champel V, Batteux B, Masmoudi K, et al. Statin induced myasthenia: a disproportionality analysis of the WHO’s VigiBase pharmacovigilance database. Muscle Nerve. 2019;60:382–386.
  • Oh S, Dhall R, Young A, et al. Statins may aggravate myasthenia gravis. Muscle Nerve. 2008;38:1101–1107.
  • Janssen L, Allard NAE, Saris CGJ, et al. Muscle toxicity of drugs: when drugs turn physiology into pathophysiology. Physiol Rev. 2020;100:633–672.
  • Muntean DM, Thompson PD, Catapano AL, et al. Statin-associated myopathy and the quest for biomarkers: can we effectively predict statin-associated muscle symptoms? Drug Discov Today. 2017;22:85–96.
  • Collins R, Reith C, Emberson J, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. 2016;388:2532–2561.
  • Ganga HV, Slim HB, Thompson PD. A systematic review of statin-induced muscle problems in clinical trials. Am Heart J. 2014;168:6–15.
  • Parker BA, Capizzi JA, Grimaldi A, et al. The effect of statins on skeletal muscle function. Circulation. 2013;127:96–103.
  • Rosenson RS, Miller K, Bayliss M, et al. The statin-associated muscle symptom clinical index (SAMS-CI): revision for clinical use, content validation, and interrater reliability. Cardiovasc Drugs Ther. 2017;31:179–186.
  • Phillips PS, Haas RH, Bannykh S, et al. Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 2002;137:581–585.
  • Fernandez G, Spatz ES, Jablecki C, et al. Statin myopathy: a common dilemma not reflected in clinical trials. Clevel Clin J Med. 2011;78:393–403.
  • Scott D, Blizzard L, Fell J, et al. Statin therapy, muscle function and falls risk in community-dwelling older adults. Q J Med. 2009;102:625–633.
  • Panza GA, Taylor BA, Dada MR, et al. Changes in muscle strength in individuals with statin-induced myopathy. J Clin Lipidol. 2015;9:351–356.
  • Taylor BA, Lorson L, White M, et al. A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy. Atherosclerosis. 2015;238:329–335.
  • Goldberg AC, Leiter LA, Stroes ESG, et al. Effect of bempedoic acid vs placebo added to maximally tolerated statin on low-density lipoprotein cholesterol in patients at high risk for cardiovascular disease: the CLEAR Wisdom randomized clinical trial. JAMA. 2019;322:1780–1788.
  • Ray KK, Bays HE, Catapano AL, et al. For the CLEAR Harmony Trial. Safety and efficacy of bempedoic acid to reduce LDL cholesterol. N Engl J Med. 2019;380:1022–1032.
  • Cholesterol Treatment Trialists’ Collaboration. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet. 2019;393:407–415.
  • Burke MJ. “It’s all in your head” – medicine’s silent epidemic. JAMA Neurol. 2019;76:1417–1418.

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