3,108
Views
4
CrossRef citations to date
0
Altmetric
Review

Suicidality and antiepileptic drugs in people with epilepsy: an update

Pages 405-410 | Received 07 Feb 2022, Accepted 07 Apr 2022, Published online: 13 Apr 2022

References

  • Busko M. FDA advisory members agree antiepileptics pose suicidality risk, need for black-box warning. Medscape Medical News. 2008.
  • Mula M, Kanner AM, Schmitz B, et al. Antiepileptic drugs and suicidality: an expert consensus statement from the task force on therapeutic strategies of the ilae commission on neuropsychobiology. Epilepsia. 2013;54:199–203.
  • Arana A, Wentworth CE, Ayuso-Mateos JL, et al. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med. 2010;363:542–551.
  • Gibbons RD, Hur K, Brown CH, et al. Gabapentin and suicide attempts. Pharmacoepidemiol Drug Saf. 2010;19:1241–1247.
  • Pugh MJV, Hesdorffer D, Wang C-P, et al. Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior. Neurology. 2013;81:1900–1906.
  • Josephson CB, Engbers JDT, Jette N, et al. Prescription trends and psychiatric symptoms following first receipt of one of seven common antiepileptic drugs in general practice. Epilepsy Behav. 2018;84:49–55.
  • Klein P, Devinsky O, French J, et al. Suicidality risk of newer antiseizure medications: a meta-analysis. JAMA Neurol. 2021;78:1118–1127.
  • Olesen JB, Hansen PR, Erdal J, et al. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf. 2010;19:518–524.
  • VanCott AC, Cramer JA, Copeland LA, et al. Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system. BMC Med. 2010;8:4.
  • Patorno E, Bohn RL, Wahl PM, et al. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA. 2010;303:1401–1409.
  • Andersohn F, Schade R, Willich SN, et al. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology. 2010;75:335–340.
  • Raju Sagiraju HK, Wang C-P, Amuan ME, et al. Antiepileptic drugs and suicide-related behavior: is it the drug or comorbidity? Neurol Clin Pract. 2018;8:331–339.
  • Pugh MJV, Copeland LA, Zeber JE, et al. Antiepileptic drug monotherapy exposure and suicide-related behavior in older veterans. J Am Geriatr Soc. 2012;60:2042–2047.
  • Dreier JW, Pedersen CB, Gasse C, et al. Antiepileptic drugs and suicide: role of prior suicidal behavior and parental psychiatric disorder. Ann Neurol. 2019;86:951–961.
  • Fertig E, Fureman BE, Bergey GK, et al. Inclusion and exclusion criteria for epilepsy clinical trials-recommendations from the April 30, 2011 NINDS workshop. Epilepsy Res. 2014;108:825–832.
  • Jones JE, Hermann BP, Barry JJ, et al. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy. Epilepsy Behav. 2003;4(Suppl 3):S31–38.
  • Hawton K, Fagg J, Marsack P. Association between epilepsy and attempted suicide. J Neurol Neurosurg Psychiatry. 1980;43:168–170.
  • Rai D, Kerr MP, McManus S, et al. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia. 2012;53:1095–1103.
  • Thurman DJ, Logroscino G, Beghi E, et al. The burden of premature mortality of epilepsy in high-income countries: a systematic review from the mortality task force of the international league against epilepsy. Epilepsia. 2017;58:17–26.
  • Mula M, Kanner AM, Jetté N, et al. Psychiatric comorbidities in people with epilepsy. Neurol Clin Pract. 2021;11:e112–e120.
  • Mula M, Kaufman KR. Double stigma in mental health: epilepsy and mental illness. BJPsych Open. 2020;6:e72.
  • Hecimovic H, Salpekar J, Kanner AM, et al. Suicidality and epilepsy: a neuropsychobiological perspective. Epilepsy Behav. 2011;22:77–84.
  • Hesdorffer DC, Ishihara L, Mynepalli L, et al. Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Ann Neurol. 2012;72:184–191.
  • Hesdorffer DC, Ishihara L, Webb DJ, et al. Occurrence and Recurrence of Attempted Suicide Among People With Epilepsy. JAMA Psychiatry. 2016;73:80–86.
  • Williams Roberson S, Rehman R, Bucurescu G. Antiepileptic drugs and suicidality in veterans with seizures. Neurology (ECronicon). 2019;11(12):Available from: https://www.ecronicon.com/ecne/pdf/ECNE-11-00610.pdf. (Accessed: February 01, 2019).
  • Bohnert KM, Ilgen MA, Louzon S, et al. Substance use disorders and the risk of suicide mortality among men and women in the US Veterans Health Administration. Addiction. 2017;112:1193–1201.
  • Grimaldi-Bensouda L, Nordon C, Rossignol M, et al. Antiepileptic drugs and risk of suicide attempts: a case-control study exploring the impact of underlying medical conditions. Pharmacoepidemiol Drug Saf. 2017;26:239–247.
  • Ding S, Li X, Hua Y, et al. Risk factors for suicidal tendency in adult patients with epilepsy in China. Epilepsy Behav. 2019;97:118–122.
  • Tian N, Cui W, Zack M, et al. Suicide among people with epilepsy: a population-based analysis of data from the U.S. National violent death reporting system, 17 states, 2003-2011. Epilepsy Behav. 2016;61:210–217.
  • Gorton HC, Webb RT, Carr MJ, et al. Risk of unnatural mortality in people with epilepsy. JAMA Neurol. 2018;75:929–938.
  • Toce MS, Hudgins JD, Yuskaitis CJ, et al. National assessment of anti-epileptic drug exposures among pre-teens and adolescents, 2000-2020. Clin Toxicol (Phila). 2022Jan;13:1–7. Online ahead of print.
  • Perucca P, Mula M. Antiepileptic drug effects on mood and behavior: molecular targets. Epilepsy Behav. 2013;26:440–449.
  • Chen B, Choi H, Hirsch LJ, et al. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy Behav. 2017;76:24–31.
  • Nilsson L, Ahlbom A, Farahmand BY, et al. Risk factors for suicide in epilepsy: a case control study. Epilepsia. 2002;43:644–651.
  • Shneker BF, Cios JS, Elliott JO. Suicidality, depression screening, and antiepileptic drugs: reaction to the FDA alert. Neurology. 2009;72:987–991.