References
- Shetty J. Neonatal seizures in hypoxic-ischaemic encephalopathy-risks and benefits of anticonvulsivant therapy. Dev Med Child Neurol. 2015;57(3):40–43.
- Pisani F, Facini C, Bianchi E, et al. Risk factors for neonatal seizures: a case-control study in the province of Parma, Italy. Epilepsy Behav. 2020;107:107075.
- Jensen FE. Neonatal seizures: an update on mechanisms and management. Clin Perinatol. 2009;36(4):881–900.
- Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr. 2016;174:98–103e1.
- Glass HC, Shellhaas RA. Acute symptomatic seizures in neonates. Semin Pediatr Neurol. 2019;32:100768.
- Pressler RN, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: modification for seizure in the neonate. Position paper by the ILAE task force on neonatal seizures. Epilepsia. 2021;62(3):615–628.
- Santarone ME, Pietrafusa N, Fusco L. Neonatal seizures: when semeiology points to etiology. Seizure. 2020;80:161–165.
- Nguyen T, Wusthoff CJ. Clinical manifestations of neonatal seizures. Pediatr Int. 2021;63(6):631–635.
- McTague A, Howell KB, Cross JH, et al. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol. 2016;15(3):304–316.
- Shellhaas RA, Chang T, Wusthoff CJ, et al. Treatment duration after acute symptomatic seizures in neonates: a multicenter cohort study. J Pediatr. 2017;181:298–301.
- Axeen EJT, Olson HE. Neonatal epilepsy genetics. Semin Fetal Neonatal Med. 2018;23(3):197–203.
- Cornet MC, Sands TT, Cilio MR. Neonatal epilepsies: clinical management. Semin Fetal Neonatal Med. 2018;23(3):204–212.
- Nunes ML, Yozawitz EG, Zuberi S, et al. Neonatal seizures: is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review. Epilepsia Open. 2019;4(1):10–29.
- Vilan A, Mendes Ribeiro J, Striano P, et al. A distinctive ictal amplitude-integrated electroencephalography pattern in newborns with neonatal epilepsy associated with KCNQ2 mutations. Neonatology. 2017;112(4):387–393.
- Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: position statement by the ILAE task force on nosology and definitions. Epilepsia. 2022;63(6):1349–1397.
- Wirrell EC, Armstrong EA, Osman LD, et al. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res. 2001;50(4):445–454.
- Glass HC, Wirrell E. Controversies in neonatal seizure management. J Child Neurol. 2009;24(5):591–599.
- Hirfanoglu T, Ozturk Z, Gokdogan GS, et al. Neonatal seizures and future epilepsy: predictive value of perinatal risk factors, electroencephalography, and imaging. J Pediatr Neurosci. 2020;15(3):190–198.
- Poston JM, Rebholz A. Neonatal seizures: core concepts. Neonatal Netw. 2021;40(6):362–368.
- Low E, Boylan GB, Mathieson SR, et al. Cooling and seizure burden in term neonates: an observational study. Arch Dis Child Fetal Neonatal Ed. 2012;97(4):F267–72.
- Srinivasakumar P, Zempel J, Wallendorf M, et al. Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013;163(2):465–470.
- Guidotti I, Lugli L, Guerra MP, et al. Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic-ischemic encephalopathy: an observational study. Dev Med Child Neurol. 2016;58(12):1235–1241.
- Kharoshankaya L, Stevenson NJ, Livingstone V, et al. Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. Dev Med Child Neurol. 2016;58(12):1242–1248.
- Boylan GB, Rennie JM, Pressler RM, et al. Phenobarbitone, neonatal seizures, and video-EEG. Arch Dis Child Fetal Neonatal Ed. 2002;86(3):F165–70.
- Shellhaas RA, Chang T, Tsuchida T, et al. The American clinical neurophysiology society’s guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol. 2011;28(6):611–617.
- Rennie JM, Chorley G, Boylan GB, et al. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed. 2004;89(1):F37–40.
- Stevenson NJ, Boylan GB, Hellström-Westas L, et al. Treatment trials for neonatal seizures: the effect of design on sample size. PLoS One. 2016;11(11):e0165693.
- Soul JS, Pressler R, Allen M, et al. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2019;85:943–954.
- Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2019;37(52):7596–7609.
- Murray DM, Boylan GB, Ali I, et al. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93(3):F187–91.
- Rennie JM, de Vries LS, Blennow M, et al. Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience. Arch Dis Child Fetal Neonatal Ed. 2019;104(5):F493–501.
- Hernan AE, Holmes GL. Antiepileptic drug treatment strategies in neonatal epilepsy. Prog Brain Res. 2016;226:179–193.
- Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341(7):485–489.
- Bittigau P, Sifringer M, Genz K, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA. 2002;99(23):15089–15094.
- Pavel AM, Rennie JM, de Vries LS, et al. Neonatal seizure management; is the timing of treatment critical? J Pediatr. 2022;243:61–68e2.
- Wusthoff CJ, Sundaram V, Abend NS, et al. Seizure control in neonates undergoing screening vs confirmatory EEG monitoring. Neurology. 2021;97(6):e587–96.
- Harris ML, Malloy KM, Lawson SN, et al. Standardized treatment of neonatal status epilepticus improves outcome. J Child Neurol. 2016;31:1546–1554.
- Bashir RA, Espinoza L, Vayalthrikkovil S, et al. Implementation of a neonatal neuro-critical care program (N-NCC): improved seizure detection and management in neonates with hypoxic ischemic encephalopathy. Pediatr Neurol. 2016;64:38–43.
- Boylan GB, Rennie JM, Chorley G, et al. Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study. Neurology. 2004;62(3):486–488.
- Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics. 2020;145(6):e20193182.
- Pisani F, Fusco C, Nagarajan L, et al. Acute symptomatic neonatal seizures, brain injury, and long-term outcome: the role of neuroprotective strategies. Expert Rev Neurother. 2021;21:189–203.
- Zhou KQ, McDouall A, Drury PP, et al. Treating seizures after Hypoxic-Ischemic Encephalopathy-Current controversies and future directions. Int J Mol Sci. 2019;22(13):7121.
- DeLaGarza-Pineda O, Mailo JA, Boylan G, et al. Management of seizures in neonates with neonatal encephalopathy treated with hypothermia. Semin Fetal Neonatal Med. 2021;26(4):101279.
- Falsaperla R, Scalia B, Giugno A, et al. Treating the symptom or treating the disease in neonatal seizures: a systematic review of the literature. Ital J Pediatr. 2021;47(1):85.
- Glass HC, Nash KB, Bonifacio SL, et al. Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy. J Pediatr. 2011;159(5):731–735.
- Rao LM, Hussain SA, Zaki T, et al. A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. Epilepsy Behav. 2018;88:212–217.
- Booth D, Evans DJ. Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev. 2002;18(4):CD004218.
- WHO. WHO guidelines approved by the guidelines review committee. In: World Health Organization, editor. Guidelines on Neonatal Seizures. Geneva. 2011. Available from: https://apps.who.int/iris/handle/10665/77756.
- Slaughter LA, Patel AD, Slaughter JL. Pharmacological treatment of neonatal seizures: a systematic review. J Child Neurol. 2013;28(3):351–364.
- Castro Conde JR, Hernández Borges AA, Doménech Martínez E, et al. Midazolam in neonatal seizures with no response to phenobarbital. Neurology. 2005;64(5):876–879.
- Shany E, Benzaqen O, Watemberg N. Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. J Child Neurol. 2007;22(3):255–259.
- Hellström-Westas L, Westgren U, Rosén I, et al. Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring. Acta Paediatr Scand. 1988;77(1):79–84.
- Tulloch JK, Carr RR, Ensom MH. A systematic review of the pharmacokinetics of antiepileptic drugs in neonates with refractory seizures. J Pediatr Pharmacol Ther. 2012;17(1):31–44.
- Pressler RM, Boylan GB, Marlow N, et al. Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurol. 2015;14:469–477.
- Soul JS, Bergin AM, Stopp C, et al. A pilot randomized, controlled, double-blind trial of bumetanide to treat neonatal seizures. Ann Neurol. 2021;89(2):327–340.
- Glass HC, Poulin C, Shevell MI. Topiramate for the treatment of neonatal seizures. Pediatr Neurol. 2011;44(6):439–442.
- Mruk AL, Garlitz KL, Leung NR. Levetiracetam in neonatal seizures: a review. J Pediatr Pharmacol Ther. 2015;20(2):76–89.
- Wilmshurst JM, Gaillard WD, Vinayan KP, et al. Summary of recommendations for the management of infantile seizures: task force report for the ILAE commission of pediatrics. Epilepsia. 2015;56:1185–1197.
- Brodie MJ, Kwan P. Current position of phenobarbital in epilepsy and its future. Epilepsia. 2012;53(8):40–46.
- Forcelli PA, Kim J, Kondratyev A, et al. Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain. Epilepsia. 2011;52(12):e207–11.
- Kaushal S, Tamer Z, Opoku F, et al. Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain. Epilepsia. 2016;57(5):727–734.
- Torolira D, Suchomelova L, Wasterlain CG, et al. Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 2016;120:47–54.
- Stefovska VG, Uckermann O, Czuczwar M, et al. Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol. 2008;64(4):434–445.
- Al-Muhtasib N, Sepulveda-Rodriguez A, Vicini S, et al. Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons. Epilepsia. 2018;59(2):333–344.
- Glass HC, Soul JS, Chang T, et al. Safety of early discontinuation of antiseizure medication after acute symptomatic neonatal seizure. JAMA Neurol. 2021;78(7):817–825.
- Sulzbacher S, Farwell JR, Temkin N, et al. Late cognitive effects of early treatment with phenobarbital. Clin Pediatr (Phila). 1999;38(7):387–394.
- Verrotti A, Coppola G, Parisi P, et al. Bone and calcium metabolism and antiepileptic drugs. Clin Neurol Neurosurg. 2010;112(1):1–10.
- Pacifici GM. Clinical pharmacology of midazolam in neonates and children: effect of disease-a review. Int J Pediatr. 2014;2014:309342.
- Kubová H, Bendová Z, Moravcová S, et al. Neonatal clonazepam administration induced Long-Lasting changes in GABAA and GABAB receptors. Int J Mol Sci. 2020;21(9):3184.
- Favié LMA, Groenendaal F, van den Broek MPH, et al. Phenobarbital, midazolam pharmacokinetics, effectiveness, and drug-drug interaction in asphyxiated neonates undergoing therapeutic hypothermia. Neonatology. 2019;116(2):154–162.
- Stevens MF, Werdehausen R, Gaza N, et al. Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling. Reg Anesth Pain Med. 2011;36(4):343–349.
- Favié LMA, Huitema ADR, van den Broek MPH, et al. Lidocaine as treatment for neonatal seizures: evaluation of previously developed population pharmacokinetic models and dosing regimen. Br J Clin Pharmacol. 2020;86(1):75–84.
- El-Dib M, Soul JS. The use of phenobarbital and other anti-seizure drugs in newborns. Semin Fetal Neonatal Med. 2017;22(5):321–327.
- Shallcross R, Bromley RL, Irwin B, et al. Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology. 2011;76:383–389.
- Maitre NL, Smolinsky C, Slaughter JC, et al. Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. J Perinatol. 2013;33:841–846.
- Manthey D, Asimiadou S, Stefovska V, et al. Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol. 2015;193:497–503.
- Celik Y, Resitoglu B, Komur M, et al. Is Levetiracetam neuroprotective in neonatal rats with hypoxic ischemic brain injury? Bratisl Lek Listy. 2016;117(12):730–733.
- Loiacono G, Masci M, Zaccara G, et al. The treatment of neonatal seizures: focus on Levetiracetam. J Matern Fetal Neonatal Med. 2016;29(1):69–74.
- Ahmad KA, Desai SJ, Bennett MM, et al. Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014. J Perinatol. 2014;37(3):296–300.
- Qiao MY, Cui HT, Zhao LZ, et al. Efficacy and safety of levetiracetam vs. phenobarbital for neonatal seizures: a systematic review and meta-analysis. Front Neurol. 2021;12:747745.
- Muller AJ, Marks JD. Hypoxic ischemic brain injury: potential therapeutic interventions for the future. Neoreviews. 2014;15:e177–86.
- Jiang H, Lei JJ, Zhang YH. Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat. Asian Pac J Trop Med. 2014;7(6):496–500.
- Filippi L, Poggi C, La Marca G, et al. Oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a safety study. J Pediatr. 2010;157(3):361–366.
- Filippi L, Fiorini P, Catarzi S, et al. Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI): a feasibility study. J Matern Fetal Neonatal Med. 2018;31(8):973–980.
- Nunez-Ramiro A, Benavente-Fernandez I, Valverde E, et al. Topiramate plus cooling for Hypoxic-ischemic encephalopathy: a randomized, controlled, multicenter, double-blinded trial. Neonatology. 2019;116(1):76–84.
- Marques MR, Garcia-Robles A, Usach I, et al. Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule. Acta Paediatr. 2020;109(2):300–308.
- Stockler S, Plecko B, Gospe SM Jr, et al. Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up. Mol Genet Metab. 2011;104(1–2):48–60.
- Mills PB, Camuzeaux SSM, Footitt EJ, et al. Epilepsy due to PNPO mutations: genotype, environment and treatment affect presen- tation and outcome. Brain. 2014;137(Pt 5):1350–1360.
- Darin N, Reid E, Prunetti L, et al. Mutations in PROSC disrupt cellular pyridoxal phosphate homeostasis and cause vitamin-B6-dependent epilepsy. Am J Hum Genet. 2016;99:1325–1337.
- Plecko B, Zweier M, Begemann A, et al. Confirmation of mutations in PROSC as a novel cause of vitamin B 6 -dependent epilepsy. J Med Genet. 2017;54:809–814.
- Baumgartner-Sigl S, Haberlandt E, Mumm S, et al. Pyridoxine- responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p. M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. Bone. 2007;40(6):1655–1661.
- Tarocco A, Ballardini E, Garani G. Use of ketamine in a newborn with refractory status epilepticus: a case report. Pediatr Neurol. 2014;51(1):154–156.
- Huntsman RJ, Strueby L, Bingham W. Are ketamine infusions a viable therapeutic option for refractory neonatal seizures? Pediatr Neurol. 2020;103:8–11.
- Bertozzi V, Bonardi CM, Biscalchin G, et al. Efficacy of lacosamide in neonatal-onset super-refractory status epilepticus: a case report. Epileptic Disord. 2021;23(4):655–660.
- Pisani F, Orsini M, Braibanti S, et al. Development of epilepsy in newborns with moderate hypoxic-ischemic encephalopathy and neonatal seizures. Brain Dev. 2009;31(1):64–68.
- Lugli L, Balestri E, Berardi A, et al. Brain cooling reduces the risk of postneonatal epilepsy in newborns affected by moderate to severe hypoxic-ischemic encephalopathy. Minerva Pediatr. 2021;73(2):150–158.
- Baudou E, Benevent J, Montastruc JL, et al. Adverse effects of treatment with valproic acid during the neonatal period. Neuropediatrics. 2019;50(1):31–40.
- Dilena R, Striano P, Gennaro E, et al. Efficacy of sodium channel blockers in SCN2A early infantile epileptic encephalopathy. Brain Dev. 2017;39(4):345–348.
- Song Y, Zhong M, Cai FC. Oxcarbazepine causes neurocyte apoptosis and developing brain damage by triggering Bax/Bcl-2 signaling pathway mediated caspase 3 activation in neonatal rats. Eur Rev Med Pharmacol Sci. 2018;22(1):250–261.
- Pisano T, Numis AL, Heavin SB, et al. Early and effective treatment of KCNQ2 encephalopathy. Epilepsia. 2015;56(5):685–691.
- Bearden D, Strong A, Ehnot J, et al. Targeted treatment of migrating partial seizures of infancy with quinidine. Ann Neurol. 2014;76(3):457–461.
- Milligan CJ, Li M, Gazina EV, et al. KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine. Ann Neurol. 2014;75(4):581–590.
- Schwahn BC, Van Spronsen FJ, Belaidi AA, et al. Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study. Lancet. 2015;386(10007):1955–1963.
- Brandt C, Seja P, Töllner K, et al. Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital’s anti-seizure efficacy. Neuropharmacology. 2018;143:186–204.
- Grosenbaugh DK, Ross BM, Wagley P, et al. The role of kainate receptors in the pathophysiology of hypoxia-induced seizures in the neonatal mouse. Sci Rep. 2018;8(1):7035.
- Huizenga MN, Sepulveda-Rodriguez A, Forcelli PA. Preclinical safety and efficacy of cannabidivarin for early life seizures. Neuropharmacology. 2019;148:189–198.
- Raol YH, Lapides DA, Keating JG, et al. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009;65(3):326–336.
- Patil MA, Matter BA, Raol YH, et al. Brain Distribution and metabolism of flupirtine, a nonopioid analgesic drug with antiseizure effects, in neonatal rats. Pharmaceutics. 2018;10(4):281.
- Sampath D, Shmueli D, White AM, et al. Flupirtine effectively prevents development of acute neonatal seizures in an animal model of global hypoxia. Neurosci Lett. 2015;607:46–51.
- Falsaperla R, D’Angelo G, Praticò AD, et al. Ketogenic diet for infants with epilepsy: a literature review. Epilepsy Behav. 2020;112:107361.