Clinical applications of exercise in Parkinson’s disease: what we need to know?

References

• Chou KL, Elm JJ, Wielinski CL, et al. Factors associated with falling in early, treated Parkinson’s disease: the NET-PD LS1 cohort. J Neurol Sci. 2017; 377:137–377–143.
   Google Scholar
• Dorsey ER, Bloem BR. The parkinson pandemic-A call to action. JAMA Neurol. 2018;75(1):9–10.
   PubMed Web of Science ®Google Scholar
• Pringsheim T, Jette N, Frolkis A, et al. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord. 2014;29(13):1583–1590.
   PubMed Web of Science ®Google Scholar
• Fujita KA, Ostaszewski M, Matsuoka Y, et al. Integrating pathways of Parkinson’s disease in a molecular interaction map. Mol Neurobiol. 2014;49(1):88–102.
   PubMed Web of Science ®Google Scholar
• Kalia LV, Lang AE. Parkinson’s disease. Lancet. 2015;386(9996):896–912.
   PubMed Web of Science ®Google Scholar
• Auyeung M, Tsoi TH, Mok V, et al. Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson’s disease patients. J Neurol Neurosurg Psychiatry. 2012;83(6):607–611.
   PubMed Web of Science ®Google Scholar
• Allen NE, Schwarzel AK, Canning CG. Recurrent falls in Parkinson’s disease: a systematic review. Parkinsons Dis. 2013;2013:906274.
   PubMedGoogle Scholar
• Tarazi FI, Sahli ZT, Wolny M, et al. Emerging therapies for Parkinson’s disease: from bench to bedside. Pharmacol Ther. 2014;144(2):123–133.
   PubMed Web of Science ®Google Scholar
• Fox SH, Katzenschlager R, Lim SY, et al. International Parkinson and movement disorder society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson’s disease. Mov Disord. 2018;33(8):1248–1266.
   PubMed Web of Science ®Google Scholar
• Oliveira de Carvalho A, Filho ASS, Murillo-Rodriguez E, et al. Physical exercise for parkinson’s disease: clinical and experimental evidence. Clin Pract Epidemiol Ment Health. 2018;1489–1498.
   Google Scholar
• Burgess S, Rassmusson X. Parkinson’s narratives: onset experiences and perceived benefits of preferred physical activity. Adv Soc Sci Res J. 2016;3150–3160.
   Google Scholar
• Mak MK, Wong-Yu IS, Shen X, et al. Long-term effects of exercise and physical therapy in people with parkinson disease. Nat Rev Neurol. 2017;13(11):689–703.
   PubMed Web of Science ®Google Scholar
• Gilat M, Ginis P, Zoetewei D, et al. A systematic review on exercise and training-based interventions for freezing of gait in Parkinson’s disease. NPJ Parkinsons Dis. 2021;7(1):81.
   PubMed Web of Science ®Google Scholar
• Rawson KS, McNeely ME, Duncan RP, et al. Exercise and parkinson disease: comparing tango, treadmill, and stretching. J Neurol Phys Ther. 2019;43(1):26–32.
   PubMed Web of Science ®Google Scholar
• Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet. 2021;397(10291):2284–2303.
   PubMed Web of Science ®Google Scholar
• van der Kolk NM, King LA. Effects of exercise on mobility in people with parkinson’s disease. Mov Disord. 2013;28(11):1587–1596.
   PubMed Web of Science ®Google Scholar
• Hirsch MA, Farley BG. Exercise and neuroplasticity in persons living with parkinson’s disease. Eur J Phys Rehabil Med. 2009;45(2):215–229.
   PubMed Web of Science ®Google Scholar
• Fisher BE, Li Q, Nacca A, et al., Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early parkinson’s disease. Neuroreport. 2013;24(10):509–514.
   PubMed Web of Science ®Google Scholar
• Sehm B, Taubert M, Conde V, et al. Structural brain plasticity in parkinson’s disease induced by balance training. Neurobiol Aging. 2014;35(1):232–239.
   PubMed Web of Science ®Google Scholar
• Beall EB, Lowe MJ, Alberts JL, et al. The effect of forced-exercise therapy for parkinson’s disease on motor cortex functional connectivity. Brain Connect. 2013;3(2):190–198.
   PubMedGoogle Scholar
• Petzinger GM, Fisher BE, McEwen S, et al. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in parkinson’s disease. Lancet Neurol. 2013;12(7):716–726.
   PubMed Web of Science ®Google Scholar
• Monteiro-Junior RS, Cevada T, Oliveira BR, et al. We need to move more: neurobiological hypotheses of physical exercise as a treatment for parkinson’s disease. Med Hypotheses. 2015;85(5):537–541.
   PubMed Web of Science ®Google Scholar
• Bougea A, Stefanis L, Paraskevas GP, et al. Plasma alpha-synuclein levels in patients with Parkinson’s disease: a systematic review and meta-analysis. Neurol Sci. 2019;40(5):929–938.
   PubMed Web of Science ®Google Scholar
• Mor DE, Daniels MJ, Ischiropoulos H. The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration. Mov Disord. 2019;34(2):167–179.
   PubMed Web of Science ®Google Scholar
• Lotharius J, Brundin P. Pathogenesis of parkinson’s disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci. 2002;3(12):932–942.
   PubMed Web of Science ®Google Scholar
• Aguilo A, Tauler P, Fuentespina E, et al. Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol Behav. 2005;84(1):1–7.
   PubMed Web of Science ®Google Scholar
• Elokda A, DiFrancisco-Donoghue J, Lamberg EM, et al. Effects of exercise induced oxidative stress on glutathione levels in Parkinson’s disease on and off medication. J Neurol. 2010;257(10):1648–1653.
   PubMed Web of Science ®Google Scholar
• Finaud J, Lac G, Filaire E. Oxidative stress: relationship with exercise and training. Sports Med. 2006;36(4):327–358.
   PubMed Web of Science ®Google Scholar
• Friedrich MJ. Parkinson disease studies yield insights. JAMA. 2005;293(4):409–410.
   PubMed Web of Science ®Google Scholar
• Bloomer RJ, Schilling BK, Karlage RE, et al. Effect of resistance training on blood oxidative stress in parkinson disease. Med Sci Sports Exerc. 2008;40(8):1385–1389.
   PubMed Web of Science ®Google Scholar
• Tuon T, Valvassori SS, Lopes-Borges J, et al. Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of parkinson’s disease. Neuroscience. 2012;227:305–312.
   Web of Science ®Google Scholar
• Campos C, Rocha NB, Lattari E, et al. Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors. Expert Rev Neurother. 2016;16(6):723–734.
   PubMed Web of Science ®Google Scholar
• Baydyuk M, Xu B. BDNF signaling and survival of striatal neurons. Front Cell Neurosci. 2014;8:254.
   PubMed Web of Science ®Google Scholar
• Hirsch MA, van Wegen EEH, Newman MA, et al. Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson’s disease: a systematic review and meta-analysis. Transl Neurodegener. 2018;7:7.
   PubMed Web of Science ®Google Scholar
• Ogborn DI, Gardiner PF. Effects of exercise and muscle type on BDNF, NT-4/5, and TrKB expression in skeletal muscle. Muscle Nerve. 2010;41(3):385–391.
   PubMed Web of Science ®Google Scholar
• Vaynman SS, Ying Z, Yin D, et al. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain Res. 2006;1070(1):124–130.
   PubMed Web of Science ®Google Scholar
• Portugal MME, Cevada T, Monteiro-Junior SR, et al. Neuroscience of exercise: from neurobiology mechanisms to mental health. Neuropsychobiology. 2013;68(1):1–14.
   PubMed Web of Science ®Google Scholar
• Marinelli L, Quartarone A, Hallett M, et al. The many facets of motor learning and their relevance for parkinson’s disease. Clin Neurophysiol. 2017;128(7):1127–1141.
   PubMed Web of Science ®Google Scholar
• Nieuwboer A, Rochester L, Muncks L, et al. Motor learning in Parkinson’s disease: limitations and potential for rehabilitation. Parkinsonism Relat Disord. 2009;15(Suppl 3):S53–S58.
   PubMedGoogle Scholar
• Marinelli L, Crupi D, Di Rocco A, et al. Learning and consolidation of visuo-motor adaptation in parkinson’s disease. Parkinsonism Relat Disord. 2009;15(1):6–11.
   PubMed Web of Science ®Google Scholar
• Nieuwboer A, Kwakkel G, Rochester L, et al., Cueing training in the home improves gait-related mobility in parkinson’s disease: the RESCUE trial. J Neurol Neurosurg Psychiatry. 2007;78(2):134–140.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang T, Liu H, et al. Dual-task training on gait, motor symptoms, and balance in patients with parkinson’s disease: a systematic review and meta-analysis. Clin Rehabil. 2020;34(11):1355–1367.
   PubMed Web of Science ®Google Scholar
• Mak MK, Hui-Chan CW. Cued task-specific training is better than exercise in improving sit-to-stand in patients with parkinson’s disease: a randomized controlled trial. Mov Disord. 2008;23(4):501–509.
   PubMed Web of Science ®Google Scholar
• Paolucci T, Sbardella S, La Russa C, et al. Evidence of rehabilitative impact of progressive resistance training (PRT) programs in parkinson disease: an umbrella review. Parkinsons Dis. 2020;2020:9748091.
   PubMed Web of Science ®Google Scholar
• Youm C, Kim Y, Noh B, et al. Impact of trunk resistance and stretching exercise on fall-related factors in patients with parkinson’s disease: a randomized controlled pilot study. Sensors (Basel). 2020;20(15):4106.
   Web of Science ®Google Scholar
• Winser SJ, Tsang WW, Krishnamurthy K, et al. Does Tai Chi improve balance and reduce falls incidence in neurological disorders? A systematic review and meta-analysis. Clin Rehabil. 2018;32(9):1157–1168.
   PubMed Web of Science ®Google Scholar
• Wu PL, Lee M, Huang TT. Effectiveness of physical activity on patients with depression and parkinson’s disease: a systematic review. PLoS One. 2017;12(7):e0181515.
   PubMed Web of Science ®Google Scholar
• Myers J, Prakash M, Froelicher V, et al. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793–801.
   PubMed Web of Science ®Google Scholar
• Robinson AG, Dennett AM, Snowdon DA. Treadmill training may be an effective form of task-specific training for improving mobility in people with parkinson’s disease and multiple sclerosis: a systematic review and meta-analysis. Physiotherapy. 2019;105(2):174–186.
   PubMed Web of Science ®Google Scholar
• Shulman LM, Katzel LI, Ivey FM, et al. Randomized clinical trial of 3 types of physical exercise for patients with parkinson disease. JAMA Neurol. 2013;70(2):183–190.
   PubMed Web of Science ®Google Scholar
• Garber CE, Blissmer B, Deschenes MR, et al., American college of sports medicine position stand. quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–1359.
   PubMed Web of Science ®Google Scholar
• Gallo P, Garber C. Parkinson’s disease: a comprehensive approach to exercise prescription for the health fitness professional. ACSMs Health Fit J. 2011;15(4):8–17.
   Web of Science ®Google Scholar
• Martignon C, Pedrinolla A, Ruzzante F, et al. Guidelines on exercise testing and prescription for patients at different stages of parkinson’s disease. Aging Clin Exp Res. 2021;33(2):221–246.
   PubMed Web of Science ®Google Scholar
• Scandalis TA, Bosak A, Berliner JC, et al. Resistance training and gait function in patients with parkinson’s disease. Am J Phys Med Rehabil. 2001;80(1):38–36.
   PubMed Web of Science ®Google Scholar
• Tomlinson CL, Patel S, Meek C, et al. Physiotherapy versus placebo or no intervention in parkinson’s disease. Cochrane Database Syst Rev. 2013; (9):CD002817. DOI:10.1002/14651858.CD002817.pub4.
   PubMed Web of Science ®Google Scholar
• Tomlinson CL, Herd CP, Clarke CE, et al. Physiotherapy for parkinson’s disease: a comparison of techniques. Cochrane Database Syst Rev. 2014; (6):CD002815. DOI:10.1002/14651858.CD002815.pub2.
   PubMed Web of Science ®Google Scholar
• Brach JS, Lowry K, Perera S, et al. Improving motor control in walking: a randomized clinical trial in older adults with subclinical walking difficulty. Arch Phys Med Rehabil. 2015;96(3):388–394.
   PubMed Web of Science ®Google Scholar
• Alves WM, Alves TG, Ferreira RM, et al. Strength training improves the respiratory muscle strength and quality of life of elderly with parkinson disease. J Sports Med Phys Fitness. 2019;59(10):1756–1762.
   PubMed Web of Science ®Google Scholar
• Corcos DM, Robichaud JA, David FJ, et al. A two-year randomized controlled trial of progressive resistance exercise for parkinson’s disease. Mov Disord. 2013;28(9):1230–1240.
   PubMed Web of Science ®Google Scholar
• Dibble LE, Addison O, Papa E. The effects of exercise on balance in persons with parkinson’s disease: a systematic review across the disability spectrum. J Neurol Phys Ther. 2009;33(1):14–26.
   PubMed Web of Science ®Google Scholar
• Wong-Yu IS, Mak MK. Multi-dimensional balance training programme improves balance and gait performance in people with parkinson’s disease: a pragmatic randomized controlled trial with 12-month follow-up. Parkinsonism Relat Disord. 2015;21(6):615–621.
   PubMed Web of Science ®Google Scholar
• Aguiar L, Rocha P, Morris M. Therapeutic dancing for parkinson’s disease. Int J Gerontol. 2016;10(2):64–70.
   Web of Science ®Google Scholar
• Rocha P, McClelland J, Morris M. Complementary physical therapies for movement disorders in Parkinson’s disease: a systematic review. Eur J Phys Rehab Med. 2015;51(6):693–704.
   PubMed Web of Science ®Google Scholar
• Santos LA, Campos C, Bento T, et al. Effects of dual-task interventions on gait performance of patients with parkinson’s disease: a systematic review. MedicalExpress. 2016;3(4):1–10.
   Google Scholar
• Blandy LM, Beevers WA, Fitzmaurice K, et al. Therapeutic argentine tango dancing for people with mild parkinson’s disease: a feasibility study. Front Neurol. 2015;6:122.
   PubMed Web of Science ®Google Scholar
• Kwok JYY, Lee JJ, Choi EPH, et al. Stay mindfully active during the coronavirus pandemic: a feasibility study of mHealth-delivered mindfulness yoga program for people with parkinson’s disease. BMC Compl Med Ther. 2022;22(1):37.
   PubMedGoogle Scholar
• Green E, Huynh A, Broussard L, et al. Systematic review of yoga and balance: effect on adults with neuromuscular impairment. Am J Occup Ther. 2019;73(1):7301205150.
   Google Scholar
• Ni M, Mooney K, Signorile JF. Controlled pilot study of the effects of power yoga in parkinson’s disease. Complement Ther Med. 2016;25:126–131.
   PubMed Web of Science ®Google Scholar
• Van Puymbroeck M, Walter AA, Hawkins BL, et al. Functional improvements in parkinson’s disease following a randomized trial of yoga. Evid Based Complement Alternat Med. 2018;2018:8516351.
   Web of Science ®Google Scholar
• van der Kolk NM, de Vries NM, Kessels RPC, et al. Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson’s disease: a double-blind, randomised controlled trial. Lancet Neurol. 2019;18(11):998–1008.
   PubMed Web of Science ®Google Scholar
• Oguh O, Eisenstein A, Kwasny M, et al. Back to the basics: regular exercise matters in parkinson’s disease: results from the national parkinson foundation QII registry study. Parkinsonism Relat Disord. 2014;20(11):1221–1225.
   PubMed Web of Science ®Google Scholar
• Kwok JY, Choi KC, Chan HY. Effects of mind-body exercises on the physiological and psychosocial well-being of individuals with Parkinson’s disease: a systematic review and meta-analysis. Complement Ther Med. 2016;29:121–131.
   PubMed Web of Science ®Google Scholar
• Zou L, SasaKi JE, Wang H, et al. A systematic review and meta-analysis baduanjin qigong for health benefits: randomized controlled trials. Evid Based Complement Alternat Med. 2017;2017:4548706.
   Google Scholar
• Liu XL, Chen S, Wang Y. Effects of health qigong exercises on relieving symptoms of parkinson’s disease. Evid Based Complement Alternat Med. 2016;2016:5935782.
   Web of Science ®Google Scholar
• Schmitz-Hubsch T, Pyfer D, Kielwein K, et al. Qigong exercise for the symptoms of parkinson’s disease: a randomized, controlled pilot study. Mov Disord. 2006;21(4):543–548.
   PubMed Web of Science ®Google Scholar
• Frazzitta G, Bertotti G, Uccellini D, et al. Parkinson’s disease rehabilitation: a pilot study with 1 year follow up. Mov Disord. 2010;25(11):1762–1763.
   PubMed Web of Science ®Google Scholar
• Pelosin E, Barella R, Bet C, et al. Effect of group-based rehabilitation combining action observation with physiotherapy on freezing of gait in parkinson’s disease. Neural Plast. 2018;2018:4897276.
   Web of Science ®Google Scholar
• Schootemeijer S, van der Kolk NM, Bloem BR, et al. Current perspectives on aerobic exercise in people with parkinson’s disease. Neurotherapeutics. 2020;17(4):1418–1433.
   PubMed Web of Science ®Google Scholar
• Lei C, Sunzi K, Dai F, et al. Effects of virtual reality rehabilitation training on gait and balance in patients with parkinson’s disease: a systematic review. PLoS One. 2019;14(11):e0224819.
   PubMed Web of Science ®Google Scholar
• Wang W, Wong S, Ho-yin Lai F. The effect of virtual reality rehabilitation on balance in patients with parkinson’s disease: a systematic review and meta-Analysis. Electronics. 2021;10(9):1–16.
   Web of Science ®Google Scholar
• Shu HF, Yang T, Yu SX, et al. Aerobic exercise for Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2014;9(7):e100503.
   PubMed Web of Science ®Google Scholar
• Heijnen S, Hommel B, Kibele A, et al. Neuromodulation of aerobic exercise-A review. Front Psychol. 2015;6:1890.
   PubMed Web of Science ®Google Scholar
• Kawashima S, Ueki Y, Kato T, et al. Changes in striatal dopamine release associated with human motor-skill acquisition. PLoS One. 2012;7(2):e31728.
   PubMed Web of Science ®Google Scholar
• Schaun GZ, Pinto SS, Silva MR, et al. Whole-body high-intensity interval training induce similar cardiorespiratory adaptations compared with traditional high-intensity interval training and moderate-intensity continuous training in healthy men. J Strength Cond Res. 2018;32(10):2730–2742.
   PubMed Web of Science ®Google Scholar
• Gibala MJ, Little JP, Macdonald MJ, et al. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol. 2012;590(5):1077–1084.
   PubMed Web of Science ®Google Scholar
• Ito S. High-intensity interval training for health benefits and care of cardiac diseases - The key to an efficient exercise protocol. World J Cardiol. 2019;11(7):171–188.
   PubMed Web of Science ®Google Scholar
• Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014;48(16):1227–1234.
   PubMed Web of Science ®Google Scholar
• Segura C, Eraso M, Bonilla J, et al. Effect of a high-intensity tandem bicycle exercise program on clinical severity, functional magnetic resonance imaging, and plasma biomarkers in parkinson’s disease. Front Neurol. 2020;11:656.
   Web of Science ®Google Scholar
• Fiorelli CM, Ciolac EG, Simieli L, et al. Differential acute effect of high-intensity interval or continuous moderate exercise on cognition in individuals with parkinson’s disease. J Phys Act Health. 2019;16(2):157–164.
   PubMed Web of Science ®Google Scholar
• Harvey M, Weston KL, Gray WK, et al. High-intensity interval training in people with parkinson’s disease: a randomized, controlled feasibility trial. Clin Rehabil. 2019;33(3):428–438.
   PubMed Web of Science ®Google Scholar
• Brys M, Fox MD, Agarwal S, et al. Multifocal repetitive TMS for motor and mood symptoms of parkinson disease: a randomized trial. Neurology. 2016;87(18):1907–1915.
   PubMed Web of Science ®Google Scholar
• Pol F, Salehinejad MA, Baharlouei H, et al. The effects of transcranial direct current stimulation on gait in patients with parkinson’s disease: a systematic review. Transl Neurodegener. 2021;10(1):22.
   PubMed Web of Science ®Google Scholar
• Donde C, Amad A, Nieto I, et al. Transcranial direct-current stimulation (tDCS) for bipolar depression: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2017;78:123–131.
   Web of Science ®Google Scholar
• Lattari E, Costa SS, Campos C, et al. Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson’s disease? Neurosci Lett. 2017;636:165–169.
   PubMed Web of Science ®Google Scholar
• Liu X, Liu H, Liu Z, et al. Transcranial direct current stimulation for parkinson’s disease: a systematic review and meta-analysis. Front Aging Neurosci. 2021;13:746797.
   Google Scholar
• Conceicao NR, Gobbi LTB, Nobrega-Sousa P, et al. Aerobic exercise combined with transcranial direct current stimulation over the prefrontal cortex in parkinson disease: effects on cortical activity, gait, and cognition. Neurorehabil Neural Repair. 2021;35(8):717–728.
   PubMed Web of Science ®Google Scholar
• Richardson JK, Thies S, Ashton-Miller JA. An exploration of step time variability on smooth and irregular surfaces in older persons with neuropathy. Clin Biomech (Bristol, Avon). 2008;23(3):349–356.
   PubMed Web of Science ®Google Scholar
• Reis J, Fritsch B. Modulation of motor performance and motor learning by transcranial direct current stimulation. Curr Opin Neurol. 2011;24(6):590–596.
   PubMed Web of Science ®Google Scholar
• Moisello C, Blanco D, Fontanesi C, et al. TMS enhances retention of a motor skill in Parkinson’s disease. Brain Stimul. 2015;8(2):224–230.
   PubMed Web of Science ®Google Scholar