233
Views
0
CrossRef citations to date
0
Altmetric
Review

Use of cenobamate for the treatment of focal epilepsy: an Italian expert opinion paper

, , , , , ORCID Icon, , , , , & show all
Pages 935-940 | Received 13 Apr 2022, Accepted 17 Jan 2023, Published online: 24 Jan 2023

References

  • Perucca E, Brodie MJ, Kwan P, et al. 30 years of second-generation antiseizure medications: impact and future perspectives. Lancet Neurol. 2020;19(6):544–556.
  • Xcopri. Prescribing information. cited Nov 16, 2021. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf
  • European Medicine Agency Cenobamate authorization [cited 2021 Dec 22]. Available from: https://www.ema.europa.eu/en/medicines/human/EPAR/ontozry
  • Krauss GL, Klein P, Brandt C, et al. Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial. Lancet Neurol. 2020 Jan;19(1):38–48. [published correction appears in Lancet Neurol. 2020;19(3):e3.
  • Chung SS, French JA, Kowalski J, et al. Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology. 2020;94(22):e2311–e2322.
  • Löscher W, Sills GJ, White HS. The ups and downs of alkyl-carbamates in epilepsy therapy: how does cenobamate differ? Epilepsia. 2021;62(3):596–614.
  • Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: a summary of the eleventh eilat conference (EILAT XI). Epilepsy Res. 2013;103(1):2–30.
  • Nakamura M, Cho JH, Shin H, et al. Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons. Eur J Pharmacol. 2019;855:175–182.
  • Sharma R, Nakamura M, Neupane C, et al. Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate. Eur J Pharmacol. 2020;879:173117.
  • Guignet M, Campbell A, White HS. Cenobamate (XCOPRI): can preclinical and clinical evidence provide insight into its mechanism of action? Epilepsia. 2020;61(11):2329–2339.
  • Vernillet L, Greene SA, Kamin M. Pharmacokinetics of cenobamate: results from single and multiple oral ascending-dose studies in healthy subjects. Clin Pharmacol Drug Dev. 2020;9(4):428–443.
  • Specchio N, Pietrafusa N, Vigevano F. Is cenobamate the breakthrough we have been wishing for? Int J Mol Sci. 2021;22(17):9339.
  • Prescribing information for XCOPRI. U.S. Food and drug administration 2019 [cited 2020 Jun 28] Available from: https://www.access-data.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf
  • Roberti R, De Caro C, Iannone LF, et al. Pharmacology of cenobamate: mechanism of action, pharmacokinetics, drug-drug interactions and tolerability. CNS Drugs. 2021;35(6):609–618.
  • French JA, Chung SS, Krauss GL, et al. Long-term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: open-label extension of a randomized clinical study. Epilepsia. 2021;62(9):2142–2150.
  • Terapeutics A. Cenobamate [summary of product characteristics]. Amsterdam: Arvelle Therapeutics Netherlands B.V; 2020.
  • Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia. 2007;48(7):1223–1244.
  • Sperling MR, Klein P, Aboumatar S, et al. Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study. Epilepsia. 2020;61(6):1099–1108.
  • Rosenfeld WE, Abou-Khalil B, Aboumatar S, et al. Post hoc analysis of a phase 3, multicenter, open-label study of cenobamate for treatment of uncontrolled focal seizures: effects of dose adjustments of concomitant antiseizure medications. Epilepsia. 2021;62(12):3016–3028.
  • Bialer M, Johannessen SI, Koepp Mj, et al. Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). II. Drugs in more advanced clinical development. Epilepsia. 2020;61(11):2365–2385.
  • Devinsky O, Hesdorffer DC, Thurman DJ, et al. Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention. Lancet Neurol. 2016;15(10):1075–1088.
  • Mula M, Sander JW. Psychosocial aspects of epilepsy: a wider approach. BJPsych Open. 2016;2(4):270–274.
  • Quintas R, Raggi A, Giovannetti AM, et al. Psychosocial difficulties in people with epilepsy: a systematic review of literature from 2005 until 2010. Epilepsy Behav. 2012;25(1):60–67.
  • Zhu L, Chen L, Xu P, et al. Genetic and molecular basis of epilepsy-related cognitive dysfunction. Epilepsy Behav. 2020;104:106848.
  • Elizebath R, Zhang E, Coe P, et al. Cenobamate treatment of focal-onset seizures: quality of life and outcome during up to eight years of treatment. Epilepsy Behav. 2021;116:107796.
  • Steinhoff BJ, Rosenfeld WE, Serratosa JM, et al. Practical guidance for the management of adults receiving adjunctive cenobamate for the treatment of focal epilepsy- expert opinion. Epilepsy Behav. Epilepsy Behav. 2021;123:108270.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.