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Expert Review of Neurotherapeutics Volume 23, 2023 - Issue 8
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Editorial

The potential of cell therapies for cerebral palsy: where are we today?

Iona Novaka Faculty of Medicine and Health, The University of Sydney, Australia;b Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaCorrespondence[email protected]
View further author information
,
Madison CB Patonb Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaView further author information
,
Alexandra R Griffinb Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaView further author information
,
Michelle Jackmanb Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaView further author information
,
Remy K Blatch-Williamsb Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaView further author information
&
Megan Finch-Edmondsonb Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaView further author information
Pages 673-675 | Received 01 May 2023, Accepted 05 Jul 2023, Published online: 10 Jul 2023

References

  • Paton MCB, Finch-Edmondson M, Fahey MC, et al. Fifteen years of human research using stem cells for cerebral palsy: A review of the research landscape. J Paediatr Child Health. 2021 Feb;57(2):295–296. doi: 10.1111/jpc.15329
  • McIntyre S, Goldsmith S, Webb A, et al. Global prevalence of cerebral palsy: A systematic analysis. Dev Med Child Neurol. 2022 Dec;64(12):1494–1506.
  • Novak I, Morgan C, Fahey M, et al. State Of the evidence traffic lights 2019: systematic review of interventions for preventing and treating children with cerebral palsy. Curr Neurol Neurosci Rep. 2020 Feb 21;20(2):3. doi: 10.1007/s11910-020-1022-z
  • Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015 Jul 2;17(1):11–22. doi: 10.1016/j.stem.2015.06.007
  • Liu X, Fu X, Dai G, et al. Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy. J Transl Med. 2017 Feb 24;15(1):48. doi: 10.1186/s12967-017-1149-0
  • Trounson A, Thakar RG, Lomax G, et al. Clinical trials for stem cell therapies. BMC Med. 2011 May 10;9(1):52. doi: 10.1186/1741-7015-9-52
  • Paton MCB, Finch-Edmondson M, Dale RC, et al. Persistent inflammation in cerebral palsy: pathogenic mediator or comorbidity? A scoping review. J Clin Med. 2022;11(24):7368. doi: 10.3390/jcm11247368
  • Paton MCB, Wall DA, Elwood N, et al. Safety of allogeneic umbilical cord blood infusions for the treatment of neurological conditions: a systematic review of clinical studies. Cytotherapy. 2022 Jan 01;24(1):2–9.
  • Novak I, Walker K, Hunt RW, et al. Concise review: stem cell interventions for people with cerebral palsy: systematic review with meta-analysis. Stem Cells Transl Med. 2016 Aug;5(8):1014–1025. doi: 10.5966/sctm.2015-0372
  • Eggenberger S, Boucard C, Schoeberlein A, et al. Stem cell treatment and cerebral palsy: systemic review and meta-analysis. World J Stem Cells. 2019 Oct 26;11(10):891–903. doi: 10.4252/wjsc.v11.i10.891
  • Kułak-Bejda A, Kułak P, Bejda G, et al. Stem cells therapy in cerebral palsy: A systematic review. Brain Dev. 2016 Sep;38(8):699–705.
  • Sun JM, Case LE, McLaughlin C, et al. Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: an open-label, randomized trial. Dev Med Child Neurol. 2022;64(12):1477–1486. doi: 10.1111/dmcn.15325
  • Finch-Edmondson M, Paton MCB, Honan I, et al. Are we getting it right? A scoping review of outcomes reported in cell therapy clinical studies for cerebral palsy. J Clin Med. 2022;11(24):7319. doi: 10.3390/jcm11247319

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