Impact of psychiatric comorbidities on the treatment of epilepsies in adults

References

• Mula M, Kanner AM, Jetté N, et al. Psychiatric comorbidities in people with epilepsy. Neurol Clin Pract. 2021;11(2):e112–e120. doi: 10.1212/CPJ.0000000000000874
   PubMedGoogle Scholar
• Fisher RS, Acevedo C, Arzimanoglou A. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–482. doi: 10.1111/epi.12550
   PubMed Web of Science ®Google Scholar
• Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies position paper of the ILAE commission for classification and terminology. Epilepsia. 2017;58:512–521. doi: 10.1111/epi.13709
   PubMed Web of Science ®Google Scholar
• Rai D, Kerr MP, McManus S, et al. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia. 2012;53(6):1095–1103. doi: 10.1111/j.1528-1167.2012.03500.x
   PubMed Web of Science ®Google Scholar
• Fiest KM, Dykeman J, Patten SB, et al. Depression in epilepsy: a systematic review and meta-analysis. Neurology. 2013;80(6):590–599. doi: 10.1212/WNL.0b013e31827b1ae0
   PubMed Web of Science ®Google Scholar
• Scott AJ, Sharpe L, Hunt C, et al. Anxiety and depressive disorders in people with epilepsy: a meta-analysis. Epilepsia. 2017;58(6):973–982. doi: 10.1111/epi.13769
   PubMed Web of Science ®Google Scholar
• Clancy MJ, Clarke MC, Connor DJ, et al. The prevalence of psychosis in epilepsy; a systematic review and meta-analysis. BMC Psychiatry. 2014;14(1):75. doi: 10.1186/1471-244X-14-75
   PubMedGoogle Scholar
• Reilly C, Atkinson P, Das KB, et al. Neurobehavioral comorbidities in children with active epilepsy: a population-based study. Pediatrics. 2014;133:e1586–1593. doi: 10.1542/peds.2013-3787
   PubMed Web of Science ®Google Scholar
• Mula M, Kaufman KR. Double stigma in mental health: epilepsy and mental illness. BJPsych Open. 2020;6(4):e72. doi: 10.1192/bjo.2020.58
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Ishihara L, Mynepalli L, et al. Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Ann Neurol. 2012;72(2):184–191. doi: 10.1002/ana.23601
   PubMed Web of Science ®Google Scholar
• Elkommos S, Mula M. A systematic review of neuroimaging studies of depression in adults with epilepsy. Epilepsy Behav. 2021;115:115. doi: 10.1016/j.yebeh.2020.107695
   Web of Science ®Google Scholar
• Allebone J, Kanaan R, Wilson SJ. Systematic review of structural and functional brain alterations in psychosis of epilepsy. J Neurol Neurosurg Psychiatry. 2018;89(6):611–617. doi: 10.1136/jnnp-2017-317102
   PubMed Web of Science ®Google Scholar
• Kanner AM. Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders? Lancet Neurol. 2012;11(12):1093–1102. doi: 10.1016/S1474-4422(12)70201-6
   PubMed Web of Science ®Google Scholar
• Agrawal N, Bird JS, von Oertzen TJ, et al. Depression correlates with quality of life in people with epilepsy independent of the measures used. Epilepsy Behav. 2016;62:246–250. doi: 10.1016/j.yebeh.2016.07.020
   PubMed Web of Science ®Google Scholar
• Sano F, Kanemura H, Tando T, et al. Depressive symptoms contribute to quality of life in children with epilepsy. Eur J Paediatr Neurol. 2014;18(6):774–779. doi: 10.1016/j.ejpn.2014.08.002
   PubMed Web of Science ®Google Scholar
• Ravizza T, Onat FY, Brooks-Kayal AR, et al. WONOEP appraisal: biomarkers of epilepsy-associated comorbidities. Epilepsia. 2017;58(3):331–342. doi: 10.1111/epi.13652
   PubMed Web of Science ®Google Scholar
• Josephson CB, Lowerison M, Vallerand I, et al. Association of depression and treated depression with epilepsy and seizure outcomes: a multicohort analysis. JAMA Neurol. 2017;74(5):533. doi: 10.1001/jamaneurol.2016.5042
   PubMed Web of Science ®Google Scholar
• Nogueira MH, Yasuda CL, Coan AC, et al. Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE. Epilepsia. 2017;58(7):1268–1276. doi: 10.1111/epi.13781
   PubMed Web of Science ®Google Scholar
• Stevelink R, Koeleman BPC, Sander JW, et al. Refractory juvenile myoclonic epilepsy: a meta-analysis of prevalence and risk factors. Eur J Neurol. 2018;26(6):856–864. doi: 10.1111/ene.13811
   PubMed Web of Science ®Google Scholar
• Fazel S, Wolf A, Långström N, et al. Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study. Lancet. 2013;382(9905):1646–1654. doi: 10.1016/S0140-6736(13)60899-5
   PubMed Web of Science ®Google Scholar
• Keezer MR, Bell GS, Neligan A, et al. Cause of death and predictors of mortality in a community-based cohort of people with epilepsy. Neurology. 2016;86(8):704–712. doi: 10.1212/WNL.0000000000002390
   PubMed Web of Science ®Google Scholar
• Gur-Ozmen S, Mula M, Agrawal N, et al. The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy. Eur J Neurol. 2017;24(9):1135–1139. doi: 10.1111/ene.13346
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Ishihara L, Webb DJ, et al. Occurrence and recurrence of attempted suicide among people with epilepsy. JAMA Psychiatry. 2016;73(1):80–86. doi: 10.1001/jamapsychiatry.2015.2516
   PubMed Web of Science ®Google Scholar
• Sveinsson O, Andersson T, Carlsson S, et al. The incidence of SUDEP: a nationwide population-based cohort study. Neurology. 2017;89(2):170–177. doi: 10.1212/WNL.0000000000004094
   PubMed Web of Science ®Google Scholar
• Wilner AN, Sharma BK, Soucy A, et al. Common comorbidities in women and men with epilepsy and the relationship between number of comorbidities and health plan paid costs in 2010. Epilepsy Behav. 2014;32:15–20. doi: 10.1016/j.yebeh.2013.12.032
   PubMed Web of Science ®Google Scholar
• Hamilton KT, Anderson CT, Dahodwala N, et al. Utilization of care among drug resistant epilepsy patients with symptoms of anxiety and depression. Seizure. 2014;23(3):196–200. doi: 10.1016/j.seizure.2013.11.012
   PubMed Web of Science ®Google Scholar
• Patel RS, Elmaadawi A, Mansuri Z, et al. Psychiatric comorbidities and outcomes in epilepsy patients: an insight from a nationwide inpatient analysis in the United States. Cureus. 2017;9:e1686. doi: 10.7759/cureus.1686
   PubMed Web of Science ®Google Scholar
• Panelli RJ, Kilpatrick C, Moore SM, et al. The Liverpool adverse events profile: relation to AED use and mood. Epilepsia. 2007;48(3):456–463. doi: 10.1111/j.1528-1167.2006.00956.x
   PubMed Web of Science ®Google Scholar
• Velissaris SL, Wilson SJ, Newton MR, et al. Cognitive complaints after a first seizure in adulthood: influence of psychological adjustment. Epilepsia. 2009;50(5):1012–1021. doi: 10.1111/j.1528-1167.2008.01893.x
   PubMed Web of Science ®Google Scholar
• Stephen LJ, Wishart A, Brodie MJ. Psychiatric side effects and antiepileptic drugs: observations from prospective audits. Epilepsy Behav. 2017;71:73–78. doi: 10.1016/j.yebeh.2017.04.003
   PubMed Web of Science ®Google Scholar
• Chen B, Choi H, Hirsch LJ, et al. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy Behav. 2017;76:24–31. doi: 10.1016/j.yebeh.2017.08.039
   PubMed Web of Science ®Google Scholar
• Mula M, Trimble MR, Sander JW. Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam. Epilepsia. 2007;48:2322–2326. doi: 10.1111/j.1528-1167.2007.01262.x
   PubMed Web of Science ®Google Scholar
• Perucca P, Mula M. Antiepileptic drug effects on mood and behavior: molecular targets. Epilepsy Behav. 2013;26(3):440–449. doi: 10.1016/j.yebeh.2012.09.018
   PubMed Web of Science ®Google Scholar
• Mula M, Trimble MR, Lhatoo SD, et al. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia. 2003;44(5):659–663. doi: 10.1046/j.1528-1157.2003.05402.x
   PubMed Web of Science ®Google Scholar
• White JR, Walczak TS, Leppik IE, et al. Discontinuation of levetiracetam because of behavioral side effects: a case-control study. Neurology. 2003;61(9):1218–1221. doi: 10.1212/01.WNL.0000091865.46063.67
   PubMed Web of Science ®Google Scholar
• Mula M, Hesdorffer DC, Trimble M, et al. The role of titration schedule of topiramate for the development of depression in patients with epilepsy. Epilepsia. 2009;50(5):1072–1076. doi: 10.1111/j.1528-1167.2008.01799.x
   PubMed Web of Science ®Google Scholar
• Mula M. Epilepsy and psychiatric comorbidities: drug selection. Curr Treat Options Neurol. 2017;19(12):44. doi: 10.1007/s11940-017-0483-0
   PubMed Web of Science ®Google Scholar
• Busco M. FDA advisory members agree antiepileptics pose suicidality risk, need for black-box warning. Medscape Medical News. 2008.
   Google Scholar
• Mula M, Kanner AM, Schmitz B, et al. Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on therapeutic strategies of the ILAE commission on neuropsychobiology. Epilepsia. 2013;54(1):199–203. doi: 10.1111/j.1528-1167.2012.03688.x
   PubMed Web of Science ®Google Scholar
• Klein P, Devinsky O, French J, et al. Suicidality risk of newer antiseizure medications: a meta-analysis. JAMA Neurol. 2021;78(9):1118–1127. doi: 10.1001/jamaneurol.2021.2480
   PubMed Web of Science ®Google Scholar
• Mula M. Suicidality and antiepileptic drugs in people with epilepsy: an update. Expert Rev Neurother. 2022;22(5):405–410. doi: 10.1080/14737175.2022.2064744
   PubMed Web of Science ®Google Scholar
• Spindler P, Bohlmann K, Straub H-B, et al. Effects of vagus nerve stimulation on symptoms of depression in patients with difficult-to-treat epilepsy. Seizure. 2019;69:77–79. doi: 10.1016/j.seizure.2019.04.001
   PubMed Web of Science ®Google Scholar
• Conway CR, Udaiyar A, Schachter SC. Neurostimulation for depression in epilepsy. Epilepsy Behav. 2018;88S:25–32. doi: 10.1016/j.yebeh.2018.06.007
   PubMedGoogle Scholar
• Aaronson ST, Carpenter LL, Conway CR, et al. Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects. Brain Stimul. 2013;6(4):631–640. doi: 10.1016/j.brs.2012.09.013
   PubMed Web of Science ®Google Scholar
• DeGiorgio CM, Fanselow EE, Schrader LM, et al. Trigeminal nerve stimulation: seminal animal and human studies for epilepsy and depression. Neurosurg Clin N Am. 2011;22(4):449–456. doi: 10.1016/j.nec.2011.07.001
   PubMed Web of Science ®Google Scholar
• DeGiorgio CM, Soss J, Cook IA, et al. Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy. Neurology. 2013;80(9):786–791. doi: 10.1212/WNL.0b013e318285c11a
   PubMed Web of Science ®Google Scholar
• DeGiorgio CM, Murray D, Markovic D, et al. Trigeminal nerve stimulation for epilepsy: long-term feasibility and efficacy. Neurology. 2009;72(10):936–938. doi: 10.1212/01.wnl.0000344181.97126.b4
   PubMed Web of Science ®Google Scholar
• Cook IA, Schrader LM, Degiorgio CM, et al. Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. Epilepsy Behav. 2013;28(2):221–226. doi: 10.1016/j.yebeh.2013.05.008
   PubMed Web of Science ®Google Scholar
• Cook IA, Abrams M, Leuchter AF. Trigeminal nerve stimulation for comorbid posttraumatic stress disorder and major depressive disorder. Neuromodulation: Technol Neural Interface. 2016;19(3):299–305. doi: 10.1111/ner.12399
   PubMed Web of Science ®Google Scholar
• Tager D, Panjeti-Moore D, Yang JC, et al. The effect of responsive neurostimulation (RNS) on neuropsychiatric and psychosocial outcomes in drug-resistant epilepsy. Epilepsy Behav. 2023;142:109207. doi: 10.1016/j.yebeh.2023.109207
   PubMed Web of Science ®Google Scholar
• Lee DJ, Lozano CS, Dallapiazza RF, et al. Current and future directions of deep brain stimulation for neurological and psychiatric disorders. J Neurosurg. 2019;131(2):333–342. doi: 10.3171/2019.4.JNS181761
   PubMed Web of Science ®Google Scholar
• Cleary DR, Ozpinar A, Raslan AM, et al. Deep brain stimulation for psychiatric disorders: where we are now. Neurosurg Focus. 2015;38(6):E2. doi: 10.3171/2015.3.FOCUS1546
   PubMed Web of Science ®Google Scholar
• Lai Y, Dai L, Wang T, et al. Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression. J Neurol Neurosurg Psychiatry. 2023;94(5):379–388. doi: 10.1136/jnnp-2022-329702
   PubMedGoogle Scholar
• Ryvlin P, Rheims S, Hirsch LJ, et al. Neuromodulation in epilepsy: state-of-the-art approved therapies. Lancet Neurol. 2021;20(12):1038–1047. doi: 10.1016/S1474-4422(21)00300-8
   PubMed Web of Science ®Google Scholar
• McClintock SM, Reti IM, Carpenter LL, et al. Consensus recommendations for the clinical application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of depression. J Clin Psychiatry. 2018;79(1):35–48. doi: 10.4088/JCP.16cs10905
   Web of Science ®Google Scholar
• Lefaucheur J-P, Antal A, Ayache SS, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol. 2017;128(1):56–92. doi: 10.1016/j.clinph.2016.10.087
   PubMed Web of Science ®Google Scholar
• Fregni F, El-Hagrassy MM, Pacheco-Barrios K, et al. Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation (tDCS) in neurological and psychiatric disorders. Int J Neuropsychopharmacol. 2020;24(4):256–313. doi: 10.1093/ijnp/pyaa051
   Web of Science ®Google Scholar
• Liu A, Bryant A, Jefferson A, et al. Exploring the efficacy of a 5-day course of transcranial direct current stimulation (TDCS) on depression and memory function in patients with well-controlled temporal lobe epilepsy. Epilepsy Behav. 2016;55:11–20. doi: 10.1016/j.yebeh.2015.10.032
   PubMed Web of Science ®Google Scholar
• Engel J, McDermott MP, Wiebe S, et al. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012;307:922–930. doi: 10.1001/jama.2012.220
   PubMed Web of Science ®Google Scholar
• Koch-Stoecker SC, Bien CG, Schulz R, et al. Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery. Epilepsia. 2017;58(6):983–993. doi: 10.1111/epi.13736
   PubMed Web of Science ®Google Scholar
• Bell GS, de Tisi J, Gonzalez-Fraile JC, et al. Factors affecting seizure outcome after epilepsy surgery: an observational series. J Neurol Neurosurg Psychiatry. 2017;88(11):933–940. doi: 10.1136/jnnp-2017-316211
   PubMed Web of Science ®Google Scholar
• Sobregrau P, Andreu C, Carreño M, et al. Psychiatric disorders in patients with resistant temporal lobe epilepsy two years after undergoing elective surgery. A longitudinal study. Epilepsy Behav. 2021;118:107921. doi: 10.1016/j.yebeh.2021.107921
   PubMed Web of Science ®Google Scholar
• Altalib HH, Berg AT, Cong X, et al. Presurgical depression and anxiety are not associated with worse epilepsy surgery outcome five years postoperatively. Epilepsy Behav. 2018;83:7–12. doi: 10.1016/j.yebeh.2018.01.040
   PubMed Web of Science ®Google Scholar
• de Araújo Filho GM, Mazetto L, Gomes FL, et al. Pre-surgical predictors for psychiatric disorders following epilepsy surgery in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis. Epilepsy Res. 2012;102:86–93. doi: 10.1016/j.eplepsyres.2012.05.005
   PubMed Web of Science ®Google Scholar
• Wrench JM, Rayner G, Wilson SJ. Profiling the evolution of depression after epilepsy surgery. Epilepsia. 2011;52(5):900–908. doi: 10.1111/j.1528-1167.2011.03015.x
   PubMed Web of Science ®Google Scholar
• Macrodimitris S, Sherman EMS, Forde S, et al. Psychiatric outcomes of epilepsy surgery: a systematic review. Epilepsia. 2011;52(5):880–890. doi: 10.1111/j.1528-1167.2011.03014.x
   PubMed Web of Science ®Google Scholar
• Ploesser M, McDonald C, Hirshman B, et al. Psychiatric outcomes after temporal lobe surgery in patients with temporal lobe epilepsy and comorbid psychiatric illness: a systematic review and meta-analysis. Epilepsy Res. 2023;189:107054. doi: 10.1016/j.eplepsyres.2022.107054
   PubMed Web of Science ®Google Scholar
• Ramos-Perdigués S, Baillés E, Mané A, et al. A prospective study contrasting the psychiatric outcome in drug-resistant epilepsy between patients who underwent surgery and a control group. Epilepsia. 2016;57(10):1680–1690. doi: 10.1111/epi.13497
   PubMed Web of Science ®Google Scholar
• Koch-Stoecker S, Schmitz B, Kanner AM. Treatment of postsurgical psychiatric complications. Epilepsia. 2013;54(Suppl 1):46–52. doi: 10.1111/epi.12105
   PubMedGoogle Scholar
• Meador K. Psychiatry problems after epilepsy surgery. Epilepsy Curr. 2005;5(1):28–29. doi: 10.1111/j.1535-7597.2005.05107.x
   PubMedGoogle Scholar
• Baite LD, Harvey EE, Fong MWK, et al. Life following epilepsy surgery: building a holistic framework for enhancing postsurgical recovery and rehabilitation. Epilepsia. 2023;64(7):1785–90.
   PubMed Web of Science ®Google Scholar
• Fasano RE, Kanner AM. Psychiatric complications after epilepsy surgery … but where are the psychiatrists? Epilepsy Behav. 2019;98:318–321. doi: 10.1016/j.yebeh.2018.12.009
   PubMed Web of Science ®Google Scholar
• de Leon J, Santoro V, D’Arrigo C, et al. Interactions between antiepileptics and second-generation antipsychotics. Expert Opin Drug Metab Toxicol. 2012;8(3):311–334. doi: 10.1517/17425255.2012.660918
   PubMed Web of Science ®Google Scholar
• Williams AM, Park SH. Seizure associated with clozapine: incidence, etiology, and management. CNS Drugs. 2015;29(2):101–111. doi: 10.1007/s40263-014-0222-y
   PubMed Web of Science ®Google Scholar
• Agrawal N, Mula M. Treatment of psychoses in patients with epilepsy: an update. Ther Adv Psychopharmacol. 2019;9:2045125319862968. doi: 10.1177/2045125319862968
   Web of Science ®Google Scholar
• Reichelt L, Efthimiou O, Leucht S, et al. Second-generation antipsychotics and seizures – a systematic review and meta-analysis of serious adverse events in randomized controlled trials. Eur Neuropsychopharmacol. 2023;68:33–46. doi: 10.1016/j.euroneuro.2022.12.010
   PubMed Web of Science ®Google Scholar
• Auvin S, Wirrell E, Donald KA, et al. Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on comorbidities of the ILAE pediatric commission. Epilepsia. 2018;59:1867–1880. doi: 10.1111/epi.14549
   PubMed Web of Science ®Google Scholar
• Calle-López Y, Ladino LD, Benjumea-Cuartas V, et al. Forced normalization: a systematic review. Epilepsia. 2019;60(8):1610–1618. doi: 10.1111/epi.16276
   PubMed Web of Science ®Google Scholar
• Brikell I, Chen Q, Kuja-Halkola R, et al. Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy. Epilepsia. 2019;60(2):284–293. doi: 10.1111/epi.14640
   PubMed Web of Science ®Google Scholar
• Mentzelou M, Dakanalis A, Vasios GK, et al. The relationship of ketogenic diet with neurodegenerative and psychiatric diseases: a scoping review from basic research to clinical practice. Nutrients. 2023;15(10):2270. doi: 10.3390/nu15102270
   PubMed Web of Science ®Google Scholar
• Giordano C, Marchiò M, Timofeeva E, et al. Neuroactive peptides as putative mediators of antiepileptic ketogenic diets. Front Neurol. 2014;5:63. doi: 10.3389/fneur.2014.00063
   PubMed Web of Science ®Google Scholar
• Dietch DM, Kerr-Gaffney J, Hockey M, et al. Efficacy of low carbohydrate and ketogenic diets in treating mood and anxiety disorders: systematic review and implications for clinical practice. BJPsych Open. 2023;9(3):e70. doi: 10.1192/bjo.2023.36
   PubMed Web of Science ®Google Scholar
• Palmer CM, Gilbert-Jaramillo J, Westman EC. The ketogenic diet and remission of psychotic symptoms in schizophrenia: two case studies. Schizophr Res. 2019;208:439–440. doi: 10.1016/j.schres.2019.03.019
   PubMed Web of Science ®Google Scholar
• Zhu D, Wang M, Wang J, et al. Ketogenic diet effects on neurobehavioral development of children with intractable epilepsy: a prospective study. Epilepsy Behav. 2016;55:87–91. doi: 10.1016/j.yebeh.2015.12.011
   PubMed Web of Science ®Google Scholar
• IJff DM, Postulart D, Lambrechts DAJE, et al. Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: a randomized controlled trial. Epilepsy Behav. 2016;60:153–157. doi: 10.1016/j.yebeh.2016.04.033
   PubMed Web of Science ®Google Scholar
• Mula M, Brodie MJ, de Toffol B, et al. ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy. Epilepsia. 2022;63(2):316–334. doi: 10.1111/epi.17140
   PubMed Web of Science ®Google Scholar
• Gilliam FG, Black KJ, Carter J, et al. A trial of sertraline or cognitive behavior therapy for depression in epilepsy. Ann Neurol. 2019;86(4):552–560. doi: 10.1002/ana.25561
   PubMed Web of Science ®Google Scholar
• Mula M. The pharmacological management of psychiatric comorbidities in patients with epilepsy. Pharmacol Res. 2016;107:147–153. doi: 10.1016/j.phrs.2016.03.022
   PubMed Web of Science ®Google Scholar
• Italiano D, Spina E, de Leon J. Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants. Expert Opin Drug Metab Toxicol. 2014;10(11):1457–1489. doi: 10.1517/17425255.2014.956081
   PubMed Web of Science ®Google Scholar
• Alper K, Schwartz KA, Kolts RL, et al. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry. 2007;62(4):345–354. doi: 10.1016/j.biopsych.2006.09.023
   PubMed Web of Science ®Google Scholar
• Steinert T, Fröscher W. Epileptic seizures under antidepressive drug treatment: systematic review. Pharmacopsychiatry. 2018;51(4):121–135. doi: 10.1055/s-0043-117962
   PubMed Web of Science ®Google Scholar
• Hasan A, Falkai P, Wobrock T, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance. World J Biol Psychiatry. 2012;13(5):318–378. doi: 10.3109/15622975.2012.696143
   PubMed Web of Science ®Google Scholar
• Nickl-Jockschat T, Paulzen M, Schneider F, et al. Drug interaction can lead to undetectable serum concentrations of quetiapine in the presence of carbamazepine. Clin Neuropharmacol. 2009;32(1):55. doi: 10.1097/WNF.0b013e31816a1cc6
   PubMed Web of Science ®Google Scholar