Contemporary diagnosis and treatment of conduct disorder in youth

References

• American Psychiatric Association. Diagnostic and statistical manual of mental disorders, DSM-5-TR. 5th ed. Washington, DC, USA: American Psychiatric Publishing; 2022.
   Google Scholar
• Sacco R, Camilleri N, Eberhardt J, et al. A systematic review and meta-analysis on the prevalence of mental disorders among children and adolescents in Europe. Eur Child Adolesc Psychiatry. 2022;1–18.
   PubMedGoogle Scholar
• Polanczyk GV, Salum GA, Sugaya LS, et al. Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatr. 2015;56:345–365. doi: 10.1111/jcpp.12381
   PubMed Web of Science ®Google Scholar
• Erskine HE, Ferrari AJ, Polanczyk GV, et al. The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010. J Child Psychol Psychiatr. 2014;55:328–336. doi: 10.1111/jcpp.12186
   PubMed Web of Science ®Google Scholar
• Copeland W, Shanahan L, Costello EJ, et al. Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the great smoky mountains study. J Am Acad Child Adolesc Psychiatry. 2011;50(3):252–261. doi: 10.1016/j.jaac.2010.12.014
   PubMed Web of Science ®Google Scholar
• Mohammadi M-R, Salmanian M, Keshavarzi Z. The global prevalence of conduct disorder: a systematic review and meta-analysis. Iran J Psychiatry. 2021;16:205–225. doi: 10.18502/ijps.v16i2.5822
   PubMedGoogle Scholar
• Wu J, Chen L, Li X, et al. Trends in the prevalence of conduct disorder from 1990 to 2019: findings from the global burden of disease study 2019. Psychiatry Res. 2022;317:114907. doi: 10.1016/j.psychres.2022.114907
   PubMed Web of Science ®Google Scholar
• Kerekes N, Zouini B, Karlsson E, et al. Conduct disorder and somatic health in children: a nationwide genetically sensitive study. BMC Psychiatry. 2020;20(1):595. doi: 10.1186/s12888-020-03003-2
   PubMed Web of Science ®Google Scholar
• Border R, Corley RP, Brown SA, et al. Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls. Addiction. 2018;113(11):2107–2115. doi: 10.1111/add.14366
   PubMed Web of Science ®Google Scholar
• Maughan B, Stafford M, Shah I, et al. Adolescent conduct problems and premature mortality: follow-up to age 65 years in a national birth cohort. Psychol Med. 2014;44(5):1077–1086. doi: 10.1017/S0033291713001402
   PubMed Web of Science ®Google Scholar
• World Health Organization. ICD-11 - international statistical classification of diseases and related health problems. 11th ed. Geneva, Switzerland: WHO; 2019.
   Google Scholar
• Maughan B, Rowe R, Messer J, et al. Conduct disorder and oppositional defiant disorder in a national sample: developmental epidemiology. J Child Psychol Psychiatr. 2004;45(3):609–621. doi: 10.1111/j.1469-7610.2004.00250.x
   PubMed Web of Science ®Google Scholar
• Loeber R, Burke JD, Lahey BB, et al. Oppositional defiant and conduct disorder: a review of the past 10 years, part I. J Am Acad Child Adolesc Psychiatry. 2000;39(12):1468–1484. doi: 10.1097/00004583-200012000-00007
   PubMed Web of Science ®Google Scholar
• Ackermann K, Kirchner M, Bernhard A, et al. Relational aggression in adolescents with conduct disorder: sex differences and behavioral correlates. J Abnorm Child Psychol. 2019;47(10):1625–1637. doi: 10.1007/s10802-019-00541-6
   PubMed Web of Science ®Google Scholar
• Konrad K, Kohls G, Baumann S, et al. Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder. J Child Psychol Psychiatr. 2022;63(2):218–228. doi: 10.1111/jcpp.13428
   PubMed Web of Science ®Google Scholar
• Davis JP, Eddie D, Prindle J, et al. Sex differences in factors predicting post-treatment opioid use. Addiction. 2021;116(8):2116–2126. doi: 10.1111/add.15396
   PubMed Web of Science ®Google Scholar
• Nock MK, Kazdin AE, Hiripi E, et al. Prevalence, subtypes, and correlates of DSM-IV conduct disorder in the national comorbidity survey replication. Psychol Med. 2006;36(5):699–710. doi: 10.1017/S0033291706007082
   PubMed Web of Science ®Google Scholar
• Hawes DJ. Debate: conduct disorder and the segregation of child mental health. Child Adolesc Ment Health. 2022;27:305–306. doi: 10.1111/camh.12582
   PubMed Web of Science ®Google Scholar
• Aebi M, Barra S, Bessler C, et al. The validity of conduct disorder symptom profiles in high-risk male youth. Eur Child Adolesc Psychiatry. 2019;28(11):1537–1546. doi: 10.1007/s00787-019-01339-z
   PubMed Web of Science ®Google Scholar
• North CS, Kotamarti V, Pollio DE. Deconstructing childhood conduct and adult antisocial criteria for the diagnosis of antisocial personality disorder. Ann Clin Psychiatry Off J Am Acad Clin Psychiatr. 2022;34:97–105. doi: 10.12788/acp.0063
   Google Scholar
• Copeland WE, Shanahan L, Erkanli A, et al. Indirect comorbidity in childhood and adolescence. Front Psychiatry. 2013;4:144. doi: 10.3389/fpsyt.2013.00144
   PubMedGoogle Scholar
• Angold A, Costello EJ, Erkanli A. Comorbidity. J Child Psychol Psychiatr. 1999;40(1):57–87. doi: 10.1111/1469-7610.00424
   PubMed Web of Science ®Google Scholar
• Thapar A, Harrington R, McGuffin P. Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psychiatry. 2001;179(3):224–229. doi: 10.1192/bjp.179.3.224
   PubMed Web of Science ®Google Scholar
• Moffitt TE, Arseneault L, Jaffee SR, et al. Research review: DSM-V conduct disorder: research needs for an evidence base. J Child Psychol Psychiatr. 2008;49(1):3–33. doi: 10.1111/j.1469-7610.2007.01823.x
   PubMed Web of Science ®Google Scholar
• Wickens CM, Kao A, Ialomiteanu AR, et al. Conduct disorder and attention-deficit/hyperactivity disorder as risk factors for prescription opioid use. Drug Alcohol Depend. 2020;213:108103. doi: 10.1016/j.drugalcdep.2020.108103
   PubMed Web of Science ®Google Scholar
• Moggi F, Schorno D, Soravia LM, et al. Screened attention deficit/hyperactivity disorder as a predictor of substance use initiation and escalation in early adulthood and the role of self-reported conduct disorder and sensation seeking: a 5-year longitudinal study with young adult Swiss men. Eur Addict Res. 2020;26(4–5):233–244. doi: 10.1159/000508304
   PubMed Web of Science ®Google Scholar
• González RA, Vélez-Pastrana MC, Blankers M, et al. Onset and severity of early disruptive behavioral disorders in treatment-seeking substance use disorder patients with and without attention-deficit/Hyperactivity disorder. Eur Addict Res. 2020;26(4–5):211–222. doi: 10.1159/000508653
   PubMed Web of Science ®Google Scholar
• Gunes H, Tanidir C, Adaletli H, et al. Oppositional defiant disorder/conduct disorder co-occurrence increases the risk of internet addiction in adolescents with attention-deficit hyperactivity disorder. J Behav Addict. 2018;7(2):284–291. doi: 10.1556/2006.7.2018.46
   PubMed Web of Science ®Google Scholar
• Jo YS, Bhang SY, Choi JS, et al. Clinical characteristics of diagnosis for internet gaming disorder: comparison of DSM-5 IGD and ICD-11 GD diagnosis. J Clin Med. 2019;8(7):945. doi: 10.3390/jcm8070945
   PubMed Web of Science ®Google Scholar
• Schoenmacker GH, Groenman AP, Sokolova E, et al. Role of conduct problems in the relation between attention-deficit hyperactivity disorder, substance use, and gaming. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. 2020;30:102–113. doi: 10.1016/j.euroneuro.2018.06.003
   PubMed Web of Science ®Google Scholar
• Berloffa S, Salvati A, D’Acunto G, et al. Internet gaming disorder in child (Basel, Switzerland) and adolescents with attention deficit hyperactivity disorder. Children. 2022;9(3):428. doi: 10.3390/children9030428
   PubMedGoogle Scholar
• Biederman J, Fitzgerald M, Woodworth KY, et al. Does the course of manic symptoms in pediatric bipolar disorder impact the course of conduct disorder? Findings from four prospective datasets. J Affect Disord. 2018;238:244–249. doi: 10.1016/j.jad.2018.05.020
   PubMed Web of Science ®Google Scholar
• Biederman J, Faraone SV, Chu MP, et al. Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children. J Am Acad Child Adolesc Psychiatry 1999 [cited 2021 Dec 6];38:468–476. https://pubmed.ncbi.nlm.nih.gov/10199120/ Available from: doi: 10.1097/00004583-199904000-00021.
   PubMed Web of Science ®Google Scholar
• Vitiello B, Stoff DM. Subtypes of aggression and their relevance to child psychiatry.J Am Acad Child Adolesc Psychiatry. 1997 [cited 2021 Dec 6];36(3):307–315. doi: 10.1097/00004583-199703000-00008.
   PubMed Web of Science ®Google Scholar
• Woodward D, Wilens TE, Yule AM, et al. Examining the clinical correlates of conduct disorder in youth with bipolar disorder. J Affect Disord. 2023;329:300–306. doi: 10.1016/j.jad.2023.02.119
   PubMed Web of Science ®Google Scholar
• Doyle AE, Faraone SV. Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder. Curr Psychiatry Rep. 2002 [cited 2021 Dec 11];4(2):146–152. Available from https://pubmed.ncbi.nlm.nih.gov/11914177/ doi: 10.1007/s11920-002-0049-y
   PubMedGoogle Scholar
• Biederman J, Faraone SV, Hatch M, et al. Conduct disorder with and without mania in a referred sample of ADHD children. J Affect Disord 1997 [cited 2021 Dec 6];44:177–188. https://pubmed.ncbi.nlm.nih.gov/9241578/ Available from: doi: 10.1016/S0165-0327(97)00043-8.
   PubMed Web of Science ®Google Scholar
• Masi G, Milone A, Manfredi A, et al. Comorbidity of conduct disorder and bipolar disorder in clinically referred children and adolescents. J Child Adolesc Psychopharmacol. 2008 [cited 2021 Dec 6];18(3):271–279. doi: 10.1089/cap.2008.0051
   PubMed Web of Science ®Google Scholar
• Sesso G, Brancati GE, Masi G. Comorbidities in youth with bipolar disorder: clinical features andPharmacological management. Curr Neuropharmacol. 2022;21(4):911–934. doi: 10.2174/1570159X20666220706104117
   Web of Science ®Google Scholar
• Muratori P, Milone A, Manfredi A, et al. Evaluation of improvement in externalizing behaviors and callous-unemotional traits in children with disruptive behavior disorder: a 1-year follow up clinic-based study. Adm Policy Ment Health. 2017;44(4):452–462. doi: 10.1007/s10488-015-0660-y
   PubMed Web of Science ®Google Scholar
• Szewczuk-Bogusławska M, Kaczmarek-Fojtar M, Halicka-Masłowska J, et al. Self-injuries and their functions with respect to suicide risk in adolescents with conduct disorder: findings from a path analysis. J Clin Med. 2021;10(19):10. doi: 10.3390/jcm10194602
   Web of Science ®Google Scholar
• Halicka-Masłowska J, Szewczuk-Bogusławska M, Rymaszewska J, et al. From emotional intelligence to self-injuries: a path analysis in adolescents with conduct disorder. Front Psychiatry. 2020;11:556278. doi: 10.3389/fpsyt.2020.556278
   PubMed Web of Science ®Google Scholar
• Szewczuk-Bogusławska M, Kaczmarek-Fojtar M, Adamska A, et al. Assessment of the association between non-suicidal self-injury disorder and suicidal behaviour disorder in females with conduct disorder. BMC Psychiatry. 2021;21(1):172. doi: 10.1186/s12888-021-03168-4
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. New Delhi (India): CBS Publishers; 2013.
   Google Scholar
• Sesso G, Masi G. Pharmacological strategies for the management of the antisocial personality disorder. Expert Rev Clin Pharmacol. 2023;16(3):181–194. doi: 10.1080/17512433.2023.2181159
   PubMed Web of Science ®Google Scholar
• Milone A, Sesso G. Disruptive behavior disorders: symptoms, evaluation and treatment. Brain Sci. 2022;12(2):225. doi: 10.3390/brainsci12020225
   PubMed Web of Science ®Google Scholar
• Colins OF, Fanti KA, Andershed H. The DSM-5 limited prosocial emotions specifier for conduct disorder: comorbid problems, prognosis, and antecedents. J Am Acad Child Adolesc Psychiatry. 2021;60(8):1020–1029. doi: 10.1016/j.jaac.2020.09.022
   PubMed Web of Science ®Google Scholar
• Frick PJ, Ray JV, Thornton LC, et al. The road forward for research on callous-unemotional traits: reply to Lahey (2014). Psychol Bull. 2014;140:64–68. doi: 10.1037/a0033710
   PubMed Web of Science ®Google Scholar
• Frick PJ, Viding E. Antisocial behavior from a developmental psychopathology perspective. Dev Psychopathol. 2009;21(4):1111–1131. doi: 10.1017/S0954579409990071
   PubMed Web of Science ®Google Scholar
• López-Romero L, Cutrín O, Maneiro L, et al. Psychopathic traits in childhood: insights from parental warmth and fearless temperament via conscience development. Brain Sci. 2021;11(7):11. doi: 10.3390/brainsci11070923
   Web of Science ®Google Scholar
• Gregory S, Blair RJ, Ffytche D, et al. Punishment and psychopathy: a case-control functional MRI investigation of reinforcement learning in violent antisocial personality disordered men. Lancet Psychiatry. 2015;2(2):153–160. doi: 10.1016/S2215-0366(14)00071-6
   PubMed Web of Science ®Google Scholar
• Pechorro P, Kahn RE, Ray JV, et al. Psychometric properties of the reactive-proactive aggression questionnaire among a sample of detained and community girls. Crim Justice Behav. 2017;44:531–550. doi: 10.1177/0093854816686395
   Web of Science ®Google Scholar
• Colins OF, Andershed H. The DSM-5 with limited prosocial emotions specifier for conduct disorder among detained girls. Law Hum Behav. 2015;39:198–207. doi: 10.1037/lhb0000108
   PubMed Web of Science ®Google Scholar
• Frick PJ. Editorial: testing the validity of the limited prosocial emotions specifier. J Am Acad Child Adolesc Psychiatry. 2021;60(8):952–954. doi: 10.1016/j.jaac.2020.12.020
   PubMed Web of Science ®Google Scholar
• Colins OF, Andershed H, Salekin RT, et al. Comparing different approaches for subtyping children with conduct problems: callous-unemotional traits only versus the multidimensional psychopathy construct. J Psychopathol Behav Assess. 2018 [cited 2021 Sep 9];40:6–15. Available from. doi: 10.1007/s10862-018-9653-y
   PubMed Web of Science ®Google Scholar
• Obradovic J, Boyce WT. Individual differences in behavioral, physiological, and genetic sensitivities to contexts: implications for development and adaptation. Dev Neurosci. 2009;31(4):300–308. doi: 10.1159/000216541
   PubMed Web of Science ®Google Scholar
• Priddis LE, Landy S, Moroney D, et al. An exploratory study of aggression in school-age children: underlying factors and implications for treatment. Aust J Guid Couns. 2014;24:18–35. doi: 10.1017/jgc.2013.12
   Google Scholar
• Fontaine NMG, McCrory EJP, Boivin M, et al. Predictors and outcomes of joint trajectories of callous-unemotional traits and conduct problems in childhood. J Abnorm Psychol. 2011;120:730–742. doi: 10.1037/a0022620
   PubMed Web of Science ®Google Scholar
• Pisano S, Muratori P, Gorga C, et al. Conduct disorders and psychopathy in children and adolescents: aetiology, clinical presentation and treatment strategies of callous-unemotional traits. Ital J Pediatr. 2017;43(1). doi: 10.1186/s13052-017-0404-6
   PubMedGoogle Scholar
• Perlstein S, Fair M, Hong E, et al. Treatment of childhood disruptive behavior disorders and callous-unemotional traits: a systematic review and two multilevel meta-analyses. J Child Psychol Psychiatr. 2023;64(9):1372–1387. doi: 10.1111/jcpp.13774
   PubMedGoogle Scholar
• Levantini V, Muratori P, Calderoni S, et al. Psychopathic traits and emotion processing in a clinical sample of children with disruptive behavior disorder. Curr Psychol. 2022;42(23):19981–19990. doi: https://doi.org/10.1007/s12144-022-03138-3
   Web of Science ®Google Scholar
• Bedford R, Pickles A, Sharp H, et al. Reduced face preference in infancy: a developmental precursor to callous-unemotional traits? Biol Psychiatry. 2015;78(2):144–150. doi: 10.1016/j.biopsych.2014.09.022
   PubMed Web of Science ®Google Scholar
• Levantini V, Muratori P, Calderoni S, et al. Parenting practices moderate the link between attention to the eyes and callous unemotional traits in children with disruptive behavior disorder: an eye-tracking study. J Psychiatr Res. 2022;146:272–278. doi: 10.1016/j.jpsychires.2021.11.016
   PubMed Web of Science ®Google Scholar
• Muratori P, Lochman JE, Lai E, et al. Which dimension of parenting predicts the change of callous unemotional traits in children with disruptive behavior disorder? Compr Psychiatry. 2016;69:202–210. doi: 10.1016/j.comppsych.2016.06.002
   PubMed Web of Science ®Google Scholar
• Frick P, Ray JV, Thornton LC, et al. Annual research review: a developmental psychopathology approach to understanding callous-unemotional traits in children and adolescents with serious conduct problems. J Child Psychol Psychiatry Allied Discip. 2014;55:532–548. doi: 10.1111/jcpp.12152
   PubMed Web of Science ®Google Scholar
• Masi G, Milone A, Pisano S, et al. Emotional reactivity in referred youth with disruptive behavior disorders: the role of the callous-unemotional traits. Psychiatry Res. 2014;220(1–2):426–432. doi: 10.1016/j.psychres.2014.07.035
   PubMed Web of Science ®Google Scholar
• White SF, Briggs-Gowan MJ, Voss JL, et al. Can the fear recognition deficits associated with callous-unemotional traits be identified in early childhood? J Clin Exp Neuropsychol. 2016;38(6):672–684. doi: 10.1080/13803395.2016.1149154
   PubMed Web of Science ®Google Scholar
• Dadds MR, Hawes DJ, Frost ADJ, et al. Learning to “talk the talk”: the relationship of psychopathic traits to deficits in empathy across childhood. J Child Psychol Psychiatry Allied Discip. 2009;50:599–606. doi: 10.1111/j.1469-7610.2008.02058.x
   PubMed Web of Science ®Google Scholar
• Jolliffe D, Farrington DP. Development and validation of the basic empathy scale. J Adolesc. 2006;29:589–611. doi: 10.1016/j.adolescence.2005.08.010
   PubMed Web of Science ®Google Scholar
• Lovett BJ, Sheffield RA. Affective empathy deficits in aggressive children and adolescents: a critical review. Clin Psychol Rev. 2007;27(1):1–13. doi: 10.1016/j.cpr.2006.03.003
   PubMed Web of Science ®Google Scholar
• Blair RJR. Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populations. Conscious Cogn. 2005 [cited 2019 Oct 24];14:698–718. http://www.ncbi.nlm.nih.gov/pubmed/16157488
   PubMed Web of Science ®Google Scholar
• Milone A, Cerniglia L, Cristofani C, et al. Empathy in youths with conduct disorder and callous-unemotional traits. Neural Plast. 2019 [[cited 2019 Oct 24]];2019:1–8.
   Web of Science ®Google Scholar
• Waller R, Wagner NJ, Barstead MG, et al. A meta-analysis of the associations between callous-unemotional traits and empathy, prosociality, and guilt. Clin Psychol Rev. 2020;75:101809. doi: 10.1016/j.cpr.2019.101809
   PubMed Web of Science ®Google Scholar
• Thornton LC, Penner EA, Nolan ZT, et al. The processing of animacy information is disrupted as a function of callous-unemotional traits in youth with disruptive behavior disorders. NeuroImage Clin. 2017;16:498–506. doi: 10.1016/j.nicl.2017.08.024
   PubMed Web of Science ®Google Scholar
• Northam JC, Dar H, Hawes DJ, et al. More than a feeling? An expanded investigation of emotional responsiveness in young children with conduct problems and callous-unemotional traits. Dev Psychopathol. 2023;35(2):494–508. doi: 10.1017/S0954579421001590
   PubMedGoogle Scholar
• Chan AB, Fleming GE, Kaouar S, et al. The measure of empathy in early childhood: testing the reliability, validity, and clinical utility of scores in early childhood. Psychol Assess. 2023;35(9):791–803. doi: 10.1037/pas0001257
   PubMedGoogle Scholar
• Paulus FW, Ohmann S, Möhler E, et al. Emotional dysregulation in children and adolescents with psychiatric disorders. A narrative review. Front Psychiatry. 2021;12:12. doi: 10.3389/fpsyt.2021.628252
   Web of Science ®Google Scholar
• Guyer AE, Mcclure EB, Adler AD, et al. Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry Allied Discip. 2007;48:863–871. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547839560&doi=10.1111%2Fj.1469-7610.2007.01758.x&partnerID=40&md5=6b583a718dbe4ecb2fb4ece972a7a64b
   PubMed Web of Science ®Google Scholar
• Martin-Key N, Brown T, Fairchild G. Empathic accuracy in male adolescents with conduct disorder and higher versus lower levels of callous-unemotional traits. J Abnorm Child Psychol. 2017;45(7):1385–1397. doi: 10.1007/s10802-016-0243-8
   PubMed Web of Science ®Google Scholar
• Kohls G, Fairchild G, Bernhard A, et al. Neuropsychological subgroups of emotion processing in youths with conduct disorder. Front Psychiatry. 2020;11:585052. doi: 10.3389/fpsyt.2020.585052
   PubMed Web of Science ®Google Scholar
• Berluti K, Ploe ML, Marsh AA. Emotion processing in youths with conduct problems: an fMRI meta-analysis. Transl Psychiatry. 2023;13(1):1–10. doi: 10.1038/s41398-023-02363-z
   PubMed Web of Science ®Google Scholar
• Faraone SV, Rostain AL, Blader J, et al. Practitioner review: emotional dysregulation in attention-deficit/hyperactivity disorder – implications for clinical recognition and intervention. J Child Psychol Psychiatry Allied Discip. 2019;60(2):133–150. doi: 10.1111/jcpp.12899
   PubMed Web of Science ®Google Scholar
• Stringaris A. Irritability in children and adolescents: a challenge for DSM-5. Eur Child Adolesc Psychiatry. 2011;20(2):61–66. doi: 10.1007/s00787-010-0150-4
   PubMed Web of Science ®Google Scholar
• Fanti KA. Understanding heterogeneity in conduct disorder: a review of psychophysiological studies. Neurosci Biobehav Rev. 2018;91:4–20. doi: 10.1016/j.neubiorev.2016.09.022
   PubMed Web of Science ®Google Scholar
• Harty SC, Miller CJ, Newcorn JH, et al. Adolescents with childhood ADHD and comorbid disruptive behavior disorders: aggression, anger, and hostility. Child Psychiatry Hum Dev. 2009;40(1):85–97. doi: 10.1007/s10578-008-0110-0
   PubMed Web of Science ®Google Scholar
• Masi G, Muratori P, Manfredi A, et al. Child behaviour checklist emotional dysregulation profiles in youth with disruptive behaviour disorders: clinical correlates and treatment implications. Psychiatry Res. 2015;225(1–2):191–196. doi: 10.1016/j.psychres.2014.11.019
   PubMed Web of Science ®Google Scholar
• Leaberry KD, Rosen PJ, Fogleman ND, et al. Comorbid internalizing and externalizing disorders predict lability of negative emotions among children with ADHD. J Atten Disord. 2020;24(14):1989–2001. doi: 10.1177/1087054717734647
   PubMed Web of Science ®Google Scholar
• Ford JD, Connor DF, Hawke J. Complex trauma among psychiatrically impaired children: a cross-sectional, chart-review study. J Clin Psychiatry. 2009;70(8):1155–1163. doi: 10.4088/JCP.08m04783
   PubMed Web of Science ®Google Scholar
• Ford JD, Fraleigh LA, Albert DB, et al. Child abuse and autonomic nervous system hyporesponsivity among psychiatrically impaired children. Child Abuse Negl. 2010;34(7):507–515. doi: 10.1016/j.chiabu.2009.11.005
   PubMed Web of Science ®Google Scholar
• Ford JD, Racusin R, Daviss WB, et al. Trauma exposure among children with oppositional defiant disorder and attention deficit-hyperactivity disorder. J Consult Clin Psychol. 1999;67:786–789. doi: 10.1037/0022-006X.67.5.786
   PubMed Web of Science ®Google Scholar
• Fanti KA, Demetriou CA, Kimonis ER. Variants of callous-unemotional conduct problems in a community sample of adolescents. J Youth Adolesc. 2013;42:964–979. doi: 10.1007/s10964-013-9958-9
   PubMed Web of Science ®Google Scholar
• Ezpeleta L, Navarro JB, de la Osa N, et al. Attention to emotion through a go/no-go task in children with oppositionality and callous-unemotional traits. Compr Psychiatry. 2017;75:35–45. doi: 10.1016/j.comppsych.2017.02.004
   PubMed Web of Science ®Google Scholar
• Craig SG, Goulter N, Moretti MM. A systematic review of primary and secondary callous-unemotional traits and psychopathy variants in youth. Clin Child Fam Psychol Rev. 2021;24(1):65–91. doi: 10.1007/s10567-020-00329-x
   PubMed Web of Science ®Google Scholar
• Fairchild G, Hawes DJ, Frick PJ, et al. Conduct disorder. Nat Rev Dis Prim. 2019;5(1). doi: 10.1038/s41572-019-0095-y
   PubMedGoogle Scholar
• Dugré JR, Potvin S. Multiple developmental pathways underlying conduct problems: a multitrajectory framework. Dev Psychopathol. 2022;34(3):1115–1124. doi: 10.1017/S0954579420001650
   PubMed Web of Science ®Google Scholar
• Waschbusch DA, Baweja R, Babinski DE, et al. Irritability and limited prosocial emotions/Callous-unemotional traits in elementary-school-age children. Behav Ther. 2020;51(2):223–237. doi: 10.1016/j.beth.2019.06.007
   PubMed Web of Science ®Google Scholar
• Zhang R, Aloi J, Bajaj S, et al. Dysfunction in differential reward-punishment responsiveness in conduct disorder relates to severity of callous-unemotional traits but not irritability. Psychol Med. 2021;54:1–11.
   Google Scholar
• Waxmonsky J, Fosco W, Waschbusch D, et al. The impact of irritability and callous unemotional traits on reward positivity in youth with ADHD and conduct problems. Res Child Adolesc Psychopathol. 2022;50(8):1027–1040. doi: 10.1007/s10802-022-00901-9
   PubMedGoogle Scholar
• Achenbach T, Rescorla L Manual for the ASEBA school-age forms and profiles: an integrated system of multi-informant assessment [internet]. Burlington (VT): University of Vermont, Research Center for Children, Youth, & Families; 2001 [cited 2020 Apr 18]. Available from: https://trove.nla.gov.au/work/9622516?q&versionId=11167240.
   Google Scholar
• Goodman R. The strengths and difficulties questionnaire. J Child Psychol Psychiatr. 1997;38:581–586. doi: 10.1111/j.1469-7610.1997.tb01545.x
   PubMed Web of Science ®Google Scholar
• Koth C, Bradshaw CP, Leaf P. Teacher observation of classroom adaptation—checklist: development and factor structure. Meas Eval Couns Dev. 2009;42(1):15–30. doi: 10.1177/0748175609333560
   Web of Science ®Google Scholar
• Eyberg S, Pincus D. Eyberg Child behavior Inventory & Sutter-Eyberg Student behavior Inventory-revised: professional manual. Odessa (FL): Psychological Assessment Resources; 1999.
   Google Scholar
• Reynolds RC, Kamphaus RW. Behavioral assessment system for children. 2nd ed. San Antonio: Pearson,; 2004.
   Google Scholar
• Raine A, Ling S, Streicher W, et al. The conduct and oppositional defiant disorder scales (CODDS) for disruptive behaviour disorders. Psychiatry Res. 2022;316:114744. doi: 10.1016/j.psychres.2022.114744
   PubMed Web of Science ®Google Scholar
• Tissue AD, Hawes DJ, Lechowicz ME, et al. Reliability and validity of the DSM-5 diagnostic interview schedule for children, adolescents, and parents-5 in externalizing disorders and common comorbidities. Clin Child Psychol Psychiatry. 2022;27(3):870–881. doi: 10.1177/13591045211061800
   PubMed Web of Science ®Google Scholar
• Kaufman J, Birmaher B, Brent D, et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36(7):980–988. doi: 10.1097/00004583-199707000-00021
   PubMed Web of Science ®Google Scholar
• Kimonis ER, Fanti KA, Anastassiou-Hadjicharalambous X, et al. Can callous-unemotional traits be reliably measured in preschoolers? J Abnorm Child Psychol. 2016;44(4):625–638. doi: 10.1007/s10802-015-0075-y
   PubMed Web of Science ®Google Scholar
• Richaud MC, Lemos VN, Mesurado B, et al. Construct validity and reliability of a new Spanish empathy questionnaire for children and early adolescents. Frontiers In Psychology. 2017;8:8. doi: 10.3389/fpsyg.2017.00979
   PubMed Web of Science ®Google Scholar
• Masi G, Milone A, Brovedani P, et al. Psychiatric evaluation of youths with disruptive behavior disorders and psychopathic traits: a critical review of assessment measures. Neurosci Biobehav Rev. 2018 [cited 2019 Oct 26];91:21–33. doi: 10.1016/j.neubiorev.2016.09.023
   PubMed Web of Science ®Google Scholar
• Frick P, Hare R. Toronto, Canada: MultiHealth System; 2001.
   Google Scholar
• Frick PJ. New Orleans, LA, USA: University of New Orleans; 2004.
   Google Scholar
• Cardinale EM, Marsh AA. The reliability and validity of the inventory of callous unemotional traits: a meta-analytic review. Assessment. 2020;27(1):57–71. doi: 10.1177/1073191117747392
   PubMed Web of Science ®Google Scholar
• Ezpeleta L, de la Osa N, Granero R, et al. Inventory of callous-unemotional traits in a community sample of preschoolers. J Clin Child Adolesc Psychol Off. 2013;42:91–105. doi: 10.1080/15374416.2012.734221
   PubMed Web of Science ®Google Scholar
• Salekin RT. Research review: what do we know about psychopathic traits in children? J Child Psychol Psychiatry Allied Discip. 2017;58(11):1180–1200. doi: 10.1111/jcpp.12738
   PubMed Web of Science ®Google Scholar
• Muratori P, Buonanno C, Gallani A, et al. Validation of the proposed specifiers for conduct disorder (PSCD) scale in a sample of Italian students. Children. 2021;8(11):1–12. doi: 10.3390/children8111020
   Google Scholar
• Kliem S, Krieg Y, Klatt T, et al. Dimensional latent structure of callous-unemotional traits in German adolescents: results from taxometric analyses. Res Child Adolesc Psychopathol. 2022;50(6):771–780. doi: 10.1007/s10802-021-00885-y
   PubMedGoogle Scholar
• Forth A, Kosson D, Hare R. The hare PCL:youth version. Toronto (Canada): Multi-Health Systems; 2003.
   Google Scholar
• Andershed H, Kerr M, Stattin H, et al. Psychopathic traits in non-referred youths: a new assessment tool. 2002.
   Google Scholar
• Colins OF, Andershed H, Frogner L, et al. A new measure to assess psychopathic personality in children: the child problematic traits inventory. J Psychopathol Behav Assess. 2014;36(1):4–21. doi: 10.1007/s10862-013-9385-y
   PubMed Web of Science ®Google Scholar
• Lynam DR. Pursuing the psychopath: capturing the fledgling psychopath in a nomological net. J Abnorm Psychol. 1997;106(3):425–438. doi: 10.1037/0021-843X.106.3.425
   PubMed Web of Science ®Google Scholar
• Salekin RT, Hare RD. The proposed specifiers for conduct disorder (PSCD) scale. Unpublished. 2016.
   Google Scholar
• López-Romero L, Romero E, Colins OF, et al. Proposed specifiers for conduct disorder (PSCD): preliminary validation of the parent version in a Spanish sample of preschoolers. Psychol Assess. 2019;31(11):1357–1367. doi: 10.1037/pas0000759
   PubMed Web of Science ®Google Scholar
• Colins OF, Bisback A, Reculé C, et al. The proposed specifiers for conduct disorder (PSCD) scale: factor structure and validation of the self-report version in a forensic sample of Belgian youth. Assessment. 2022;30(4):1302–1320. doi: 10.1177/10731911221094256
   PubMed Web of Science ®Google Scholar
• Elhami Athar M, Kargari Padar L, Sharifi Nejad A, et al. Validation of the proposed specifiers for conduct disorder (PSCD) self-report version in Iranian school-attending adolescents. J Pers Assess. 2022;54:1–11.
   Google Scholar
• Luo J, Wang M-C, Neumann CS, et al. Factor structure and construct validity of the proposed specifiers for conduct disorder (PSCD) scale in Chinese adolescents. Assessment. 2020 [cited 2020 Aug 31];28(7):1765–1784. Available from. http://www.ncbi.nlm.nih.gov/pubmed/32815378 doi: 10.1177/1073191120949914
   PubMed Web of Science ®Google Scholar
• Ribeiro da Silva D, Sousa R, Rijo D, et al. Proposed specifiers for conduct disorder (PSCD): factor structure and validation of the self-report version in community and forensic samples of Portuguese youth. Assessment. 2023;30:124–143. doi: 10.1177/10731911211044534
   PubMed Web of Science ®Google Scholar
• López-Romero L, Cutrín O, Maneiro L, et al. Proposed specifiers for conduct disorder-short version (PSCD-SV): psychometric properties, concurrent correlates and parenting predictors. Child Psychiatry Hum Dev. 2022;54(5):1258–1273. doi: 10.1007/s10578-022-01335-6
   PubMed Web of Science ®Google Scholar
• Kyranides MN, Fanti KA, Sikki M, et al. Triarchic dimensions of psychopathy in young adulthood: associations with clinical and physiological measures after accounting for adolescent psychopathic traits. Pers Disord: Theory Res Treat. 2017;8(2):140–149. doi: 10.1037/per0000193
   Web of Science ®Google Scholar
• Miller PA, Eisenberg N. The relation of empathy to aggressive and externalizing/antisocial behavior.Psychol Bull. 1988 [[cited 2019 Oct 24]];103(3):324–344. doi: 10.1037/0033-2909.103.3.324
   PubMed Web of Science ®Google Scholar
• Sesso G, Brancati GE, Fantozzi P, et al. Measures of empathy in children and adolescents: a systematic review of questionnaires. World J Psychiatry. 2021;11:876–896. doi: 10.5498/wjp.v11.i10.876
   PubMed Web of Science ®Google Scholar
• Davis. A multidimensional approach to individual difference in empathy. JSAS Cat Sel Doc Psychol. 1980 [cited 2019 Oct 26];85. Available from http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.462.7754
   Google Scholar
• Marwaha S, He Z, Broome M, et al. How is affective instability defined and measured? A systematic review. Psychol Med. 2014;44(9):1793–1808. Cambridge University Press. doi: 10.1017/S0033291713002407
   PubMed Web of Science ®Google Scholar
• Holtmann M, Becker A, Banaschewski T, et al. Psychometric validity of the strengths and difficulties questionnaire-dysregulation profile. Psychopathology. 2011;44(1):53–59. doi: 10.1159/000318164
   PubMed Web of Science ®Google Scholar
• Jose Carballo J, Serrano-Drozdowskyj E, Garcia Nieto R, et al. Prevalence and correlates of psychopathology in children and adolescents evaluated with the strengths and difficulties questionnaire dysregulation profile in a clinical setting. Psychopathology. 2014;47(5):303–311. doi: 10.1159/000360822
   PubMed Web of Science ®Google Scholar
• Caro-Cañizares I, Serrano-Drozdowskyj E, Pfang B, et al. SDQ dysregulation profile and its relation to the severity of psychopathology and psychosocial functioning in a sample of children and adolescents with ADHD. J Atten Disord. 2020;24(11):1557–1564. doi: 10.1177/1087054717691829
   PubMed Web of Science ®Google Scholar
• Deutz MHF, Shi Q, Vossen HGM, et al. Evaluation of the strengths and difficulties questionnaire-dysregulation profile (SDQ-DP). Psychol Assess. 2018;30(9):1174–1185. doi: 10.1037/pas0000564
   PubMed Web of Science ®Google Scholar
• Levantini V, Camodeca M, Gelati C. The strengths and difficulties questionnaire dysregulation profile teacher-report: psychometric properties and associations with aspects of school experience. Child Psychiatry Hum Dev. 2022. doi: 10.1007/s10578-022-01441-5
   PubMed Web of Science ®Google Scholar
• Young KS, Sandman CF, Craske MG. Positive and negative emotion regulation in adolescence: links to anxiety and depression. Brain Sci. 2019;9(4):76. doi: 10.3390/brainsci9040076
   PubMed Web of Science ®Google Scholar
• Gross JJ, John OP. Individual differences in two emotion regulation Processes: implications for affect, relationships, and well-being. J Pers Soc Psychol. 2003;85(2):348–362. doi: 10.1037/0022-3514.85.2.348
   PubMed Web of Science ®Google Scholar
• Gullone E, Taffe J. The emotion regulation questionnaire for children and adolescents (ERQ-CA): a psychometric evaluation. Psychol Assess. 2012;24:409–417. doi: 10.1037/a0025777
   PubMed Web of Science ®Google Scholar
• Weinberg A, Klonsky ED. Measurement of emotion dysregulation in adolescents. Psychol Assess. 2009;21(4):616–621. doi: 10.1037/a0016669
   PubMed Web of Science ®Google Scholar
• Garnefski N, Kraaij V, van Etten M. Specificity of relations between adolescents’ cognitive emotion regulation strategies and internalizing and externalizing psychopathology. J Adolesc. 2005;28:619–631. doi: 10.1016/j.adolescence.2004.12.009
   PubMed Web of Science ®Google Scholar
• Reis AH, Silva De Oliveira SE, Bandeira DR, et al. Emotion regulation Checklist (ERC): preliminary studies of cross-cultural adaptation and validation for use in Brazil [emotion regulation Checklist (ERC): estudos preliminares da adaptação e validação para a cultura Brasileira]. Temas em Psicol. 2016;24:77–96. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012206932&doi=10.9788%2FTP2016.1-06&partnerID=40&md5=2422de56e2b8dee766d579a4eb47a6de
   Google Scholar
• Klonsky E, Victor S, Hibbert A, et al. The multidimensional emotion questionnaire (MEQ): rationale and initial psychometric properties. J Psychopathol Behav Assess. 2019;41(3):409–424. doi: 10.1007/s10862-019-09741-2
   Web of Science ®Google Scholar
• Stringaris A, Goodman R, Ferdinando S, et al. The affective reactivity index: a concise irritability scale for clinical and research settings. J Child Psychol Psychiatry Allied Discip 2012 [cited 2020 Dec 29];53:1109–1117. https://pubmed.ncbi.nlm.nih.gov/22574736/ Available from: doi: 10.1111/j.1469-7610.2012.02561.x
   PubMed Web of Science ®Google Scholar
• Hantouche EG. Les Tempéraments Affectifs: L’Architecture Naturelle des Nos Emotions. Lyon, France: Josette; 2014.
   Google Scholar
• Brancati GE, Barbuti M, Pallucchini A, et al. Reactivity, intensity, polarity and stability questionnaire (RIPoSt-40) assessing emotional dysregulation: development, reliability and validity. J Affect Disord. 2019;257:187–194. doi: 10.1016/j.jad.2019.07.028
   PubMed Web of Science ®Google Scholar
• Sesso G, Milone A, Drago F, et al. A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: reactivity, intensity, polarity and stability questionnaire–youth version (RIPoSt–Y). J Affect Disord. 2021 [[cited 2021 Jul 9]];291:359–367.
   PubMed Web of Science ®Google Scholar
• Masi G, Sesso G, Pfanner C, et al. An exploratory study of emotional dysregulation dimensions in youth with attention deficit hyperactivity disorder and/or bipolar spectrum disorders. Front Psychiatry. 2021;12: doi: 10.3389/fpsyt.2021.619037
   Web of Science ®Google Scholar
• Gioia GA, Isquith PK, Guy SC, et al. Behavior rating inventory of executive function. Child Neuropsychol. 2000;6(3):235–238. doi: 10.1076/chin.6.3.235.3152
   PubMed Web of Science ®Google Scholar
• Conners CK. Conners’ rating scales-revised: technical manual. North Tonawanda (NY): Multi-Health Systems; 1997.
   Google Scholar
• Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997;121(1):65–94. doi: 10.1037/0033-2909.121.1.65
   PubMed Web of Science ®Google Scholar
• Gatti U, Grattagliano I, Rocca G. Evidence-based psychosocial treatments of conduct problems in children and adolescents: an overview. Psychiatry Psychol Law. 2019;26:171–193. doi: 10.1080/13218719.2018.1485523
   PubMed Web of Science ®Google Scholar
• NICE. Antisocial behaviour and conduct disorders in children and young people: recognition, intervention and management. Leicester (UK): NICE; 2013.
   Google Scholar
• Weisz JR, Kuppens S, Eckshtain D, et al. Performance of evidence-based youth psychotherapies compared with usual clinical care: a multilevel meta-analysis. JAMA Psychiatry. 2013;70(7):750–761. doi: 10.1001/jamapsychiatry.2013.1176
   PubMed Web of Science ®Google Scholar
• Lundahl B, Risser HJ, Lovejoy MC. A meta-analysis of parent training: moderators and follow-up effects. Clin Psychol Rev. 2006;26(1):86–104. doi: 10.1016/j.cpr.2005.07.004
   PubMed Web of Science ®Google Scholar
• McCart MR, Priester PE, Davies WH, et al. Differential effectiveness of behavioral parent-training and cognitive-behavioral therapy for antisocial youth: a meta-analysis. J Abnorm Child Psychol. 2006;34:527–543. doi: 10.1007/s10802-006-9031-1
   PubMed Web of Science ®Google Scholar
• Bakker MJ, Greven CU, Buitelaar JK, et al. Practitioner review: psychological treatments for children and adolescents with conduct disorder problems - a systematic review and meta-analysis. J Child Psychol Psychiatr. 2017;58:4–18. doi: 10.1111/jcpp.12590
   PubMed Web of Science ®Google Scholar
• Sampaio F, Barendregt JJ, Feldman I, et al. Population cost-effectiveness of the Triple P parenting programme for the treatment of conduct disorder: an economic modelling study. Eur Child Adolesc Psychiatry. 2018;27(7):933–944. doi: 10.1007/s00787-017-1100-1
   PubMed Web of Science ®Google Scholar
• Comer JS, Chow C, Chan PT, et al. Psychosocial treatment efficacy for disruptive behavior problems in very young children: a meta-analytic examination. J Am Acad Child Adolesc Psychiatry. 2013;52(1):26–36. doi: 10.1016/j.jaac.2012.10.001
   PubMed Web of Science ®Google Scholar
• Leijten P, Gardner F, Melendez-Torres GJ, et al. Meta-analyses: key parenting program components for disruptive child behavior. J Am Acad Child Adolesc Psychiatry. 2019;58(2):180–190. doi: 10.1016/j.jaac.2018.07.900
   PubMed Web of Science ®Google Scholar
• Webster-Stratton C. The incredible years® series: a developmental approach [internet]. Fam Prev Programs Child Adolesc Theory Res Large-Scale Dissem. 2015. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092553446&partnerID=40&md5=388e5cb391d1c726f3b94d7cc549b517
   Google Scholar
• Menting ATA, Orobio de Castro B, Matthys W. Effectiveness of the incredible years parent training to modify disruptive and prosocial child behavior: a meta-analytic review. Clin Psychol Rev. 2013;33(8):901–913. doi: 10.1016/j.cpr.2013.07.006
   PubMed Web of Science ®Google Scholar
• Thomas R, Abell B, Webb HJ, et al. Parent-child interaction therapy: a meta-analysis. Pediatrics. 2017;140(3):140. doi: 10.1542/peds.2017-0352
   Web of Science ®Google Scholar
• Fleming GE, Neo B, Briggs NE, et al. Parent training adapted to the needs of children with callous-unemotional traits: a randomized controlled trial. Behav Ther. 2022;53:1265–1281. doi: 10.1016/j.beth.2022.07.001
   PubMed Web of Science ®Google Scholar
• Fleming G, Kimonis E. PCIT for children with callous-unemotional traits. 2018;p. 19–34.
   Google Scholar
• Kimonis ER, Fleming G, Briggs N, et al. Parent-child interaction therapy adapted for preschoolers with callous-unemotional traits: An open trial pilot study. J Clin Child Adolesc Psychol Off. 2019;48:S347–S361. doi: 10.1080/15374416.2018.1479966
   PubMed Web of Science ®Google Scholar
• Kaminski JW, Claussen AH. Evidence base update for psychosocial treatments for disruptive behaviors in children. J Clin Child Adolesc Psychol Off. 2017;46:477–499. doi: 10.1080/15374416.2017.1310044
   PubMed Web of Science ®Google Scholar
• Garland AF, Hawley KM, Brookman-Frazee L, et al. Identifying common elements of evidence-based psychosocial treatments for children’s disruptive behavior problems. J Am Acad Child Adolesc Psychiatry. 2008;47(5):505–514. doi: 10.1097/CHI.0b013e31816765c2
   PubMed Web of Science ®Google Scholar
• Lochman JE, Wells KC. The coping power program at the middle-school transition: universal and indicated prevention effects. Psychol Addict Behav J Soc Psychol Addict Behav. 2002;16:S40–54. doi: 10.1037/0893-164X.16.4S.S40
   PubMed Web of Science ®Google Scholar
• Zonnevylle-Bender MJS, Matthys W, van de Wiel NMH, et al. Preventive effects of treatment of disruptive behavior disorder in middle childhood on substance use and delinquent behavior. J Am Acad Child Adolesc Psychiatry. 2007;46(1):33–39. doi: 10.1097/01.chi.0000246051.53297.57
   PubMed Web of Science ®Google Scholar
• Lochman JE, Baden RE, Boxmeyer CL, et al. Does a booster intervention augment the preventive effects of an abbreviated version of the coping power program for aggressive children? J Abnorm Child Psychol. 2014;42(3):367–381. doi: 10.1007/s10802-013-9727-y
   PubMed Web of Science ®Google Scholar
• Mushtaq A, Lochman JE, Tariq PN, et al. Preliminary effectiveness study of coping power program for aggressive children in Pakistan. Prev Sci. 2017;18(7):762–771. doi: 10.1007/s11121-016-0721-9
   PubMed Web of Science ®Google Scholar
• Lochman JE, Boxmeyer CL, Bui C, et al. Substance use outcomes from two formats of a cognitive-behavioral intervention for aggressive children: moderating roles of inhibitory control and intervention engagement. Brain Sci. 2021;11(7):11. doi: 10.3390/brainsci11070950
   Web of Science ®Google Scholar
• Muratori P, Bertacchi I, Giuli C, et al. Implementing coping power adapted as a Universal prevention program in Italian primary schools: a randomized control trial. Prev Sci. 2017;18(7):754–761. doi: 10.1007/s11121-016-0715-7
   PubMed Web of Science ®Google Scholar
• Masi G, Muratori P, Manfredi A, et al. Response to treatments in youth with disruptive behavior disorders. Compr Psychiatry. 2013;54:1009–1015. Available from. doi: 10.1016/j.comppsych.2013.04.007.
   PubMed Web of Science ®Google Scholar
• Romero-Ayuso D, Toledano-González A, Rodríguez-Martínez MDC, et al. Effectiveness of virtual reality-based interventions for children and adolescents with ADHD: a systematic review and meta-analysis. Children. 2021; 8.
   Google Scholar
• Borgnis F, Baglio F, Pedroli E, et al. Available virtual reality-based tools for executive functions: a systematic review. Front Psychol. 2022;13:833136. doi: 10.3389/fpsyg.2022.833136
   PubMed Web of Science ®Google Scholar
• Jahn FS, Skovbye M, Obenhausen K, et al. Cognitive training with fully immersive virtual reality in patients with neurological and psychiatric disorders: a systematic review of randomized controlled trials. Psychiatry Res. 2021;300:113928. doi: 10.1016/j.psychres.2021.113928
   PubMed Web of Science ®Google Scholar
• Cieślik B, Mazurek J, Rutkowski S, et al. Virtual reality in psychiatric disorders: a systematic review of reviews. Complement Ther Med. 2020;52:102480. doi: 10.1016/j.ctim.2020.102480
   PubMed Web of Science ®Google Scholar
• Asaoka Y, Won M, Morita T, et al. Distinct situational cue processing in individuals with Kleptomania: a preliminary study. Int J Neuropsychopharmacol. 2023;26(5):340–349. doi: 10.1093/ijnp/pyad005
   PubMed Web of Science ®Google Scholar
• Alsem SC, van Dijk A, Verhulp EE, et al. Using virtual reality to treat aggressive behavior problems in children: a feasibility study. Clin Child Psychol Psychiatry. 2021;26(4):1062–1075. doi: 10.1177/13591045211026160
   PubMed Web of Science ®Google Scholar
• Klein Schaarsberg RE, Popma A, Lindauer RJL, et al. The effects of a virtual reality-based training program for adolescents with disruptive behavior problems on cognitive distortions and treatment motivation: protocol for a multiple baseline single-case experimental design. JMIR Res Protoc. 2022;11:e33555. doi: 10.2196/33555
   PubMed Web of Science ®Google Scholar
• Alsem SC, van Dijk A, Verhulp EE, et al. Treating children’s aggressive behavior problems using cognitive behavior therapy with virtual reality: a multicenter randomized controlled trial. Child Dev. 2023. doi:10.1111/cdev.13966.
   PubMed Web of Science ®Google Scholar
• Muratori P, Milone A, Levantini V, et al. Six-year outcome for children with ODD or CD treated with the coping power program. Psychiatry Res. 2019;271:454–458. doi: 10.1016/j.psychres.2018.12.018
   PubMed Web of Science ®Google Scholar
• Dadds MR, English T, Wimalaweera S, et al. Can reciprocated parent-child eye gaze and emotional engagement enhance treatment for children with conduct problems and callous-unemotional traits: a proof-of-concept trial. J Child Psychol Psychiatr. 2019;60:676–685. doi: 10.1111/jcpp.13023
   PubMed Web of Science ®Google Scholar
• Dadds MR, Cauchi AJ, Wimalaweera S, et al. Outcomes, moderators, and mediators of empathic-emotion recognition training for complex conduct problems in childhood. Psychiatry Res. 2012;199(3):201–207. doi: 10.1016/j.psychres.2012.04.033
   PubMed Web of Science ®Google Scholar
• White BA, Dede B, Heilman M, et al. Facial affect sensitivity training for young children with emerging CU traits: an experimental therapeutics approach. J Clin Child Adolesc Psychol Off. 2022;51:264–276. doi: 10.1080/15374416.2022.2056895
   PubMed Web of Science ®Google Scholar
• Trillingsgaard T, Trillingsgaard A, Webster-Stratton C. Assessing the effectiveness of the “incredible years(®) parent training” to parents of young children with ADHD symptoms - a preliminary report. Scand J Psychol. 2014;55:538–545.
   PubMed Web of Science ®Google Scholar
• Graziano PA, Hart K. Beyond behavior modification: benefits of social-emotional/self-regulation training for preschoolers with behavior problems. J Sch Psychol. 2016;58:91–111. doi: 10.1016/j.jsp.2016.07.004
   PubMed Web of Science ®Google Scholar
• Mayes SD, Waxmonsky JD, Calhoun SL, et al. Disruptive mood dysregulation disorder symptoms and association with oppositional defiant and other disorders in a general population child sample. J Child Adolesc Psychopharmacol. 2016 [cited 2021 May 3];26(2):101–106. doi: 10.1089/cap.2015.0074
   PubMed Web of Science ®Google Scholar
• Boxmeyer CL, Miller S, Romero DE, et al. Mindful coping power: comparative effects on children’s reactive aggression and self-regulation. Brain Sci. 2021;11(9):11. doi: 10.3390/brainsci11091119
   Web of Science ®Google Scholar
• Rajkumar RP. Antipsychotics in the management of disruptive behavior disorders in children and adolescents: an update and critical review. Biomedicines. 2022;10(11) :2818.
   PubMed Web of Science ®Google Scholar
• Gorman DA, Gardner DM, Murphy AL, et al. Canadian guidelines on pharmacotherapy for disruptive and aggressive behaviour in children and adolescents with attention-deficit hyperactivity disorder, oppositional defiant disorder, or conduct disorder. Can J Psychiatry. 2015;60(2):62–76. doi: 10.1177/070674371506000204
   PubMed Web of Science ®Google Scholar
• Balia C, Carucci S, Coghill D, et al. The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous-unemotional traits modulate the efficacy of medication? Neurosci Biobehav Rev. 2018;91:218–238. doi: 10.1016/j.neubiorev.2017.01.024
   PubMed Web of Science ®Google Scholar
• Campbell M, Small AM, Green WH, et al. Behavioral efficacy of haloperidol and lithium carbonate: a comparison in hospitalized aggressive children with conduct disorder. Arch Gen Psychiatry 1984 [cited 2021 Dec 11];41:650–656. https://pubmed.ncbi.nlm.nih.gov/6428371/ Available from: doi: 10.1001/archpsyc.1984.01790180020002
   PubMed Web of Science ®Google Scholar
• Loy JH, Merry SN, Hetrick SE, et al. Atypical antipsychotics for disruptive behaviour disorders in children and youths. Cochrane Database Syst Rev. 2017;8:CD008559. doi: 10.1002/14651858.CD008559.pub3
   PubMed Web of Science ®Google Scholar
• Schur SB, Sikich L, Findling RL, et al. Treatment recommendations for the use of antipsychotics for aggressive youth (TRAAY). Part I: a review. J Am Acad Child Adolesc Psychiatry. 2003;42(2):132–144. doi: 10.1097/00004583-200302000-00007
   PubMed Web of Science ®Google Scholar
• van Schalkwyk G, Lewis A, Beyer C, et al. Efficacy of antipsychotics for irritability and aggression in children: a meta-analysis. Expert Rev Neurother. 2017;17(10):1045–1053. doi: 10.1080/14737175.2017.1371012
   PubMed Web of Science ®Google Scholar
• Seok J-W, Soltis-Vaughan B, Lew BJ, et al. Psychopharmacological treatment of disruptive behavior in youths: systematic review and network meta-analysis. Sci Rep. 2023;13(1):6921. doi: 10.1038/s41598-023-33979-2
   PubMed Web of Science ®Google Scholar
• Balia C, Carucci S, Coghill D, et al. The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous—unemotional traits modulate the efficacy of medication? Neurosci Biobehav Rev. 2018;91:218–238. Available from doi: 10.1016/j.neubiorev.2017.01.024
   PubMed Web of Science ®Google Scholar
• Pringsheim T, Hirsch L, Gardner D, et al. The pharmacological management of oppositional behaviour, conduct problems, and aggression in children and adolescents with attention-deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder: a systematic review and meta-analys. Can J Psychiatry. 2015;60:42–51. doi: 10.1177/070674371506000202
   PubMed Web of Science ®Google Scholar
• Pringsheim T, Gorman D. Second-generation antipsychotics for the treatment of disruptive behaviour disorders in children: a systematic review. Can J Psychiatry. 2012;57(12):722–727. doi: 10.1177/070674371205701203
   PubMed Web of Science ®Google Scholar
• Findling RL, Townsend L, Brown NV, et al. The treatment of severe childhood aggression study: 12 weeks of extended, blinded treatment in clinical responders. J Child Adolesc Psychopharmacol. 2017;27:52–65. doi: 10.1089/cap.2016.0081
   PubMed Web of Science ®Google Scholar
• Jahangard L, Akbarian S, Haghighi M, et al. Children with ADHD and symptoms of oppositional defiant disorder improved in behavior when treated with methylphenidate and adjuvant risperidone, though weight gain was also observed - results from a randomized, double-blind, placebo-controlled clinical. Psychiatry Res. 2017;251:182–191. doi: 10.1016/j.psychres.2016.12.010
   PubMed Web of Science ®Google Scholar
• Blader JC, Pliszka SR, Kafantaris V, et al. Stepped treatment for attention-deficit/Hyperactivity disorder and aggressive behavior: a randomized, controlled trial of adjunctive risperidone, divalproex sodium, or placebo after stimulant medication optimization. J Am Acad Child Adolesc Psychiatry. 2021;60(2):236–251. doi: 10.1016/j.jaac.2019.12.009
   PubMed Web of Science ®Google Scholar
• Juárez-Treviño M, Esquivel AC, Isida LML, et al. Clozapine in the treatment of aggression in conduct disorder in children and adolescents: a randomized, double-blind, controlled trial. Clin Psychopharmacol Neurosci Off Sci J Korean Coll Neuropsychopharmacol. 2019;17(1):43–53. doi: 10.9758/cpn.2019.17.1.43
   PubMed Web of Science ®Google Scholar
• Masi G, Manfredi A, Nieri G, et al. A naturalistic comparison of methylphenidate and risperidone monotherapy in Drug-Naive youth with attention-deficit/Hyperactivity disorder comorbid with oppositional defiant disorder and aggression. J Clin Psychopharmacol. 2017 [[cited 2021 Jul 6]];37(5):590–594. doi: 10.1097/JCP.0000000000000747
   PubMed Web of Science ®Google Scholar
• Aman M, Bukstein O, Gadow K, et al. What does risperidone add to stimulant and parent training for severe aggression in child attention-deficit/Hyperactivity disorder? JAACAP. 2014;53:47–60. doi: 10.1016/j.jaac.2013.09.022
   Google Scholar
• Farmer CA, Brown NV, Gadow KD, et al. Comorbid symptomatology moderates response to risperidone, stimulant, and parent training in children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2015;25:213–224. doi: 10.1089/cap.2014.0109
   PubMed Web of Science ®Google Scholar
• Findling RL, Wigal SB, Bukstein OG, et al. Long-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trials. Clin Ther. 2009;31(8):1844–1855. doi: 10.1016/j.clinthera.2009.08.002
   PubMed Web of Science ®Google Scholar
• Ercan ES, Uysal T, Ercan E, et al. Aripiprazole in children and adolescents with conduct disorder: a single-center, open-label study. Pharmacopsychiatry. 2012;45(1):13–19. doi: 10.1055/s-0031-1286348
   PubMed Web of Science ®Google Scholar
• Holzer B, Lopes V, Lehman R. Combination use of atomoxetine hydrochloride and olanzapine in the treatment of attention-deficit/hyperactivity disorder with comorbid disruptive behavior disorder in children and adolescents 10-18 years of age. J Child Adolesc Psychopharmacol. 2013;23:415–418. doi: 10.1089/cap.2013.0029
   PubMed Web of Science ®Google Scholar
• Masi G, Milone A, Canepa G, et al. Olanzapine treatment in adolescents with severe conduct disorder. Eur Psychiatry. 2006;21(1):51–57. doi: 10.1016/j.eurpsy.2004.11.010
   PubMed Web of Science ®Google Scholar
• Connor DF, McLaughlin TJ, Jeffers-Terry M. Randomized controlled pilot study of quetiapine in the treatment of adolescent conduct disorder. J Child Adolesc Psychopharmacol. 2008;18(2):140–156. doi: 10.1089/cap.2006.0007
   PubMed Web of Science ®Google Scholar
• Findling RL, Reed MD, O’Riordan MA, et al. Effectiveness, safety, and pharmacokinetics of quetiapine in aggressive children with conduct disorder. J Am Acad Child Adolesc Psychiatry. 2006;45(7):792–800. doi: 10.1097/01.chi.0000219832.23849.31
   PubMed Web of Science ®Google Scholar
• Kronenberger WG, Giauque AL, Lafata DE, et al. Quetiapine addition in methylphenidate treatment-resistant adolescents with comorbid ADHD, conduct/oppositional-defiant disorder, and aggression: a prospective, open-label study. J Child Adolesc Psychopharmacol. 2007;17(3):334–347. doi: 10.1089/cap.2006.0012
   PubMed Web of Science ®Google Scholar
• Wozniak J, DiSalvo M, Farrell A, et al. Can pediatric bipolar disorder be successfully treated when comorbid with conduct disorder? A secondary analysis of clinical trials of risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole. J Psychopharmacol. 2022;36(5):637–644. doi: 10.1177/02698811221087673
   PubMed Web of Science ®Google Scholar
• Krakowski M, Tural U, Czobor P. The importance of conduct disorder in the treatment of violence in schizophrenia: efficacy of clozapine compared with olanzapine and haloperidol. Am J Psychiatry. 2021;178(3):266–274. doi: 10.1176/appi.ajp.2020.20010052
   PubMed Web of Science ®Google Scholar
• Arnsten AFT, Pliszka SR. Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacol Biochem Behav. 2011;99(2):211–216. doi: 10.1016/j.pbb.2011.01.020
   PubMed Web of Science ®Google Scholar
• Leucht S, Tardy M, Komossa K, et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet (London, England). 2012;379:2063–2071. doi: 10.1016/S0140-6736(12)60239-6
   PubMed Web of Science ®Google Scholar
• Coghill DR, Banaschewski T, Soutullo C, et al. Systematic review of quality of life and functional outcomes in randomized placebo-controlled studies of medications for attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry. 2017;26(11):1283–1307. doi: 10.1007/s00787-017-0986-y
   PubMed Web of Science ®Google Scholar
• Mannuzza S, Klein RG, Truong NL, et al. Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry. 2008;165(5):604–609. doi: 10.1176/appi.ajp.2008.07091465
   PubMed Web of Science ®Google Scholar
• Lichtenstein P, Halldner L, Zetterqvist J, et al. Medication for attention deficit-hyperactivity disorder and criminality. N Engl J Med. 2012;367:2006–2014. doi: 10.1056/NEJMoa1203241
   PubMed Web of Science ®Google Scholar
• Pappadopulos E, Woolston S, Chait A, et al. Pharmacotherapy of aggression in children and adolescents: efficacy and effect size. J Can Acad Child Adolesc Psychiatry = J l’Academie Can Psychiatr L’enfant L’adolescent. 2006;15:27–39.
   PubMedGoogle Scholar
• Connor DF, Glatt SJ, Lopez ID, et al. Psychopharmacology and aggression. I: a meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. J Am Acad Child Adolesc Psychiatry. 2002;41:253–261. doi: 10.1097/00004583-200203000-00004
   PubMed Web of Science ®Google Scholar
• Blader J, Pliszka S, Kafantaris V, et al. Callous-unemotional traits, proactive aggression, and treatment outcomes of aggressive children with attention-deficit/Hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013;52(12):1281–1293. doi: 10.1016/j.jaac.2013.08.024
   PubMed Web of Science ®Google Scholar
• Kutlu A, Akyol Ardic U, Ercan ES. Effect of methylphenidate on emotional dysregulation in children with attention-deficit/Hyperactivity disorder + oppositional defiant disorder/conduct disorder. J Clin Psychopharmacol. 2017;37(2):220–225. doi: 10.1097/JCP.0000000000000668
   PubMed Web of Science ®Google Scholar
• Man KKC, Häge A, Banaschewski T, et al. Long-term safety of methylphenidate in children and adolescents with ADHD: 2-year outcomes of the attention deficit hyperactivity disorder drugs use chronic effects (ADDUCE) study. Lancet Psychiatry. 2023;10(5):323–333. doi: 10.1016/S2215-0366(23)00042-1
   PubMed Web of Science ®Google Scholar
• Park J, Lee DY, Kim C, et al. Long-term methylphenidate use for children and adolescents with attention deficit hyperactivity disorder and risk for depression, conduct disorder, and psychotic disorder: a nationwide longitudinal cohort study in South Korea. Child Adolesc Psychiatr Ment Health. 2022;16(1):80. doi: 10.1186/s13034-022-00515-5
   PubMed Web of Science ®Google Scholar
• Amaladoss A, Roberts N, Amaladoss F. Evidence for use of mood stabilizers and anticonvulsants in the treatment of nonaffective disorders in children and adolescents. Clin Neuropharmacol. 2010;33(6):303–311. doi: 10.1097/WNF.0b013e3181f8d4ed
   PubMed Web of Science ®Google Scholar
• Campbell M, Adamas P, Small A, et al. Lithium in hospitalized aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry 1995 [cited 2021 Dec 11];34:445–453. https://pubmed.ncbi.nlm.nih.gov/7751258/ Available from: doi: 10.1097/00004583-199504000-00011.
   PubMed Web of Science ®Google Scholar
• Rifkin A, Karajgi B, Dicker R, et al. Lithium treatment of conduct disorders in adolescents. Am J Psychiatry. 1997;154:554–555.
   PubMed Web of Science ®Google Scholar
• Malone RP, Delaney MA, Luebbert JF, et al. A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. Arch Gen Psychiatry. 2000;57(7):649–654. doi: 10.1001/archpsyc.57.7.649
   PubMed Web of Science ®Google Scholar
• Carlson GA, Rapport MD, Pataki CS, et al. Lithium in hospitalized children at 4 and 8 weeks: mood, behavior and cognitive effects. J Child Psychol Psychiatr. 1992;33(2):411–425. doi: 10.1111/j.1469-7610.1992.tb00876.x
   PubMed Web of Science ®Google Scholar
• Masi G, Milone A, Manfredi A, et al. Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study. CNS Drugs. 2009;23(1):59–69. doi: 10.2165/0023210-200923010-00004
   PubMed Web of Science ®Google Scholar
• Donovan SJ, Stewart JW, Nunes EV, et al. Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Am J Psychiatry. 2000;157:818–820. doi: 10.1176/appi.ajp.157.5.818
   PubMed Web of Science ®Google Scholar
• Blader JC, Schooler NR, Jensen PS, et al. Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. Am J Psychiatry. 2009;166(12):1392–1401. doi: 10.1176/appi.ajp.2009.09020233
   PubMed Web of Science ®Google Scholar
• Mechler K, Banaschewski T, Hohmann S, et al. Evidence-based pharmacological treatment options for ADHD in children and adolescents. Pharmacol Ther. 2022;230:107940. doi: 10.1016/j.pharmthera.2021.107940
   PubMed Web of Science ®Google Scholar
• Kaplan S, Heiligenstein J, West S, et al. Efficacy and safety of atomoxetine in childhood attention-deficit/hyperactivity disorder with comorbid oppositional defiant disorder. J Atten Disord. 2004;8(2):45–52. doi: 10.1177/108705470400800202
   PubMedGoogle Scholar
• Dittmann RW, Schacht A, Helsberg K, et al. Atomoxetine versus placebo in children and adolescents with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder: a double-blind, randomized, multicenter trial in Germany. J Child Adolesc Psychopharmacol. 2011;21(2):97–110. doi: 10.1089/cap.2009.0111
   PubMed Web of Science ®Google Scholar
• Ziegenhorn AA, Roepke S, Schommer NC, et al. Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2009;29(2):170–173. doi: 10.1097/JCP.0b013e31819a4bae
   PubMed Web of Science ®Google Scholar
• Connor DF, Fletcher KE, Swanson JM. A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1999;38(12):1551–1559. doi: 10.1097/00004583-199912000-00017
   PubMed Web of Science ®Google Scholar
• Connor DF, Barkley RA, Davis HT. A pilot study of methylphenidate, clonidine, or the combination in ADHD comorbid with aggressive oppositional defiant or conduct disorder. Clin Pediatr. 2000;39:15–25. doi: 10.1177/000992280003900102
   PubMed Web of Science ®Google Scholar
• Hazell PL, Stuart JE. A randomized controlled trial of clonidine added to psychostimulant medication for hyperactive and aggressive children. J Am Acad Child Adolesc Psychiatry. 2003;42(8):886–894. doi: 10.1097/01.CHI.0000046908.27264.00
   PubMed Web of Science ®Google Scholar
• Hunt RD, Arnsten AF, Asbell MD. An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1995;34:50–54. doi: 10.1097/00004583-199501000-00013
   PubMed Web of Science ®Google Scholar
• Connor DF, Rubin J. Guanfacine extended release in the treatment of attention deficit hyperactivity disorder in children and adolescents. Drugs Today. 2010;46:299–314. Available from: https://openathens.ovid.com/secure-ssl/home.oa?idpselect=https://kclidp.kcl.ac.uk/idp/shibboleth&entityID=https://kclidp.kcl.ac.uk/idp/shibboleth&?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed11&AN=359198728
   PubMed Web of Science ®Google Scholar
• Sagar-Ouriaghli I, Milavic G, Barton R, et al. Comparing the DSM-5 construct of disruptive mood dysregulation disorder and ICD-10 mixed disorder of emotion and conduct in the UK longitudinal assessment of manic symptoms (UK-LAMS) study. Eur Child Adolesc Psychiatry. 2018;27(9):1095–1104. doi: 10.1007/s00787-018-1149-5
   PubMed Web of Science ®Google Scholar
• Miller S, Pike J, Shono Y, et al. The role of negative affect in the persistence of nicotine dependence among alternative high school students: a latent growth curve analysis. Drug Alcohol Depend. 2020;209:107883. doi: 10.1016/j.drugalcdep.2020.107883
   PubMed Web of Science ®Google Scholar