128
Views
0
CrossRef citations to date
0
Altmetric
Drug Profile

An overview of the utility of prasugrel hydrochloride as a treatment option for ischemic stroke

, , , &
Pages 139-144 | Received 13 Sep 2023, Accepted 12 Dec 2023, Published online: 30 Dec 2023

References

  • Khanevski AN, Bjerkreim AT, Novotny V, et al. NOR-STROKE study group. Recurrent ischemic stroke: incidence, predictors, and impact on mortality. Acta Neurol Scand. 2019;140(1):3–8. doi: 10.1111/ane.13093
  • Bangad A, Abbasi M, de Havenon A. Secondary ischemic stroke prevention. Neurotherapeutics. 2023;20(3):721–731. doi: 10.1007/s13311-023-01352-w
  • Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a Guideline from the American Heart Association/American stroke Association. Stroke. 2021;52(7):e364–e467. doi: 10.1161/STR.0000000000000375
  • Dawson J, Béjot Y, Christensen LM, et al. European stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack. Eur Stroke J. 2022;7(3):I–II. doi: 10.1177/23969873221100032
  • Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11–19. doi: 10.1056/NEJMoa1215340
  • Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med. 2018;379(3):215–225. doi: 10.1056/NEJMoa1800410
  • Johnston SC, Amarenco P, Denison H, et al. THALES investigators. Ticagrelor and aspirin or aspirin Alone in acute ischemic stroke or TIA. N Engl J Med. 2020;383(3):207–217. doi: 10.1056/NEJMoa1916870
  • Wiviott SD, Braunwald E, McCabe CH, et al. TRITON-TIMI 38 investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–2015. doi: 10.1056/NEJMoa0706482
  • EFFIENT package insert. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022307s002lbl.pdf. Accessed 2023 jun 8.
  • Kitazono T, Kamouchi M, Matsumaru Y, et al. Efficacy and safety of prasugrel vs clopidogrel in thrombotic stroke patients with risk factors for ischemic stroke recurrence: a double-blind, phase III study (PRASTRO-III). J Atheroscler Thromb. 2023;30(3):222–236. doi: 10.5551/jat.63473
  • Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354(16):1706–1717. doi: 10.1056/NEJMoa060989
  • Benavente OR, Hart RG, McClure LA, et al. The SPS3 investigators. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012;367:817–825.
  • Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364(9431):331–337. doi: 10.1016/S0140-6736(04)16721-4
  • Johnston SC, Elm JJ, Easton JD, et al. POINT and neurological emergencies treatment trials network investigators. Time course for benefit and risk of clopidogrel and aspirin after acute transient ischemic attack and minor ischemic stroke. Circulation. 2019;140(8):658–664. doi: 10.1161/CIRCULATIONAHA.119.040713
  • Wang Y, Pan Y, Li H, et al. Time Course for benefit and risk of ticagrelor and aspirin in acute ischemic stroke or transient ischemic attack. Neurology. 2022;99(1):e46–e54. doi: 10.1212/WNL.0000000000200355
  • Wang Y, Meng X, Wang A, et al. CHANCE-2 investigators. Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA. N Engl J Med. 2021;385(27):2520–2530. doi: 10.1056/NEJMoa2111749
  • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–2015. doi: 10.1056/NEJMoa0706482
  • Hira RS, Kennedy K, Jneid H, et al. Frequency and practice-level variation in inappropriate and nonrecommended prasugrel prescribing: insights from the NCDR PINNACLE registry. J Am Coll Cardiol. 2014;63(25):2876–2877. doi: 10.1016/j.jacc.2014.04.011
  • Sandhu A, Seth M, Dixon S, et al. Contemporary use of prasugrel in clinical practice: insights from the Blue cross Blue Shield of Michigan Cardiovascular Consortium. Circ Cardiovasc Qual Outcomes. 2013;6(3):293–298. doi: 10.1161/CIRCOUTCOMES.111.000060
  • Chin CT, Neely B, Magnus Ohman E, et al. Time-varying effects of prasugrel versus clopidogrel on the long-term risks of stroke after acute coronary syndromes: results from the TRILOGY ACS trial. Stroke. 2016;47(4):1135–1139. doi: 10.1161/STROKEAHA.115.012454
  • Nagao T, Toyoda K, Kitagawa K, et al. A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial – PRASTRO-I trial. Expert Opin Pharmacother. 2018;19(6):529–535. doi: 10.1080/14656566.2018.1444029.
  • Ogawa A, Toyoda K, Kitagawa K, et al. Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I). Lancet Neurol. 2019;18(3):238–247. doi: 10.1016/S1474-4422(18)30449-6
  • Kitazono T, Toyoda K, Kitagawa K, et al. Efficacy and safety of prasugrel by stroke subtype: a sub-analysis of the PRASTRO-I randomized controlled trial. J Atheroscler Thromb. 2021;28(2):169–180. doi: 10.5551/jat.56093
  • Amarenco P, Albers GW, Denison H, et al. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol. 2017;16(4):301–310. doi: 10.1016/S1474-4422(17)30038-8
  • Liu L, Wong KSL, Leng X, et al. Dual antiplatelet therapy in stroke and ICAS: subgroup analysis of CHANCE. Neurology. 2015;85(13):1154–62. doi: 10.1212/WNL.0000000000001972
  • Investigators SPS3, Benavente OR, Hart RG, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012;367:817–25.
  • Toyoda K, Yamagami H, Kitagawa K, et al. Blood pressure Level and variability during long-term prasugrel or clopidogrel medication after stroke: PRASTRO-I. Stroke. 2021;52(4):1234–1243. doi: 10.1161/STROKEAHA.120.032824
  • Kitagawa K, Toyoda K, Kitazono T, et al. Safety and efficacy of prasugrel in Elderly/low body weight Japanese patients with ischemic stroke: randomized PRASTRO-II. Cerebrovasc Dis. 2020;49(2):152–159. doi: 10.1159/000506825
  • Ohkubo K, Fujimoto Y, Iwata Y, et al. Efficacy and safety of low-dose clopidogrel in Japanese patients after drug-eluting stent implantation: a randomized pilot trial. Heart Vessels. 2014;29(1):1–6. doi: 10.1007/s00380-012-0318-6
  • Kitazono T, Kamouchi M, Matsumaru Y, et al. Comparison of prasugrel and clopidogrel in thrombotic stroke patients with risk factors for ischemic stroke recurrence: an Integrated analysis of PRASTRO-I, PRASTRO-II, and PRASTRO-III. Cerebrovasc Dis. 2023 Apr;3:1–10. doi: 10.1159/000529149
  • EFIENT®(package insert). Tokyo Japan: Daiichi Sankyo Co. Ltd.; 2021 (ver.3). Available from:https://www.info.pmda.go.jp/go/pack/3399009F1020120/view=frame&style=XML&lang=ja
  • Daiichi Sankyo submits supplemental application in Japan for approval of partial changes related to additional indication for the antiplatelet agent, prasugrel hydrochloride. https://www.daiichisankyo.com/media/press_release/detail/index_4103.html
  • Gurbel PA, Tantry US. Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents. Circulation. 2012;125(10):1276–1287. discussion 1287. doi: 10.1161/CIRCULATIONAHA.111.031195
  • Kim HK, Tantry US, Smith SJ, et al. The East Asian Paradox: an updated position statement on the challenges to the Current antithrombotic strategy in patients with cardiovascular disease. Thromb Haemost. 2021;121:422–432.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.