375
Views
0
CrossRef citations to date
0
Altmetric
Meta-analysis

Phase-specific strategies and interventions to enhance medication adherence across different phases in ADHD: a systematic review and meta-analysis

ORCID Icon & ORCID Icon
Pages 711-722 | Received 14 Mar 2024, Accepted 22 May 2024, Published online: 11 Jun 2024

References

  • Mirabella G. Inhibitory control and impulsive responses in neurodevelopmental disorders. Dev Med Child Neurol. 2021;63(5):520–526. doi: 10.1111/dmcn.14778
  • Leffa DT, Caye A, Rohde LA. ADHD in children and adults: diagnosis and prognosis. New Discov Behav Neurosci Attention-Deficit Hyper Dis. 2022;57:1–18.
  • Thomas R, Sanders S, Doust J, et al. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics. 2015;135(4):e994–e1001. doi: 10.1542/peds.2014-3482
  • Song P, Zha M, Yang Q, et al. The prevalence of adult attention-deficit hyperactivity disorder: a global systematic review and meta-analysis. J Glob Health. 2021;11:04009. doi: 10.7189/jogh.11.04009
  • Sayal K, Prasad V, Daley D, et al. ADHD in children and young people: prevalence, care pathways, and service provision. Lancet Psychiatry. 2018;5(2):175–186. doi: 10.1016/S2215-0366(17)30167-0
  • Chhibber A, Watanabe AH, Chaisai C, et al. Global economic burden of attention-deficit/hyperactivity disorder: a systematic review. PharmacoEconomics. 2021;39(4):399–420. doi: 10.1007/s40273-020-00998-0
  • Wolraich ML, Hagan JF, Allan C, et al. Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2019;144(4):e20192528. doi: 10.1542/peds.2019-2528
  • Australian guidelines on attention-deficit-hyperactivity/disorder. Royal Australasian college of physicians. 2009 [cited 2024 Jan]. Available from: https://www.racp.edu.au/docs/default-source/advocacy-library/pa-australian-guidelines-on-adhd-draft.pdf?sfvrsn=c905321a_8
  • NICE guideline: attention deficit hyperactivity disorder: diagnosis and management. 2018 [cited 2024 Jan]. Available from: https://www.nice.org.uk/guidance/ng87
  • Canadian ADHD Practice Guidelines. Canadian ADHD resource alliance (CADDRA). Available at 2018 [cited 2024 Jan]. Available from: https://adhdlearn.caddra.ca/wp-content/uploads/2022/08/Canadian-ADHD-Practice-Guidelines-4.1-January-6-2021.pdf
  • Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705. doi: 10.1111/j.1365-2125.2012.04167.x
  • Gajria K, Lu M, Sikirica V, et al. Adherence, persistence, and medication discontinuation in patients with attention-deficit/hyperactivity disorder–a systematic literature review. Neuropsychiatr Dis Treat. 2014;10:1543. doi: 10.2147/NDT.S65721
  • Schein J, Childress A, Adams J, et al. Treatment patterns among children and adolescents with attention-deficit/hyperactivity disorder in the United States - a retrospective claims analysis. BMC Psychiatry. 2022;22(1):555. doi: 10.1186/s12888-022-04188-4
  • Biederman J, Fried R, DiSalvo M, et al. Further evidence of low adherence to stimulant treatment in adult ADHD: an electronic medical record study examining timely renewal of a stimulant prescription. Psychopharmacology. 2020;237(9):2835–2843. doi: 10.1007/s00213-020-05576-y
  • Khan MU, Aslani P. Exploring factors influencing medication adherence from initiation to discontinuation in parents and adolescents with attention deficit hyperactivity disorder. Clin Pediatr. 2020;59(3):285–296. doi: 10.1177/0009922819900973
  • Biederman J, Fried R, DiSalvo M, et al. Perlis RHA novel text message intervention to improve adherence to stimulants in adults with attention deficit/hyperactivity disorder. J Clin Psychopharmacol. 2019;39(4):351–356. doi: 10.1097/JCP.0000000000001055
  • Montoya A, Hervas A, Fuentes J, et al. Cluster-randomized, controlled 12-month trial to evaluate the effect of a parental psychoeducation program on medication persistence in children with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat. 2014;10:1081. doi: 10.2147/NDT.S62487
  • Parkin R, Mc Nicholas F, Hayden JC. A systematic review of interventions to enhance adherence and persistence with ADHD pharmacotherapy. J Psychiatr Res. 2022;152(2022):201–218. doi: 10.1016/j.jpsychires.2022.05.044
  • Thongseiratch T, Chalermphol K, Traipidok P, et al. Promoting medication adherence in children with attention deficit hyperactivity disorder: a mixed-methods systematic review with meta-analysis and qualitative comparative analysis. JAtten Disord. 2024;28(2):139–150. doi: 10.1177/10870547231211021
  • Weisman O, Schonherz Y, Harel T, et al. Testing the efficacy of a smartphone application in improving medication adherence, among children with ADHD. Isr J Psychiatry. 2018;55(2):59–67.
  • Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. doi: 10.7326/0003-4819-151-4-200908180-00135
  • Roter DL, Hall JA, Merisca R, et al. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med care. 1998;36(8):1138–1161. doi: 10.1097/00005650-199808000-00004
  • Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540–549. doi: 10.1001/archinte.167.6.540
  • Sapkota S, Brien JAE, Greenfield JR, et al. A systematic review of interventions addressing adherence to anti-diabetic medications in patients with type 2 diabetes—components of interventions. PLoS One. 2015;10(6):e0128581. doi: 10.1371/journal.pone.0128581
  • Fried R, DiSalvo M, Kelberman C, et al. An innovative SMS intervention to improve adherence to stimulants in children with ADHD: preliminary findings. J Psychopharmacol. 2020;34(8):883–890. doi: 10.1177/0269881120908014
  • Hogue A, Lichvar E, Bobek M. Pilot evaluation of the medication integration protocol for adolescents with ADHD in behavioural care: treatment fidelity and medication uptake. J Emot Behav Disord. 2016;24(4):223–234. doi: 10.1177/1063426615611648
  • Meyers J, Gajria K, Candrilli SD, et al. The impact of adjunctive guanfacine extended release on stimulant adherence in children/adolescents with attention-deficit/hyperactivity disorder. J Comp Eff Res. 2017;6(2):109–125. doi: 10.2217/cer-2016-0039
  • Monastra VJ. Overcoming the barriers to effective treatment for attention-deficit/hyperactivity disorder: a neuro-educational approach. Int J Psychophysiol. 2005;58(1):71–80. doi: 10.1016/j.ijpsycho.2005.03.010
  • Bai GN, Wang YF, Yang L, et al. Effectiveness of a focused, brief psychoeducation program for parents of ADHD children: improvement of medication adherence and symptoms. Neuropsychiatr Dis Treat. 2015;11:2721. doi: 10.2147/NDT.S88625
  • Gau H, Zhu D. The role of group parent education on medication adherence in children with Attention-Deficit/Hyperactivity Disorder. Conference: 5th world congress on ADHD: from child to adult disorder, Glasgow United Kingdom, 2015. Conference Publication. 2015;7(SUPPL. 1):S41–S42.
  • Zheng X, Shen L, Jiang L, et al. Parent and teacher training increases medication adherence for primary school children with attention-deficit/hyperactivity disorder. Front Pediatr. 2020;8:486353. doi: 10.3389/fped.2020.486353
  • Enns JE, Randall JR, Smith M, et al. A multimodal intervention for children with ADHD reduces inequity in health and education outcomes. Can J Psychiatry. 2017;62(6):403–412. doi: 10.1177/0706743717692301
  • Naenen-Hernani K, Palazón-Bru A, Colomina-Climent F, et al. Influence of written informed consent for methylphenidate on medicine persistence rates in children with attention-deficit hyperactivity disorder. J Dev Behav Pediatr. 2017;38(8):603–610. doi: 10.1097/DBP.0000000000000495
  • Ramos-Quiroga JA, Bosch R, Castells X, et al. Effect of switching drug formulations from immediate-release to extended-release OROS methylphenidate: a chart review of Spanish adults with attention-deficit hyperactivity disorder. CNS Drugs. 2008;22(7):603–611. doi: 10.2165/00023210-200822070-00005
  • Williams L, Hall CL, Brown S, et al. Optimising medication management in children and young people with ADHD using a computerised test (QbTest): a feasibility randomised controlled trial. Pilot And Feasibility Stud. 2021;7(68):1–18. doi: 10.1186/s40814-021-00788-1
  • Carvalho LR, Haas LM, Zeni G, et al. Evaluation of the effectiveness of the FOCUS ADHD app in monitoring adults with attention-deficit/hyperactivity disorder. Eur Psychiatry. 2023;66(1):e53. doi: 10.1192/j.eurpsy.2023.2422
  • Nagae M, Tokunaga A, Morifuji K, et al. Efficacy of a group psychoeducation program focusing on the attitudes towards medication of children and adolescents with ADHD and their parents: a pilot study. Acta Medica Nagasakiensia. 2019;62(3):77–86.
  • Deeks JJ, Higgins JPT, Altman DG. Chapter 10: analysing data and undertaking meta-analyses. In: Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M Welch V, editors. Cochrane handbook for systematic reviews of interventions version 6.4 (updated August 2023). Cochrane; 2023. Available from: www.training.cochrane.org/handbook
  • IntHout J, Ioannidis JP, Borm GF, et al. Small studies are more heterogeneous than large ones: a meta-meta-analysis. J Clin Epidemiol. 2015;68(8):860–869.
  • Khan MU, Aslani P. A review of measures used to examine medication adherence in people with ADHD at initiation, implementation and discontinuation of pharmacotherapy. Res Social Adm Pharm. 2020;16(3):277–289. doi: 10.1016/j.sapharm.2019.06.001
  • Roloff V, Higgins JP, Sutton AJ. Planning future studies based on the conditional power of a meta‐analysis. Stat Med. 2013;32(1):11–24. doi: 10.1002/sim.5524
  • Khan MU, Aslani P. A review of factors influencing the three phases of medication adherence in people with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2019;29(6):398–418. doi: 10.1089/cap.2018.0153
  • Khan MU, Kohn M, Aslani P. The need for a paradigm shift in adherence research: the case of ADHD. Res Social Adm Pharm. 2019;15(3):318–320. doi: 10.1016/j.sapharm.2018.04.033
  • Charach A, Yeung E, Volpe T, et al. Exploring stimulant treatment in ADHD: narratives of young adolescents and their parents. BMC Psychiatry. 2014;14(1):1–11. doi: 10.1186/1471-244X-14-110
  • Chong WW, Aslani P, Chen TF. Effectiveness of interventions to improve antidepressant medication adherence: a systematic review. Int J Clin Pract. 2011;65(9):954–975. doi: 10.1111/j.1742-1241.2011.02746.x
  • Pakpour AH, Modabbernia A, Lin CY, et al. Promoting medication adherence among patients with bipolar disorder: a multicenter randomized controlled trial of a multifaceted intervention. Psychol Med. 2017;47(14):2528–2539. doi: 10.1017/S003329171700109X
  • Barnard-Brak L, Roberts B, Valenzuela E. Examining breaks and resistance in medication adherence among adolescents with ADHD as associated with school outcomes. J Atten Disord. 2020;24(8):1148–1155. doi: 10.1177/1087054718763738
  • DosReis S, Myers MA. Parental attitudes and involvement in psychopharmacological treatment for ADHD: a conceptual model. Int Rev Psychiatry. 2008;20(2):135–141. doi: 10.1080/09540260801933084
  • Ribaut J, Leppla L, Teynor A, et al. Theory-driven development of a medication adherence intervention delivered by eHealth and transplant team in allogeneic stem cell transplantation: the SMILe implementation science project. BMC Health Serv Res. 2020;20(1):1–22. doi: 10.1186/s12913-020-05636-1
  • Easthall C, Barnett N. Using theory to explore the determinants of medication adherence; moving away from a one-size-fits-all approach. Pharmacy. 2017;5(3):50. doi: 10.3390/pharmacy5030050
  • Nieuwlaat R, Wilczynski N, Navarro T, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014;11(11):CD000011. doi: 10.1002/14651858.CD000011.pub4
  • Sirey JA, Bruce ML, Kales HC. Improving antidepressant adherence and depression outcomes in primary care: the treatment initiation and participation (TIP) program. Am J Geriatr Psychiatry. 2010;18(6):554–562. doi: 10.1097/JGP.0b013e3181cdeb7d
  • Nili M, Mohamed R, Kelly KM. A systematic review of interventions using health behavioural theories to improve medication adherence among patients with hypertension. Transl Behav Med. 2020;10(5):1177–1186. doi: 10.1093/tbm/ibaa020
  • Ibrahim K, Donyai P. Drug holidays from ADHD medication: international experience over the past four decades. J Atten Disord. 2015;19(7):551–568. doi: 10.1177/1087054714548035
  • Hopewell S, Clarke MJ, Stewart L, et al. Time to publication for results of clinical trials. Cochrane Database Syst Rev. 2005;2:MR000011.
  • Sterne JA, Harbord RM. Funnel plots in meta-analysis. Stata J. 2004;4(2):127–141. doi: 10.1177/1536867X0400400204