The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review

References

• Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196.
   PubMed Web of Science ®Google Scholar
• Palazzo C, Ravaud JF, Trinquart L, et al. Respective contribution of chronic conditions to disability in France: results from the national Disability-Health Survey. PLoS One. 2012;7(9):e44994.
   PubMed Web of Science ®Google Scholar
• Palazzo C, Ravaud JF, Papelard A, et al. The burden of musculoskeletal conditions. PLoS One. 2014;9(3):e90633.
   PubMed Web of Science ®Google Scholar
• Hochberg MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012;644:465–474.
   PubMed Web of Science ®Google Scholar
• McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;223:363–388.
   PubMed Web of Science ®Google Scholar
• Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62(12):1145–1155.
   PubMed Web of Science ®Google Scholar
• Roman-Blas JA, Bizzi E, Largo R, et al. An update on the up and coming therapies to treat osteoarthritis, a multifaceted disease. Expert Opin Pharmacother. 2016;17(13):1745–1756.
   PubMed Web of Science ®Google Scholar
• Richette P, Latourte A, Frazier A. Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: which drug to recommend? Expert Opin Drug Saf. 2015;14(8):1259–1268.
   PubMed Web of Science ®Google Scholar
• Roberts E, Delgado Nunes V, Buckner S, et al. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis. 2015;75(3):552–559.
   Google Scholar
• Nguyen C, Lefèvre-Colau MM, Poiraudeau S, et al. Evidence and recommendations for use of intra-articular injections for knee osteoarthritis. Ann Phys Rehabil Med. 2016;59(3):184–189.
   PubMedGoogle Scholar
• Bannuru RR, Schmid CH, Kent DM, et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;1621:46–54.
   PubMed Web of Science ®Google Scholar
• Creamer P. Intra-articular corticosteroid injections in osteoarthritis: do they work and if so, how? Ann Rheum Dis. 1997;56(11):634–636.
   PubMed Web of Science ®Google Scholar
• Miller JH, White J, Norton TH. The value of intra-articular injections in osteoarthritis of the knee. J Bone Joint Surg Br. 1958;40-B(4):636–643.
   PubMedGoogle Scholar
• Conrozier T, Mathieu P, Vignon E, et al. Differences in the osteoarthritic synovial fluid composition and rheology between patients with or without flare: a pilot study. Clin Exp Rheumatol. 2012;30(5):729–734.
   PubMed Web of Science ®Google Scholar
• Juni P, Hari R, Rutjes AW, et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015;10:CD005328.
   Google Scholar
• Petrella RJ, Emans PJ, Alleyne J, et al. Safety and performance of Hydros and Hydros-TA for knee osteoarthritis: a prospective, multicenter, randomized, double-blind feasibility trial. BMC Musculoskelet Disord. 2015;16:57.
   PubMed Web of Science ®Google Scholar
• Wright V, Chandler GN, Morison RA, et al. Intra-articular therapy in osteo-arthritis; comparison of hydrocortisone acetate and hydrocortisone tertiary-butylacetate. Ann Rheum Dis. 1960;19:257–261.
   PubMed Web of Science ®Google Scholar
• de Campos GC, Rezende MU, Pailo AF, et al. Adding triamcinolone improves viscosupplementation: a randomized clinical trial. Clin Orthop Relat Res. 2013;471(2):613–620.
   PubMed Web of Science ®Google Scholar
• Henriksen M, Christensen R, Klokker L, et al. Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial. JAMA Intern Med. 2015;175(6):923–930.
   PubMed Web of Science ®Google Scholar
• Lyons C, Majeed A, Banarsee R. Effectiveness of high volume intra-articular injection of cortisone and lignocaine in osteoarthritis of the knee. Pilot study. Nwljgp. 2005;11(1):23–28.
   Google Scholar
• Ozturk C, Atamaz F, Hepguler S, et al. The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis: 1-year, single-blind, randomized study. Rheumatol Int. 2006;26(4):314–319.
   PubMed Web of Science ®Google Scholar
• Ravaud P, Moulinier L, Giraudeau B, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. Arthritis Rheum. 1999;42(3):475–482.
   PubMed Web of Science ®Google Scholar
• Gachoud D, Guinot-Bourquin S, Monti M, et al. Ponctions et infiltrations articulaires. Rev Med Suisse. 2008;4:2330–2336.
   PubMedGoogle Scholar
• Berthelot JM, Tortellier L, Guillot P, et al. Tachon’s syndrome (suracute back and/or thoracic pain following local injections of corticosteroids). A report of 318 French cases. Joint Bone Spine. 2005;72(1):66–68.
   PubMed Web of Science ®Google Scholar
• Herrero-Beaumont G, Guerrero R, Sanchez-Pernaute O, et al. Cartilage and bone biological markers in the synovial fluid of osteoarthritic patients after hyaluronan injections in the knee. Clin Chim Acta. 2001;308(1–2):107–115.
   PubMed Web of Science ®Google Scholar
• Pohlig F, Guell F, Lenze U, et al. Hyaluronic acid suppresses the expression of metalloproteinases in osteoarthritic cartilage stimulated simultaneously by interleukin 1beta and mechanical load. PLoS One. 2016;11(3):e0150020.
   PubMed Web of Science ®Google Scholar
• Arrich J, Piribauer F, Mad P, et al. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. Cmaj. 2005;172(8):1039–1043.
   PubMed Web of Science ®Google Scholar
• Bellamy N, Campbell J, Robinson V, et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;2:CD005328.
   PubMedGoogle Scholar
• Miller LE, Block JE. US-approved intra-articulr hyaluronic acid injections are safe and effective in patients with knee osteoarthritis: systematic review and meta-analysis of randomized, saline-controlled trials. Clin Med Insights Arthritis Musculoskelet Disord. 2013;6:57–63.
   PubMedGoogle Scholar
• Rutjes AW, Jüni P, da Costa BR, et al. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012;157:180–191.
   PubMed Web of Science ®Google Scholar
• Wang CT, Lin J, Chang CJ, et al. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. J Bone Joint Surg Am. 2004;86-A(3):538–545.
   PubMed Web of Science ®Google Scholar
• McAlindon TE, Bannuru RR. Osteoarthritis: is viscosupplementation really so unsafe for knee OA? Nat Rev Rheumatol. 2012;8(11):635–636.
   PubMed Web of Science ®Google Scholar
• Cutolo M, Berenbaum F, Hochberg M, et al. Commentary on recent therapeutic guidelines for osteoarthritis. Semin Arthritis Rheum. 2015;44(6):611–617.
   PubMed Web of Science ®Google Scholar
• Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016;45(4 Suppl):S28–33.
   PubMed Web of Science ®Google Scholar
• Adams ME, Lussier AJ, Peyron JG. A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee. Drug Saf. 2000;23(2):115–130.
   PubMed Web of Science ®Google Scholar
• Chen AL, Desai P, Adler EM, et al. Granulomatous inflammation after hylan G-F 20 viscosupplementation of the knee: a report of six cases. J Bone Joint Surg Am. 2002;84-A(7):1142–1147.
   PubMed Web of Science ®Google Scholar
• Richette P, Chevalier X, Ea HK, et al. Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias. RMD Open. 2015;1(1):e000071.
   PubMed Web of Science ®Google Scholar
• Leopold SS, Warme WJ, Pettis PD, et al. Increased frequency of acute local reaction to intra-articular hylan GF- 20 (Synvisc) in patients receiving more than one course of treatment. J Bone Joint Surg Am. 2002;84-A(9):1619–1623.
   PubMed Web of Science ®Google Scholar
• Morton AH, Shannon P. Increased frequency of acute local reaction to intra-articular Hylan G-F 20 (Synvisc) in patients receiving more than one course of treatment. J Bone Joint Surg Am. 2003;85-A(10):2050; author reply 50-51.
   PubMed Web of Science ®Google Scholar
• Navarro-Sarabia F, Coronel P, Collantes E, et al. A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project. Ann Rheum Dis. 2011;70(11):1957–1962.
   PubMed Web of Science ®Google Scholar
• Altman RD, Rosen JE, Bloch DA, et al. Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial. Osteoarthritis Cartilage. 2011;19(10):1169–1175.
   PubMed Web of Science ®Google Scholar
• Lo GH, LaValley M, McAlindon T, et al. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA. 2003;290(23):3115–3121.
   PubMed Web of Science ®Google Scholar
• Reichenbach S, Blank S, Rutjes AW, et al. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Arthritis Rheum. 2007;57(8):1410–1418.
   PubMed Web of Science ®Google Scholar
• Petrella RJ, Cogliano A, Decaria J. Comparison of avian and nonavian hyaluronic acid in osteoarthritis of the knee. Orthop Res Rev. 2010;1:5–9.
   Google Scholar
• Pintan GF, De Oliveira AS Jr., Lenza M, et al. Update on biological therapies for knee injuries: osteoarthritis. Curr Rev Musculoskelet Med. 2014;7(3):263–269.
   PubMedGoogle Scholar
• Zhu Y, Yuan M, Meng HY, et al. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthritis Cartilage. 2013;21(11):1627–1637.
   PubMed Web of Science ®Google Scholar
• Meheux CJ, McCulloch PC, Lintner DM, et al.Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review. Arthroscopy. 2015;32(3):495–505.
   PubMed Web of Science ®Google Scholar
• Cerza F, Carni S, Carcangiu A, et al. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med. 2012;40(12):2822–2827.
   PubMed Web of Science ®Google Scholar
• Filardo G, Kon E, Di Martino A, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord. 2012;13:229.
   PubMed Web of Science ®Google Scholar
• Raeissadat SA, Rayegani SM, Hassanabadi H, et al. Knee osteoarthritis injection choices: platelet- rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015;8:1–8.
   PubMed Web of Science ®Google Scholar
• Sanchez M, Fiz N, Azofra J, et al. A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis. Arthroscopy. 2012;28(8):1070–1078.
   PubMed Web of Science ®Google Scholar
• Vaquerizo V, Plasencia MA, Arribas I, et al. Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: a randomized controlled trial. Arthroscopy. 2013;29(10):1635–1643.
   PubMed Web of Science ®Google Scholar
• Patel S, Dhillon MS, Aggarwal S, et al. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356–364.
   PubMed Web of Science ®Google Scholar
• Filardo G, di Matteo B, di Martino A, et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med. 2015;43(7):1575–1582.
   PubMed Web of Science ®Google Scholar
• Gormeli G, Gormeli CA, Ataoglu B, et al. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc. 2015;25(3):958–965.
   PubMed Web of Science ®Google Scholar
• Montanez-Heredia E, Irizar S, Huertas PJ, et al. Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish national health care system. Int J Mol Sci. 2016;17(7):1064.
   PubMed Web of Science ®Google Scholar
• Paterson KL, Nicholls M, Bennell KL, et al. Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study. BMC Musculoskelet Disord. 2016;17:67.
   PubMed Web of Science ®Google Scholar
• Forogh B, Mianehsaz E, Shoaee S, et al. Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J Sports Med Phys Fitness. 2015;56(7–8):901–908.
   PubMed Web of Science ®Google Scholar
• Dai WL, Zhou AG, Zhang H, et al.Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Arthroscopy. 2016;33(3):659–670.
   PubMed Web of Science ®Google Scholar
• Sugiyama H. Clostridium botulinum neurotoxin. Microbiol Rev. 1980;44(3):419–448.
   PubMedGoogle Scholar
• Dressler D, Adib Saberi F. Botulinum toxin: mechanisms of action. Eur Neurol. 2005;53(1):3–9.
   PubMed Web of Science ®Google Scholar
• Balash Y, Giladi N. Efficacy of pharmacological treatment of dystonia: evidence-based review including meta-analysis of the effect of botulinum toxin and other cure options. Eur J Neurol. 2004;11(6):361–370.
   PubMed Web of Science ®Google Scholar
• Simpson DM, Blitzer A, Brashear A, et al. Assessment: botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;70(19):1699–1706.
   PubMed Web of Science ®Google Scholar
• Singh JA. Use of botulinum toxin in musculoskeletal pain. F1000Res. 2013;2:52.
   PubMedGoogle Scholar
• Sun SF, Hsu CW, Lin HS, et al. Efficacy of intraarticular botulinum toxin A and intraarticular hyaluronate plus rehabilitation exercise in patients with unilateral ankle osteoarthritis: a randomized controlled trial. J Foot Ankle Res. 2014;7(1):9.
   PubMed Web of Science ®Google Scholar
• Boon AJ, Smith J, Dahm DL, et al. Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PM R. 2010;2(4):268–276.
   PubMedGoogle Scholar
• Mahowald ML, Singh JA, Dykstra D. Long term effects of intra-articular botulinum toxin A for refractory joint pain. Neurotox Res. 2006;9(2–3):179–188.
   PubMed Web of Science ®Google Scholar
• Hsieh LF, Wu CW, Chou CC, et al. Effects of botulinum toxin landmark-guided intra-articular injection in subjects with knee osteoarthritis. PM R. 2016;8(12):1127–1135.
   PubMedGoogle Scholar