Efficacy and safety of dronedarone in the treatment of patients with atrial fibrillation

References

• Chugh SS, Havmoeller R, Narayanan K, et al. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129:837–847.
   PubMed Web of Science ®Google Scholar
• Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Europace. 2016;18:1609–1678.
   PubMed Web of Science ®Google Scholar
• Gao S, Dai W, Zhang L, et al. Risk of cardiovascular events, stroke, congestive heart failure, interstitial lung disease, and acute liver injury: dronedarone versus amiodarone and other antiarrhythmics. J Atr Fibrillation. 2013;6:890.
   PubMedGoogle Scholar
• Wyse DG, Waldo AL, DiMarco JP, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002;347:1825–1833.
   PubMed Web of Science ®Google Scholar
• Carlsson J, Miketic S, Windeler J, et al. Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the strategies of treatment of atrial fibrillation (STAF) study. J Am Coll Cardiol. 2003;41:1690–1696.
   PubMed Web of Science ®Google Scholar
• Chung MK, Shemanski L, Sherman DG, et al. Functional status in rate- versus rhythm-control strategies for atrial fibrillation: results of the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) functional status substudy. J Am Coll Cardiol. 2005;46:1891–1899.
   PubMed Web of Science ®Google Scholar
• January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64:e1–e76.
   PubMed Web of Science ®Google Scholar
• Freemantle N, Lafuente-Lafuente C, Mitchell S, et al. Mixed treatment comparison of dronedarone, amiodarone, sotalol, flecainide, and propafenone, for the management of atrial fibrillation. Europace. 2011;13:329–345.
   PubMed Web of Science ®Google Scholar
• Patel C, Yan G-X, Kowey PR. Dronedarone. Circulation. 2009;120:636–644.
   PubMed Web of Science ®Google Scholar
• Touboul P, Brugada J, Capucci A, et al. Dronedarone for prevention of atrial fibrillation: a dose-ranging study. Eur Heart J. 2003;24:1481–1487.
   PubMed Web of Science ®Google Scholar
• Singh BN, Connolly SJ, Crijns HJGM, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007;357:987–999.
   PubMed Web of Science ®Google Scholar
• Hohnloser SH, Crijns HJGM, Van Eickels M, et al. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med. 2009;360:668–678.
   PubMed Web of Science ®Google Scholar
• Singh D, Cingolani E, Diamond GA, et al. Dronedarone for atrial fibrillation. Have we expanded the antiarrhythmic armamentarium? J Am Coll Cardiol. 2010;55:1569–1576.
   PubMed Web of Science ®Google Scholar
• Ezekowitz MD, Ellenbogen KA, DiMarco JP, et al. A placebo-controlled, double-blind, randomized, multicenter study to assess the effects of dronedarone 400 mg twice daily for 12 weeks on atrial fibrillation burden in subjects with permanent pacemakers. J Interv Card Electrophysiol. 2015;42:69–76.
   PubMed Web of Science ®Google Scholar
• Reiffel JA, Camm AJ, Belardinelli L, et al. The HARMONY trial: combined ranolazine and dronedarone in the management of paroxysmal atrial fibrillation: mechanistic and therapeutic synergism. Circ Arrhythmia Electrophysiol. 2015;8:1048–1056.
   PubMed Web of Science ®Google Scholar
• Le Heuzey JY, De Ferrari GM, Radzik D, et al. A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the dionysos study. J Cardiovasc Electrophysiol. 2010;21:597–605.
   PubMed Web of Science ®Google Scholar
• Chun KJ, Byeon K, Im SI, et al. Efficacy of dronedarone versus propafenone in the maintenance of sinus rhythm in patients with atrial fibrillation after electrical cardioversion. Clin Ther. 2014;36:1169–1175.
   PubMed Web of Science ®Google Scholar
• Davy JM, Herold M, Hoglund C, et al. Dronedarone for the control of ventricular rate in permanent atrial fibrillation: the Efficacy and safety of dRonedArone for The cOntrol of ventricular rate during atrial fibrillation (ERATO) study. Am Heart J. 2008;156:527e–527e9.
   Web of Science ®Google Scholar
• Doyle JF, Ho KM. Benefits and risks of long-term amiodarone therapy for persistent atrial fibrillation: a meta-analysis. Mayo Clin Proc. 2009;84:234–242.
   PubMed Web of Science ®Google Scholar
• Køber L, Torp-Pedersen C, McMurray JJV, et al. Increased mortality after dronedarone therapy for severe heart failure. N Engl Mass Med Soc. 2008 Jun 19;358(25):2678–2687.
   PubMed Web of Science ®Google Scholar
• Connolly SJS, Camm AJ, Halperin JLJ, et al. Dronedarone in high-risk permanent atrial fibrillation PALLAS. N Engl J Med. 2011;365:2268–2276.
   Web of Science ®Google Scholar
• Hohnloser SH, Halperin JL, Camm AJ, et al. Interaction between digoxin and dronedarone in the PALLAS trial. Circ Arrhythmia Electrophysiol. 2014 Dec 1;7(6):1019–1025.
   PubMed Web of Science ®Google Scholar
• Rathore SS, Curtis JP, Wang Y, et al. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA. 2003;289:871–878.
   PubMed Web of Science ®Google Scholar
• Duray GZ, Torp-Pedersen C, Connolly SJ, et al. Effects of dronedarone on clinical outcomes in patients with lone atrial fibrillation: pooled post hoc analysis from the ATHENA/EURIDIS/ADONIS studies. J Cardiovasc Electrophysiol. 2011;22:770–776.
   PubMed Web of Science ®Google Scholar
• By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63:2227–2246.
   PubMed Web of Science ®Google Scholar
• Tschuppert Y, Buclin T, Rothuizen LE, et al. Effect of dronedarone on renal function in healthy subjects. Br J Clin Pharmacol. 2007;64:785–791.
   PubMed Web of Science ®Google Scholar
• Roden DM. Taking the “idio” out of “idiosyncratic”: predicting torsades de pointes. Pacing Clin Electrophysiol. 1998;21:1029–1034.
   PubMed Web of Science ®Google Scholar
• Eckardt L, Breithardt G, Haverkamp W. Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. J Pharmacol Exp Ther. 2002;300:64–71.
   PubMed Web of Science ®Google Scholar
• Milberg P, Eckardt L, Bruns H-J, et al. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. J Pharmacol Exp Ther. 2002;303:218–225.
   PubMed Web of Science ®Google Scholar
• Milberg P, Frommeyer G, Kleideiter A, et al. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. Hear Rhythm. 2011;8:1492–1500.
   PubMed Web of Science ®Google Scholar
• Milberg P, Frommeyer G, Uphaus T, et al. Electrophysiologic profile of dronedarone on the ventricular level: beneficial effect on postrepolarization refractoriness in the presence of rapid phase 3 repolarization. J Cardiovasc Pharmacol. 2012;59:92–100.
   PubMed Web of Science ®Google Scholar
• van Opstal JM, Schoenmakers M, Verduyn SC, et al. Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome. Circulation. 2001;104:2722–2727.
   PubMed Web of Science ®Google Scholar
• Friberg L. Safety of dronedarone in routine clinical care. J Am Coll Cardiol. 2014;63:2376–2384.
   PubMed Web of Science ®Google Scholar
• Wu J, Thammakhoune J, Dai W, et al. Assessment of dronedarone utilization using US claims databases. Clin Ther. 2014;36:264–272.
   PubMed Web of Science ®Google Scholar