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Expert Opinion on Drug Safety Volume 22, 2023 - Issue 12
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Original Research

Proton pump inhibitors use prior to COVID-19 hospitalization is associated with higher Clostridioides difficile infection rate

Marko Lucijanica Hematology Department, University Hospital Dubrava, Zagreb, Croatia;b School of Medicine, University of Zagreb, Zagreb, CroatiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1372-2040View further author information
ORCID Icon,
Nikolina Busicc Department of Internal Medicine, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Josip Stojicd Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Mislav Barisic-Jamand Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Nikola Zagorece Nephrology Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Karla Lazibatb School of Medicine, University of Zagreb, Zagreb, CroatiaView further author information
,
Antica Pasaricf Clinical Immunology, Allergology and Rheumatology Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Anamarija Vrkljan Vuka Hematology Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Ivan Durlene Nephrology Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Josko Mitrovicb School of Medicine, University of Zagreb, Zagreb, Croatia;c Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia;f Clinical Immunology, Allergology and Rheumatology Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
,
Ivica Luksicb School of Medicine, University of Zagreb, Zagreb, Croatia;g Maxillofacial Surgery Department, University Hospital Dubrava, Zagreb, CroatiaView further author information
&
Bruno Barsicb School of Medicine, University of Zagreb, Zagreb, CroatiaView further author information
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Pages 1265-1270 | Received 27 Mar 2023, Accepted 23 May 2023, Published online: 10 Jul 2023

References

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  • Kodvanj I, Homolak J, Trkulja V. People exposed to proton-pump inhibitors shortly preceding COVID-19 diagnosis are not at an increased risk of subsequent hospitalizations and mortality: A nationwide matched cohort study. Br J Clin Pharmacol. 2023;89(2):787–831. doi: 10.1111/bcp.15525
  • Yan C, Chen Y, Sun C, et al. Does proton pump inhibitor use lead to a higher risk of coronavirus disease 2019 infection and progression to severe disease? A meta-analysis. Jpn J Infect Dis. 2022 Jan 24;75(1):10–15. doi: 10.7883/yoken.JJID.2021.074
  • Pranata R, Huang I, Lawrensia S, et al. Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis. Pharmacol Rep. 2021 Dec;73(6):1642–1649.
  • World Health Organization. Clinical management of COVID-19: interim guidance, 27 May 2020. Geneva: World Health Organization. Contract No.: WHO/2019-nCoV/clinical/2020.5. 2020.
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  • D’Silva KM, Mehta R, Mitchell M, et al. Proton pump inhibitor use and risk for recurrent clostridioides difficile infection: a systematic review and meta-analysis. Clin Microbiol Infect. 2021 Jan 16;27(5):697–703. doi: 10.1016/j.cmi.2021.01.008
  • Mehta P, Nahass RG, Brunetti L. Acid suppression medications during hospitalization as a risk factor for recurrence of Clostridioides difficile infection: systematic review and meta-analysis. Clin Infect Dis. 2021 Jul 1;73(1):e62–e68. doi: 10.1093/cid/ciaa545
  • Busic N, Lucijanic T, Barsic B, et al. Vaccination provides protection from respiratory deterioration and death among hospitalized COVID-19 patients: differences between vector and mRNA vaccines. J Med Virol. 2022 Jun;94(6):2849–2854.
  • Lucijanic M, Marelic D, Stojic J, et al. Predictors of prolonged hospitalization of COVID-19 patients. Eur Geriatr Med. 2023 Apr 27;14(3):511–516. doi: 10.1007/s41999-023-00787-w

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