1,005
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Renal drug dosage adjustments and adverse drug events in patients with chronic kidney disease admitted to the hospital: a cross-sectional study

ORCID Icon, , ORCID Icon & ORCID Icon
Pages 457-467 | Received 24 Aug 2023, Accepted 28 Nov 2023, Published online: 08 Feb 2024

References

  • Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease - a systematic review and meta-analysis. PLoS One. 2016;11(7):e0158765. doi: 10.1371/journal.pone.0158765
  • Hayward S, Hole B, Denholm R, et al. International prescribing patterns and polypharmacy in older people with advanced chronic kidney disease: results from the European quality study. Nephrol Dial Transplant. 2021 Feb 20;36(3):503–511. doi: 10.1093/ndt/gfaa064
  • Offurum A, Wagner LA, Gooden T. Adverse safety events in patients with chronic kidney disease (CKD). Expert Opin Drug Saf. 2016 Dec;15(12):1597–1607. doi: 10.1080/14740338.2016.1236909
  • Leendertse AJ, van Dijk EA, De Smet PA, et al. Contribution of renal impairment to potentially preventable medication-related hospital admissions. Ann Pharmacother. 2012 May;46(5):625–33.
  • Helldén A, Bergman U, von Euler M, et al. Adverse drug reactions and impaired renal function in elderly patients admitted to the emergency department: a retrospective study. Drugs Aging. 2009;26(7):595–606. doi: 10.2165/11315790-000000000-00000
  • van Dijk EA, Drabbe NR, Kruijtbosch M, et al. Drug dosage adjustments according to renal function at hospital discharge. Ann Pharmacother. 2006 Jul;40(7–8):1254–60. doi: 10.1345/aph.1G742
  • Drenth-van Maanen AC, van Marum RJ, Jansen PA, et al. Adherence with dosing guideline in patients with impaired renal function at hospital discharge. PLoS One. 2015;10(6):e0128237. doi: 10.1371/journal.pone.0128237
  • Laville SM, Metzger M, Stengel B, et al. Evaluation of the adequacy of drug prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort. Br J Clin Pharmacol. 2018 Dec;84(12):2811–2823.
  • O’Shaughnessy M, Allen N, O’Regan J, et al. Agreement between renal prescribing references and determination of prescribing appropriateness in hospitalized patients with chronic kidney disease. QJM. 2017 Oct 1;110(10):623–628. doi: 10.1093/qjmed/hcx086
  • Alruqayb WS, Price MJ, Paudyal V, et al. Drug-related problems in hospitalised patients with chronic kidney disease: a systematic review. Drug Saf. 2021 Oct;44(10):1041–1058. doi: 10.1007/s40264-021-01099-3
  • Dörks M, Allers K, Schmiemann G, et al. Inappropriate medication in non-hospitalized patients with renal insufficiency: a systematic review. J Am Geriatr Soc. 2017 Apr;65(4):853–862.
  • Hanlon JT, Wang X, Handler SM, et al. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients. J Am Med Dir Assoc. 2011 Jun;12(5):377–83.
  • Papaioannou A, Clarke JA, Campbell G, et al. Assessment of adherence to renal dosing guidelines in long-term care facilities. J Am Geriatr Soc. 2000 Nov;48(11):1470–3. doi: 10.1111/j.1532-5415.2000.tb02639.x
  • Sweileh WM, Janem SA, Sawalha AF, et al. Medication dosing errors in hospitalized patients with renal impairment: a study in Palestine. Pharmacoepidemiol Drug Saf. 2007 Aug;16(8):908–12.
  • Steinman MA, Miao Y, Boscardin WJ, et al. Prescribing quality in older veterans: a multifocal approach. J Gen Intern Med. 2014 Oct;29(10):1379–86.
  • Blix HS, Viktil KK, Moger TA, et al. Use of renal risk drugs in hospitalized patients with impaired renal function–an underestimated problem? Nephrol Dial Transplant. 2006 Nov;21(11):3164–71. doi: 10.1093/ndt/gfl399
  • Alahdal AM, Elberry AA. Evaluation of applying drug dose adjustment by physicians in patients with renal impairment. Saudi Pharm J. 2012 Jul;20(3):217–20. doi: 10.1016/j.jsps.2011.12.005
  • Chang F, O’Hare AM, Miao Y, et al. Use of renally inappropriate medications in older veterans: a National study. J Am Geriatr Soc. 2015 Nov;63(11):2290–7. doi: 10.1111/jgs.13790
  • Yap C, Dunham D, Thompson J, et al. Medication dosing errors for patients with renal insufficiency in ambulatory care. Jt Comm J Qual Patient Saf. 2005 Sep;31(9):514–21. doi: 10.1016/S1553-7250(05)31066-X
  • Khanal A, Peterson GM, Castelino RL, et al. Potentially inappropriate prescribing of renally cleared drugs in elderly patients in community and aged care settings. Drugs Aging. 2015 May;32(5):391–400. doi: 10.1007/s40266-015-0261-1
  • Sönnerstam E, Sjölander M, Gustafsson M. Inappropriate prescription and renal function among older patients with cognitive impairment. Drugs Aging. 2016 Dec;33(12):889–899. doi: 10.1007/s40266-016-0408-8
  • Schmidt-Mende K, Wettermark B, Andersen M, et al. Prevalence of renally inappropriate medicines in older people with renal impairment - a cross-sectional register-based study in a large primary care population. Basic Clin Pharmacol Toxicol. 2019 Mar;124(3):256–265.
  • Pillans PI, Landsberg PG, Fleming AM, et al. Evaluation of dosage adjustment in patients with renal impairment. Intern Med J. 2003 Jan;33(1–2):10–3.
  • Rothberg MB, Kehoe ED, Courtemanche AL, et al. Recognition and management of chronic kidney disease in an elderly ambulatory population. J Gen Intern Med. 2008 Aug;23(8):1125–30.
  • Decloedt E, Leisegang R, Blockman M, et al. Dosage adjustment in medical patients with renal impairment at Groote Schuur hospital. S Afr Med J. 2010 May 4;100(5):304–6. doi: 10.7196/SAMJ.3955
  • Očovská Z, Maříková M, Kočí J, et al. Drug-related hospital admissions via the department of emergency medicine: a cross-sectional study from the Czech Republic. Front Pharmacol. 2022;13:899151. doi: 10.3389/fphar.2022.899151
  • Lexicomp database. [internet]. Waltham (MA): UpToDate, Inc. Available from: https://www.uptodate.com Subscription required to view.
  • Micromedex database [internet]. Merative. Available from: https://www.micromedexsolutions.com Subscription required to view.
  • Joint Formulary Committee. BNF 84: September 2022-March 2023. London: Pharmaceutical Press; 2022. p. 84.
  • Ashley C, Dunleavy A. The renal drug Handbook: the ultimate prescribing guide for renal practitioners. 5th ed. Boca Raton, Florida: CRC Press; 2018.
  • Thevelin S, Spinewine A, Beuscart JB, et al. Development of a standardized chart review method to identify drug-related hospital admissions in older people. Br J Clin Pharmacol. 2018 Nov;84(11):2600–2614.
  • Uppsala Monitoring Centre. The use of the WHO-UMC system for standardised case causality assessment: World Health Organisation-Uppsala Monitoring Centre; 2018. Available from: https://who-umc.org/media/164200/who-umc-causality-assessment_new-logo.pdf
  • Hallas J, Harvald B, Gram LF, et al. Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med. 1990 Aug;228(2):83–90.
  • American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023 May;71(7):2052–2081.
  • O’Mahony D, Cherubini A, Guiteras AR, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3. Eur Geriatr Med. 2023 May 31;14(4):625–632. doi: 10.1007/s41999-023-00777-y
  • Foubert K, Capiau A, Mehuys E, et al. Ghent older people’s prescriptions community pharmacy screening (GheOP(3)S)-tool version 2: update of a tool to detect drug-related problems in older people in primary care. Drugs Aging. 2021 Jun;38(6):523–533.
  • Renom-Guiteras A, Meyer G, Thürmann PA. The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries. Eur J Clin Pharmacol. 2015 Jul;71(7):861–75. doi: 10.1007/s00228-015-1860-9
  • Saad R, Hallit S, Chahine B. Evaluation of renal drug dosing adjustment in chronic kidney disease patients at two university hospitals in Lebanon. Pharm Pract (Granada). 2019 Jan;17(1):1304. doi: 10.18549/PharmPract.2019.1.1304
  • Jones SA, Bhandari S. The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease. Postgrad Med J. 2013 May;89(1051):247–50. doi: 10.1136/postgradmedj-2012-130889
  • Hoffmann F, Boeschen D, Dörks M, et al. Renal insufficiency and medication in nursing home residents. A cross-sectional study (IMREN). Dtsch Arztebl Int. 2016 Feb 12;113(6):92–8. doi: 10.3238/arztebl.2016.0092
  • Yang P, Chen N, Wang RR, et al. Inappropriateness of medication prescriptions about chronic kidney disease patients without dialysis therapy in a Chinese tertiary teaching hospital. Ther Clin Risk Manag. 2016;12:1517–1524. doi: 10.2147/TCRM.S116789
  • Doody HK, Peterson GM, Watson D, et al. Retrospective evaluation of potentially inappropriate prescribing in hospitalized patients with renal impairment. Curr Med Res Opin. 2015 Mar;31(3):525–35. doi: 10.1185/03007995.2015.1010036
  • Getachew H, Tadesse Y, Shibeshi W. Drug dosage adjustment in hospitalized patients with renal impairment at tikur anbessa specialized hospital, Addis Ababa, Ethiopia. BMC Nephrol. 2015 Oct 7;16:158. doi: 10.1186/s12882-015-0155-9
  • Bilge U, Sahin G, Unluoglu I, et al. Inappropriate use of nonsteroidal anti-inflammatory drugs and other drugs in chronic kidney disease patients without renal replacement therapy. Ren Fail. 2013 Jul;35(6):906–10.
  • Prajapati A, Ganguly B. Appropriateness of drug dose and frequency in patients with renal dysfunction in a tertiary care hospital: a cross-sectional study. J Pharm Bioallied Sci. 2013 Apr;5(2):136–40. doi: 10.4103/0975-7406.111829
  • Salomon L, Deray G, Jaudon MC, et al. Medication misuse in hospitalized patients with renal impairment. Int J Qual Health Care. 2003 Aug;15(4):331–5.
  • Nielsen AL, Henriksen DP, Marinakis C, et al. Drug dosing in patients with renal insufficiency in a hospital setting using electronic prescribing and automated reporting of estimated glomerular filtration rate. Basic Clin Pharmacol Toxicol. 2014 May;114(5):407–13.
  • Altunbas G, Yazc M, Solak Y, et al. Renal drug dosage adjustment according to estimated creatinine clearance in hospitalized patients with heart failure. Am J Ther. 2016 Jul;23(4):e1004–8.
  • Bertsche T, Fleischer M, Pfaff J, et al. Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiency. Eur J Clin Pharmacol. 2009 Aug;65(8):823–9.
  • Desmedt S, Spinewine A, Jadoul M, et al. Impact of a clinical decision support system for drug dosage in patients with renal failure. Int J Clin Pharm. 2018 Oct;40(5):1225–1233.
  • Gheewala PA, Peterson GM, Curtain CM, et al. Impact of the pharmacist medication review services on drug-related problems and potentially inappropriate prescribing of renally cleared medications in residents of aged care facilities. Drugs Aging. 2014 Nov;31(11):825–35.
  • Castelino RL, Saunder T, Kitsos A, et al. Quality use of medicines in patients with chronic kidney disease. BMC Nephrol. 2020 Jun 5;21(1):216. doi: 10.1186/s12882-020-01862-1
  • Marquito AB, Pinheiro HS, Fernandes N, et al. Pharmacotherapy assessment in chronic kidney disease: validation of the PAIR instrument for use in Brazil. J Bras Nefrol. 2020 Oct;42(4):400–412. doi: 10.1590/2175-8239-jbn-2019-0205
  • Van Pottelbergh G, Mertens A, Azermai M, et al. Drug prescriptions unadapted to the renal function in patients aged 80 years and older. Eur J Gen Pract. 2014 Sep;20(3):190–5.
  • Hayat M, Ahmad N, Khan SLA, et al. Pattern, frequency and factors associated with inappropriate high dosing in chronic kidney disease patients at a tertiary care hospital in Pakistan. BMC Nephrol. 2023 May 1;24(1):118. doi: 10.1186/s12882-023-03167-5
  • Guirguis-Blake J, Keppel GA, Holmes J, et al. Prescription of high-risk medications among patients with chronic kidney disease: a cross-sectional study from the Washington, Wyoming, Alaska, Montana and Idaho region practice and research network. Fam Pract. 2018 Sep 18;35(5):589–594. doi: 10.1093/fampra/cmy001
  • Markota NP, Markota I, Tomic M, et al. Inappropriate drug dosage adjustments in patients with renal impairment. J Nephrol. 2009 Jul;22(4):497–501.
  • Holm H, Bjerke K, Holst L, et al. Use of renal risk drugs in patients with renal impairment. Int J Clin Pharm. 2015 Dec;37(6):1136–42. doi: 10.1007/s11096-015-0175-3
  • Kassa Birarra M, Mekonnen GB, Gelayee DA, et al. Drug dose adjustment in patients with renal impairment attending a specialized referral hospital, Northwest Ethiopia. Metabol Open. 2022 Dec;16:100211.
  • MacRae C, Mercer S, Guthrie B. Potentially inappropriate primary care prescribing in people with chronic kidney disease: a cross-sectional analysis of a large population cohort. Br J Gen Pract. 2021 Jul;71(708):e483–e490. doi: 10.3399/BJGP.2020.0871
  • Saleem A, Masood I. Pattern and predictors of medication dosing errors in chronic kidney disease patients in Pakistan: a single center retrospective analysis. PLoS One. 2016;11(7):e0158677. doi: 10.1371/journal.pone.0158677
  • Tesfaye WH, Castelino RL, Wimmer BC, et al. Inappropriate prescribing in chronic kidney disease: a systematic review of prevalence, associated clinical outcomes and impact of interventions. Int J Clin Pract. 2017 Jul;71(7). doi: 10.1111/ijcp.12960.
  • Hassan Z, Ali I, Ullah AR, et al. Assessment of medication dosage adjustment in hospitalized patients with chronic kidney disease. Cureus. 2021 Feb 20;13(2):e13449. doi: 10.7759/cureus.13449
  • Erler A, Beyer M, Petersen JJ, et al. How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trial. BMC Fam Pract. 2012 Sep 6;13:91. doi: 10.1186/1471-2296-13-91
  • Deskur-Śmielecka E, Chudek J, Neumann-Podczaska A, et al. Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database. BMC Geriatr. 2019 Mar 5;19(1):70. doi: 10.1186/s12877-019-1075-5
  • Bezabhe WM, Kitsos A, Saunder T, et al. Medication prescribing quality in Australian primary care patients with chronic kidney disease. J Clin Med. 2020 Mar 13;9(3):783. doi: 10.3390/jcm9030783
  • Barbieri MA, Rottura M, Cicala G, et al. Chronic kidney disease management in general practice: a focus on inappropriate drugs prescriptions. J Clin Med. 2020 May 4;9(5):1346. doi: 10.3390/jcm9051346
  • Golightly IT LK, Kiser TH, Levin DA, editors . Renal pharmacotherapy: dosage adjustment of medications eliminated by the kidneys. 2nd ed. New york (NY): Springer; 2021.
  • Yau K, Dharia A, Alrowiyti I, et al. Prescribing SGLT2 inhibitors in patients with CKD: expanding indications and practical considerations. Kidney Int Rep. 2022 Jul;7(7):1463–1476. doi: 10.1016/j.ekir.2022.04.094
  • Sellier E, Colombet I, Sabatier B, et al. Effect of alerts for drug dosage adjustment in inpatients with renal insufficiency. J Am Med Inform Assoc. 2009 Mar;16(2):203–10.
  • Jones M, Denieffe S, Griffin C, et al. Evaluation of cystatin C in malignancy and comparability of estimates of GFR in oncology patients. Pract Lab Med. 2017 Aug;8:95–104.
  • Manetti L, Pardini E, Genovesi M, et al. Thyroid function differently affects serum cystatin C and creatinine concentrations. J Endocrinol Invest. 2005 Apr;28(4):346–9.
  • Seiberth S, Bauer D, Schönermarck U, et al. Correct use of non-indexed eGFR for drug dosing and renal drug-related problems at hospital admission. Eur J Clin Pharmacol. 2020 Dec;76(12):1683–1693.