T-wave morphology abnormalities in the STREAM stage 1 trial

References

• Nunn AJ, Phillips PPJ, Meredith SK, et al. A trial of a shorter regimen for rifampin-resistant tuberculosis. N Engl J Med. 2019;2019(13):1201–1213. doi: 10.1056/nejmoa1811867
   Google Scholar
• Volberg WA, Koci BJ, Su W, et al. Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics. J Pharmacol Exp Ther. 2002;302(1):320–327. doi: 10.1124/jpet.302.1.320
   PubMed Web of Science ®Google Scholar
• Alexandrou AJ, Duncan RS, Sullivan A, et al. Mechanism of hERG K + channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br J Pharmacol. 2006;147:905–916. doi: 10.1038/sj.bjp.0706678
   PubMed Web of Science ®Google Scholar
• Priori SG, Napolitano C, Schwartz PJ. Clinical impact of low penetrance long qt. Circulation. 1999;99(4):529–533. doi: 10.1161/01.CIR.99.4.529
   PubMed Web of Science ®Google Scholar
• Schwartz PJ, Ackerman MJ. The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy. Eur Heart J. 2013;34:3109–3116. doi: 10.1093/eurheartj/eht089
   PubMed Web of Science ®Google Scholar
• Vicente J, Johannesen L, Mason JW, et al. Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil. J Am Heart Assoc. 2015;4:1–13. doi: 10.1161/JAHA.114.001615
   Web of Science ®Google Scholar
• Graff C, Matz J, Andersen MP, et al. Moxifloxacin-induced changes in T-wave morphology. J Electrocardiol. 2009;42(6):610. doi: 10.1016/j.jelectrocard.2009.08.016
   Google Scholar
• Anderson ME, Al-Khatib SM, Roden DM, et al. Cardiac repolarization: Current knowledge, critical gaps, and new approaches to drug development and patient management. Am Heart J. 2002;144:769–781. doi: 10.1067/mhj.2002.125804
   PubMed Web of Science ®Google Scholar
• Porta-Sánchez A, Spillane DR, Harris L, et al. T-Wave morphology analysis in congenital long QT syndrome discriminates patients from healthy individuals. JACC Clin Electrophysiol. 2017;3:374–381. doi: 10.1016/j.jacep.2016.10.013
   PubMedGoogle Scholar
• Al V, Timothy KW, Leppert M. The spectrum of symptoms and QT intervals in carriers of the gene for the long-qt syndrome. N Engl J Med. 1992;1992(12):846–852. doi: 10.1056/NEJM199209173271204
   Google Scholar
• Isaksen JL, Ghouse J, Graff C, et al. Electrocardiographic T-wave morphology and risk of mortality. Int J Cardiol. 2021;328:199–205. doi: 10.1016/j.ijcard.2020.12.016
   PubMed Web of Science ®Google Scholar
• Ramírez J, Kiviniemi A, van Duijvenboden S, et al. ECG T-Wave morphologic variations predict ventricular arrhythmic risk in low-and moderate-risk populations. JAHA. 20 ;11(17):11. doi: 10.1161/JAHA.121.025897
   Google Scholar
• Zhang L, Timothy KW, Vincent GM, et al. Spectrum of ST-T–wave patterns and repolarization parameters in congenital long-QT syndrome. Circulation. 2000;102(23):2849–2855. doi: 10.1161/01.CIR.102.23.2849
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Toda H, Nishimura M. Clinical electrocardiographic studies of bifid T waves. Br Heart J. 1984;52:207–214. doi: 10.1136/hrt.52.2.207
   PubMedGoogle Scholar
• Chorin E, Havakuk O, Adler A, et al. Diagnostic value of T-wave morphology changes during “QT stretching” in patients with long QT syndrome. Heart Rhythm. 2015;12:2263–2271. doi: 10.1016/j.hrthm.2015.06.040
   PubMed Web of Science ®Google Scholar
• Malfatto G, Beria G, Sala S, et al. Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic long QT syndrome. J Am Coll Cardiol. 1994;23:296–301. doi: 10.1016/0735-1097(94)90410-3
   PubMed Web of Science ®Google Scholar
• Couderc JP, McNitt S, Hyrien O, et al. Improving the detection of subtle IKr-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin. Drug Saf. 2008;31:249–260. doi: 10.2165/00002018-200831030-00006
   PubMed Web of Science ®Google Scholar
• Matz J, Graff C, Vainio PJ, et al. Effect of nalmefene 20 and 80mg on the corrected QT interval and T-wave morphology: a randomized, double-blind, parallel-group, placebo- and moxifloxacin-controlled, single-centre study. Clin Drug Investig. 2011;31(11):799–811. doi: 10.2165/11592950
   PubMed Web of Science ®Google Scholar
• Jervell A, Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death. Am Heart J. 1957;54:59–68. doi: 10.1016/0002-8703(57)90079-0
   PubMed Web of Science ®Google Scholar
• Khositseth A, Hejlik J, Shen WK, et al. Epinephrine-induced T-wave notching in congenital long QT syndrome. Heart Rhythm. 2005;2:141–146. doi: 10.1016/j.hrthm.2004.11.008
   PubMed Web of Science ®Google Scholar
• Bos JM, Attia ZI, Albert DE, et al. Use of artificial intelligence and deep neural networks in evaluation of patients with electrocardiographically concealed long QT syndrome from the surface 12-lead electrocardiogram. JAMA Cardiol. 2021;6:532–538. doi: 10.1001/jamacardio.2020.7422
   PubMed Web of Science ®Google Scholar
• Schwartz PJ, Tan HL. Long QT syndrome, artificial intelligence, and common sense. Eur Heart J. 2021;42:3962–3964. doi: 10.1093/eurheartj/ehab611
   PubMed Web of Science ®Google Scholar