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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 3
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Research Article

Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

Béatrice Tchédam-Ngatcha Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Québec (CHUQ) and Université Laval, Pavillon CHUL, 2705 Laurier Blvd, Québec, Que., Canada G1 V 4G2
,
Van Luu-The Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Québec (CHUQ) and Université Laval, Pavillon CHUL, 2705 Laurier Blvd, Québec, Que., Canada G1 V 4G2
&
Donald Poirier Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Québec (CHUQ) and Université Laval, Pavillon CHUL, 2705 Laurier Blvd, Québec, Que., Canada G1 V 4G2
Pages 155-165 | Published online: 30 Sep 2008

  • Peltoketo, H., Luu-The, V., Simard, J. and Adamski, J. (1999) Endocrinology 23, 1-11.
  • Labrie, F., Luu-The, V., Lin, S.X., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G. and Bélanger, A. (2000) J. Mol. Endocrinol. 25, 1-16.
  • Labrie, F., Luu-The, V., Lin, S.X., Labrie, C., Simard, J., Breton, R. and Bélanger, A. (1997) Steroids 62, 148-158.
  • Penning, T.M. (1996) Endocr.-Rel. Cancer 3, 41-56.
  • Smith, H.J., Nicholls, P.J., Simons, C. and Le Lain, R. (2001) Exp. Opin. Ther. Patents 11, 789-824.
  • Andersson, S., Geissler, W.M., Patel, S. and Wu, L. (1995) J. Steroid Biochem. Mol. Biol. 53, 37-39.
  • Geissler, W.M., Davis, D.L., Wu, L., Bradshaw, K.D., Patel, S., Mendonca, B.B., Elliston, K.O., Wilson, J.D., Russell, D.W. and Andersson, S. (1994) Nature Genet. 7, 34-39.
  • Labrie, F., Dupont, A. and Bélanger, A. (1985) In: DeVita, Jr., V.T., Hellman, S. and Rosenberg, S.A., eds, Important Advances in Oncology 1985 (Lippincott, Philadelphia), pp 193-217.
  • Sansone, G.L. and Reisner, R.M. (1971) J. Imvst. Dermatol. 56, 366-372.
  • Kuttenn, F., Mowszowicz, I., Shaison, G. and Mauvais-Jarvis, P. (1977) J. Endocrinol. 75, 83-91.
  • Bingham, K.D. and Shaw, D.A. (1973) J. Endocrinol. 57, 111-121.
  • Bratoeff, E., Ramirez, E., Murillo, E., Flores, G. and Gabeza, M. (1999) Curr. Med. Chem. 6, 1107-1123.
  • Kenny, B., Ballard, S., Blagg, J. and Fox, D. (1997) J. Med. Chem. 40, 1293-1315.
  • Abell, A.D. and Henderson, B.R. (1995) Curr. Med. Chem. 2, 583-597.
  • Maltais, R. and Poirier, D. (1998) Tetrahedron Lett. 39, 4151-4154.
  • Tchédam-Ngatcha, B., Luu-The, V. and Poirier, D. (2000) Bioorg. Med. Chem. Lett. 10, 2533-2536.
  • Le Lain, R., Nicholls, P.J., Smith, H.J. and Maharlouie, F.H. (2001) J. Enz. Inhib. 16, 35-45.
  • Maltais, R., Luu-The, V. and Poirier, D. (2000) Bioorg. Med. Chem. 9, 3101-3111.
  • Poirier, D., Labrie, F. and Luu-The, V. (1995) Med.-Sci. 11(Suppl. 2), 24.
  • Pittaway, D.E. (1983) Contraception 27, 431-436.
  • Sam, K.M., Boivin, R.P., Auger, S. and Poirier, D. (1994) Bioorg. Med. Chem. Lett. 4, 2129-2132.
  • Sam, K.M., Boivin, R.P., Tremblay, M.R., Auger, S. and Poirier, D. (1998) Drug Design Discov. 15, 157-180.
  • Tremblay, M.R. and Poirier, D. (1998) J. Steroid Biochem. Mol. Biol. 66, 179-191.
  • Luu-The, V., Zhang, Y., Poirier, D. and Labrie, F. (1995) J. Steroid Biochem. Mol. Biol. 55, 581-587.
  • Kingston, R.E., Chen, C.A. and Okayama, H. (1991) In: Ausubel, E.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K., eds, Current Protocols in Molecular Biology (Wiley and Sons, New York), pp 9.1.1-9.1.9.
  • Luo, S., Martel, C., Sourla, A., Gauthier, S., Mérand, Y., Bélanger, A. and Labrie, C. (1997) Int. J. Cancer 73, 381-391.
  • Luo, S., Martel, C., Leblanc, G., Candas, B., Singh, S.M., Labrie, C., Simard, J., Bélanger, A. and Labrie, F. (1996) Endocr.-Rel. Cancer 3, 229-241.
  • Asselin, J., Melançon, R., Moachon, G. and Bélanger, A. (1980) Cancer Res. 40, 1612-1622.
  • Sam, K.M., Labrie, F. and Poirier, D. (2000) Eur. J. Med. Chem. 35, 217-225.
  • Tremblay, M.R. and Poirier, D. (1995) Bioorg. Med. Chem. 3, 505-523.
  • Tietze, L.F., Wölfling, J., Schneider, G. and Noltemeyer, M. (1994) Steroids 59, 305-309.
  • Neri, R., Florance, K., Koziol, P. and Van Cleave, S. (1972) Endocrinology 91, 427-437.
  • Poyet, P. and Labrie, F. (1985) Mol. Cell. Endocr. 42, 283-288.

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