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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 6
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Research Article

Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles

Pascal Marchand Laboratoires de Chimie Organique et de Chimie Thérapeutique, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
,
Marc Le Borgne Laboratoires de Chimie Organique et de Chimie Thérapeutique, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
,
Young Min Na Laboratoires de Chimie Organique et de Chimie Thérapeutique, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
,
Fabrice Pagniez Laboratoire de Parasitologie et Mycologie Médicale, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
,
Hiam Abdala Laboratoire de Parasitologie et Mycologie Médicale, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
,
Guillaume Le Baut Laboratoires de Chimie Organique et de Chimie Thérapeutique, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
&
Patrice Le Pape Laboratoire de Parasitologie et Mycologie Médicale, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035 Nantes, France
 show all
Pages 353-358 | Published online: 30 Sep 2008

  • Alvar, J., Canavate, C., Gutierrez-Solar, B., Jimenez, M., Laguna, F., Lopez-Velez, R., Molina, R. and Moreno, J. (1997) "Lcisliniania and human immunodeficiency virus coinfection: the first 10 years", Clinical Microbiology Reviews 10, 298-319.
  • Berman, J.D. (1997) "Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years", Clinical Infectious Diseases 24, 684-703.
  • Olliaro, P.L. and Bryceson, A.D.M. (1993) "Practical progress and new drugs for changing patterns of leishmaniasis", Parasitology Today 9, 323-328.
  • Ouellette, M. and Papadopoulou, B. (1993) "Mechanisms of drug resistance in Leishmania", Parasitology Today 9, 150-153.
  • United Nations Development Program/World Health Organization. Special Programme for Research and Training in Tropical Diseases (TDR) (1990) "Antimonials: large-scale failure in leishmaniasis "alarming", TDR News 34, 7.
  • Yardley, V. and Croft, S.L. (2000) "A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis", International Journal of Antimicrobial Agents 13, 243-248.
  • Thakur, C.P. (2001) "A single high dose treatment of kala-azar with Ambisome (amphotericin B lipid complex): a pilot study", International Journal of Antimicrobial Agents 17, 67-70.
  • Murray, H.W. (2001) "Clinical and experimental advances in treatment of visceral leishmaniasis", Antimicrobial Agents and Chemotherapy 45, 2185-2197.
  • Berman, J.D., Goad, L.J., Beach, D.H. and HoIz, Jr., G.G. (1986) "Effects of ketoconazole on sterol biosynthesis by Leishmania mexicana mexicana amastigotes in murine macrophage tumor cells", Molecular and Biochemical Parasitology 20, 85-92.
  • Dogra, J. and Saxena, V.N. (1996) "Itraconazole and leishmaniasis: a randomised double-blind trial in cutaneous disease", International Journal of Parasitology 26, 1413-1415.
  • Momeni, A.Z., Jalayer, T., Emamjomeh, M., Bashardost, N., Ghassemi, R.L., Meghdadi, M., Javadi, A. and Aminjavaheri, M. (1996) "Treatment of cutaneous leishmaniasis with itraconazole. Randomized double-blind study", Archives of Dermatology 132, 784-786.
  • WaIi, J.P., Aggarwal, P., Gupta, U., Saluja, S. and Singh, S. (1992) "Ketoconazole in the treatment of antimony- and pentamidine-resistant kala-azar", Journal of Infectious Diseases 166, 214-215.
  • Davidson, R.N. and Croft, S.L. (1993) "Recent advances in the treatment of visceral leishmaniasis", Transactions of the Royal Society of Tropical Medicine and Hygiene 87, 130-131.
  • Rashid, J.R., Wasunna, K.M., Gachihi, G.S., Nyakundi, P.M., Mbugua, J. and Kirigi, G. (1994) "The efficacy and safety of ketoconazole in visceral leishmaniasis", East African Medicinal Journal 71, 392-395.
  • Al-Abdely, H.M., Graybill, J.R., Loebenberg, D. and Melby, P.C. (1999) "Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases", Antimicrobial Agents and Chemotherapy 43, 2910-2914.
  • Ketcha, D.M. and Gribble, G.W. (1985) "A convenient synthesis of 3-acylindoles via Friedel-Crafts acylation of 1(phenylsulfonyl)indole. A new route to pyridocarbazole-5,11quinones and Ellipticine", Journal of Organic Chemistry 50, 5451-5457.
  • Satoshi, O., Kozo, S., Natsuko, K., Yuki, S., Hirokazu, T., Masashi, H. (1991) "Indole derivatives". European Patent. 458,207.
  • Le Borgne, M., Na, Y.M., Pagniez, F., Abdala, H., Le Baut, G., Le Pape, P. (2000) "Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux dérivés de l'indole à titre de principes actifs d'une telle composition". French Patent 62937 L.
  • Berman, J.D. and Wyler, D. (1980) "An in vitro model for investigation of chemotherapeutic agents in leishmaniasis", Journal of Infectious Diseases 142, 83-86.
  • Katiyar, J.C., Anuradha and Sharma, S. (1992) "Kala-Azar: current status of experimental chemotherapy", Medicinal Research Reviews 12, 473-504.
  • Abdala, H., Robert, J-M., Le Pape, P., Wielgosz, G., RobertPiessard, S. and Le Baut, G. (2000) "Synthesis and antileishmanial activity of new 1-(pyridin-2-yl)imidazolidin2-ones derived from 2-amino-4,6-dimethylpyridine", Arzneimittel-Forschung/Drug Research 50(1), 479-484.

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