Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 6
Submit an article Journal homepage
244
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Rho-kinase Inhibitors: Pharmacomodulations on the Lead Compound Y-32885

Cédric Logé Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
,
Valérie Wallez Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
,
Elizabeth Scalbert Institut de Recherches Internationales Servier, 6 place des Pléiades, 92415 Courbevoie Cedex, France
,
Christelle Cario-Tourmaniantz INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
,
Gervaise Loirand INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
,
Pierre Pacaud INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
&
Daniel Lesieur Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
 show all
Pages 381-390 | Published online: 30 Sep 2008

  • Kamm, K.E. and Stull, J.T. (1985) "The function of myosin and myosin light chain kinase phosphorylation in smooth muscle", Annual Review of Pharmacology and Toxicology 25, 593-603.
  • Sellers, J.R. and Adelstein, R.S. (1987) In: Boyer, P. and Erevs, E.G., eds, The Enzymes (Academic Press, San Diego), pp. 381-418.
  • Hartshorne, D.J. (1987) In: Johnson, D.R., ed, Physiology of the Gastrointestinal Tract (Raven Press, New York), pp. 423-482.
  • Giuliano, K.A. and Taylor, D.L. (1995) "Measurement and manipulation of cytoskeletal dynamics in living cells", Current Opinion in Cell Biology 7, 4-12.
  • Somlyo, A.P. and Somlyo, A.V. (1994) "Signal transduction and regulation in smooth muscle", Nature 372, 231-236.
  • Hirata, K.I., Kibuchi, A., Sasaki, T., Kuroda, S., Kaibuchi, K., Matsuura, Y., Seki, H., Saida, K. and Takai, Y (1992) "Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction", Journal of Biological Chemistry 267, 8719-8722.
  • Gong, M.C. (1996) "Role of guanine nucleotide-binding proteins ras-family or trimeric proteins or both in Ca2+ sensitization of smooth muscle", Proceedings of the National Academy of Sciences of the United States of America 93, 1340-1345.
  • Noda, M., Yasuda-Fukazawa, C., Moriishi, K., Kato, T., Okuda, T., Kurokawa, K. and Takuwa, Y. (1995) "Involvement of rho in GTP-?S-induced enhancement of phosphorylation of 20kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity", FEBS Letters 367, 246-250.
  • Nobes, C.D. and Hall, A. (1994) "Regulation and function of the Rho subfamily of small GTPases", Current Opinion in Genetics and Development 4, 77-81.
  • Seasholtz, T.M (1999) "Rho as a mediator of G proteincoupled receptor signaling", Molecular Pharmacology 55, 949-956.
  • Van Aelst, L. and D'souza-Schorey, C. (1997) "Rho GTPases and signaling networks", Gene and Development 11, 2295-2322.
  • Kaibuchi, K. (1999) "Regulation of the cytosqueleton and cell adhesion by the Rho family GTPases in mammalians cells", Annual Review of Biochemistry 68, 459-486.
  • Hall, A. (1998) "Rho GTPase and the actin cytoskeleton", Science 279, 509-514.
  • Leung, T. (1995) "A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes", Journal of Biological Chemistry 270, 29051-29054.
  • Nakagawa, O., Fujisawa, K., Ishisaki, T., Saito, Y., Nakao, K. and Narumiya, S. (1996) "ROCK-1 and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonin kinase in mice", FEBS Letters 392, 189-193.
  • Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., ItO, M., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K. (1996) "Rho-associated kinase, a novel serine/thréonine kinase, as a putative target for the small GTP binding protein Rho", EMBO Journal 15, 2208-2216.
  • Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N. and Narumiya, S. (1996) "The small GTPbinding protein rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase", EMBO Journal 15, 1885-1893.
  • Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, K. and Kaibuchi, K. (1996) "Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)", Journal of Biological Chemistry 271, 20246-20249.
  • Kimura, K., Ito, M., Mutsuki, A., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K. (1996) "Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rhokinase)", Science 273, 245-248.
  • Leung, T., Chen, X.Q., Manser, E. and Lim, L. (1996) "The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton", Molecular and Cell Biology 16, 5313-5327.
  • Amano, M., Fukata, Y., Nakamura, N., Matsuura, Y. and Kaibuchi, K. (1997) "Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase", Science 275,1308-1311.
  • Ishizaki, T., Naito, M., Fujisawa, K., Maekawa, M and Watanabe, N. (1997) "p160 ROCK, a Rho-associated coiled coil forming protein kinase, works dowstream of Rho and induces focal adhesions", FEBS Letters 404,118-124.
  • Kureishi, Y., Kobayashi, S., Amano, M., Kimura, K. and Kanaide, H. (1997) "Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation", Journal of Biological Chemistry 272, 12257-12260.
  • Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M. and Narumiya, S. (1997) "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension", Nature 389,990-993.
  • Amano, M., Chihara, K. and Kaibuchi, K. (2000) "Regulation and functions of Rho-associated kinase", Experimental Cell Research 261, 44-51.
  • Loirand, G., Cario-Toumaniantz, C., Chardin, P. and Pacaud, P. (1999) "The rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle", Journal of PhysiologyLondon 516,825-834.
  • Guibert, C., Pacaud, P., Loirand, G., Marthan, R. and Savineau, J.P. (1996) "Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes", American Journal of Physiology 271, L450-L458.
  • Knowles, G.C. and McCulloch, C.A.G. (1992) "Simultaneous localization and quantification of relative G and F actin content: optimization of fluorescence labeling methods", Journal of Histochemistry and Cytochemistry 40, 1605-1612.
  • Muro, T. and Seki, T. (1990) "Trans-4-amino(alkyl)-1-pyridylcarbamoyl cydohexane compounds and pharmaceutical use thereof", European Patent Application, EP 0 370 498 A2.
  • Isoda, S. and Hirata, M. (1979) "Medicinal chemical studies on antiplasmin drugs. 4-aminomethylcyclohexanecarboxylic acid and its derivates having a methyl group", Chemical and Pharmaceutical Bulletin 27, 2735-2742.
  • Feng, A.S., Speer, D.V., Dimagnos, S.G., Konings, M.S. and Streitwieser, A. (1992) "The structure and reactivity of 1,2,3,3 Tetrakis(4-(dimethylamino)pyridinium-1-yl) cyclopropene", Journal of the Organic Chemistry 57, 2902-2909.
  • ElAmin, B., Anantharamaiah, G., Royer, G. and Means, G. (1979) "Removal of benzyl-type protecting groups from peptides by catalytic transfer hydrogenation with acid formic", Journal of the Organic Chemistry 44, 3442-3444
  • Borch, R.F. (1971) "The cyanohydridoborate anion as a selective reducing agent", Journal of the American Chemical Society 93, 2897.
  • Kelley, J.L. (1990) "Benzodiazepine receptor binding activity of 9-(1-phenylethyl) purines", Journal of Medicinal Chemistry 33, 1910-1914
  • Fields, E. (1949) "Benzamide derivatives", Journal of the American Chemical Society 71, 1495.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.