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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
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Research Paper

Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice

Xiaowei WeiEndocrinology Department, First Hospital, Peking University, Beijing, ChinaView further author information
,
Nan GuEndocrinology Department, First Hospital, Peking University, Beijing, ChinaORCID Iconhttp://orcid.org/0000-0001-9852-0060View further author information
ORCID Icon,
Nan FengEndocrinology Department, First Hospital, Peking University, Beijing, ChinaView further author information
,
Xiaohui GuoEndocrinology Department, First Hospital, Peking University, Beijing, ChinaView further author information
&
Xiaowei MaEndocrinology Department, First Hospital, Peking University, Beijing, ChinaCorrespondence[email protected]
View further author information
Pages 1494-1500 | Received 10 Apr 2018, Accepted 11 May 2018, Published online: 04 Oct 2018

References

  • Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science 2005;307:380–4.
  • Kahn SE. Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001;86:4047–58.
  • Donath MY, Ehses JA, Maedler K, et al. Mechanisms of beta-cell death in type 2 diabetes. Diabetes 2005;54 (Suppl 2):S108–S13.
  • Lomas DA, Lipson DA, Miller BE, et al. An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease. J Clin Pharmacol 2012;52:416–24.
  • Elkhawad M, Rudd JH, Sarov-Blat L, et al. Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imag 2012;5:911–22.
  • Cheriyan J, Webb AJ, Sarov-Blat L, et al. Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia. Circulation 2011;123:515–23.
  • Schindler JF, Monahan JB, Smith WG. p38 pathway kinases as anti-inflammatory drug targets. J Dental Res 2007; 86:800–11.
  • Song H, Wohltmann M, Tan M, et al. Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling. J Biol Chem 2012;287:5528–41.
  • Larsen CM, Wadt KA, Juhl LF, et al. Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem 1998;273:15294–300.
  • Saldeen J, Lee JC, Welsh N. Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem Pharmacol 2001;61:1561–9.
  • Yamaguchi K, Takeda K, Kadowaki H, et al. Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ss cell exhaustion. Biochimica Et Biophysica Acta 2013;1830:3656–63.
  • Feng N, Ma X, Zhang J, et al. The efects of p38βMAPK gene polymorphysm on its mRNA and protein levels in a Han population in Beijing. Chin J Diabetes 2013;21:106–8.
  • Suzuki T, Sasano H, Tamura M, et al. Temporal and spatial localization of steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and immunohistochemical study. Mol Cell Endocrinol 1993;97:135–43.
  • Dinarello CA. Anti-inflammatory agents: present and future. Cell 2010;140:935–50.
  • Maedler K, Sergeev P, Ris F, et al. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002;110(9):851–60
  • Thandavarayan RA, Watanabe K, Ma M, et al. Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol 2009;297:H911–19.
  • Daulhac L, Mallet C, Courteix C, et al. Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms. Mol Pharmacol 2006;70:1246–54.
  • Jin M, Ma X, Zhang J, et al. p38βMAPK gene polymorphism and prediabetes in a Han population in Beijing. People′s Military Surg 2016;59:354–7.
  • Kawasaki S, Motoshima H, Hanatani S, et al. Regulation of TNFα converting enzyme activity in visceral adipose tissue of obese mice. Biochem Biophys Res Commun 2013;430:1189–94.
  • Kim SH, Hwang JT, Park HS, et al. Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway. Biochem Biophys Res Commun 2013;439:66–70.

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