Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis

References

• Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004;4:437–47.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
   PubMed Web of Science ®Google Scholar
• Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 2014;14:430–9.
   PubMed Web of Science ®Google Scholar
• Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999;59:5830–5.
   PubMed Web of Science ®Google Scholar
• Pastoreková S, Závadová Z, Kostál M, et al. A novel quasi-viral agent, MaTu, is a two-component system. Virology 1992;187:620–6.
   PubMed Web of Science ®Google Scholar
• Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000;60:7075–83.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008;7:168–81.
   PubMed Web of Science ®Google Scholar
• Eckert AW, Kappler M, Schubert J, Taubert H. Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients. Oral Maxillofac Surg 2012;16:189–96.
   PubMedGoogle Scholar
• Pérez-Sayáns M, Supuran CT, Pastorekova S, et al. The role of carbonic anhydrase IX in hypoxia control in OSCC. J Oral Pathol Med 2013;42:1–8.
   PubMed Web of Science ®Google Scholar
• Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45:309–16.
   PubMed Web of Science ®Google Scholar
• Lydiatt WM, Patel SG, O'Sullivan B, et al. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67:122–37.
   PubMed Web of Science ®Google Scholar
• Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer 2011;11:9–22.
   PubMed Web of Science ®Google Scholar
• Yap T, Celentano A, Seers C, et al. Molecular diagnostics in oral cancer and oral potentially malignant disorders-A clinician’s guide. J Oral Pathol Med 2020;49:1–8.
   PubMed Web of Science ®Google Scholar
• Zhu S, Schuerch C, Hunt J. Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. Arch Pathol Lab Med 2015;139:55–66.
   PubMed Web of Science ®Google Scholar
• Rivera C, Oliveira AK, Costa RAP, et al. Prognostic biomarkers in oral squamous cell carcinoma: a systematic review. Oral Oncol 2017;72:38–47.
   PubMed Web of Science ®Google Scholar
• Zhang X, Kim KY, Zheng Z, et al. Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers. Oral Oncol 2017;72:132–9.
   PubMed Web of Science ®Google Scholar
• Pérez-Sayáns M, Suárez-Peñaranda JM, Torres-López M, et al. The use of CA-IX as a diagnostic method for oral leukoplakia. Biotech Histochem 2015;90:124–31.
   PubMed Web of Science ®Google Scholar
• Zhang X, Han S, Han HY, et al. Risk prediction for malignant conversion of oral epithelial dysplasia by hypoxia related protein expression. Pathology 2013;45:478–83.
   PubMed Web of Science ®Google Scholar
• Peridis S, Pilgrim G, Athanasopoulos I, Parpounas K. Carbonic anhydrase-9 expression in head and neck cancer: a meta-analysis. Eur Arch Otorhinolaryngol 2011;268:661–70.
   PubMed Web of Science ®Google Scholar
• Wong DT, Todd R, Tsuji T, Donoff RB. Molecular biology of human oral cancer. Crit Rev Oral Biol Med 1996;7:319–28.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700.
   PubMed Web of Science ®Google Scholar
• Troiano G, Caponio VCA, Zhurakivska K, et al. High PD-L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: a meta-analysis of the literature. Cell Prolif 2019;52:e12537.
   PubMed Web of Science ®Google Scholar
• Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform metaanalyses of the published literature for survival endpoints. Stat Med 1998;17:2815–34.
   PubMed Web of Science ®Google Scholar
• Tierney JF, Stewart LA, Ghersi D, et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16.
   PubMed Web of Science ®Google Scholar
• Takkouche B, Khudyakov P, Costa-Bouzas J, Spiegelman D. Confidence intervals for heterogeneity measures in meta-analysis. Am J Epidemiol 2013;178:993–1004.
   PubMed Web of Science ®Google Scholar
• Costa-Bouzas J, Takkouche B, Cadarso-Suárez C, Spiegelman D. HEpiMA: software for the identification of heterogeneity in meta-analysis. Comput Methods Programs Biomed 2001;64:101–7.
   PubMed Web of Science ®Google Scholar
• Sakata K, Someya M, Nagakura H, et al. Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers. Jpn J Clin Oncol 2008;38:402–7.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Shin HJ, Jung KY, Baek SK, et al. Prognostic value of carbonic anhydrase IX and Ki-67 expression in squamous cell carcinoma of the tongue. Jpn J Clin Oncol 2007;37:812–9.
   PubMed Web of Science ®Google Scholar
• Choi SW, Kim JY, Park JY, et al. Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma. Hum Pathol 2008;39:1317–22.
   PubMed Web of Science ®Google Scholar
• Roh JL, Cho KJ, Kwon GY, et al. The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol 2009;45:63–8.
   PubMed Web of Science ®Google Scholar
• Eckert AW, Lautner MH, Schütze A, et al. Co-expression of Hif1alpha and CAIX is associated with poor prognosis in oral squamous cell carcinoma patients. J Oral Pathol Med 2010;39:313–7.
   PubMed Web of Science ®Google Scholar
• Han MW, Lee HJ, Cho KJ, et al. Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer. Head Neck 2012;34:1395–402.
   PubMed Web of Science ®Google Scholar
• Kondo Y, Yoshikawa K, Omura Y, et al. Clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, Ki-67 and p53 expression in oral squamous cell carcinoma. Oncol Rep 2011;25:1227–33.
   PubMed Web of Science ®Google Scholar
• Brockton NT, Klimowicz AC, Bose P, et al. High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma. Oral Oncol 2012;48:615–22.
   PubMed Web of Science ®Google Scholar
• Heo K, Kim YH, Sung HJ, et al. Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients. Oral Oncol 2012;48:500–6.
   PubMed Web of Science ®Google Scholar
• Pérez-Sayáns M, Suárez-Peñaranda JM, Pilar GD, et al. Expression of CA-IX is associated with advanced stage tumors and poor survival in oral squamous cell carcinoma patients. J Oral Pathol Med 2012;41:667–74.
   PubMed Web of Science ®Google Scholar
• Hwa JS, Kwon OJ, Park JJ, Woo SH, et al. The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. Eur Arch Otorhinolaryngol 2015;272:2953–9.
   PubMed Web of Science ®Google Scholar
• Yang JS, Lin CW, Chuang CY, et al. Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma. Tumour Biol 2015;36:9517–24.
   PubMed Web of Science ®Google Scholar
• Vasconcelos MG, Vasconcelos RG, Pereira de Oliveira DH, et al. Distribution of hypoxia-inducible factor-1α and glucose transporter-1 in human tongue cancers. J Oral Maxillofac Surg 2015;73:1753–60.
   PubMed Web of Science ®Google Scholar
• Simões-Sousa S, Granja S, Pinheiro C, et al. Prognostic significance of monocarboxylate transporter expression in oral cavity tumors. Cell Cycle 2016;15:1865–73.
   PubMed Web of Science ®Google Scholar
• Brockton NT, Lohavanichbutr P, Enwere EK, et al. Impact of tumoral carbonic anhydrase IX and Ki-67 expression on survival in oral squamous cell carcinoma patients. Oncol Lett 2017;14:5434–42.
   PubMed Web of Science ®Google Scholar
• Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Secades P, et al. Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation. Oncotarget 2017;8:13730–46.
   PubMedGoogle Scholar
• Peterle GT, Maia LL, Trivilin LO, et al. PAI-1, CAIX, and VEGFA expressions as prognosis markers in oral squamous cell carcinoma. J Oral Pathol Med 2018;47:566–74.
   PubMedGoogle Scholar
• Eckert AW, Horter S, Bethmann D, et al. Investigation of the prognostic role of carbonic anhydrase 9 (CAIX) of the cellular mRNA/protein level or soluble CAIX protein in patients with oral squamous cell carcinoma. Int J Mol Sci 2019;20:375.
   Web of Science ®Google Scholar
• Svastová E, Hulíková A, Rafajová M, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004;577:439–45.
   PubMed Web of Science ®Google Scholar
• Inci Gul H, Yamali C, Tugce Yasa A, et al. Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol. J Enzyme Inhib Med Chem 2016;31:1375–80.
   PubMed Web of Science ®Google Scholar
• Yamali C, Gul HI, Sakagami H, Supuran CT. Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases. J Enzyme Inhib Med Chem 2016;31(Supp 4):125–31.
   Web of Science ®Google Scholar
• Supuran CT. Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors. Expert Opin Investig Drugs 2018;27:963–70.
   PubMed Web of Science ®Google Scholar
• Yamali C, Gul HI, Ece A, et al. Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors. Bioorg Chem 2019;92:103222.
   PubMed Web of Science ®Google Scholar