747
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells

ORCID Icon & ORCID Icon
Article: 2247181 | Received 23 Mar 2023, Accepted 07 Aug 2023, Published online: 17 Aug 2023

References

  • Massari NA, Nicoud MB, Medina VA. Histamine receptors and cancer pharmacology: an update. Br J Pharmacol. 2020;177(3):516–538.
  • Sarasola M. d l P, Táquez Delgado MA, Nicoud MB, Medina VA. Histamine in cancer immunology and immunotherapy. Current status and new perspectives. Pharmacol Res Perspect. 2021;9(5):e00778.
  • Stoyanov E, Uddin M, Mankuta D, Dubinett SM, Levi-Schaffer F. Mast cells and histamine enhance the proliferation of non-small cell lung cancer cells. Lung Cancer. 2012;75(1):38–44.
  • Della Rovere F, Granata A, Familiari D, Zirilli A, Cimino F, Tomaino A. Histamine and selenium in lung cancer. Anticancer Res. 2006;26(4B):2937–2942.
  • Clauzure M, Taquez Delgado MA, Phillip JM, et al. Histamine H4 receptor agonism induces antitumor effects in human T-cell lymphoma. Int J Mol Sci. 2022;23(3):1378.
  • Kim HJ, Lee PCW, Hong JH. Lamin-A/C is modulated by the involvement of histamine-mediated calcium/calmodulin-dependent kinase II in lung cancer cells. Int J Mol Sci. 2022;23(16):9075.
  • Singh S, Lomelino CL, Mboge MY, et al. Cancer drug development of carbonic anhydrase inhibitors beyond the active site. Molecules. 2018;23(5):1045.
  • Hsieh M-J, Chen K-S, Chiou H-L, Hsieh Y-S. Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway. Eur J Cell Biol. 2010;89(8):598–606.
  • Williams KJ, Gieling RG. Preclinical evaluation of ureidosulfamate carbonic anhydrase IX/XII inhibitors in the treatment of cancers. Int J Mol Sci. 2019;20(23):6080.
  • Daunys S, Petrikaitė V. The roles of carbonic anhydrases IX and XII in cancer cell adhesion, migration, invasion and metastasis. Biol Cell. 2020;112(12):383–397.
  • Guerrini G, Criscuoli M, Filippi I, Naldini A, Carraro F. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018;233(12):9799–9811.
  • Hwang S, Shin DM, Hong JH. Drug repurposing as an antitumor agent: disulfiram-mediated carbonic anhydrase 12 and anion exchanger 2 modulation to inhibit cancer cell migration. Molecules. 2019;24(18):3409.
  • He Q, Chen H, Wong CHY, Tsang LL, Chan HC. Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: role of estrogen. Reproduction. 2010;140(6):903–910.
  • Hong JH, Muhammad E, Zheng C, Hershkovitz E, Alkrinawi S, Loewenthal N, Parvari R, Muallem S. Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation. J Physiol. 2015;593(24):5299–5312.
  • Kong SC, Giannuzzo A, Novak I, Pedersen SF. Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential. Biochem Cell Biol. 2014;92(6):449–459.
  • Parks SK, Pouyssegur J. The Na+/HCO3- co-transporter SLC4A4 plays a role in growth and migration of colon and breast cancer cells. J Cell Physiol. 2015;230(8):1954–1963.
  • Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E. Disrupting Na+, HCO3–cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. Oncogene. 2016;35(16):2112–2122.
  • Lee S, Mele M, Vahl P, Christiansen PM, Jensen VED, Boedtkjer E. Na+,HCO3 (-)-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane. Pflugers Arch. 2015;467(2):367–377.
  • Song L-J, Liu R-J, Zeng Z, Alper SL, Cui H-J, Lu Y, Zheng L, Yan Z-W, Fu G-H. Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. J Mol Med (Berl)). 2012;90(6):707–718.
  • Ji M, Kim HJ, Ahn CB, Son KH, Hong JH. Cellular channelopathy mediated by hypergravity: IL-6-mediated Nkcc1 activation and enhanced Trpm2 expression in rat atrium. Cell Tissue Res. 2021;383(3):1017–1024.
  • Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T. Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Sci Rep. 2021;11(1):1492.
  • Waheed A, Sly WS. Carbonic anhydrase XII functions in health and disease. Gene. 2017;623:33–40.
  • Hwang S, Shin DM, Hong JH. Protective role of IRBIT on sodium bicarbonate cotransporter-n1 for migratory cancer cells. Pharmaceutics. 2020;12(9):816.
  • Lee D, Hong JH. The fundamental role of bicarbonate transporters and associated carbonic anhydrase enzymes in maintaining ion and ph homeostasis in non-secretory organs. Int J Mol Sci. 2020;21(1):339.
  • Cingolani HE, Ennis IL. Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007;115(9):1090–1100.
  • Jeong YS, Hong JH. Governing effect of regulatory proteins for Cl-/HCO3- exchanger 2 activity. Channels (Austin)). 2016;10(3):214–224.
  • Hwang S, Shin DM, Hong JH. Intracellular Ca2+-mediated AE2 is involved in the vectorial movement of HaCaT keratinocyte. Int J Mol Sci. 2020;21(22):8429.
  • Clyne CD, Nguyen A, Rainey WE. The effects of KN62, a Ca2+/calmodulin-dependent protein kinase II inhibitor, on adrenocortical cell aldosterone production. Endocr Res. 1995;-May21(1-2):259–265.
  • Stenbeck G, Horton MA. Endocytic trafficking in actively resorbing osteoclasts. J Cell Sci. 2004;117(Pt 6):827–836.
  • Okiyoneda T, Niibori A, Harada K, Kohno T, Hashimoto Y, Kusuhara H, Takada T, Shuto T, Suico MA, Sugiyama Y, et al. Bafilomycin Al-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator. Biochim Biophys Acta. 2006;1763(10):1017–1023.
  • Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, et al. Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma. Oncotarget. 2018;9(40):25993–26006.
  • Wang H, An JX, Jin H, et al. Roles of Cl-/HCO3- anion exchanger 2 in the physiology and pathophysiology of the digestive system (Review). Mol Med Rep. 2021;24(1):491.
  • Park Y, Jeong J, Seong S, et al. In silico evaluation of natural compounds for an acidic extracellular environment in human breast cancer. Cells. 2021;10(10):2673.
  • Logozzi M, Spugnini E, Mizzoni D, Di Raimo R, Fais S. Extracellular acidity and increased exosome release as key phenotypes of malignant tumors. Cancer Metastasis Rev. 2019;38(1-2):93–101.
  • Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, et al. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet. 2009;41(5):585–590.
  • McDonald PC, Swayampakula M, Dedhar S. Coordinated regulation of metabolic transporters and migration/invasion by carbonic anhydrase IX. Metabolites. 2018;8(1):20.
  • Schwab A, Fabian A, Hanley PJ, Stock C. Role of ion channels and transporters in cell migration. Physiol Rev. 2012;92(4):1865–1913.
  • Hwang S, Lee PC-W, Shin DM, Hong JH. Modulated start-up mode of cancer cell migration through spinophilin-tubular networks. Front Cell Dev Biol. 2021;9:652791.
  • Cai W-K, Hu J, Li T, Meng J-R, Ma X, Yin S-J, Zhao C-H, He G-H, Xu G-L. Activation of histamine H4 receptors decreases epithelial-to-mesenchymal transition progress by inhibiting transforming growth factor-beta1 signalling pathway in non-small cell lung cancer. Eur J Cancer. 2014;50(6):1195–1206.
  • Nicoud MB, Formoso K, Medina VA. Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications. Front Pharmacol. 2019;10:556.
  • Saada M-C, Montero J-L, Vullo D, Scozzafava A, Winum J-Y, Supuran CT. Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms. J Med Chem. 2011;54(5):1170–1177.
  • Provensi G, Nocentini A, Passani MB, Blandina P, Supuran CT. Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives. J Enzyme Inhib Med Chem. 2021;36(1):719–726.