Defending against smallpox: a focus on vaccines

References

• Wiser I, Balicer RD, Cohen D. An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies. Vaccine. 2007;25(6):976–984.
   PubMed Web of Science ®Google Scholar
• Paran N, Sutter G. Smallpox vaccines: new formulations and revised strategies for vaccination. Hum Vaccin. 2009;5(12):824–831.
   PubMed Web of Science ®Google Scholar
• Walsh SR, Dolin R. Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors. Exp Rev Vaccines. 2011;10(8):1221–1240.
   PubMed Web of Science ®Google Scholar
• Verardi PH, Titong A, Hagen CJ. A vaccinia virus renaissance: new vaccine and immunotherapeutic uses after smallpox eradication. Hum Vaccin Immunother. 2012;8(7):961–970.
   PubMed Web of Science ®Google Scholar
• Kennedy RB, Ovsyannikova I, Poland GA. Smallpox vaccines for biodefense. Vaccine. 2009;27 Suppl 4:D73–D79.
   PubMed Web of Science ®Google Scholar
• Kennedy RB, Ovsyannikova IG, Jacobson RM, et al. The immunology of smallpox vaccines. Curr Opin Immunol. 2009;21(3):314–320.
   PubMed Web of Science ®Google Scholar
• Cohen J. BIOTERRORISM: smallpox vaccinations: how much protection remains? Science. 2001;294(5544):985.
   PubMed Web of Science ®Google Scholar
• Parrino J, Graham BS. Smallpox vaccines: past, present, and future. J Allergy Clin Immunol. 2006;118(6):1320–1326.
   PubMed Web of Science ®Google Scholar
• Fenner F, Henderson DA, Arita I, et al. Smallpox and its eradication. Switzerland: World Health Organization; 1988.
   Google Scholar
• Henderson DA. The eradication of smallpox–an overview of the past, present, and future. Vaccine. 2011;29 Suppl 4:D7–D9.
   PubMed Web of Science ®Google Scholar
• Bazin H, Jenner E. The eradication of smallpox: Edward Jenner and the first and only eradication of a human infectious disease. San Diego (CA): Academic Press; 2000.
   Google Scholar
• Dixon MF. Smallpox vaccination. Br Med J. 1970;2(5708):539.
   PubMed Web of Science ®Google Scholar
• Hopkins DR. The greatest killer: smallpox in history. Chicago: University of Chicago Press; 2002.
   Google Scholar
• Li Y, Carroll DS, Gardner SN, et al. On the origin of smallpox: correlating variola phylogenics with historical smallpox records. Proc Natl Acad Sci U S A. 2007;104(40):15787–15792.
   PubMed Web of Science ®Google Scholar
• Shchelkunov SN. Emergence and reemergence of smallpox: the need for development of a new generation smallpox vaccine. Vaccine. 2011;29 Suppl 4:D49–D53.
   PubMed Web of Science ®Google Scholar
• Shchelkunov SN. How long ago did smallpox virus emerge? Arch Virol. 2009;154(12):1865–1871.
   PubMed Web of Science ®Google Scholar
• Kennedy RB, Lane JM, Henderson DA, et al. Smallpox and vaccinia. In: Plotkin SA, Orenstein WA, Offit PA, editors. Vaccines. New York (NY): Elsevier; 2013. p. 718–745.
   Google Scholar
• Milton DK. What was the primary mode of smallpox transmission? Implications for biodefense. Front Cell Infect Microbiol. 2012;2:150.
   PubMed Web of Science ®Google Scholar
• Miller G. Letters of Edward Jenner and other documents concerning the early history of vaccination. Baltimore (MD): Johns Hopkins University Press; 1983.
   Google Scholar
• Jenner E, Miller G. Letters of Edward Jenner, and other documents concerning the early history of vaccination. Baltimore: Johns Hopkins University Press; 1983.
   Google Scholar
• Crookshank EM. History and pathology of vaccination. Philadelphia: P. Blackiston; 1889.
   Google Scholar
• Shchelkunov SN. An increasing danger of zoonotic orthopoxvirus infections. Plos Path. 2013;9(12):e1003756.
   PubMed Web of Science ®Google Scholar
• Tulman ER, Delhon G, Afonso CL, et al. Genome of horsepox virus. J Virol. 2006;80(18):9244–9258.
   PubMed Web of Science ®Google Scholar
• Collier LH. The development of a stable smallpox vaccine. J Hyg (Lond). 1955;53(1):76–101.
   PubMedGoogle Scholar
• Pattanayak S, Arora DD, Sehgal CL, et al. Comparative studies of smallpox vaccination by the bifurcated needle and rotary lancet techniques. Bull World Health Org. 1970;42(2):305–310.
   PubMed Web of Science ®Google Scholar
• Lane JM, Poland GA. Why not destroy the remaining smallpox virus stocks? Vaccine. 2011;29:2823–2824.
   PubMed Web of Science ®Google Scholar
• Arita I. Discovery of forgotten variola specimens at the National Institutes of Health in the USA. Exp Rev Anti Infect Ther. 2014;12(12):1419–1421.
   PubMed Web of Science ®Google Scholar
• Alibek KHS. Biohazard. New York (NY): Random House; 1999.
   Google Scholar
• Wolff HL, Croon JJAB. The survival of smallpox virus (variola minor) in natural circumstances. Bull World Health Org. 1968;8:492–493.
   Google Scholar
• Reardon S. Infectious diseases: smallpox watch. Nature. 2014;509(7498):22–24.
   PubMed Web of Science ®Google Scholar
• Biagini P, Theves C, Balaresque P, et al. Variola virus in a 300-year-old Siberian mummy. N Engl J Med. 2012;367(21):2057–2059.
   PubMed Web of Science ®Google Scholar
• Shchelkunov SN, Resenchuk SM, Totmenin AV, et al. Comparison of the genetic maps of variola and vaccinia viruses. Febs Letters. 1993;327(3):321–324.
   PubMed Web of Science ®Google Scholar
• Massung RF, Liu LI, Qi J, et al. Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975. Virology. 1994;201(2):215–240.
   PubMed Web of Science ®Google Scholar
• Di Giulio DB, Eckburg PB. Human monkeypox: an emerging zoonosis. Lancet Infect Dis. 2004;4(1):15–25.
   PubMed Web of Science ®Google Scholar
• Essbauer S, Pfeffer M, Meyer H. Zoonotic poxviruses. Vet Microbiol. 2010;140(3–4):229–236.
   PubMed Web of Science ®Google Scholar
• Parker S, Nuara A, Buller RM, et al. Human monkeypox: an emerging zoonotic disease. Future Microbiol. 2007;2(1):17–34.
   PubMed Web of Science ®Google Scholar
• Hutin YJ, Williams RJ, Malfait P, et al. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg Infect Dis. 2001;7(3):434–438.
   PubMed Web of Science ®Google Scholar
• McCollum AM, Nakazawa Y, Ndongala GM, et al. Human monkeypox in the Kivus, a conflict region of the Democratic Republic of the Congo. Am J Trop Med Hyg. 2015;93(4):718–721.
   PubMed Web of Science ®Google Scholar
• Meyer H, Perrichot M, Stemmler M, et al. Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001. J Clin Microbiol. 2002;40(8):2919–2921.
   PubMed Web of Science ®Google Scholar
• Rimoin AW, Mulembakani PM, Johnston SC, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010;107(37):16262–16267.
   PubMed Web of Science ®Google Scholar
• Gross E. Update on emerging infections: news from the centers for disease control and prevention. Update: multistate outbreak of monkeypox–Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. Ann Emerg Med. 2003;42(5):660–662. discussion 662- 664
   PubMed Web of Science ®Google Scholar
• Croft DR, Sotir MJ, Williams CJ, et al. Occupational risks during a monkeypox outbreak, Wisconsin, 2003. Emerg Infect Dis. 2007;13(8):1150–1157.
   PubMed Web of Science ®Google Scholar
• Huhn GD, Bauer AM, Yorita K, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease. Clin Infect Dis. 2005;41(12):1742–1751.
   PubMed Web of Science ®Google Scholar
• Hammarlund E, Lewis MW, Carter SV, et al. Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med. 2005;11(9):1005–1011.
   PubMed Web of Science ®Google Scholar
• Karem KL, Reynolds M, Hughes C, et al. Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol. 2007;14(10):1318–1327.
   PubMed Web of Science ®Google Scholar
• Bhanuprakash V, Venkatesan G, Balamurugan V, et al. Zoonotic infections of buffalopox in India. Zoonoses Public Health. 2010;57(7–8):e149–e155.
   PubMed Web of Science ®Google Scholar
• Bera BC, Shanmugasundaram K, Barua S, et al. Zoonotic cases of camelpox infection in India. Vet Microbiol. 2011;152(1–2):29–38.
   PubMed Web of Science ®Google Scholar
• Trindade GS, Emerson GL, Carroll DS, et al. Brazilian vaccinia viruses and their origins. Emerg Infect Dis. 2007;13(7):965–972.
   PubMed Web of Science ®Google Scholar
• Osadebe LU, Manthiram K, McCollum AM, et al. Novel poxvirus infection in 2 patients from the United States. Clin Infect Dis. 2015;60(2):195–202.
   PubMed Web of Science ®Google Scholar
• Fulginiti VA, Papier A, Lane JM, et al. Smallpox vaccination: a review, part I. Background, vaccination technique, normal vaccination and revaccination, and expected normal reactions. Clin Infect Dis. 2003;37(2):241–250.
   PubMed Web of Science ®Google Scholar
• Poland GA, Grabenstein JD, Neff JM, The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program. Vaccine. 2005;23:2078–2081.
   PubMed Web of Science ®Google Scholar
• Engler RJ, Nelson MR, Collins LC Jr., et al. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination. PLoS One. 2015;10(3):e0118283.
   PubMed Web of Science ®Google Scholar
• Halsell JS, Riddle JR, Atwood JE, et al. Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel. Jama. 2003;289:3283–3289.
   PubMed Web of Science ®Google Scholar
• Putz MM, Midgley CM, Law M, et al. Quantification of antibody responses against multiple antigens of the two infectious forms of vaccinia virus provides a benchmark for smallpox vaccination. Nat Med. 2006;12(11):1310–1315.
   PubMed Web of Science ®Google Scholar
• Hsieh S-M, Chen S-Y, Sheu G-C, et al. Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. Vaccine. 2006;24(4):510–515.
   PubMed Web of Science ®Google Scholar
• Talbot TR, Stapleton JT, Brady RC, et al. Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial. Jama. 2004;292(10):1205–1212.
   PubMed Web of Science ®Google Scholar
• Kim S-H, Yeo S-G, Jang H-C, et al. Clinical responses to smallpox vaccine in vaccinia-naive and previously vaccinated populations: undiluted and diluted Lancy-Vaxina vaccine in a single-blind, randomized, prospective trial. J Infect Dis. 2005;192(6):1066–1070.
   PubMed Web of Science ®Google Scholar
• Cummings JF, Polhemus ME, Hawkes C, et al. Lack of vaccinia viremia after smallpox vaccination. Clin Infect Dis. 2004;38(3):456–458.
   PubMed Web of Science ®Google Scholar
• Kennedy JS, Frey SE, Yan L, et al. Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination. J Infect Dis. 2004;190(7):1286–1294.
   PubMed Web of Science ®Google Scholar
• Amanna IJ, Slifka MK, Crotty S. Immunity and immunological memory following smallpox vaccination. Immunol Rev. 2006;211:320–337.
   PubMed Web of Science ®Google Scholar
• Amara RR, Nigam P, Sharma S, et al. Long-lived poxvirus immunity, robust CD4 help, and better persistence of CD4 than CD8 T cells. J Virol. 2004;78(8):3811–3816.
   PubMed Web of Science ®Google Scholar
• Hammarlund E, Lewis MW, Hansen SG, et al. Duration of antiviral immunity after smallpox vaccination. Nat Med. 2003;9(9):1131–1137.
   PubMed Web of Science ®Google Scholar
• Crotty S, Felgner P, Davies H, et al. Cutting edge: long-term B cell memory in humans after smallpox vaccination. J Immunol. 2003;171(10):4969–4973.
   PubMed Web of Science ®Google Scholar
• Chaudhri G, Panchanathan V, Bluethmann H, et al. Obligatory requirement for antibody in recovery from a primary poxvirus infection. J Virol. 2006;80(13):6339–6344.
   PubMed Web of Science ®Google Scholar
• Cohen JI, Hohman P, Fulton R, et al. Kinetics of serum cytokines after primary or repeat vaccination with the smallpox vaccine. J Infect Dis. 2010;201(8):1183–1191.
   PubMed Web of Science ®Google Scholar
• Simon WL, Salk HM, Ovsyannikova IG, et al. Cytokine production associated with smallpox vaccine responses. Immunotherapy. 2014;6(10):1097–1112.
   PubMed Web of Science ®Google Scholar
• Ovsyannikova IG, Haralambieva IH, Kennedy RB, et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. Gene. 2012;510(1):59–65.
   PubMed Web of Science ®Google Scholar
• Kennedy RB, Ovsyannikova IG, Pankratz VS, et al. Gender effects on humoral immune responses to smallpox vaccine. Vaccine. 2009;27(25–26):3319–3323.
   PubMed Web of Science ®Google Scholar
• Haralambieva IH, Ovsyannikova IG, Kennedy RB, et al. Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals. Hum Immunol. 2013;74(10):1263–1266.
   PubMed Web of Science ®Google Scholar
• Gordon SN, Cecchinato V, Andresen V, et al. Smallpox vaccine safety is dependent on T cells and not B cells. J Infect Dis. 2011;203(8):1043–1053.
   PubMed Web of Science ®Google Scholar
• Cornberg M, Sheridan BS, Saccoccio FM, et al. Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry. J Virol. 2007;81(2):934–944.
   PubMed Web of Science ®Google Scholar
• Xu R, Johnson AJ, Liggitt D, et al. Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol. 2004;172(10):6265–6271.
   PubMed Web of Science ®Google Scholar
• Lane JM, Ruben FL, Neff JM, et al. Complications of smallpox vaccination, 1968: results of ten statewide surveys. J Infect Dis. 1970;122(4):303–309.
   PubMed Web of Science ®Google Scholar
• Demkowicz WE, Littaua RA, Wang JM, et al. Human cytotoxic T-cell memory: long-lived responses to vaccinia virus. J Virol. 1996;70(4):2627–2631.
   PubMed Web of Science ®Google Scholar
• Moyron-Quiroz JE, McCausland MM, Kageyama R, et al. The smallpox vaccine induces an early neutralizing IgM response. Vaccine. 2009;28(1):140–147.
   PubMed Web of Science ®Google Scholar
• McCarthy K, Downie AW, Bradley WH. The antibody response in man following infection with viruses of the pox group. II. Antibody response following vaccination. J Hyg (Lond). 1958;56(4):466–478.
   PubMedGoogle Scholar
• Viner KM, Isaacs SN. Activity of vaccinia virus-neutralizing antibody in the sera of smallpox vaccinees. Microbes Infect. 2005;7(4):579–583.
   PubMed Web of Science ®Google Scholar
• Benhnia MR, Maybeno M, Blum D, et al. Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine. J Virol. 2013;87(3):1569–1585.
   PubMed Web of Science ®Google Scholar
• Dixon CW. Smallpox in Tripolitania, 1946; an epidemiological and clinical study of 500 cases, including trials of penicillin treatment. J Hyg (Lond). 1948;46(4):351–377.
   PubMedGoogle Scholar
• Mortimer PP. Can postexposure vaccination against smallpox succeed? Clin Infect Dis. 2003;36(5):622–629.
   PubMed Web of Science ®Google Scholar
• Bicknell WJ, James K. Smallpox vaccination after a bioterrorism-based exposure. Clin Infect Dis. 2003;37(3):467.
   PubMed Web of Science ®Google Scholar
• Massoudi MS, Barker L, Schwartz B. Effectiveness of postexposure vaccination for the prevention of smallpox: results of a delphi analysis. J Infect Dis. 2003;188(7):973–976.
   PubMed Web of Science ®Google Scholar
• Feery BJ. Adverse reactions after smallpox vaccination. Med J Aust. 1977;2(6):180–183.
   PubMed Web of Science ®Google Scholar
• Jacobson IG, Smith TC, Smith B, et al. US military service members vaccinated against smallpox in 2003 and 2004 experience a slightly higher risk of hospitalization postvaccination. Vaccine. 2008;26(32):4048–4056.
   PubMed Web of Science ®Google Scholar
• Cono J, Casey CG, Bell DM. Smallpox vaccination and adverse reactions. Guidance for clinicians. Mmwr. 2003;52(RR–4):1–28.
   PubMedGoogle Scholar
• Sejvar J, Boneva R, Lane JM, et al. Severe headaches following smallpox vaccination. Headache. 2005;45(1):87–88.
   PubMed Web of Science ®Google Scholar
• Lane JM, Ruben FL, Abrutyn E, et al. Deaths attributable to smallpox vaccination, 1959 to 1966, and 1968. JAMA. 1970;212:441–444.
   PubMed Web of Science ®Google Scholar
• Neff JM, Levine RH, Lane JM, et al. Complications of smallpox vaccination United States 1963. II. Results obtained by four statewide surveys. Pediatrics. 1967;39(6):916–923.
   PubMed Web of Science ®Google Scholar
• Lane JM, Ruben FL, Neff JM, et al. Complications of smallpox vaccination, 1968. N Engl J Med. 1969;281(22):1201–1208.
   PubMed Web of Science ®Google Scholar
• Neff JM, Lane JM, Pert JH, et al. Complications of smallpox vaccination. I. National survey in the United States, 1963. N Engl J Med. 1967;276(3):125–132.
   PubMed Web of Science ®Google Scholar
• Ratner LH, Lane JM, Vicens CN. Complications of smallpox vaccination: surveillance during an island-wide program in Puerto Rico, 1967-1968. Am J Epidemiol. 1970;91(3):278–285.
   PubMed Web of Science ®Google Scholar
• Fulginiti VA, Papier A, Lane JM, et al. Smallpox vaccination: a review, part II. Adverse events. Clin Infect Dis. 2003;37(2):251–271.
   PubMed Web of Science ®Google Scholar
• Pepose JS, Margolis TP, LaRussa P, et al. Ocular complications of smallpox vaccination. Am J Ophthalmol. 2003;136(2):343–352.
   PubMed Web of Science ®Google Scholar
• Fillmore GL, Ward TP, Bower KS, et al. Ocular complications in the Department of Defense Smallpox Vaccination Program. Ophthalmology. 2004;111(11):2086–2093.
   PubMed Web of Science ®Google Scholar
• Ryan MA, Gumbs GR, Conlin AM, et al. Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine. Birth Defects Res A Clin Mol Teratol. 2008;82(7):533–539.
   PubMed Web of Science ®Google Scholar
• Arness MK, Eckart RE, Love SS, et al. Myopericarditis following smallpox vaccination. Am J Epidemiol. 2004;160(7):642–651.
   PubMed Web of Science ®Google Scholar
• Eckart RE, Shry EA, Atwood JE, et al. Smallpox vaccination and ischemic coronary events in healthy adults. Vaccine. 2007;25(50):8359–8364.
   PubMed Web of Science ®Google Scholar
• Vora S, Damon I, Fulginiti V, et al. Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis. 2008;46(10):1555–1561.
   PubMed Web of Science ®Google Scholar
• Kempe CH, Berge TO, England B. Hyperimmune vaccinal gamma globulin; source, evaluation, and use in prophylaxis and therapy. Pediatrics. 1956;18:177–188.
   PubMed Web of Science ®Google Scholar
• Monath TP, Caldwell JR, Mundt W, et al. ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain)–a second-generation smallpox vaccine for biological defense. Int J Infect Dis. 2004;8 Suppl 2:S31–S44.
   PubMed Web of Science ®Google Scholar
• Greenberg RN, Kennedy JS, Clanton DJ, et al. Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial. Lancet. 2005;365(9457):398–409.
   PubMed Web of Science ®Google Scholar
• Stittelaar KJ, Van AG, Kondova I, et al. Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus. J Virol. 2005;79(12):7845–7851.
   PubMed Web of Science ®Google Scholar
• Kim N-H, Kang YM, Kim G, et al. An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults. Vaccine. 2013;31(45):5239–5242.
   PubMed Web of Science ®Google Scholar
• Greenberg RN, Hurley Y, Dinh DV, et al. A multicenter, open-label, controlled phase ii study to evaluate safety and immunogenicity of MVA smallpox vaccine (IMVAMUNE) in 18-40 year old subjects with diagnosed atopic dermatitis. PLoS One. 2015;10(10):e0138348.
   PubMed Web of Science ®Google Scholar
• Morikawa S, Sakiyama T, Hasegawa H, et al. An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection. J Virol. 2005;79(18):11873–11891.
   PubMed Web of Science ®Google Scholar
• Tartaglia J, Perkus ME, Taylor J, et al. NYVAC: a highly attenuated strain of vaccinia virus. Virology. 1992;188(1):217–232.
   PubMed Web of Science ®Google Scholar
• Coulibaly S, Bruhl P, Mayrhofer J, et al. The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection. Virology. 2005;341(1):91–101.
   PubMed Web of Science ®Google Scholar
• Hooper JW, Ferro AM, Golden JW, et al. Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates. Vaccine. 2009;28(2):494–511.
   PubMed Web of Science ®Google Scholar
• Xiao Y, Aldaz-Carroll L, Ortiz AM, et al. A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost. Vaccine. 2007;25(7):1214–1224.
   PubMed Web of Science ®Google Scholar
• Moise L, Buller RM, Schriewer J, et al. VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone. Vaccine. 2011;29(3):501–511.
   PubMed Web of Science ®Google Scholar
• Frey SE, Newman FK, Kennedy JS, et al. Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adults. Vaccine. 2009;27(10):1637–1644.
   PubMed Web of Science ®Google Scholar
• Nalca A, Zumbrun EE. ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. Drug Des Devel Ther. 2010;4:71–79.
   PubMed Web of Science ®Google Scholar
• Pugh C, Keasey S, Korman L, et al. Human antibody responses to the polyclonal Dryvax vaccine for smallpox prevention can be distinguished from responses to the monoclonal replacement vaccine ACAM2000. Clin Vaccine Immunol. 2014;21(6):877–885.
   PubMed Web of Science ®Google Scholar
• Qin L, Upton C, Hazes B, et al. Genomic analysis of the vaccinia virus strain variants found in Dryvax vaccine. J Virol. 2011;85(24):13049–13060.
   PubMed Web of Science ®Google Scholar
• Jang H-C, Kim CJ, Kim KH, et al. A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers. Vaccine. 2010;28(36):5845–5849.
   PubMed Web of Science ®Google Scholar
• Antoine G, Scheiflinger F, Dorner F, et al. The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses. Virology. 1998;244(2):365–396.
   PubMed Web of Science ®Google Scholar
• Earl PL, Americo JL, Wyatt LS, et al. Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. Nature. 2004;428(6979):182–185.
   PubMed Web of Science ®Google Scholar
• Von Sonnenburg F, Perona P, Darsow U, et al. Safety and immunogenicity of modified vaccinia Ankara as a smallpox vaccine in people with atopic dermatitis. Vaccine. 2014;32(43):5696–5702.
   PubMed Web of Science ®Google Scholar
• Overton ET, Stapleton J, Frank I, et al. Safety and immunogenicity of modified vaccinia Ankara-Bavarian nordic smallpox vaccine in vaccinia-naive and experienced human immunodeficiency virus-infected individuals: an open-label, controlled clinical phase ii trial. Open Forum Infect Dis. 2015;2(2):ofv040.
   PubMed Web of Science ®Google Scholar
• Frey SE, Wald A, Edupuganti S, et al. Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naive subjects. Vaccine. 2015;33(39):5225–5234.
   PubMed Web of Science ®Google Scholar
• Hatch GJ, Graham VA, Bewley KR, et al. Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques. J Virol. 2013;87(14):7805–7815.
   PubMed Web of Science ®Google Scholar
• Morita M, Aoyama Y, Arita M, et al. Comparative studies of several vaccinia virus strains by intrathalamic inoculation into cynomolgus monkeys. Archi Virol. 1977;53(3):97–208.
   Google Scholar
• Yokote H, Shinmura Y, Kanehara T, et al. Vaccinia virus strain LC16m8 defective in the B5R gene keeps strong protection comparable to its parental strain Lister in immunodeficient mice. Vaccine. 2015;33(45):6112–6119.
   PubMed Web of Science ®Google Scholar
• Saijo M, Ami Y, Suzaki Y, et al. LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox. J Virol. 2006;80(11):5179–5188.
   PubMed Web of Science ®Google Scholar
• Nishiyama Y, Fujii T, Kanatani Y, et al. Freeze-dried live attenuated smallpox vaccine prepared in cell culture “LC16-KAKETSUKEN”: post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice. Vaccine. 2015;33(45):6120–6127.
   PubMed Web of Science ®Google Scholar
• Saito T, Fujii T, Kanatani Y, et al. Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8. Jama. 2009;301(10):1025–1033.
   PubMed Web of Science ®Google Scholar
• Kennedy JS, Gurwith M, Dekker CL, et al. Safety and immunogenicity of LC16m8, an attenuated smallpox vaccine in vaccinia-naive adults. J Infect Dis. 2011;204(9):1395–1402.
   PubMed Web of Science ®Google Scholar
• Kidokoro M, Tashiro M, Shida H. Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8. Proc Natl Acad Sci U S A. 2005;102(11):4152–4157.
   PubMed Web of Science ®Google Scholar
• Gomez CE, Najera JL, Krupa M, et al. MVA and NYVAC as vaccines against emergent infectious diseases and cancer. Curr Gene Ther. 2011;11(3):189–217.
   PubMed Web of Science ®Google Scholar
• Guerra S, Najera JL, Gonzalez JM, et al. Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC. J Virol. 2007;81(16):8707–8721.
   PubMed Web of Science ®Google Scholar
• Mooij P, Balla-Jhagjhoorsingh SS, Koopman G, et al. Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates. J Virol. 2008;82(6):2975–2988.
   PubMed Web of Science ®Google Scholar
• Midgley CM, Putz MM, Weber JN, et al. Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax. J Gen Virol. 2008;89(Pt 12):2992–2997.
   PubMed Web of Science ®Google Scholar
• Ober BT, Bruhl P, Schmidt M, et al. Immunogenicity and safety of defective vaccinia virus lister: comparison with modified vaccinia virus Ankara. J Virol. 2002;76(15):7713–7723.
   PubMed Web of Science ®Google Scholar
• Pulford DJ, Gates A, Bridge SH, et al. Differential efficacy of vaccinia virus envelope proteins administered by DNA immunisation in protection of BALB/c mice from a lethal intranasal poxvirus challenge. Vaccine. 2004;22(25–26):3358–3366.
   PubMed Web of Science ®Google Scholar
• Hooper JW, Custer DM, Schmaljohn CS, et al. DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge. Virology. 2000;266(2):329–339.
   PubMed Web of Science ®Google Scholar
• Sakhatskyy P, Wang S, Chou TH, et al. Immunogenicity and protection efficacy of monovalent and polyvalent poxvirus vaccines that include the D8 antigen. Virology. 2006;355(2):164–174.
   PubMed Web of Science ®Google Scholar
• Golden JW, Josleyn M, Mucker EM, et al. Side-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primates. PLoS One. 2012;7(7):e42353.
   PubMed Web of Science ®Google Scholar
• Aldaz-Carroll L, Xiao Y, Whitbeck JC, et al. Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6. J Virol. 2007;81(15):8131–8139.
   PubMed Web of Science ®Google Scholar
• Golden JW, Hooper JW. Heterogeneity in the A33 protein impacts the cross-protective efficacy of a candidate smallpox DNA vaccine. Virology. 2008;377(1):19–29.
   PubMed Web of Science ®Google Scholar
• Sakhatskyy P, Wang S, Zhang C, et al. Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens. Virology. 2008;371(1):98–107.
   PubMed Web of Science ®Google Scholar
• Martinez O, Miranda E, Ramirez M, et al. Immunomodulator-based enhancement of anti smallpox immune responses. PLoS One. 2015;10(4):e0123113.
   Google Scholar
• Fogg C, Lustig S, Whitbeck JC, et al. Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions. J Virol. 2004;78(19):10230–10237.
   PubMed Web of Science ®Google Scholar
• Buchman GW, Cohen ME, Xiao Y, et al. A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. Vaccine. 2010;28(40):6627–6636.
   PubMed Web of Science ®Google Scholar
• Portocarrero C, Markley K, Koprowski H, et al. Immunogenic properties of plant-derived recombinant smallpox vaccine candidate pB5. Vaccine. 2008;26(43):5535–5540.
   PubMed Web of Science ®Google Scholar
• Berhanu A, Wilson RL, Kirkwood-Watts DL, et al. Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge. J Virol. 2008;82(7):3517–3529.
   PubMed Web of Science ®Google Scholar
• Poland GA. Pharmacology, vaccinomics, and the second golden age of vaccinology. Clin Pharmacol Ther. 2007;82(6):623–626.
   PubMed Web of Science ®Google Scholar
• Poland GA, Ovsyannikova IG, Jacobson RM. Adversomics: the emerging field of vaccine adverse event immunogenetics. Pediatr Infect Dis J. 2009;28(5):431–432.
   PubMed Web of Science ®Google Scholar
• Berhanu A, King DS, Mosier S, et al. Impact of ST-246(R) on ACAM2000 smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice. Vaccine. 2010;29(2):289–303.
   PubMed Web of Science ®Google Scholar
• Pittman PR, Garman PM, Kim S-H, et al. Smallpox vaccine, ACAM2000: sites and duration of viral shedding and effect of povidone iodine on scarification site shedding and immune response. Vaccine. 2015;33(26):2990–2996.
   PubMed Web of Science ®Google Scholar
• Hagan T, Nakaya HI, Subramaniam S, et al. Systems vaccinology: Enabling rational vaccine design with systems biological approaches. Vaccine. 2015;33(40):5294–5301.
   PubMed Web of Science ®Google Scholar
• Querec TD, Akondy RS, Lee EK, et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol. 2009;10(1):116–125.
   PubMed Web of Science ®Google Scholar
• Nakaya HI, Wrammert J, Lee EK, et al. Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011;12(8):786–795.
   PubMed Web of Science ®Google Scholar
• Tsang JS, Schwartzberg PL, Kotliarov Y, et al. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 2014;157(2):499–513.
   PubMed Web of Science ®Google Scholar
• Bucasas KL, Franco LM, Shaw CA, et al. Early patterns of gene expression correlate with the humoral immune response to influenza vaccination in humans. J Infect Dis. 2011;203(7):921–929.
   PubMed Web of Science ®Google Scholar
• Nakaya HI, Clutterbuck E, Kazmin D, et al. Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A. 2016;113(7):1853–1858.
   PubMed Web of Science ®Google Scholar
• Poland GA, Ovsyannikova IG, Jacobson RM. Personalized vaccines: the emerging field of vaccinomics. Exp Opin Biol Ther. 2008;8(11):1659–1667.
   PubMed Web of Science ®Google Scholar
• Poland GA, Kennedy RB, McKinney BA, et al. Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century. Semin Immunol. 2013;25(2):89–103.
   PubMed Web of Science ®Google Scholar
• Ovsyannikova IG, Kennedy RB, O’Byrne M, et al. Genome-wide association study of antibody response to smallpox vaccine. Vaccine. 2012;30(28):4182–4189.
   PubMed Web of Science ®Google Scholar
• Kan S, Jia P, Sun L, et al. Generation of an attenuated Tiantan vaccinia virus by deletion of the ribonucleotide reductase large subunit. Arch Virol. 2014;159(9):2223–2231.
   PubMed Web of Science ®Google Scholar
• Kennedy RB, Oberg AL, Ovsyannikova IG, et al. Transcriptomic profiles of high and low antibody responders to smallpox vaccine. Genes Immunity. 2013;14(5):277–285.
   PubMed Web of Science ®Google Scholar
• Johnson KL, Ovsyannikova IG, Mason CJ, et al. Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development. Vaccine. 2009;28(1):38–47.
   PubMed Web of Science ®Google Scholar
• Reif DM, McKinney BA, Motsinger AA, et al. Genetic basis for adverse events after smallpox vaccination. J Infect Dis. 2008;198(1):16–22.
   PubMed Web of Science ®Google Scholar
• Li G, Chen N, Feng Z, et al. Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. Virology J. 2006;3:88.
   PubMed Web of Science ®Google Scholar
• Osborne JD, Da Silva M, Frace AM, et al. Genomic differences of vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. Vaccine. 2007;25(52):8807–8832.
   PubMed Web of Science ®Google Scholar
• Garcel A, Crance J-M, Drillien R, et al. Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses. J Gen Virol. 2007;88(Pt 7):1906–1916.
   PubMed Web of Science ®Google Scholar