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Review

Evaluating the relationship between myocarditis and mRNA vaccination

&
Pages 83-89 | Received 24 Jul 2021, Accepted 02 Nov 2021, Published online: 18 Nov 2021

References

  • Cooper LTJ. Myocarditis. N Engl J Med. 2009;360:1526–1538.
  • Caforio ALP, Marcolongo R, Cheng C-Y, et al. Clinical presentation of myocarditis BT - Myocarditis: pathogenesis, diagnosis and treatment. In: Caforio ALP, editor., Cham: Springer International Publishing; 2020, p. 19–36. https://doi.org/10.1007/978-3-030-35276-9_2.
  • Yamada E, Vannan MA, Moscucci M Acute pericarditis/pericardial effusion BT - Practical cardiology: evaluation and treatment of common cardiovascular disorders. In: Baliga RR, Eagle KA, editors., Cham: Springer International Publishing; 2020, p. 289–295. https://doi.org/10.1007/978-3-030-28328-5_24.
  • Imazio M, Gaita F, LeWinter M. Evaluation and treatment of pericarditis: a systematic review. JAMA. 2015;314:1498–1506.
  • Engler RJM, Nelson MR, Collins LCJ, et al. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination. PLoS One. 2015;10:e0118283.
  • Mei R, Raschi E, Forcesi E, et al. Myocarditis and pericarditis after immunization: gaining insights through the vaccine adverse event reporting system. Int J Cardiol. 2018;273:183–186.
  • Morgan J, Roper MH, Sperling L, et al. Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States. Clinical Infectious Diseases. 2003 January-October ;46(Suppl 3):S242–50. https://doi.org/10.1086/524747
  • Kuntz J, Crane B, Weinmann S, et al. Myocarditis and pericarditis are rare following live viral vaccinations in adults. Vaccine. 2018;36:1524–1527.
  • Mei R, Raschi E, Poluzzi E, et al. Recurrence of pericarditis after influenza vaccination: a case report and review of the literature. BMC Pharmacol Toxicol. 2018;19:20.
  • Cassimatis DC, Atwood JE, Engler RM, et al. Smallpox vaccination and myopericarditis: a clinical review. J Am Coll Cardiol. 2004;43:1503–1510.
  • Keinath K, Church T, Kurth B, et al. Myocarditis secondary to smallpox vaccination. BMJ Case Rep. 2018;2018. DOI:https://doi.org/10.1136/bcr-2017-223523
  • Lin AH, Phan H-AL, Barthel RV, et al. Myopericarditis and pericarditis in the deployed military member: a retrospective series. Mil Med. 2013;178:18–20.
  • Taylor CL, Eckart RE. Chest pain, ST elevation, and positive cardiac enzymes in an austere environment: differentiating smallpox vaccination-mediated myocarditis and acute coronary syndrome in operation iraqi freedom. J Emerg Med. 2012;42:267–270.
  • Halsell JS, Riddle, JR, and Atwood, JE . Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel. JAMA. 2003;289:3283–3289.
  • Abu S, Roguin A, and Hellou E, et al. Myocarditis following COVID-19 mRNA vaccination Vaccine. 2021;39:3790–3793.
  • Gargano JW, Wallace M, Hadler SC, et al. Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients : update from the advisory committee on. MMWR. Morbidity and Mortality Weekly Report. 2021;70:977–982.
  • Ontario Agency for Health Protection and Promotion (Public Health Ontario). Myocarditis and pericarditis following COVID-19 mRNA vaccines. Toronto, Ontario, Canada: Queen's Printer for Ontario 2021.
  • Ontario Agency for Health Protection and Promotion (Public Health Ontario). Weekly summary: adverse events following immunization (AEFIs) for COVID-19 in Ontario: December 13, 2020 to July 3, 2021. Toronto, Ontario, Canada: Queen’s Printer for Ontario 2021 13 Dec.
  • Marshall M, Ferguson ID, and Lewis P, et al. Symptomatic acute myocarditis in seven adolescents following pfizer-bioNTech COVID- 19 vaccination Pediatrics. 2021;148:3 . DOI:https://doi.org/10.1542/peds.2021-052478 e2021052478
  • Center for Disease Control and Prevention. Interim Clinical Considerations for Use of COVID-19. Vaccines currently authorized in the United States 2021. https://www.cdc.gov/vaccines/covid-19/clinical-considerations/covid-19-vaccines-us.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fvaccines%2Fcovid-19%2Finfo-by-product%2Fclinical-considerations.html (cited 2021 Jul 10
  • Park J, Brekke DR, and Bratincsak A. Self-limited myocarditis presenting with chest pain and ST segment elevation in adolescents after vaccination with the BNT162b2 mRNA vaccine Cardiology in the Young . 2021;22–25 Accessed10 November 2021. doi: https://doi.org/10.1017/S1047951121002547
  • Minocha PK, Better D, and Singh RK, et al. Recurrence of acute myocarditis temporally associated with receipt of the mRNA COVID-19 vaccine in an adolescent male. J Pediatr. 2021;238:321–323. doi:https://doi.org/10.1016/j.jpeds.2021.06.035 .
  • Larson RT, Larson KF, and Ammirati E, et al. Myocarditis after BNT162b2 and mRNA-1273 vaccination Circulation . 2021(144)6:506–508 doi:https://doi.org/10.1161/CIRCULATIONAHA.121.055913. Epub 2021 Jun 16. PMID: 34133884; PMCID: PMC8340725. .
  • Public Health Agency of Canada. Canadian COVID-19 vaccination safety report. Ottawa: n.d.
  • Shimabukuro T. COVID-19 Vaccine safety updates 2021.
  • Montgomery J, Ryan M, and Engler R, et al. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military JAMA Cardiology . 2021;6(10): 1202:1206 doi:https://doi.org/10.1001/jamacardio.2021.2833 Retrieved10 November 2021https://doi.org/10.1001/jamacardio.2021.2833 • of interest due to long risk-window period evaluating young adult males, deemed to be the highest risk group for developing myocarditis secondary to mRNA vaccination
  • Shay DK, Shimabukuro TT, and Destefano F. Myocarditis occurring after immunization with mRNA-BASED COVID-19 vaccines JAMA Cardiology 2021;6(10) :1115–1117. doi:https://doi.org/10.1001/jamacardio.2021.2821. Retrieved10 November 2021. .
  • Chen W-H, Guo Y-S, Zhang D-H, et al. Long-Term prognosis of suspected myocarditis and cardiomyopathy associated with viral infection of the myocardial tissue: a meta-analysis of cohort studies. Cardiovasc Ther. 2019;2019:9342792.
  • Sanguineti F, Garot P, Mana M, et al. Cardiovascular magnetic resonance predictors of clinical outcome in patients with suspected acute myocarditis. J Cardiovasc Magn Reson. 2015;17:1–9.
  • Gräni C, Eichhorn C, Bière L, et al. Prognostic value of cardiac magnetic resonance tissue characterization in risk stratifying patients with suspected myocarditis. J Am Coll Cardiol. 2017;70:1964–1976.
  • Gutberlet M, Spors B, Thoma T, et al. Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence. Radiology. 2008;246:401–409.
  • Grün S, Schumm J, Greulich S, et al. Long-term follow-up of biopsy-proven viral myocarditis: predictors of mortality and incomplete recovery. J Am Coll Cardiol. 2012;59:1604–1615.
  • Spieker M, Haberkorn S, Gastl M, et al. Abnormal T2 mapping cardiovascular magnetic resonance correlates with adverse clinical outcome in patients with suspected acute myocarditis. J Cardiovasc Magn Reson. 2017;19:1–9.
  • Caforio ALP, Calabrese F, Angelini A, et al. A prospective study of biopsy-proven myocarditis: prognostic relevance of clinical and aetiopathogenetic features at diagnosis. Eur Heart J. 2007;28:1326–1333.
  • Ammirati E, Cipriani M, Moro C, et al. Clinical presentation and outcome in a contemporary cohort of patients with acute myocarditis: multicenter lombardy registry. Circulation. 2018;138:1088–1099.
  • Pollack A, Kontorovich AR, Fuster V, et al. Viral myocarditis–diagnosis, treatment options, and current controversies. Nat Rev Cardiol. 2015;12:670–680.
  • Shchendrygina A, Nagel E, Puntmann VO, et al. COVID-19myocarditis and prospective heart failure burden. Expert Rev Cardiovasc Ther. 2021;19:5–14.
  • Azevedo RB, Botelho BG. Hollanda JVG de, ferreira LVL, junqueira de andrade LZ, Oei SSML, et al. Covid-19 and the cardiovascular system: a comprehensive review. J Hum Hypertens. 2021;35:4–11.
  • Chung MK, Zidar DA, and Bristow MR, et al. COVID-19 and Cardiovascular Disease: From Bench to Bedside. Circ Res 2021 128 8 :1214–1236 doi:https://doi.org/10.1161/CIRCRESAHA.121.317997. Retrieved10 November 2021.https://doi.org/10.1161/CIRCRESAHA.121.317997.
  • Centers for Disease Control & Prevention (CDC) Update: cardiac and other adverse events following civilian smallpox vaccination–United States. MMWR Morb Mortal Wkly Rep. 2003;52 7 :639–642 Retrieved10 November 2021.
  • Witberg G, Barda N, Hoss S, et al. Myocarditis after Covid-19 vaccination in a large health care organization. N Engl J Med. 2021. DOI:https://doi.org/10.1056/NEJMoa2110737.
  • Barda N, Dagan N, Ben-Shlomo Y, et al. Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting. N Engl J Med. 2021;385:1078–1090.
  • Fine PEM. Herd immunity : history, Theory, practice 1993; 15.
  • Fox JP, Elveback L, Scott W, et al. Herd immunity: basic concept and relevance to public health immunization practices. Am J Epidemiol. 1995;141:187–197.
  • Mevorach D, Anis E, and Cedar N, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N Engl J Med. 2021;1–10. doi:https://doi.org/10.1056/NEJMoa2109730 Retrieved10 November 2021 .
  • Abbate A, Gavin J, Madanchi N, et al. Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients. Int J Cardiol. 2021;340:119–121.
  • Engler RJM, Nelson MR, and Collins LC, et al. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination PLoS One , 2015;10(3):1–18. DOI:https://doi.org/10.1371/journal.pone.0118283 Retrieved10 November 2021
  • Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019;16:69.
  • Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280.e8.
  • Hamming I, Timens W, Bulthuis MLC, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203:631–637.
  • Mendoza-Torres E, Oyarzún A, Mondaca-Ruff D, et al. ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension. Ther Adv Cardiovasc Dis. 2015;9:217–237.
  • Wang J, Li N, Gao F, et al. Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure. Journal of the Renin-Angiotensin-Aldosterone System. 2015;16:553–558.
  • Li S, Wang Z, Yang X, et al. Association between circulating angiotensin-converting enzyme 2 and cardiac remodeling in hypertensive patients. Peptides. 2017;90:63–68.
  • Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828.
  • Zhong J, Basu R, Guo D, et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 2010;122:717–728. 18 p following 728.
  • Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol. 2018;15:586–594.
  • Kurrer MO, Kopf M, Penninger JM, et al. Cytokines that regulate autoimmune myocarditis. Swiss Med Wkly. 2002;132:408–413.
  • Forbester JL, Humphreys IR. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunol. 2021;14:14–25.
  • Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020;383:2255–2273.
  • Ye Q, Wang B, Mao J. The pathogenesis and treatment of the `cytokine storm’ in COVID-19. J Infect. 2020;80:607–613.
  • Kenney AD, Dowdle JA, Bozzacco L, et al. Human genetic determinants of viral diseases. Annu Rev Genet. 2017;51:241–263.
  • Cusick MF, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol. 2012;42:102–111.
  • Ovsyannikova IG, Vierkant RA, Pankratz VS, et al. Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine. J Infect Dis. 2011;203:1546–1555.
  • Caforio ALP, Pankuweit S, Arbustini E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European society of cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2013;34:2636–2648. 2648a-2648d.

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