Adverse events following influenza immunization: understanding the role of age and sex interactions

References

• Canova L, Birchmeier M, D’Acremont V, et al. Prevalence rate and reasons for refusals of influenza vaccine in the elderly [Article]. Swiss Med Wkly. 2003;133(43–44):598–602.
   PubMed Web of Science ®Google Scholar
• Parrella A, Gold M, Marshall H, et al. Parental views on vaccine safety and future vaccinations of children who experienced an adverse event following routine or seasonal influenza vaccination in 2010 [Article]. Hum Vaccines Immunother. 2012;8(5):662–667.
   PubMed Web of Science ®Google Scholar
• Suzuki S, Hosono A. No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women results of the Nagoya study [Article]. Papillomavirus Res. 2018;5:96–103.
   PubMed Web of Science ®Google Scholar
• Díez-Domingo J, Planelles MV, Baldó JM, et al. Ibuprofen prophylaxis for adverse reactions to diphtheria-tetanus- pertussis vaccination: a randomized trial [Article]. Curr Therap Res - Clin Exp. 1998;59(8):579–588.
   Web of Science ®Google Scholar
• Wysocki J, Center KJ, Brzostek J, et al. A randomized study of fever prophylaxis and the immunogenicity of routine pediatric vaccinations. Vaccine. 2017;35(15):1926–1935. 2017/04/04/.
   PubMed Web of Science ®Google Scholar
• Fischinger S, Boudreau CM, Butler AL, et al. Sex differences in vaccine-induced humoral immunity [Review]. Semin Immunopathol. 2019;41(2):239–249.
   PubMed Web of Science ®Google Scholar
• Flanagan KL, Fink AL, Plebanski M, et al., Sex and gender differences in the outcomes of vaccination over the life course. Annu Rev Cell Dev Biol. 33(1): 577–599. 2017.
   PubMed Web of Science ®Google Scholar
• Clothier HJ, Lawrie J, Lewis G, et al. SAEFVIC: surveillance of adverse events following immunisation (AEFI) in Victoria, Australia, 2018 [Article]. Communicable Diseases Intelligence (2018). 2020;44. https://doi.org/10.33321/cdi.2020.44.46
   Google Scholar
• Halsey NA, Griffioen M, Dreskin SC, et al. Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: reports to VAERS [Article]. Vaccine. 2013;31(51):6107–6112.
   PubMed Web of Science ®Google Scholar
• Klein SL, Marriott I, Fish EN. Sex-based differences in immune function and responses to vaccination. Trans R Soc Trop Med Hyg. 2015;109(1):9–15.
   PubMed Web of Science ®Google Scholar
• Tadount F, Doyon-Plourde P, Rafferty E, et al. Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females? – a systematic review [Review]. Vaccine. 2020;38(3):444–459.
   PubMed Web of Science ®Google Scholar
• Drutz J Diphtheria, tetanus, and pertussis immunization in children 6 weeks through 6 years of age. 15 Feb 2021 [cited 2021 May 23]. In: UpToDate: Evidence-based Clinical Decision Support [Internet]. Wolters Kluwer, [cited 23 May 2021]. Available from: https://www.uptodate.com/contents/diphtheria-tetanus-and-pertussis-immunization-in-children-6-weeks-through-6-years-of-age#H26.
   Google Scholar
• Drutz J. Diphtheria, tetanus, and pertussis immunization in children 7 through 18 years of age. 2020 29 Jan [ cited 23 May 2021]. In: UpToDate: Evidence-based Clinical Decision Support [Internet]. Wolters Kluwer, [cited 2021 May 23]. Available from: https://www.uptodate.com/contents/diphtheria-tetanus-and-pertussis-immunization-in-children-7-through-18-years-of-age?topicRef=2844&source=see_link#H117306647.
   Google Scholar
• Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial [Article]. Lancet. 2020;396(10267):1979–1993.
   PubMed Web of Science ®Google Scholar
• Pillsbury AJ, Fathima P, Quinn HE, et al. Comparative Postmarket Safety Profile of Adjuvanted and High-Dose Influenza Vaccines in Individuals 65 Years or Older [Article]. JAMA Network Open. 2020;3(5):e204079.
   PubMed Web of Science ®Google Scholar
• Petousis-Harris H, Poole T, Turner N, et al. Febrile events including convulsions following the administration of four brands of 2010 and 2011 inactivated seasonal influenza vaccine in NZ infants and children: the importance of routine active safety surveillance [Article]. Vaccine. 2012;30(33):4945–4952.
   PubMed Web of Science ®Google Scholar
• Bohn-Goldbaum E, Ross L, Booy R, et al. Vaccination reaction rate is unaltered by ambient temperature on the day. Heliyon. 2020 ;6(11):e05527. 2020/11/01/.
   PubMed Web of Science ®Google Scholar
• Pillsbury A, Quinn H, Cashman P, et al. Active SMS-based influenza vaccine safety surveillance in Australian children [Article]. Vaccine. 2017;35(51):7101–7106.
   PubMed Web of Science ®Google Scholar
• Langlois PH, Smolensky MH, Glezen WP, et al. Diurnal variation in responses to influenza vaccine [Article]. Chronobiol Int. 1995;12(1):28–36.
   PubMed Web of Science ®Google Scholar
• Pollmann L, Pollmann B. Circadian variations of the efficiency of hepatitis B vaccination [Article]. Annual Review of Chronopharmacology. 1988;5:45–48.
   Google Scholar
• Australian Technical Advisory Group on Immunisation. Statement on the administration of seasonal influena vaccines in 2020. In: Department of Health, editor. Commonwealth of Australia; 2020.
   Google Scholar
• Wood SN. Thin-plate regression splines. Journal of the Royal Statistical Society (B). 2003;65(1):95–114
   Google Scholar
• Wickham H. ggplot2: elegant Graphics for Data Analysis. New York: Springer-Verlag; 2016.
   Google Scholar
• Sarkar R, Ajjampur SS, Ward HD, et al. Analysis of human immune responses in quasi-experimental settings: tutorial in biostatistics [Article]. BMC Med Res Methodol. 2012;12:12.
   PubMed Web of Science ®Google Scholar
• Bernard DM, Cooper Robbins SC, McCaffery KJ, et al. The domino effect: adolescent girls’ response to human papillomavirus vaccination [Article]. Med J Aust. 2011;194(6):297–300.
   PubMed Web of Science ®Google Scholar
• Hervé C, Laupèze B, Del Giudice G, et al. The how’s and what’s of vaccine reactogenicity [Review]. NPJ Vaccines. 2019;4(1). DOI:https://doi.org/10.1038/s41541-019-0132-6
   PubMedGoogle Scholar
• Crooke SN, Ovsyannikova IG, Poland GA, et al. Immunosenescence and human vaccine immune responses. Immunity Ageing. 2019;16(1):25. 2019/09/13.
   PubMed Web of Science ®Google Scholar
• Cowling BJ, Thompson MG, Twy N, et al. Comparative reactogenicity of enhanced influenza vaccines in older adults. J Infect Dis. 2020;222(8):1383–1391. Article.
   PubMed Web of Science ®Google Scholar
• Zhuang C-L, Lin Z-J, Bi Z-F, et al. Inflammation-related Adverse Reactions Following Vaccination Potentially Indicate a Stronger Immune Response. Emerg Microbes Infect. 2021;1–41. DOI:https://doi.org/10.1080/22221751.2021.1891002.
   Google Scholar
• Bupp MRG, Potluri T, Fink AL, et al. The confluence of sex hormones and aging on immunity [Review]. Front Immunol. 2018 JUN;9. https://doi.org/10.3389/fimmu.2018.01269
   Google Scholar
• Scepanovic P, Alanio C, Hammer C, et al. Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines [Article]. Genome Med. 2018;10(1). https://doi.org/10.1186/s13073-018-0568-8
   Google Scholar
• de Vries ST, Denig P, Ekhart C, et al. Sex differences in adverse drug reactions reported to the National Pharmacovigilance Centre in the Netherlands: an explorative observational study. Br J Clin Pharmacol. 2019;85(7):1507–1515.
   PubMed Web of Science ®Google Scholar
• Breiman RF, Brooks WA, Goswami D, et al. A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children [Article]. Vaccine. 2009;27(40):5472–5479.
   PubMed Web of Science ®Google Scholar
• Thomas S, Cashman P, Islam F, et al. Tailoring immunisation service delivery in a disadvantaged community in Australia; views of health providers and parents [Article]. Vaccine. 2018;36(19):2596–2603.
   PubMed Web of Science ®Google Scholar
• Leeb A, Carcione D, Richmond PC, et al. Reactogenicity of two 2010 trivalent inactivated influenza vaccine formulations in adults [Article]. Vaccine. 2011;29(45):7920–7924.
   PubMed Web of Science ®Google Scholar
• Stuurman AL, Rizzo C, Haag M. Investigating the procurement system for understanding seasonal influenza vaccine brand availability in Europe. PLOS ONE. 2021;16(4):e0248943.
   PubMed Web of Science ®Google Scholar
• Cunningham M, Dow A. Critical shortage of flu shots hits regional areas. Sydney Morning Herald. 2020 May 28, [cited 2021 Jul 4]. Available from: https://www.smh.com.au/national/critical-shortage-of-flu-shots-hits-regional-areas-20200527-p54wt6.html
   Google Scholar
• Harper A, Flanagan KL. Effect of sex on vaccination outcomes: important but frequently overlooked. Curr Opin Pharmacol. 2018Aug; 41: 122–127 PubMed PMID: 29883854; eng
   PubMed Web of Science ®Google Scholar
• Klein SL, Pekosz A. Sex-based biology and the rational design of influenza vaccination strategies [Article]. J Infect Dis. 2014;209(3):S114–S119.
   PubMedGoogle Scholar
• Engler RJ, Nelson, MR, Klote, MM, et al. Half- vs full-dose trivalent inactivated influenza vaccine (2004–2005): age, dose, and sex effects on immune responses. Arch Internal Med. 2008Dec8;168(22):2405–2414. PubMed PMID: 19064822; eng.
   PubMedGoogle Scholar
• Roy M, Sherrard L, Dubé É, et al. Determinants of non-vaccination against seasonal influenza [Article]. Health Rep. 2018;29(10):12–22.
   PubMed Web of Science ®Google Scholar
• Green MS, Abdullah R, Vered S, et al. A study of ethnic, gender and educational differences in attitudes toward COVID-19 vaccines in Israel – implications for vaccination implementation policies [Article]. Isr J Health Policy Res. 2021;10(1). DOI:https://doi.org/10.1186/s13584-021-00458-w
   Google Scholar
• Fens T, De Boer PT, Van Puijenbroek EP, et al. Inclusion of safety-related issues in economic evaluations for seasonal influenza vaccines: a systematic review [Article]. Vaccines (Basel). 2021;9(2):1–28.
   Web of Science ®Google Scholar
• Frew PM, Paine MB, Rouphael N, et al. Acceptability of an inactivated influenza vaccine delivered by microneedle patch: results from a phase I clinical trial of safety, reactogenicity, and immunogenicity [Article]. Vaccine. 2020;38(45):7175–7181.
   PubMed Web of Science ®Google Scholar
• Rouphael NG, Paine M, Mosley R, et al. The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial. Lancet. 2017 ;390(10095):649–658. 2017/08/12/.
   PubMed Web of Science ®Google Scholar
• Carter C, Houser KV, Yamshchikov GV, et al. Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: an open-label randomized phase 1 clinical trial [Article]. PLoS ONE. 2019;14(9). https://doi.org/10.1371/journal.pone.0222178
   Google Scholar
• GuildLink. Australian product information - Fluquadri influenza virus haemagglutinin: guildLink Pty Ltd; 2020 [cited 2021 Feb 20]. Available from: https://apps.medicines.org.au/files/swpfluqu.pdf
   Google Scholar
• Durovic A, Widmer AF, Dangel M, et al. Low rates of influenza vaccination uptake among healthcare workers: distinguishing barriers between occupational groups [Article]. Am J Infect Control. 2020;48(10):1139–1143.
   PubMed Web of Science ®Google Scholar
• Robinson E, Jones A, Lesser I, et al. International estimates of intended uptake and refusal of COVID-19 vaccines: a rapid systematic review and meta-analysis of large nationally representative samples [Review]. Vaccine. 2021;39(15):2024–2034.
   PubMed Web of Science ®Google Scholar