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Review Article

Cellulite: Is there a role for injectables?

, &
Pages 147-154 | Received 29 Sep 2005, Accepted 17 Oct 2005, Published online: 12 Jul 2009

References

  • Pistor M. What is mesotherapy?. Chir Dent Fr 1976; 46: 59–60
  • Guazzetti R., Iotti E., Marinoni E. Mesotherapy with naproxin sodium in musculoskeletal diseases. Riv Eur Sci Med Farmacol 1988; 10: 539–42
  • Donini I., De Anna D., Carella G., et al. Mesotherapy in the treatment of lymphedema: histologic and ultrastructural observations. Chir Patol Sper 1982; 30: 25–34
  • Gallo R. Mesotherapy in phlebology. Phlebologie 1980; 33: 153–6
  • Medioni G. Orodental mesotherapy. Chir Dent Fr 1976; 46: 97–102
  • Medioni G. Results of 6 years of treatment of painful periodontal episodes by mesotherapy. Chir Dent Fr 1980; 50: 35–7
  • Rotunda A. M., Kolodney M. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg, 2005 (in press)
  • American Society for Aesthetic Plastic Surgery. Cellulite: an update. 11 August 2004. URL: http://www.surgery.org/press/news‐release.php?iid = 212#top
  • Stahl L. Sound of success. 48 Hours. 2 August 2003. URL
  • Gallegos D. Liposuction alternative targets fat cells., Denver Post, 2 August 2004
  • American Society for Aesthetic Plastic Surgery. Liposuction (lipoplasty) without surgery update? 15 July 2004. URL: http://www.cbsnews.com/stories/2003/04/28/48hours/main551361.shtml
  • Leisenring A. Thinjections. 3 November 2003. URL: http://www.elle.com/article.asp?section_id = 36&article_id = 2694&page_number = 1
  • American Society for Aesthetic Plastic Surgery. Fat‐melting fad: too good to be true? 5 November 2004. URL: http://www.surgery.org/press/news‐release.php?iid = 387
  • The Saturday Early Show. Burn fat away with an injection? 30 November 2002. URL: http://www.cbsnews.com/stories/2002/11/27/earlyshow/saturday/main531099.shtml
  • Rotunda A. M., Suzuki H., Moy R. L., Kolodney M. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatol Surg 2004; 30: 1001–8
  • Matarasso A., Pfeifer T. Mesotherapy for body contouring. Plast Reconstr Surg 2005; 115: 1420–4
  • Avram M. Cellulite: a review of its physiology and treatment. J Cosmet Laser Ther 2004; 6: 181–5
  • Draelos Z., Marenus K. Cellulite etiology and purported treatment. Dermatol Surg 1997; 23: 1177–81
  • Nürnberger F., Müller G. So‐called cellulite: an invented disease. J Dermatol Surg Oncol 1978; 4: 221–9
  • Scherwitz C., Braun‐Falco O. So‐called cellulite. J Dermatol Surg Oncol 1978; 4: 230–4
  • Rossi A. B. R., Vergnanini A. Cellulite: a review. J Eur Acad Dermatol Venereol 2000; 14: 251–62
  • Curri S. Cellulite and fatty tissue microcirculation. Cosmetic Toilet 1993; 108: 51–8
  • Curri S. B., Bambardelli E. Local lipodystrophy and districtual micro‐circulation. Cosmetic Toilet 1994; 109: 51–65
  • Lotti T., Ghersetich I., Grappone C., et al. Proteoglycans in so‐called cellulite. Int J Dermotol 1990; 29: 272–4
  • Kligman A. Cellulite: facts and fiction. J Geriatric Dermatol 1997; 5: 136–9
  • Rosenbaum M., Prieto V., Hellmer J., et al. An exploratory investigation of the morphology and biochemistry of cellulite. Plast Reconstr Surg 1998; 101: 1934–9
  • Piérard G. E., Nizet J. L., Piérard‐Franchimont C. Cellulite: from standing fat herniation to hypodermal stretch marks. Am J Dermatopathol 2000; 22: 34–7
  • Querleux B., Cornillon C., Jolivet O., et al. Anatomy and physiology of subcutaneous adipose tissue by in vivo magnetic resonance imaging and spectroscopy: relationships with sex and presence of cellulite. Skin Res Technol 2002; 8: 118–24
  • Lucassen G. W., van der Sluys W. L. N., van Herk J. J., et al. The effectiveness of message treatment on cellulite as monitored by ultrasound imaging. Skin Res Technol 1997; 3: 154–60
  • Prins J. B., O'Rahilly S. Regulation of adipose cell number in man. Clin Sci 1997; 92: 3–11
  • Ramsay T. Fat cells. Endocrinol Metab Clin North Am 1996; 25: 847–70
  • Londos C., Brasaemle D. L., Schultz C. J., et al. On the control of lipolysis in adipocytes. Ann N Y Acad Sci 1999; 892: 155–68
  • Arner P. Control of lipolysis and its relevance to development of obesity in men. Diabetes Metab Rev 1988; 4: 507–15
  • Iwao N., Oshida Y., Sato Y. Regional difference in lipolysis caused by a beta‐adrenergic agonist as determined by the microdialysis technique. Acta Physiol Scand 1997; 161: 481–7
  • Leibel R. L., Ebens N. K., Fried S. Physiologic basis for the control of body fat distribution in humans. Ann Rev Nutr 1989; 9: 417–43
  • Mauriege P., Galitzky J., Berlan M., et al. Heterogeneous distribution of beta‐ and alpha‐2 adrenoreceptor binding sites in human fat cells from various deposits: functional consequences. Eur J Clin Invest 1987; 17: 156–65
  • Coppack S. W., Jensen M. D., Miles J. In vivo regulation of lipolysis in humans. J Lipid Res 1994; 35: 177–93
  • Wajchenberg B. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21: 697–738
  • Lonnqvist F., Krief S., Strosberg A. D., et al. Evidence for a functional beta‐adrenoreceptor in man. Br J Pharmacol 1993; 110: 929–36
  • Østerlund T. Structure–function relationships of hormone‐sensitive lipase. Eur J Biochem 2001; 268: 1899–907
  • Belfrage P., Fredrikson G., Nilsson N. O., et al. Regulation of adipose tissue lipolysis: phosphorylation of hormone‐sensitive lipase in intact rat adipocytes. FEBS Lett 1980; 111: 120–4
  • Holm C., Langin D., Manganiello V. C., et al. Regulation of hormone‐sensitive lipase activity in adipose tissue. Methods Enzymol 1997; 286: 45–67
  • Steinberg D., Huttunen J. The role of cyclic AMP in activation of hormone‐sensitive lipase of adipose tissue. Adv Cyclic Nucleotide Res 1972; 1: 47–62
  • Egan J. J., Greenberg A. S., Chang M. K., et al. Mechanism of hormone‐stimulated lipolysis in adipocytes: translocation of cytosolic hormone‐sensitive lipase to the surfaces of lipid storage droplets. Proc Natl Acad Sci U S A 1992; 89: 8537–41
  • Clifford G. M., Londos C., Kraemer F. B., et al. Translocation of hormone‐sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J Biol Chem 2000; 275: 5011–15
  • Lafontan M., Berlan M., Galitzky J., et al. Alpha‐2 adrenoreceptors in lipolysis: alpha 2 antagonists and lipid mobilizing strategies. Am J Clin Nutr 1992; 55: S219–27
  • Kobilka B. K., Matsui H., Kobilka T. Cloning sequencing and expression of the gene coding for the human platelet alpha‐2 adrenergic receptor. Science 1987; 238: 650
  • Wahrenberg H., Lonnqvist F., Arner P. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J Clin Invest 1989; 84: 458–67
  • Castan I., Valet P., Larrouy D., et al. Distribution of PYY receptors in human fat cells: An antilipolytic system alongside the alpha 2‐adrenergic one. Am J Physiol 1993; 265: E74–80
  • Berlan M., Lafontan M. Evidence that epinephrine acts preferentially as an antilipolytic agent in abdominal human subcutaneous fat cells: Assessment by analysis of beta and alpha 2‐adrenoreceptor properties. Eur J Clin Invest 1985; 15: 341–8
  • Arner P., Hellstrom L., Wahrenberg H., et al. Beta‐adrenoreceptor expression in human fat cells from different regions. J Clin Invest 1990; 86: 1595–600
  • Arner P. Differences in lipolysis between human subcutaneous and omental adipose tissue. Ann Med 1995; 27: 435–8
  • Manganiello V. C., Degerman E., Taira M., et al. Type III cyclic nucleotide phosphodiesterases and insulin action. Curr Top Cell Regul 1996; 34: 63–100
  • Degerman E., Belfrage P., Manganiello V. Structure, localization, and regulation of cGMP‐inhibited phosphodiesterase (PDE3). J Biol Chem 1997; 272: 6823–6
  • Snyder P. B., Esselstyn J. M., Loughney K., et al. The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis. J Lipid Res 2005; 46: 494–503
  • Honnor R. C., Dhillon G. S., Londos C. cAMP‐independent protein kinase and lipolysis in rat adipocytes. II. Definition of steady‐state relationship with lipolytic and antilipolytic modulators. J Biol Chem 1985; 260: 15 130–8
  • Arner P. Adenosine, prostaglandins and phosphodiesterase as targets for obesity pharmacotherapy. Int J Obes Relat Metab Disord 1993; 17: S57–9
  • Ohisalo J. J. Effects of adenosine on lipolysis in human subcutaneous fat cells. J Clin Endocrinol Metab 1981; 52: 359–63
  • LaNoue K. F., Martin L. Abnormal A1 adenosine receptor function in genetic obesity. FASEB J 1994; 8: 72–80
  • Hetzler R. K., Knowlton R. G., Somani S. M., et al. Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans. J Appl Physiol 1990; 68: 44–7
  • Rohrich R. 2005. Mesotherapy: what is it? Does it work? Plast Reconstr Surg. 115. 1425
  • American Society for Dermatologic Surgery. Emerging technology report: mesotherapy. URL: http://www.asds.net/Media/PositionStatements/emerging_technology‐mesotherapy.html
  • Asaadi M., Salas A. P., Motamedi B. Mesoplasty: a new approach to non‐surgical liposculpture. 2004, American Society of Plastic Surgery, Philadelphia, PA, October 9–13
  • Nagore E., Ramos P., Botella‐Estrada R., et al. Cutaneous infection with Mycobacterium fortuitum after localized microinjections (mesotherapy) treated successfully with a triple drug regimen. Acta Derm Venereol 2001; 81: 291–3
  • Cooksey R. C., de Waard J. H., Yakrus M. A., et al. Mycobacterium cosmeticum sp. nov., a novel rapidly growing species isolated from a cosmetic infection and from a nail salon. Int J Syst Evol Microbiol 2004; 54: 2385–91
  • Marco‐Bonnet J., Beylot‐Barry M., Texier‐Maugein J., et al. Mycobacterial bovis BCG cutaneous infections following mesotherapy: 2 cases. Ann Dermatol Venereol 2002; 129: 728–31
  • Rosina P., Chieregato C., Miccolis D., et al. Psoriasis and side‐effects of mesotherapy. Int J Dermotol 2001; 40: 581–3
  • Bessis D., Guilhou J. J., Guillot B. Localized urticaria pigmentosa triggered by mesotherapy. Dermatology 2004; 209: 343–4
  • Lee D. P., Chang S. Subcutaneous nodules showing fat necrosis owing to mesotherapy. Dermatol Surg 2005; 31: 250–1
  • Vaillant L., De Muret A., Muller C., et al. Lichenoid drug eruption after mesotherapy. Ann Dermatol Venereol 1992; 119: 936–7
  • Urbani C. Urticarial reaction to ethylenediamine in aminophylline following mesotherapy. Contact Dermatitis 1994; 31: 198–9
  • Beer K. Mesotherapy: will it prove safe and effective?. Skin Aging 2005; 13: 5
  • Wenkeova J., Kuhn E., Wenke M. Adrenergic lipolysis in human adipose tissue in vitro. Eur J Pharmacol 1975; 30: 49–55
  • Insel P. A., Ostrom R. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol 2003; 23: 305–14
  • Arner P., Hellmer J., Hagstrom‐Toft E., et al. Effect of phosphodiesterase inhibition with amrinone or theophylline on lipolysis and blood flow in human adipose tissue in vivo as measured with microdialysis. J Lipid Res 1993; 34: 1737–43
  • Parsons W. J., Ramkumar V., Stiles G. Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, G1. Mol Pharmacol 1988; 34: 37–41
  • Fredholm B. On the mechanism of action of theophylline and caffeine. Acta Medica Scand 1985; 217: 149–53
  • De Santis R. A., Gorenstein T., Livingston J. N., et al. Role of phosphodiesterase in glucagon resistance of large adipocytes. J Lipid Res 1974; 15: 33–8
  • Butcher R. W., Baird C. E., Sutherland E. Effects of lipolytic and antilipolytic substances on adenosine 3',5'‐monophosphate levels in isolated fate cells. J Biol Chem 1968; 243: 1705–12
  • Bellet S., Roman L., de Castro O., et al. Effect of coffee ingestion on catecholamine release. Metabolism 1969; 18: 288–91
  • Otto W., Taylor T. G., York D. Glycerol release in vitro from adipose tissue of obese (ob/ob) mice treated with thyroid hormones. J Endocrinol 1976; 71: 143–55
  • Heinonen O. Carnitine and physical exercise. Sports Med 1996; 22: 109–32
  • Ferrari R., Merli E., Cicchitelli G., et al. Therapeutic effects of l‐carnitine and propionyl‐l‐carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci 2004; 1033: 79–91
  • Baccard N., Mechiche H., Nazeyrollas P., et al. Effects of 7‐hydroxycoumarin (umbelliferone) on isolated perfused and ischemic‐reperfused rat heart. Arzneimittelforschung 2000; 50: 890–6
  • Borzeix M. G., Angignard J., Dedieu F., et al. Effect of a combination of coumarin derivatives and rutoside on venous and lymphatic circulations during severe constriction of the caudal vena cava in rabbits. Arzneimittelforschung 1995; 45: 262–6
  • Casley‐Smith J. R., Casley‐Smith J. High‐protein oedemas and the benzo‐pyrones. JB Lippincott, SidneyAustralia 1986
  • Piller N. B. Lymphoedema, macrophages and benzopyrones. Lymphology 1980; 13: 109–19
  • McKenna D. J., Jones K., Hughes K. Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern Ther Health Med 2001; 7: 70–86; 88–90
  • Boelsma E., Lamers R. J., Hendriks H. F., et al. Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans. Planta Med 2004; 70: 1052–7
  • Leonhardt H., Grigoleit H. Effects of pentoxifylline on red blood cell deformability and blood viscosity under hyperosmolar conditions. Naunyn Schmiedebergs Arch Pharmacol 1977; 299: 197–200
  • Arner P., Bolinder J., Eliasson A., et al. Microdialysis of adipose tissue and blood for in vivo lipolysis studies. Am J Physiol 1988; 255: E737–42
  • Stich V., Pelikanova T., Wohl P., et al. Activation of alpha2‐adrenergic receptors blunts epinephrine‐induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic euglycemic clamp in men. Am J Physiol 2003; 285: E599–607
  • Boschmann M., Krupp G., Luft F. C., et al. In vivo response to alpha(1)‐adrenoreceptor stimulation in human white adipose tissue. Obesity Res 2002; 10: 555–8
  • Millet L., Barbe P., Lafontan M., et al. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue. J Appl Physiol 1998; 85: 181–8
  • Arner P., Kriegholm E., Engfeldt P. In situ studies of catecholamine‐induced lipolysis in human adipose tissue using microdialysis. J Pharmacol Exp Ther 1990; 254: 284–8
  • Enoksson S., Blaak E., Arner P. Forskolin potentiates isoprenaline‐induced glycerol output and local blood flow in human adipose tissue in vivo. Pharmacol Toxicol 1997; 81: 214–18
  • Large V., Reynisdottir S., Eleborg L., et al. Lipolysis in human fat cells obtained under local and general anesthesia. Int J Obes Relat Metab Disord 1997; 21: 78–82
  • Smith U., Isaksson O., Nyberg G., et al. Human adipose tissue in culture. IV. Evidence for the formation of a hormone antagonist by catecholamines. Eur J Clin Invest 1976; 6: 35–42
  • Matuszek M. Studies on antilipolytic activity of antipyretics. Part II. Influence of sodium salicylate, aminophenazone, and acetophenidin on lipolysis stimulated by noradrenaline and aminophylline in vitro. Pol J Pharmacol Pharm 1976; 28: 437–42
  • Arciero P. J., Gardner A. W., Calles‐Escandon J., et al. Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men. Am J Physiol 1995; 268: E1192–8
  • Acheson K. J., Gremaud G., Meirim I., et al. Metabolic effects of caffeine in humans: Lipid oxidation or futile cycling?. Am J Clin Nutr 2004; 79: 40–6
  • Costill D. L., Dalsky G. P., Fink W. Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports 1978; 10: 155–8
  • Scotini E., Carpenedo F., Fassina G. New derivatives of methyl‐xanthines: effect of thiocaffeine thiotheophylline and 8‐phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacol Res Commun 1983; 15: 131–43
  • Nedvidkova J., Haluzik M., Bartak V., et al. Changes of noradrenergic activity and lipolysis in the subcutaneous abdominal adipose tissue of hypo‐ and hyperthyroid patients: an in vivo microdialysis study. Ann N Y Acad Sci 2004; 1018: 541–9
  • Haluzik M., Nedvidkova J., Bartak V., et al. Effects of hypo‐ and hyperthyroidism on noradrenergic activity and glycerol concentrations in human subcutaneous abdominal adipose tissue assessed with microdialysis. J Clin Endocrinol Metabol 2003; 88: 5605–8
  • Dyck D. Dietary fat intake, supplements, and weight loss. Can J Appl Physiol 2000; 25: 495–523
  • Gimble J., Guilak F. Adipose‐derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 2003; 5: 362–9
  • Boschert M. T., Beckert B. W., Puckett C. L., et al. Analysis of lipocyte viability after liposuction. Plast Reconstr Surg 2002; 109: 761–5
  • Monzon J. R., Basile R., Heneghan S., et al. Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obes Res 2002; 10: 266–9
  • Chung J. H., Seo J. Y., Choi H. R., et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 2001; 117: 1218–24
  • Brennan M., Bhatti H., Nerusu K. C., et al. Matrix metalloproteinase‐1 is the major collagenolytic enzyme responsible for collagen damage in UV‐irradiated human skin. Photochem Photobiol 2003; 78: 43–8
  • Gerut Z. Lypolysin: the enzymatic dissolution of human fat in the lipoma model. 2003, Research and Innovations in Technology luncheon of the American Society for Aesthetic Plastic Surgery. Boston, MA
  • Alkrad J. A., Mrestani Y., Stroehl D., et al. Characterization of enzymatically digested hyaluronic acid using NMR, Raman, IR, and UV‐Vis spectroscopies. J Pharm Biomed Anal 2003; 31: 545–50
  • Soparkar C. N., Patrinely J. R., Tschen J. Erasing restylane. Ophthal Plast Reconstr Surg 2004; 20: 317–18
  • Casley‐Smith J. R., Morgan R. G., Piller N. Treatment of lymphedema of the arms and legs with 5,6‐benzo‐a‐pyrone. N Engl J Med 1993; 329: 1158–63
  • Loprinzi C. L., Kugler J. W., Sloan J. A., et al. Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. N Engl J Med 1999; 340: 346–50
  • Casley‐Smith J. Benzo‐pyrones in the treatment of lymphoedema. Int Angiol 1999; 18: 31–41
  • Casley‐Smith J. Treatment of lymphedema by complex physical therapy, with and without oral and topical benzopyrones: what should therapists and patients expect. Lymphology 1996; 29: 76–82
  • Plesca‐Manea L., Parvu A. E., Parvu M., et al. Effects of Melilotus officinalis on acute inflammation. Phytother Res 2002; 16: 316–19
  • Pastura G., Mesiti M., Saitta M., et al. Lymphedema of the upper extremity in patients operated for carcinoma of the breast: clinical experience with coumarinic extract from Melilotus officinalis. Clin Ter 1999; 150: 403–8
  • Ahlemeyer B., Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci 2003; 60: 1779–92
  • Mehlsen J., Drabaek H., Wiinberg N., Winther K. Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers. Clin Physiol Funct Imaging 2002; 22: 375–8
  • Coe D. A., Freischlag J. A., Johnson D., et al. Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. J Surg Res 1997; 67: 21–5
  • Pickens J. P., Rodman S. M., Wetmore S. The effects of extended perioperative pentoxifylline on random skin flap survival. Am J Otolaryngol 1994; 15: 358–69
  • Karacaoglan N., Akbas H. Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival. Otolaryngol Head Neck Surg 1999; 120: 272–4
  • Li H., Xia N., Brausch I., et al. Flavonoids from artichoke (Cynara scolymus L.) up‐regulate endothelial‐type nitric‐oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther 2004; 310: 926–32
  • Grande S., Bogani P., de Saizieu A., et al. Vasomodulating potential of mediterranean wild plant extracts. J Agric Food Chem 2004; 52: 5021–6
  • Coleman W. P., Hanke C. W., AltTH, et al. Liposuction cosmetic surgery of the skin: Principles and practice. BC Decker, Inc., Philadelphia, PA 1991; 213–38
  • Arner P., Kriegholm E., Engfeldt P. In vivo interactions between beta‐1 and beta‐2 adrenoreceptors regulate catecholamine tachyphylaxia in human adipose tissue. J Pharmacol Exp Ther 1991; 259: 317–22

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