Idiopathic vaginal bleeding during pregnancy as the only clinical manifestation of intrauterine infection

References

• Ananth CV, Savitz DA. Vaginal bleeding and adverse reproductive outcomes: A meta-analysis. Paediatr Perinat Epidemiol 1994;8:62–78.
   PubMed Web of Science ®Google Scholar
• Harger JH, Hsing AW, Tuomala RE, et al. Risk factors for preterm premature rupture of fetal membranes: A multicenter case-control study. Am J Obstet Gynecol 1990;163:130–137.
   PubMed Web of Science ®Google Scholar
• Sipila P, Hartikainen-Sorri AL, Oja H, et al. Perinatal outcome of pregnancies complicated by vaginal bleeding. Br J Obstet Gynaecol 1992;99:959–963.
   PubMedGoogle Scholar
• Strobino B, Pantel-Silverman J. Gestational vaginal bleeding and pregnancy outcome. Am J Epidemiol 1989;129:806–815.
   PubMed Web of Science ®Google Scholar
• Williams MA, Hickok DE, Zingheim RW, et al. Low birth weight and preterm delivery in relation to early-gestation vaginal bleeding and elevated maternal serum alpha-fetopro-tein. Obstet Gynecol 1992;80:745–749.
   PubMed Web of Science ®Google Scholar
• Romero R, Hanaoka S, Mazor M, et al. Meconium-stained amniotic fluid: a risk factor for microbial invasion of the amniotic cavity. Am J Obstet Gynecol 1991;164:859–862.
   PubMed Web of Science ®Google Scholar
• Alger LS, Kisner HJ, Nagey DA. The presence of a meconium-like substance in second-trimester amniotic fluid. Am J Obstet Gynecol 1984;150:380–385.
   Google Scholar
• Zorn EM, Hanson FW, Greve LC, et al. Analysis of the significance of discolored amniotic fluid detected at mid-trimester amniocentesis. Am J Obstet Gynecol 1986;154: 1234–1240.
   PubMed Web of Science ®Google Scholar
• Darby MJ, Caritis SN, Shen-Schwarz S. Placental abruption in the preterm gestation: An association with chorioamnioni-tis. Obstet Gynecol 1989;74:88–92.
   Google Scholar
• De Felice C, Toti P, Picciolini E, et al. High incidence of histologic chorioamnionitis in women with gestational vaginal bleeding. Acta Obstet Gynecol Scand 1997;76:85–86.
   PubMed Web of Science ®Google Scholar
• Rana A, Sawhney H, Gopalan S, et al. Abruptio placentae and chorioamnionitis-microbiological and histologic correlation. Acta Obstet Gynecol Scand 1999;78:363–366.
   PubMed Web of Science ®Google Scholar
• Romero R, Emamian M, Quintero R, et al. The value and limitations of the Gram stain examination in the diagnosis of intraamniotic infection. Am J Obstet Gynecol 1988;159:114–119.
   PubMed Web of Science ®Google Scholar
• Romero R, Jimenez C, Lohda AK, et al. Amniotic fluid glucose concentration: A rapid and simple method for the detection of intraamniotic infection in preterm labor. Am J Obstet Gynecol 1990;163:968–974.
   PubMed Web of Science ®Google Scholar
• Romero R, Quintero R, Nores J, et al. Amniotic fluid white blood cell count: A rapid and simple test to diagnose microbial invasion of the amniotic cavity and predict preterm delivery. Am J Obstet Gynecol 1991;165:821–830.
   PubMed Web of Science ®Google Scholar
• Gibbs RS, Blanco JD, St Clair PJ, et al. Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis 1982;145:1–8.
   PubMed Web of Science ®Google Scholar
• Pacora P, Chaiworapongsa T, Maymon E, et al. Funisitis and chorionic vasculitis: The histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2002;11:18–25.
   PubMedGoogle Scholar
• Eskes TK. Abruptio placentae. A 'classic' dedicated to Elizabeth Ramsey. Eur J Obstet Gynecol Reprod Biol 1997;75:63–70.
   PubMed Web of Science ®Google Scholar
• Reece EA, Chervenak FA, Moya FR, et al. Amniotic fluid arborization: Effect of blood, meconium, and pH alterations. Obstet Gynecol 1984;64:248–250.
   PubMed Web of Science ®Google Scholar
• Gomez R, Romero R, Edwin SS, et al. Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. Infect Dis Clin North Am 1997;11:135–176.
   PubMed Web of Science ®Google Scholar
• Romero R, Sirtori M, Oyarzun E, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraam-niotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989;161:817–824.
   Google Scholar
• Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3–13.
   PubMedGoogle Scholar
• Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998;179:1254–1260.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Chang JW, Romero R. Isolation of Ureaplasma urealyticum from the amniotic cavity and adverse outcome in preterm labor. Obstet Gynecol 1998;92:77–82.
   Google Scholar
• Yoon BH, Romero R, Kim M, et al. Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol 2000;183:1130–1137.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Lim JH, et al. The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol 2003;189:919–924.
   PubMed Web of Science ®Google Scholar
• McKennett M, Fullerton JT. Vaginal bleeding in pregnancy. Am Fam Physician 1995;51:639–646.
   PubMed Web of Science ®Google Scholar
• Nielson EC, Varner MW, Scott JR. The outcome of pregnancies complicated by bleeding during the second trimester. Surg Gynecol Obstet 1991;173:371–374.
   Google Scholar
• Leigh J, Garite TJ. Amniocentesis and the management of premature labor. Obstet Gynecol 1986;67:500–506.
   PubMed Web of Science ®Google Scholar
• Hitti J, Tarczy-Hornoch P, Murphy J, et al. Amniotic fluid infection, cytokines, and adverse outcome among infants at 34 weeks' gestation or less. Obstet Gynecol 2001;98:1080–1088
   PubMed Web of Science ®Google Scholar
• Jacobsson B, Mattsby-Baltzer I, Andersch B, et al. Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women in preterm labor. Acta Obstet Gynecol Scand 2003;82:120–128.
   PubMed Web of Science ®Google Scholar
• Javert CT. Decidual bleeding in pregnancy. Ann N Y Acad Sci 1955;61:700–712
   PubMed Web of Science ®Google Scholar
• Romero R, Wu YK, Brody DT, et al. Human decidua: A source of interleukin-1. Obstet Gynecol 1989;73:31–34.
   PubMed Web of Science ®Google Scholar
• Romero R, Mazor M, Manogue K, et al. Human decidua: A source of cachectin-tumor necrosis factor. Eur J Obstet Gynecol Reprod Biol 1991;41:123–127.
   PubMed Web of Science ®Google Scholar
• Esmon CT. Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. Baillieres Best Pract Res Chin Haematol 1999;12:343–359.
   PubMed Web of Science ®Google Scholar
• Esmon CT. Does inflammation contribute to thrombotic events? Haemostasis 2000;30 (Suppl. 2):34–40.
   Google Scholar
• Phillippe M, Elovitz M, Saunders T. Thrombin-stimulated uterine contractions in the pregnant and nonpregnant rat. J Soc Gynecol Investig 2001;8:260–265.
   PubMedGoogle Scholar
• Elovitz MA, Saunders T, Ascher-Landsberg J, et al. Effects of thrombin on myometrial contractions in vitro and in vivo. Am J Obstet Gynecol 2000;183:799–804.
   PubMed Web of Science ®Google Scholar
• Elovitz MA, Ascher-Landsberg J, Saunders T, et al. The mechanisms underlying the stimulatory effects of thrombin on myometrial smooth muscle. Am J Obstet Gynecol 2000;183: 674–681.
   PubMed Web of Science ®Google Scholar
• Elovitz MA, Baron J, Phillippe M. The role of thrombin in preterm parturition. Am J Obstet Gynecol 2001;185:1059–1063.
   PubMed Web of Science ®Google Scholar
• Rosen T, Schatz F, Kuczynski E, et al. Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the mem-branes. J Matern Fetal Neonatal Med 2002;11:11–17.
   PubMedGoogle Scholar
• Bryant-Greenwood GD, Yamamoto SY. Control of peripartal collagenolysis in the human chorion-decidua. Am J Obstet Gynecol 1995;172:63–70.
   PubMed Web of Science ®Google Scholar
• Vadillo-Ortega F, Gonzalez-Avila G, Karchmer S, et al. Collagen metabolism in premature rupture of amniotic membranes. Obstet Gynecol 1990;75:84–88.
   PubMed Web of Science ®Google Scholar
• Vadillo-Ortega F, Gonzalez-Avila G, Furth EE, et al. 92-kd type IV collagenase (matrix metalloproteinase-9) activity in human amniochorion increases with labor. Am J Pathol 1995;146:148–156.
   PubMed Web of Science ®Google Scholar
• Fortunato SJ, Menon R Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes. Am J Obstet Gynecol 2001;184:1399–1405.
   PubMed Web of Science ®Google Scholar
• McGregor JA, French JI, Lawellin D, et al. Bacterial protease-induced reduction of chorioamniotic membrane strength and elasticity. Obstet Gynecol 1987;69:167–174.
   PubMed Web of Science ®Google Scholar
• Lei H, Furth EE, Kalluri R, et al. A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor. J Chin Invest 1996;98:1971–1978.
   PubMed Web of Science ®Google Scholar
• Fortunato SJ, Menon R. IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6. Placenta 2003;24:922–928.
   PubMed Web of Science ®Google Scholar
• Fortunato SJ, Menon R, Bryant C, et al. Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes. Am J Obstet Gynecol 2000;182:1468–1476.
   PubMed Web of Science ®Google Scholar
• Fortunato SJ, Menon R, Lombardi SJ. Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathways. Am J Obstet Gynecol 2002;187: 1159–1162.
   Google Scholar
• Athayde N, Edwin SS, Romero R, et al. A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes. Am J Obstet Gynecol 1998;179:1248–1253.
   PubMed Web of Science ®Google Scholar
• Maymon E, Romero R, Pacora P, et al. Evidence for the participation of interstitial collagenase (matrix metalloprotei-nase 1) in preterm premature rupture of membranes. Am J Obstet Gynecol 2000;183:914–920.
   PubMed Web of Science ®Google Scholar
• Maymon E, Romero R, Chaiworapongsa T, et al. Amniotic fluid matrix metalloproteinase-8 in preterm labor with intact membranes. Am J Obstet Gynecol 2001;185:1149–1155.
   PubMed Web of Science ®Google Scholar
• Helmig BR, Romero R, Espinoza J, et al. Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection. J Matern Fetal Neonatal Med 2002;12:237–246.
   PubMedGoogle Scholar
• Lockwood CJ, Krikun G, Aigner S, et al. Effects of thrombin on steroid-modulated cultured endometrial stromal cell fibrinolytic potential. J Chin Endocrinol Metab 1996;81:107–112.
   PubMed Web of Science ®Google Scholar