A significant linear association exists between nuchal translucency thickness and adverse perinatal outcome in euploid fetuses

References

• Nicolaides K H, Azar G, Byrne D, Mansur C, Marks K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. BMJ 1992; 304: 867–869
   PubMed Web of Science ®Google Scholar
• Snijders R J, Noble P, Sebire N, Souka A, Nicolaides K H. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet 1998; 352: 343–346
   PubMed Web of Science ®Google Scholar
• Snijders R J, Sundberg K, Holzgreve W, Henry G, Nicolaides K H. Maternal age- and gestation-specific risk for trisomy 21. Ultrasound Obstet Gynecol 1999; 13: 167–170
   PubMed Web of Science ®Google Scholar
• Sheiner E, Levy A, Hershkovitz R, Hallak M, Hammel R D, Katz M, Mazor M. Determining factors associated with shoulder dystocia: a population-based study. Eur J Obstet Gynecol Reprod Biol 2006; 126: 11–15
   PubMed Web of Science ®Google Scholar
• Kagan K O, Avgidou K, Molina F S, Gajewska K, Nicolaides K H. Relation between increased fetal nuchal translucency thickness and chromosomal defects. Obstet Gynecol 2006; 107: 6–10
   PubMed Web of Science ®Google Scholar
• Comstock C H, Malone F D, Ball R H, Nyberg D A, Saade G R, Berkowitz R L, Ferreira J, Dugoff L, Craigo S D, Timor-Tritsch I E, et al. Is there a nuchal translucency millimeter measurement above which there is no added benefit from first trimester serum screening. Am J Obstet Gynecol 2006; 195: 843–847
   PubMed Web of Science ®Google Scholar
• Nicolaides K H. Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004; 191: 45–67
   PubMed Web of Science ®Google Scholar
• Souka A P, Snijders R J, Novakov A, Soares W, Nicolaides K H. Defects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10–14 weeks of gestation. Ultrasound Obstet Gynecol 1998; 11: 391–400
   PubMed Web of Science ®Google Scholar
• Souka A P, Von Kaisenberg C S, Hyett J A, Sonek J D, Nicolaides K H. Increased nuchal translucency with normal karyotype. Am J Obstet Gynecol 2005; 192: 1005–1021
   PubMed Web of Science ®Google Scholar
• Hyett J, Perdu M, Sharland G, Snijders R, Nicolaides K H. Using fetal nuchal translucency to screen for major congenital cardiac defects at 10–14 weeks of gestation: population based cohort study. BMJ 1999; 318: 81–85
   PubMed Web of Science ®Google Scholar
• Sherod C, Sebire N J, Soares W, Snijders R J, Nicolaides K H. Prenatal diagnosis of trisomy 18 at the 10–14-week ultrasound scan. Ultrasound Obstet Gynecol 1997; 10: 387–390
   PubMed Web of Science ®Google Scholar
• Pandya P P, Snijders R J, Johnson S P, De Lourdes B M, Nicolaides K H. Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation. Br J Obstet Gynaecol 1995; 102: 957–962
   PubMedGoogle Scholar
• Maymon R, Jauniaux E, Cohen O, Dreazen E, Weinraub Z, Herman A. Pregnancy outcome and infant follow-up of fetuses with abnormally increased first trimester nuchal translucency. Hum Reprod 2000; 15: 2023–2027
   PubMed Web of Science ®Google Scholar
• Westin M, Saltvedt S, Almstrom H, Grunewald C, Valentin L. By how much does increased nuchal translucency increase the risk of adverse pregnancy outcome in chromosomally normal fetuses? A study of 16,260 fetuses derived from an unselected pregnant population. Ultrasound Obstet Gynecol 2007; 29: 150–158
   PubMed Web of Science ®Google Scholar
• Zoppi M A, Ibba R M, Floris M, Manca F, Axiana C, Monni G. Changes in nuchal translucency thickness in normal and abnormal karyotype fetuses. BJOG 2003; 110: 584–588
   PubMed Web of Science ®Google Scholar
• Michailidis G D, Economides D L. Nuchal translucency measurement and pregnancy outcome in karyotypically normal fetuses. Ultrasound Obstet Gynecol 2001; 17: 102–105
   PubMed Web of Science ®Google Scholar
• Hiippala A, Eronen M, Taipale P, Salonen R, Hiilesmaa V. Fetal nuchal translucency and normal chromosomes: a long-term follow-up study. Ultrasound Obstet Gynecol 2001; 18: 18–22
   PubMed Web of Science ®Google Scholar
• Leipold H, Worda C, Ozbal A, Husslein P, Krampl E. First-trimester nuchal translucency screening in pregnant women who subsequently developed gestational diabetes. J Soc Gynecol Investig 2005; 12: 529–532
   PubMedGoogle Scholar
• Kelekci S, Yilmaz B, Savan K, Sonmez S. Can increased nuchal translucency in the first trimester of pregnancy predict gestational diabetes mellitus. J Obstet Gynaecol 2005; 25: 579–582
   PubMedGoogle Scholar
• Senat M V, De Keersmaecker B, Audibert F, Montcharmont G, Frydman R, Ville Y. Pregnancy outcome in fetuses with increased nuchal translucency and normal karyotype. Prenat Diagn 2002; 22: 345–349
   PubMed Web of Science ®Google Scholar
• Nicolaides K H, Snijders R J, Cuckle H S. Correct estimation of parameters for ultrasound nuchal translucency screening. Prenat Diagn 1998; 18: 519–523
   PubMed Web of Science ®Google Scholar
• Spencer K, Bindra R, Nix A B, Heath V, Nicolaides K H. Delta-NT or NT MoM: which is the most appropriate method for calculating accurate patient-specific risks for trisomy 21 in the first trimester. Ultrasound Obstet Gynecol 2003; 22: 142–148
   PubMed Web of Science ®Google Scholar
• Nicolaides K H, Heath V, Cicero S. Increased fetal nuchal translucency at 11–14 weeks. Prenat Diagn 2002; 22: 308–315
   PubMed Web of Science ®Google Scholar
• Haak M C, van Vugt J M. Pathophysiology of increased nuchal translucency: a review of the literature. Hum Reprod Update 2003; 9: 175–184
   PubMed Web of Science ®Google Scholar
• Plante G E, Chakir M, Ettaouil K, Lehoux S, Sirois P. Consequences of alteration in capillary permeability. Can J Physiol Pharmacol 1996; 74: 824–833
   PubMed Web of Science ®Google Scholar
• Brausewetter F, Jehle P M, Jung M F, Boehm B O, Brueckel J, Hombach V, Osterhues H H. Microvascular permeability is increased in both types of diabetes and correlates differentially with serum levels of insulin-like growth factor I (IGF-I) and vascular endothelial growth factor (VEGF). Horm Metab Res 2001; 33: 713–720
   PubMed Web of Science ®Google Scholar
• Bartha J L, Wood J, Kyle P M, Soothill P W. The effect of metabolic control on fetal nuchal translucency in women with insulin-dependent diabetes: a preliminary study. Ultrasound Obstet Gynecol 2003; 21: 451–454
   PubMed Web of Science ®Google Scholar
• Bilardo C M, Muller M A, Pajkrt E, Clur S A, van Zalen M M, Bijlsma E K. Increased nuchal translucency thickness and normal karyotype: time for parental reassurance. Ultrasound Obstet Gynecol 2007; 30: 11–18
   PubMed Web of Science ®Google Scholar